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Articles 1 - 30 of 417
Full-Text Articles in Entire DC Network
Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias
Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias
Ana Maria Salicioni
The low density lipoprotein receptor–related protein (LRP-1) binds and mediates the endocytosis of multiple ligands, transports the urokinase-type plasminogen activator receptor (uPAR) and other membrane proteins into endosomes, and binds intracellular adaptor proteins involved in cell signaling. In this paper, we show that in murine embryonic fibroblasts (MEFs) and L929 cells, LRP-1 functions as a major regulator of Rac1 activation, and that this activity depends on uPAR. LRP-1–deficient MEFs demonstrated increased Rac1 activation compared with LRP-1–expressing MEFs, and this property was reversed by expressing the VLDL receptor, a member of the same gene family as LRP-1, with overlapping ligand-binding specificity. …
Electricity Production By Geobacter Sulfurreducens Attached To Electrodes, Daniel R. Bond, Derek Lovley
Electricity Production By Geobacter Sulfurreducens Attached To Electrodes, Daniel R. Bond, Derek Lovley
Derek Lovley
Previous studies have suggested that members of the Geobacteraceae can use electrodes as electron acceptors for anaerobic respiration. In order to better understand this electron transfer process for energy production, Geobacter sulfurreducens was inoculated into chambers in which a graphite electrode served as the sole electron acceptor and acetate or hydrogen was the electron donor. The electron-accepting electrodes were maintained at oxidizing potentials by connecting them to similar electrodes in oxygenated medium (fuel cells) or to potentiostats that poised electrodes at +0.2 V versus an Ag/AgCl reference electrode (poised potential). When a small inoculum of G. sulfurreducens was introduced into …
Osaka University: A Focus Of Polymer Science: 70th Anniversary Celebration, Otto Vogl, Koichi Hatada
Osaka University: A Focus Of Polymer Science: 70th Anniversary Celebration, Otto Vogl, Koichi Hatada
Emeritus Faculty Author Gallery
No abstract provided.
Personalities In Polymer Science: Cover Page, Title Page, Introduction, And List Of Articles, Otto Vogl
Personalities In Polymer Science: Cover Page, Title Page, Introduction, And List Of Articles, Otto Vogl
Emeritus Faculty Author Gallery
A compilation of articles with short biographies of the scientists who played leading roles in the field and provided the basis of Polymer Science and Technology throughout the 20th century.
Cell Population Modelling Of Yeast Glycolytic Oscillations, Michael A. Henson, Dirk Muller, Matthias Reuss
Cell Population Modelling Of Yeast Glycolytic Oscillations, Michael A. Henson, Dirk Muller, Matthias Reuss
Michael A Henson
We investigated a cell-population modelling technique in which the population is constructed from an ensemble of individual cell models. The average value or the number distribution of any intracellular property captured by the individual cell model can be calculated by simulation of a sufficient number of individual cells. The proposed method is applied to a simple model of yeast glycolytic oscillations where synchronization of the cell population is mediated by the action of an excreted metabolite. We show that smooth one-dimensional distributions can be obtained with ensembles comprising 1000 individual cells. Random variations in the state and}or structure of individual …
Osaka University: A Focus Of Polymer Science: 70th Anniversary Celebration, Otto Vogl, Koichi Hatada
Osaka University: A Focus Of Polymer Science: 70th Anniversary Celebration, Otto Vogl, Koichi Hatada
Otto Vogl
No abstract provided.
Personalities In Polymer Science: Cover Page, Title Page, Introduction, And List Of Articles, Otto Vogl
Personalities In Polymer Science: Cover Page, Title Page, Introduction, And List Of Articles, Otto Vogl
Otto Vogl
A compilation of articles with short biographies of the scientists who played leading roles in the field and provided the basis of Polymer Science and Technology throughout the 20th century.
