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Uow Outlook, University Of Wollongong Dec 2013

Uow Outlook, University Of Wollongong

Wollongong Outlook: The University Alumni Magazine

No abstract provided.


The National And The Transnational In British Anti-Suffragists’ Views Of Australian Women Voters, Sharon Crozier-De Rosa Dec 2013

The National And The Transnational In British Anti-Suffragists’ Views Of Australian Women Voters, Sharon Crozier-De Rosa

Faculty of Law, Humanities and the Arts - Papers (Archive)

The issue of woman suffrage, and the unevenness of its development worldwide, provoked much heated discussion in the early twentieth century. In Britain women were campaigning – often violently – for the vote, while in the antipodes women already had at least the national vote. This paper looks at national and transnational aspects of this debate as it was played out in the pages of the British Anti-Suffrage Review. It looks at how conservatives in the British metropole were compelled to articulate, even reformulate, their sense of national and imperial identity in light of the existence of the Australian woman …


A Knowledge Economy Approach In Empirical Growth Models For The Nordic Countries, Arusha Cooray, Marcella Lucchetta, Antonio Paradiso Dec 2013

A Knowledge Economy Approach In Empirical Growth Models For The Nordic Countries, Arusha Cooray, Marcella Lucchetta, Antonio Paradiso

Faculty of Business - Economics Working Papers

We estimate, employing a “knowledge economy” approach, the steady state growth rate for the Nordic countries. An endogenous growth framework is developed, in which total factor productivity is a function of human capital (measured by average years of education), trade openness, research and development, and investment ratio. We identify the key variables having a significant level and growth effects within this framework. We find that education plays an important role on the long-run growth rates of Sweden, Norway, and Denmark; trade openness, instead, has growth effects in Sweden, Finland, and Iceland. The investment ratio is able to explain patterns of …


Core-Leaf Onion-Like Carbon/Mno2 Hybrid Nano-Urchins For Rechargeable Lithium-Ion Batteries, Ye Wang, Zhao Jun Han, Siu Fung Yu, Ran Ran Song, Huai He Song, Kostya (Ken) Ostrikov, Hui Ying Yang Nov 2013

Core-Leaf Onion-Like Carbon/Mno2 Hybrid Nano-Urchins For Rechargeable Lithium-Ion Batteries, Ye Wang, Zhao Jun Han, Siu Fung Yu, Ran Ran Song, Huai He Song, Kostya (Ken) Ostrikov, Hui Ying Yang

Australian Institute for Innovative Materials - Papers

A hybrid nano-urchin structure consisting of spherical onion-like carbon and MnO2 nanosheets is synthesized by a facile and environmentally-friendly hydrothermal method. Lithium-ion batteries incorporating the hybrid nano-urchin anode exhibit reversible lithium storage with superior specific capacity, enhanced rate capability, stable cycling performance, and nearly 100% Coulombic efficiency. These results demonstrate the effectiveness of designing hybrid nano-architectures with uniform and isotropic structure, high loading of electrochemically-active materials, and good conductivity for the dramatic improvement of lithium storage.


Magnetic Properties And Magnetocaloric Effect Of Ndmn2−Xtixsi2 Compounds, M F. Md Din, Jianli Wang, S J. Campbell, R Zeng, W D. Hutchison, M Avdeev, S J. Kennedy, S X. Dou Oct 2013

Magnetic Properties And Magnetocaloric Effect Of Ndmn2−Xtixsi2 Compounds, M F. Md Din, Jianli Wang, S J. Campbell, R Zeng, W D. Hutchison, M Avdeev, S J. Kennedy, S X. Dou

Australian Institute for Innovative Materials - Papers

The structural and magnetic properties of the intermetallic compounds NdMn2−xTixSi2(x = 0, 0.1, 0.2, and 0.3) have been studied by x-ray and high resolution neutron powder diffraction, specific heat, dc magnetization, and differential scanning calorimetry measurements over the temperature range 3–450 K. The Curie temperature and Néel temperature of NdMn2Si2 decrease from TC = 36 K and TN = 380 K to TC = 14 K and TN = 360 K, respectively, on substitution of Ti (x = 0.3) for Mn. The magnetocaloric effect …


