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Comparison Of Assays For Measuring Plasma Paracetamol. Possibility Of Calibration Error Needs Evaluation, Alison L. Jones, D R. Jarvie, D Simpson, L F. Prescott
Comparison Of Assays For Measuring Plasma Paracetamol. Possibility Of Calibration Error Needs Evaluation, Alison L. Jones, D R. Jarvie, D Simpson, L F. Prescott
Graduate School of Medicine - Papers (Archive)
Egleston et al report a significant difference in plasma paracetamol concen trations assayed with the AcetaSite bench assay and a standard laboratory assay. Rapid and accurate determinations of plasma paracetamol concentrations are crucial in the expeditious and appropriate administration of antidotal treatment, which prevents severe liver damage if given sufficiently early in the course of poisoning.
Evidence Of Multiple Mechanisms Of Avermectin Resistance In Haemonchus Contortus--Comparison Of Selection Protocols, Jennifer H. Gill, Caroline A. Kerr, Wesley L. Shoop, Ernest Lacey
Evidence Of Multiple Mechanisms Of Avermectin Resistance In Haemonchus Contortus--Comparison Of Selection Protocols, Jennifer H. Gill, Caroline A. Kerr, Wesley L. Shoop, Ernest Lacey
Graduate School of Medicine - Papers (Archive)
Three isolates of Haemonchus contortus selected for avermectin resistance in sheep were compared in three in vitro pharmacological tests previously shown to discriminate between field isolates of H. contortus resistant and susceptible to the avermectins. Two isolates, F7-A and IVC, were selected for avermectin resistance in the laboratory from a reference susceptible isolate using suboptimal doses of ivermectin (LD95) for 7 and 16 generations, respectively. In these isolates avermectin resistance was not associated with a decreased sensitivity to avermectin inhibition of larval development or L3 motility but was associated with an increased sensitivity to paraherquamide. The third isolate, Warren, was …