Self-Consistent Three Dimensional Models For Quantum Ballistic Transport In Open Systems, Eric Polizzi, N. Ben Abdallah
Self-Consistent Three Dimensional Models For Quantum Ballistic Transport In Open Systems, Eric Polizzi, N. Ben Abdallah
Eric Polizzi
A quasi-three-dimensional model for quantum ballistic transport in nanostructures is proposed. The model goes beyond the Thomas-Fermi approximation and is numerically more tractable than the full three-dimensional Schrödinger-Poisson model. Its derivation relies on the strong confinement of electrons at the heterojunction which allows us to split the three-dimensional Schrödinger equation into a one-dimensional Schrödinger equation for the confined direction and a two-dimensional Schrödinger equation in the transport direction. The space charge effects are taken into account in a three-dimensional framework. Numerical simulations of quantum waveguide devices such as T stubs and directional couplers are used to illustrate the accuracy of …
Whole-Genome Analysis Of Dorsal-Ventral Patterning In The Drosophila Embryo, Angelike Stathopoulos, Madeleine Van Drenth, Albert Erives, Michele Markstein, Michael Levine
Whole-Genome Analysis Of Dorsal-Ventral Patterning In The Drosophila Embryo, Angelike Stathopoulos, Madeleine Van Drenth, Albert Erives, Michele Markstein, Michael Levine
Michele Markstein
The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represent …
The Use Of 4-Substituted Pyridines To Afford Amphiphilic, Pegylated Cadmium Selenide Nanoparticles, Habib Skaff, Todd S. Emrick
The Use Of 4-Substituted Pyridines To Afford Amphiphilic, Pegylated Cadmium Selenide Nanoparticles, Habib Skaff, Todd S. Emrick
Todd S. Emrick
Amphiphilic cadmium selenide (CdSe) nanoparticles were prepared by surface functionalization with novel ligands 1 and 2, composed of pyridine moieties substituted in the 4-position with polyethylene glycol (PEG) chains.
1. Yukio Imanishi, Otto Vogl
1. Yukio Imanishi, Otto Vogl
Plant Rac-Like Gtpases Are Activated By Auxin And Mediate Auxin-Responsive Gene Expression, L. Z. Tao, Alice Cheung, H. M. Wu
Plant Rac-Like Gtpases Are Activated By Auxin And Mediate Auxin-Responsive Gene Expression, L. Z. Tao, Alice Cheung, H. M. Wu
Alice Cheung
The auxin indole-3-acetic acid is a key plant hormone essential for a broad range of growth and developmental processes. Here, we show that auxin activates Rac-like GTPases (referred to as Rac/Rop GTPases), and they in turn stimulate auxin-responsive gene expression. In particular, we show that overexpressing a wild-type tobacco Rac/Rop GTPase, NtRac1, and its constitutively active mutant form activates auxin-responsive gene expression. On the other hand, overexpressing dominant-negative NtRac1 and Rac-negative regulators, or reducing the endogenous NtRac1 level, suppresses auxin-induced gene expression. Furthermore, overexpression of NtRac1 activity or suppression of its expression in transgenic seedlings induces phenotypes that are similar …
A Study Of Indoor Carbon Dioxide Levels And Sick Leave Among Office Workers, Theodore A. Myatt, John W. Staudenmayer, Kate Adams, Michael Walters, Stephen N. Rudnick, Donald K. Milton
A Study Of Indoor Carbon Dioxide Levels And Sick Leave Among Office Workers, Theodore A. Myatt, John W. Staudenmayer, Kate Adams, Michael Walters, Stephen N. Rudnick, Donald K. Milton
John W Staudenmayer
Background A previous observational study detected a strong positive relationship between sick leave absences and carbon dioxide (CO2) concentrations in office buildings in the Boston area. The authors speculated that the observed association was due to a causal effect associated with low dilution ventilation, perhaps increased airborne transmission of respiratory infections. This study was undertaken to explore this association. Methods We conducted an intervention study of indoor CO2 levels and sick leave among hourly office workers employed by a large corporation. Outdoor air supply rates were adjusted periodically to increase the range of CO2 concentrations. We recorded indoor CO2 concentrations …
18th Annual International Conference On Contaminated Soils, Sediments And Water
18th Annual International Conference On Contaminated Soils, Sediments And Water
Annual Conference on Soils, Sediments and Water: Abstracts
Conference at a Glance Monday, October 21, 2002 Workshops Workshops # 1, 2 & 3 - 10:00 am - 5:00 pm Workshops # 4 & 5 - 1:00 - 5:00 pm 1: The Indoor Air Exposure Pathway from Chlorinated Solvent Contaminated Groundwater 2: Theory and Use of Field Portable X-ray Fluorescence for Soil Analysis 3: In-Situ Chemical Oxidation Workshop 4: Workshop on Current Spectrochemical Techniques for Determining Heavy Metals in Sediments and Soils 5: Practical Remediation of Volatile Organic Compounds in Soil and Groundwater Tuesday, October 22, 2002 Platform Presentations 8:30am-Noon Session 1: Advances in In-Situ Remediation Session 2: Phytoremediation …
2. Toshinobu Higashimura, Otto Vogl
2. Toshinobu Higashimura, Otto Vogl
Emeritus Faculty Author Gallery
No abstract provided.