Actor Training Across Cultures: The Interplace In Actor Training (Keynote Address - Apb Forum), Janys Hayes Sep 2013

Actor Training Across Cultures: The Interplace In Actor Training (Keynote Address - Apb Forum), Janys Hayes

Faculty of Law, Humanities and the Arts - Papers (Archive)

A friend recently told me that he taught a condensed course in Acting at the Australian Film and Television School, in Sydney, specifically designed for film directors in which he introduced film directors to 12 differing methods of actor training. The methods ranged over Russian techniques, Japanese techniques, a Brazilian method and several American methods. Yes. There is a multitude of actor training methods and if one searches historically there are even more to be found from the past.


The Premium For Part-Time Work In Australia, Iris Day, Joan Rodgers Sep 2013

The Premium For Part-Time Work In Australia, Iris Day, Joan Rodgers

Faculty of Business - Economics Working Papers

Booth and Wood (2008), using longitudinal data from 2001 through 2004, found a large part-time wage premium for both men and women in Australia. Longitudinal studies of the full-time/part-time wage differential in other countries find small penalties or premiums, or no significant wage differentials. The objective of this paper is to explain the nature of the premium in Australia. We find the premium is pervasive across age groups, occupations and industries. It is not explained by the way part-time work is defined, or by the pay loading received in Australia by employees on casual contracts. We find substantial hourly wage …


Systematic Enso-Driven Nutrient Variability Recorded By Central Equatorial Pacific Corals, Michele Lavigne, Intan S. Nurhati, Kim M. Cobb, Helen V. Mcgregor, Daniel Sinclair, Robert M. Sherrell Aug 2013

Systematic Enso-Driven Nutrient Variability Recorded By Central Equatorial Pacific Corals, Michele Lavigne, Intan S. Nurhati, Kim M. Cobb, Helen V. Mcgregor, Daniel Sinclair, Robert M. Sherrell

Faculty of Science, Medicine and Health - Papers: part A

[1] Variations in ocean productivity are driven largely by nutrient supply to the photic zone, but temporal records of nutrient variability are sparse. Here we show scleractinian coral P/Ca proxy records of variations in phosphate concentrations during El Niño Southern Oscillation (ENSO) cycles in the central equatorial Pacific. Covarying P/Ca records in Porites corals from Christmas and Fanning Islands show a regional ~40% decrease during the upwelling relaxation of the 1997–1998 El Niño, consistent with less frequent nutrient measurements from this area. Similar ~35–45% skeletal P/Ca decreases occur during the 1982–1983 and 1986–1987 El Niño events, which predate satellite color …


Family Impacts On Cognitive Development Of Young Children: Evidence From Australia, Jessica Meredith, Frank Neri, Joan Rodgers Aug 2013

Family Impacts On Cognitive Development Of Young Children: Evidence From Australia, Jessica Meredith, Frank Neri, Joan Rodgers

Faculty of Business - Economics Working Papers

This paper investigates the manner and extent to which family structure impacts upon the cognitive development of young Australian children. Our methodology draws on the standard household production model of Becker but also includes control variables emphasised by parental investment and good-parent theories of child development. We use data from the Longitudinal Study of Australian Children (LSAC) and from the National Assessment Program – Literacy and Numeracy (NAPLAN) in cross sectional, panel, instrumental variables and fixed-effects analyses. Our results suggest that the large negative effects initially associated with single parent families disappear when child characteristics and parental preferences for education …


Would A Rational Underage Binge-Drink?, Amnon Levy Aug 2013

Would A Rational Underage Binge-Drink?, Amnon Levy

Faculty of Business - Economics Working Papers

This paper provides a utility-based definition of binge drinking and examines the compatibility of this phenomenon with rational decision making. Prohibition of young people’s consumption of alcohol is frequently violated with binge-drinking in groups. The analysis considers the roles of peer-pressure, full price of alcohol and crowding in underage group-drinking sessions and identifies the conditions for binge-drinking by expected utility maximizing members. Rational binge-drinking occurs when the impact of the peer-pressure on the individual member’s utility exceeds the loss of utility from the forgone spending on all other goods associated with the expected full marginal cost of consuming alcohol.


