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Fat Lowering Effects Of Fisetin In Caenorhabditis Elegans, Nikolas J. Rodriguez
Fat Lowering Effects Of Fisetin In Caenorhabditis Elegans, Nikolas J. Rodriguez
Masters Theses
Fisetin, a flavanol with anti-inflammatory, anti-cancer, and anti-aging properties, has shown promise for reducing fat accumulation in tissue culture and animal models. This plant sourced compound has limited studies supporting its effects on fat accumulation. Therefore, this study was completed to determine fisetin’s role in fat reduction along with its mechanism of action using Caenorhabditis elegans. C. elegans is a small roundworm with roughly 65% of its genes being conserved in humans related to disease. In this study, 100 and 200 µM fisetin has shown to reduce fat accumulation in wild-type worms. Body size, locomotion, and pumping rate were …
Potential Bioactives And Inflammatory Mediators Regulating Adipose Tissue Function In Obesity, Seok-Yeong Yu
Potential Bioactives And Inflammatory Mediators Regulating Adipose Tissue Function In Obesity, Seok-Yeong Yu
Doctoral Dissertations
Obesity is a serious health problem in the U.S. and worldwide and is associated with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Observational studies have also shown an inverse relationship between obesity and reduced bioavailability of fat-soluble vitamins, which is due in part to increased sequestration in expanded adipose tissue (AT). AT serves as the primary site of storage organ for excess energy, however, in morbid obesity enlarged adipocytes exhibit decreased lipid uptake, impaired lipid hydrolysis and oxidation and increased inflammation, which are collectively referred to as AT dysfunction. Substantial evidence characterizes AT …