2. Toshinobu Higashimura, Otto Vogl
Additionality Of Debt Relief And Debt Forgiveness, And Implications For Future Volumes Of Official Assistance, Léonce Ndikumana
Additionality Of Debt Relief And Debt Forgiveness, And Implications For Future Volumes Of Official Assistance, Léonce Ndikumana
Léonce Ndikumana
This paper examines the impact of debt forgiveness and debt relief on official development assistance. From the recipient side, the econometric analysis suggests that countries that received debt relief also received more aid compared to those that did not qualify for debt relief. From the donor side, while the data indicate a decline in aid disbursement since the early 1990s, there is no econometric evidence for any direct causal relationship between the decline in aid and debt relief/forgiveness. Nonetheless, the decline in aid raises serious concerns given that developing countries’ need in external resources cannot be met by debt relief …
Decoding Cis-Regulatory Dnas In The Drosophila Genome, Michele Markstein, Michael Levine
Decoding Cis-Regulatory Dnas In The Drosophila Genome, Michele Markstein, Michael Levine
Michele Markstein
Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.
A Discrete Nonlinear Model With Substrate Feedback, Panos Kevrekidis, B. A. Malomed, A. R. Bishop
A Discrete Nonlinear Model With Substrate Feedback, Panos Kevrekidis, B. A. Malomed, A. R. Bishop
Panos Kevrekidis
We consider a prototypical model in which a nonlinear field (continuum or discrete) evolves on a flexible substrate which feeds back to the evolution of the main field. We identify the underlying physics and potential applications of such a model and examine its simplest one-dimensional Hamiltonian form, which turns out to be a modified Frenkel-Kontorova model coupled to an extra linear equation. We find static kink solutions and study their stability, and then examine moving kinks (the continuum limit of the model is studied too). We observe how the substrate effectively renormalizes properties of the kinks. In particular, a nontrivial …
A Model System For Study Of Sex Chromosome Effects On Sexually Dimorphic Neural And Behavioral Traits, Geert De Vries, E. F. Rissman, R. B. Simerly, Y. L. Yang, E. M. Scordalakes, C. J. Auger, A. Swain, R. Lovell-Badge, P. S. Burgoyne, A. P. Arnold
A Model System For Study Of Sex Chromosome Effects On Sexually Dimorphic Neural And Behavioral Traits, Geert De Vries, E. F. Rissman, R. B. Simerly, Y. L. Yang, E. M. Scordalakes, C. J. Auger, A. Swain, R. Lovell-Badge, P. S. Burgoyne, A. P. Arnold
Geert De Vries
We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion ofSry from the Y and subsequent insertion of anSry transgene onto an autosome), so that the determination of testis development occurred independently of the complement of X or Y chromosomes. We compared XX and XY mice with ovaries (females) and XX and XY mice with testes (males). These comparisons allowed us to assess the effect of sex chromosome …
Meridian Hill Park: The Making Of An American Neoclassical Landscape, Elizabeth Brabec
Meridian Hill Park: The Making Of An American Neoclassical Landscape, Elizabeth Brabec
Landscape Architecture & Regional Planning Faculty Publication Series
The neoclassical design was the dominant design movement in landscape architecture at the turn of the last century, dictating the form and design of public parks for most of the first half of the twentieth century. Meridian Hill Park, located just north of the White ouse in Washington, DC, is considered the most ambitious neoclassical park ever conceived in the United States. The paper provides an overview of the design development of the park, illustrating how classical design precedents were used to create a contemporary neo-classical park.