Crossing Cultures: A Vietnamese Experience, Janys Hayes Jul 2013

Crossing Cultures: A Vietnamese Experience, Janys Hayes

Faculty of Law, Humanities and the Arts - Papers (Archive)

Intercultural theatrical performances, groups and workshops are not unusual events in Ho Chi Minh City despite an artistic environment still highly censored by government intervention. Performance collaborations between international theatre artists and Vietnamese practitioners have been facilitated through policies promoting international ‘educational’ exchange projects. In November 2011, I was invited to Ho Chi Minh City, by Australian-trained theatre director Le Quy Duong to lead a 10-day theatrical workshop, introducing western theatrical training techniques to his students. The LeQuyDuong Company is a festival events company, working across Vietnamese provinces to produce large-scale festival performance works. The nature and extent of my …


Rapid Cascade Synthesis Of Poly-Heterocyclic Architectures From Indigo, Alireza Shakoori Ghasabi, John Bremner, Anthony C. Willis, Rachada Haritakun, Paul A. Keller Jun 2013

Rapid Cascade Synthesis Of Poly-Heterocyclic Architectures From Indigo, Alireza Shakoori Ghasabi, John Bremner, Anthony C. Willis, Rachada Haritakun, Paul A. Keller

Faculty of Science, Medicine and Health - Papers: part A

The base-induced propargylation of the dye indigo results in the rapid and unprecedented one-pot synthesis of highly functionalized representatives of the pyrazino[1,2-a:4,3-a′]diindole, pyrido[1,2-a:3,4-b′]diindole and benzo[b]indolo[1,2-h]naphthyridine heterocyclic systems, with the last two reflecting the core skeleton of the anticancer/antiplasmodial marine natural products fascaplysin and homofascaplysins and a ring B-homologue, respectively. The polycyclic compounds 6–8, whose structures were confirmed through single-crystal X-ray crystallographic analysis, arise from sequential inter/intramolecular substitution–addition reactions, and in some cases, ring rearrangement reactions. Preliminary studies on controlling the reaction path selectivity, and the potential reaction mechanisms, are also described. Initial biological activity studies with these new heterocyclic derivatives …


Blog: Petty Politics Overshadows Policy, Anthony Ashbolt Jun 2013

Blog: Petty Politics Overshadows Policy, Anthony Ashbolt

Faculty of Law, Humanities and the Arts - Papers (Archive)

The coming federal election is already highlighting aspects of Australian politics that are cause for concern. The "mock menu" (which initially was thought to be for a Liberal Party fundraising dinner) with its vulgar and demeaning reference to our Prime Minister is not only ample confirmation of Julia Gillard’s argument about misogyny but also a further signal of the decline of civility in Australian political life. When school children see it as somehow natural to throw sandwiches at the Prime Minister, we can sense this decline vividly. The media are partly responsible for this, whipping up hysteria around all sorts …


Rates Of Shoreline Change Along The Coast Of Bangladesh, Md. Golam Mahabub Sarwar, Colin D. Woodroffe May 2013

Rates Of Shoreline Change Along The Coast Of Bangladesh, Md. Golam Mahabub Sarwar, Colin D. Woodroffe

Faculty of Science, Medicine and Health - Papers: part A

Bangladesh, at the confluence of the sediment-laden Ganges and Brahmaputra Rivers, supports an enormous and rapidly growing population (>140 million in 2011), across low-lying alluvial and delta plains that have accumulated over the past few thousand years. It has been identified as one of the most vulnerable places in the world to the impacts of climate change and sea-level rise. Although abundant sediment supply has resulted in accretion on some parts of the coast of Bangladesh, others are experiencing rapid erosion. We report a systematic assessment of rates of shoreline change over a 20-year period from 1989 to 2009, …


Concise Synthesis Of (-)-Steviamine And Analogues And Their Glycosidase Inhibitory Activities, Nadechanok Jiangseubchatveera, Marc E. Bouillon, Boonsom Liawruangrath, Saisunee Liawruangrath, Robert J. Nash, Stephen G. Pyne Apr 2013

Concise Synthesis Of (-)-Steviamine And Analogues And Their Glycosidase Inhibitory Activities, Nadechanok Jiangseubchatveera, Marc E. Bouillon, Boonsom Liawruangrath, Saisunee Liawruangrath, Robert J. Nash, Stephen G. Pyne

Faculty of Science, Medicine and Health - Papers: part A

A concise synthesis of (−)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL−1 concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50–54% inhibition of α-L-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-D-glucosaminidase (from Jack bean) at the same concentration (760 μM).


Uv Photodissociation Action Spectroscopy Of Haloanilinium Ions In A Linear Quadrupole Ion Trap Mass Spectrometer, Christopher S. Hansen, Benjamin B. Kirk, Stephen J. Blanksby, Richard A. J O'Hair, Adam J. Trevitt Apr 2013

Uv Photodissociation Action Spectroscopy Of Haloanilinium Ions In A Linear Quadrupole Ion Trap Mass Spectrometer, Christopher S. Hansen, Benjamin B. Kirk, Stephen J. Blanksby, Richard A. J O'Hair, Adam J. Trevitt

Faculty of Science, Medicine and Health - Papers: part A

UV-vis photodissociation action spectroscopy is becoming increasingly prevalent because of advances in, and commercial availability of, ion trapping technologies and tunable laser sources. This study outlines in detail an instrumental arrangement, combining a commercial ion-trap mass spectrometer and tunable nanosecond pulsed laser source, for performing fully automated photodissociation action spectroscopy on gas-phase ions. The components of the instrumentation are outlined, including the optical and electronic interfacing, in addition to the control software for automating the experiment and performing online analysis of the spectra. To demonstrate the utility of this ensemble, the photodissociation action spectra of 4-chloroanilinium, 4-bromoanilinium, and 4-iodoanilinium cations …


Switching Radical Stability By Ph-Induced Orbital Conversion, Ganna Gryn'ova, David L. Marshall, Stephen J. Blanksby, Michelle L. Coote Apr 2013

Switching Radical Stability By Ph-Induced Orbital Conversion, Ganna Gryn'ova, David L. Marshall, Stephen J. Blanksby, Michelle L. Coote

Faculty of Science, Medicine and Health - Papers: part A

In most radicals the singly occupied molecular orbital (SOMO) is the highest-energy occupied molecular orbital (HOMO); however, in a small number of reported compounds this is not the case. In the present work we expand significantly the scope of this phenomenon, known as SOMO–HOMO energy-level conversion, by showing that it occurs in virtually any distonic radical anion that contains a sufficiently stabilized radical (aminoxyl, peroxyl, aminyl) non-π-conjugated with a negative charge (carboxylate, phosphate, sulfate). Moreover, regular orbital order is restored on protonation of the anionic fragment, and hence the orbital configuration can be switched by pH. Most importantly, our theoretical …


Five Practical Uses Of Spatial Autocorrelation For Studies Of Coral Reef Ecology, S Hamylton Mar 2013

Five Practical Uses Of Spatial Autocorrelation For Studies Of Coral Reef Ecology, S Hamylton

Faculty of Science, Medicine and Health - Papers: part A

The organisation of benthic communities across coral reefs is underpinned by spatially structured ecological processes and neighbourhood interactions such as larval dispersal, migration, competition and the spread of disease. These give rise to spatial autocorrelation in reef communities. This paper demonstrates how the measurement of spatial autocorrelation can profitably be incorporated into studies of coral reef ecology through a series of 5 simple statistical exercises: for the generation of maps depicting the strength of spatial relationships between ecological communities, as an indicator of optimal dimensions for sampling ecological communities on coral reefs, as a diagnostic tool for model misspecification, as …


Biofabrication: An Overview Of The Approaches Used For Printing Of Living Cells, Cameron J. Ferris, Kerry G. Gilmore, Gordon G. Wallace, Marc In Het Panhuis Mar 2013

Biofabrication: An Overview Of The Approaches Used For Printing Of Living Cells, Cameron J. Ferris, Kerry G. Gilmore, Gordon G. Wallace, Marc In Het Panhuis

Faculty of Science, Medicine and Health - Papers: part A

The development of cell printing is vital for establishing biofabrication approaches as clinically relevant tools. Achieving this requires bio-inks which must not only be easily printable, but also allow controllable and reproducible printing of cells. This review outlines the general principles and current progress and compares the advantages and challenges for the most widely used biofabrication techniques for printing cells: extrusion, laser, microvalve, inkjet and tissue fragment printing. It is expected that significant advances in cell printing will result from synergistic combinations of these techniques and lead to optimised resolution, throughput and the overall complexity of printed constructs.