Reflection Of Jozef Obrebski’S Work In Macedonia From The Perspective Of American Anthropology, Joel Halpern
Reflection Of Jozef Obrebski’S Work In Macedonia From The Perspective Of American Anthropology, Joel Halpern
Emeritus Faculty Author Gallery
Jozef Obrebski (1905-1967) had a moderately long, interesting, and, in some respects, tragic life. The consequences of the Second World War and the subsequent Communist domination of Eastern Europe altered his life profoundly. While he and his immediate family escaped relatively unscathed and even his relatively voluminous scholarly documents were preserved he was never able to successfully readapt to the life he chose first in the lands of the then British Empire and finally in America. It would indeed be a limited approach to judge a person's life simply by their public record, in this case by a published output. …
3. Otto Vogl, Gerald S. Kirshenbaum, Helga Roder
3. Otto Vogl, Gerald S. Kirshenbaum, Helga Roder
Emeritus Faculty Author Gallery
No abstract provided.
Reflection Of Jozef Obrebski’S Work In Macedonia From The Perspective Of American Anthropology, Joel Halpern
Reflection Of Jozef Obrebski’S Work In Macedonia From The Perspective Of American Anthropology, Joel Halpern
Anthropology Department Faculty Publication Series
Jozef Obrebski (1905-1967) had a moderately long, interesting, and, in some respects, tragic life. The consequences of the Second World War and the subsequent Communist domination of Eastern Europe altered his life profoundly. While he and his immediate family escaped relatively unscathed and even his relatively voluminous scholarly documents were preserved he was never able to successfully readapt to the life he chose first in the lands of the then British Empire and finally in America. It would indeed be a limited approach to judge a person's life simply by their public record, in this case by a published output. …
The Regulation Of Actin Organization By Actin-Depolymerizing Factor In Elongating Pollen Tubes, C. Y. Chen, E. I. Wong, L. Vidali, A. Estavillo, P. K. Hepler, H. M. Wu, Alice Cheung
The Regulation Of Actin Organization By Actin-Depolymerizing Factor In Elongating Pollen Tubes, C. Y. Chen, E. I. Wong, L. Vidali, A. Estavillo, P. K. Hepler, H. M. Wu, Alice Cheung
Alice Cheung
Pollen tube elongation is a polarized cell growth process that transports the male gametes from the stigma to the ovary for fertilization inside the ovules. Actomyosin-driven intracellular trafficking and active actin remodeling in the apical and subapical regions of pollen tubes are both important aspects of this rapid tip growth process. Actin-depolymerizing factor (ADF) and cofilin are actin binding proteins that enhance the depolymerization of microfilaments at their minus, or slow-growing, ends. A pollen-specific ADF from tobacco, NtADF1, was used to dissect the role of ADF in pollen tube growth. Overexpression of NtADF1 resulted in the reduction of fine, axially …
3. Otto Vogl, Gerald S. Kirshenbaum, Helga Roder
Nelig Meeting - August 15, 2002, New England Library Instruction Group
Nelig Meeting - August 15, 2002, New England Library Instruction Group
New England Library Instruction Group
NELIG quarterly meeting.
Medusae Fossae Formation: New Perspectives From Mars Global Surveyor, Bethany Bradley, S. E.H Sakimoto, H. Frey, J. R. Zimbelman
Medusae Fossae Formation: New Perspectives From Mars Global Surveyor, Bethany Bradley, S. E.H Sakimoto, H. Frey, J. R. Zimbelman
Bethany Bradley
The nature and origin of the Medusae Fossae Formation (MFF) on Mars has been debated since the return of the first Viking images. The MFF's young age, distinctive surface texture, and lack of obvious source have prompted multiple hypotheses for its origin. This study uses data from the Mars Global Surveyor (MGS) mission to examine the MFF at all available scales. We discuss and quantify observations from Mars Orbiter Laser Altimeter (MOLA) topography and Mars Orbiter Camera (MOC) images to better constrain the origin of the MFF. Topographic grid estimates yield a present extent of 2.1 × 106 km2 and …