Carbon Dioxide Rebreathing In Respiratory Protective Devices: Influence Of Speech And Work Rate In Full-Face Masks, Carmen L. Smith, Jane L. Whitelaw, Brian Davies Mar 2013

Carbon Dioxide Rebreathing In Respiratory Protective Devices: Influence Of Speech And Work Rate In Full-Face Masks, Carmen L. Smith, Jane L. Whitelaw, Brian Davies

Faculty of Science, Medicine and Health - Papers: part A

Carbon dioxide (CO2) rebreathing has been recognised as a concern regarding respirator use and is related to symptoms of discomfort, fatigue, dizziness, headache, muscular weakness and drowsiness. Previous investigations are limited by small sample size and have not evaluated the relationship between CO2 inhalation and phonic respiration (breathing during speech) in respiratory protective devices (RPDs). A total of 40 workers trained in the use of RPDs performed a graded exercise test on a cycle ergonometer that increased in workload every 5 min. During the third minute of each stage, participants read aloud a prepared text. Measures of mixed expired CO2 …


A More Meaningful Developed Nation By 2020, Eric Loo Mar 2013

A More Meaningful Developed Nation By 2020, Eric Loo

Faculty of Law, Humanities and the Arts - Papers (Archive)

WHERE you from? Where you go?" cab drivers often ask. Depending on which departure city in Asia and who is asking, I would say Malaysia or Australia. Australia is beyond their affordability. Too far and expensive, they say. Malaysia, however, usually strikes a sense of cultural affinity and wonder.

Many have heard of our mega malls, the Petronas Twin Towers, Putrajaya and work opportunities. "Very rich country," they say, comparing their 10-hour six-day week toiling away in the madness of their clogged-up streets and polluted cities to places like Kuala Lumpur.


Diversifying Ethnicity In Australia's Population And Environment Debates, Natascha Klocker, Lesley Head Feb 2013

Diversifying Ethnicity In Australia's Population And Environment Debates, Natascha Klocker, Lesley Head

Faculty of Science, Medicine and Health - Papers: part A

Population–environment debates in Australia are at an impasse. While the ability of this continent to sustain more migrants has attracted persistent scrutiny, nuanced explorations of diverse migrant cultures and their engagements with Australian landscapes have scarcely begun. Yet as we face the challenges of a climate changing world we would undoubtedly benefit from the most varied knowledges we can muster. This paper brings together three arenas of environmental debate circulating in Australia—the immigration/carrying capacity debate, comparisons between Indigenous and Anglo-European modes of environmental interaction, and research on household sustainability dilemmas—to demonstrate the exclusionary tendencies of each. We then attempt to …


Welcome To Bogan-Ville: Reframing Class And Place Through Humour, Chris Gibson Feb 2013

Welcome To Bogan-Ville: Reframing Class And Place Through Humour, Chris Gibson

Faculty of Science, Medicine and Health - Papers: part A

On August 4, 2009, Australian online news commentary website the Punch announced that Albion Park, in the Australian industrial city of Wollongong, was one of the nation's top ten “most bogan” places. This paper explores what it means to be bogan in Australia, tracing historical antecedents, local debate at the time of this media event, and the manner in which the politics of class and place identity are negotiated through humour. Some local residents railed against associations with “lower-class” culture or feared damaged reputations for their neighbourhoods; others responded in sometimes unexpected and creative ways—through humour, and by claiming bogan …


Effects Of Atmospheric Light Scattering On Spectroscopic Observations Of Greenhouse Gases From Space. Part 2: Algorithm Intercomparison In The Gosat Data Processing For Co2 Retrievals Over Tccon Sites, Sergey Oshchepkov, Andrey Bril, Tatsuya Yokota, Paul O. Wennberg, Nicholas M. Deutscher, Debra Wunch, Geoffrey C. Toon, Yukio Yoshida, Christopher W. O'Dell, David Crisp, Charles E. Miller, Christian Frankenberg, Andre Butz, Ilse Aben, Sandrine Guerlet, Otto Hasekamp, Hartmut Boesch, Austin Cogan, Robert Parker, David Griffith, Ronald Macatangay, Justus Notholt, Ralf Sussmann, Markus Rettinger, Vanessa Sherlock, John Robinson, Esko Kyro, Pauli Heikkinen, Dietrich G. Feist, Isamu Morino, Nikolay Kadygrov, Dmitry Belikov, Shamil Maksyutov, Tsuneo Matsunaga, Osamu Uchino, Hiroshi Watanabe Feb 2013

Effects Of Atmospheric Light Scattering On Spectroscopic Observations Of Greenhouse Gases From Space. Part 2: Algorithm Intercomparison In The Gosat Data Processing For Co2 Retrievals Over Tccon Sites, Sergey Oshchepkov, Andrey Bril, Tatsuya Yokota, Paul O. Wennberg, Nicholas M. Deutscher, Debra Wunch, Geoffrey C. Toon, Yukio Yoshida, Christopher W. O'Dell, David Crisp, Charles E. Miller, Christian Frankenberg, Andre Butz, Ilse Aben, Sandrine Guerlet, Otto Hasekamp, Hartmut Boesch, Austin Cogan, Robert Parker, David Griffith, Ronald Macatangay, Justus Notholt, Ralf Sussmann, Markus Rettinger, Vanessa Sherlock, John Robinson, Esko Kyro, Pauli Heikkinen, Dietrich G. Feist, Isamu Morino, Nikolay Kadygrov, Dmitry Belikov, Shamil Maksyutov, Tsuneo Matsunaga, Osamu Uchino, Hiroshi Watanabe

Faculty of Science, Medicine and Health - Papers: part A

This report is the second in a series of companion papers describing the effects of atmospheric light scattering in observations of atmospheric carbon dioxide (CO2) by the Greenhouse gases Observing SATellite (GOSAT), in orbit since 23 January 2009. Here we summarize the retrievals from six previously published algorithms; retrieving column-averaged dry air mole fractions of CO2 (XCO2) during 22 months of operation of GOSAT from June 2009. First, we compare data products from each algorithm with ground-based remote sensing observations by Total Carbon Column Observing Network (TCCON). Our GOSAT-TCCON coincidence criteria select satellite observations within a 5° radius of 11 …


Dinosaur Lactation?, Paul L. Else Feb 2013

Dinosaur Lactation?, Paul L. Else

Faculty of Science, Medicine and Health - Papers: part A

Lactation is a process associated with mammals, yet a number of birds feed their newly hatched young on secretions analogous to the milk of mammals. These secretions are produced from various sections (crop organ, oesophageal lining and proventriculus) of the upper digestive tract and possess similar levels of fat and protein, as well as added carotenoids, antibodies and, in the case of pigeons and doves, epidermal growth factor. Parental care in avian species has been proposed to originate from dinosaurs. This study examines the possibility that some dinosaurs used secretory feeding to increase the rate of growth of their young, …


Sequential Extraction Procedures For The Determination Of Phosphorus Forms In Sediment, Changyou Wang, Yong Zhang, Hongli Li, R John Morrison Jan 2013

Sequential Extraction Procedures For The Determination Of Phosphorus Forms In Sediment, Changyou Wang, Yong Zhang, Hongli Li, R John Morrison

Faculty of Science, Medicine and Health - Papers: part A

This article summarizes the main extraction methods for sedimentary phosphorus (P) determination. With sequential chemical extractions, P is supposed to be selectively removed from different compounds in the sediments. Extraction schemes using strong acids and alkaline solutions have been tested on different sediments and found not to extract well-defined fractions. In addition, several systematic errors in these schemes have been detected. Thus, these schemes have been modified and simplified accordingly. The Standards Measurements and Testing Program of the European Commission (SMT) method is a popular modification of these extraction schemes, as it is simple to handle, allows laboratories to achieve …


Single Molecule Characterization Of The Interactions Between Amyloid-Β Peptides And The Membranes Of Hippocampal Cells, Priyanka Narayan, Kristina A. Ganzinger, James Mccoll, Laura Weimann, Sarah Meehan, Seema Qamar, John A. Carver, Mark R. Wilson, Peter St George-Hyslop, Christopher M. Dobson, David Klenerman Jan 2013

Single Molecule Characterization Of The Interactions Between Amyloid-Β Peptides And The Membranes Of Hippocampal Cells, Priyanka Narayan, Kristina A. Ganzinger, James Mccoll, Laura Weimann, Sarah Meehan, Seema Qamar, John A. Carver, Mark R. Wilson, Peter St George-Hyslop, Christopher M. Dobson, David Klenerman

Faculty of Science, Medicine and Health - Papers: part A

Oligomers of the 40 and 42 residue amyloid-β peptides (Aβ40 and Aβ42) have been implicated in the neuronal damage and impaired cognitive function associated with Alzheimer’s disease. However, little is known about the specific mechanisms by which these misfolded species induce such detrimental effects on cells. In this work, we use single-molecule imaging techniques to examine the initial interactions between Aβ monomers and oligomers and the membranes of live cells. This highly sensitive method enables the visualization of individual Aβ species on the cell surface and characterization of their oligomerization state, all at biologically relevant, nanomolar concentrations. The results indicate …


Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman Jan 2013

Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman

Faculty of Science, Medicine and Health - Papers: part A

CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a …


Food Synergy: The Key To A Healthy Diet, David R. Jacobs Jr, Linda C. Tapsell Jan 2013

Food Synergy: The Key To A Healthy Diet, David R. Jacobs Jr, Linda C. Tapsell

Faculty of Science, Medicine and Health - Papers: part A

Food synergy is the concept that the non-random mixture of food constituents operates in concert for the life of the organism eaten and presumably for the life of the eater. Isolated nutrients have been extensively studied in well-designed, long-term, large randomised clinical trials, typically with null and sometimes with harmful effects. Therefore, although nutrient deficiency is a known phenomenon, serious for the sufferer, and curable by taking the isolated nutrient, the effect of isolated nutrients or other chemicals derived from food on chronic disease, when that chemical is not deficient, may not have the same beneficial effect. It appears that …


Synthesis, Characterization, And Photophysics Of Oxadiazole- And Diphenylaniline-Substituted Re(I) And Cu(I) Complexes, Raphael Horvath, Michael G. Fraser, Scott A. Cameron, Allan G. Blackman, Pawel Wagner, David L. Officer, Keith C. Gordon Jan 2013

Synthesis, Characterization, And Photophysics Of Oxadiazole- And Diphenylaniline-Substituted Re(I) And Cu(I) Complexes, Raphael Horvath, Michael G. Fraser, Scott A. Cameron, Allan G. Blackman, Pawel Wagner, David L. Officer, Keith C. Gordon

Faculty of Science, Medicine and Health - Papers: part A

Transition-metal complexes of the types [Re(CO)3Cl(NN)], [Re(CO)3py(NN)]+, and [Cu(PPh3)2(NN)]+, where NN = 4,4′-bis(5-phenyl-1,3,4-oxadiazol-2-yl)-2,2′-bipyridine (OX) and 4,4′-bis(N,N-diphenyl-4-[ethen-1-yl]-aniline)-2,2′-bipyridine (DPA), have been synthesized and characterized. Crystal structures for [Re(CO)3Cl(DPA)] and [Cu(PPh3)2(OX)]BF4 are presented. The crystal structure of the rhenium complex shows a trans arrangement of the ethylene groups, in agreement with density functional theory calculations. The structure of the copper complex displays the planar aromatic nature of the bpy–oxadiazole ligand. Density functional theory modeling of the complexes was supported by comparison of calculated and experimental normalized Raman spectra; the mean absolute deviations of the complexes were <10 cm–1. The Franck–Condon state was investigated using UV–vis and resonance Raman spectroscopic as well as density functional theory computational techniques. It was shown that the lowest energy absorption peaks are metal to ligand charge transfer and ligand-centered charge transfer for the oxadiazole- and diphenylaniline-substituted bipyridine ligands, respectively. The lowest energy excited states were characterized using transient emission and absorption spectroscopic techniques in conjunction with density functional theory calculations. These showed that the DPA complexes had ligand-centered nonemissive “dark” states with lifetimes ranging from 300 to 2000 ns.