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Effects Of N-3 Pufa-Derived Epoxides Combined With Seh Inhibition On Brown Adipose Tissue And Brown Adipocytes In Obesity, Yang Yang

Doctoral Dissertations

Brown adipose tissue (BAT) has become a promising target for obesity treatment and prevention. However, effective dietary factors to promote BAT mass and function have not been identified. 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) are two prominent epoxy fatty acids (EpFAs) produced from n-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. EpFAs are quickly metabolized to less active diols by soluble epoxide hydrolase (sEH). In this dissertation, the effects of an sEH inhibitor (t-TUCB) (which stabilizes EpFAs) alone or combined with n-3 EpFAs on thermogenic activity in the BAT and brown adipocytes in …

The Relationship Between Food Environments And Obesity Rates In The United States; Measured By The Modified Retail Food Environment Index, Mary Katherine Miller

All Theses

The modified Retail Food Environment Index (mRFEI) is a measurement created by the Centers for Disease Control and Prevention (CDC) designed to capture the number of healthy and less healthy food retailers in an area. Out of the total number of food retailers in that area considered either healthy or less healthy, the mRFEI represents the healthy percentage. The mRFEI index is commonly used to measure obesity amongst different levels of food access. Rather than simply relying on broad categorizations of food environments, using the raw index gives a more complete picture of the relationship between food availability and obesity. …

The Physiological Benefits Of A Plant-Based Diet On Cardiovascular Health, Jenevieve Petray

Nursing | Senior Theses

Cardiovascular disease (CVD) is increasingly more prevalent in today’s society and is attributed to an alarming percentage of American hospitalizations and deaths. Americans are unhealthier than ever before, and the main contributor is the Western diet. Diet is a double-edged sword that can offer benefits or detriments to one’s health. CVD encompasses numerous diagnoses originating from various underlying physiological alterations. These alterations are downstream effects of increased body weight and BMI, increased cholesterol levels, decreased insulin sensitivity and increased arterial plaque buildup. Research shows that a plant-based diet has the potential to manage and reverse all fundamental physiological alterations that …

Stress As A Contributing Factor For Pediatric Obesity: Literature Review And Internship Experience, Jessica Handley

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This article is an examination of how stress drives diet and physical activity behaviors that contribute to pediatric obesity in the United States. An increasing rate of childhood obesity is being reported in the United States and therefore a multitude of studies and reviews have been conducted on the topic. This review of the literature systematically analyzes how stress, diet, and physical activity behaviors contribute to this rising rate of pediatric obesity. An analysis of the chosen articles for review indicates that stress and its counterpart (resilience) tend to be driving forces in how American children and adolescents participate in …

The Effects Of Resistance Training On Cognition And Brain Health In Older Adults At Risk For Diabetes: A Pilot Feasibility Study, Joyla Furlano

Electronic Thesis and Dissertation Repository

Type 2 diabetes is associated with neurocognitive deficits and increased risk for dementia, with high prevalence of diabetes occurring in old age. There are many known risk factors for diabetes, including physical inactivity, obesity, and prediabetes. Studies show that individuals who are at risk for diabetes (i.e., have one or more risk factors) already experience some brain deficits seen in diabetes. One way to combat these deficits is aerobic exercise; however, the effects of resistance exercise in this population are relatively unknown. The objectives of this thesis were to report on the current evidence of brain deficits in prediabetes, and …

Role Of Smad2 And Smad3 On Adipose Tissue Development And Function, Roshan Kumari

Theses and Dissertations (ETD)

Introduction: Obesity and its associated metabolic syndrome are major medical problems worldwide including United States. Adipose tissue is the primary site of energy storage, playing important roles in health. Adipose tissue also has other critical functions, producing adipocytokines and contributing to normal nutrient metabolism, which in turn play important roles in satiety, inflammation, and total energy homeostasis. Activin A and activin B play important roles in maintaining body composition and energy homeostasis. This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.

SMAD2/3 proteins are downstream mediators of transforming growth factor-β (TGFβ) family signaling, including …

The Effect Of Obesity On Revision Total Knee Arthroplasty: Functional Outcome, Ninety-Day Costs, Reoperations, Readmissions And Cost-Effectiveness, Mohamad Nasser Eddine

Electronic Thesis and Dissertation Repository

The demand for revision total knee arthroplasty (RTKA) is increasing due to obesity and an aging population. The purpose of this study is to evaluate the effect of different body mass index (BMI) categories on RTKA using a retrospective cohort analysis. The first part was to assess patients’ functionality post-RTKA. The second part was to determine the survival of RTKA and re-revision rate. The third part was to explore the complication and readmission rates, and to estimate the 90-day costs of RTKA. We found the most common indication for RTKA in super obese patients is infection, unlike other BMI categories, …

Free Fatty Acid Treatment Alters Autophagy During Mouse Preimplantation Embryo Development, Zuleika C. L. Leung

Electronic Thesis and Dissertation Repository

Obesity-induced hyperlipidemia is one of the main factors for female infertility. Hyperlipidemia, specifically with high levels of palmitic acid (PA) and oleic acid (OA), interferes with preimplantation development. Autophagy is essential in early embryo development but, it is unknown whether hyperlipidemia affects autophagic mechanisms in preimplantation embryos. It was hypothesized that PA will alter autophagy in preimplantation mouse embryos and that the subsequent effects will be reversed by OA. PA impaired blastocyst development by arresting embryos at the 8-cell stage. PA also elevated early embryo autophagy by increasing autophagosome formation, decreasing maturation, and disrupting degradation. Co-treatment with OA showed developmental …

Food Addiction And Obesity, Lisa Ling

Electronic Theses and Dissertations

The obesity rate in the U.S. adult population has increased to epidemic levels despite attempts to decrease obesity through evidence-based knowledge, clinical practice guidelines, medical interventions, and individual efforts. For certain individuals, food addiction behaviors such as food cravings, loss of control, and binge eating contribute to obesity and require a different approach to care. Little work has been done on adding the possibility of food addiction to obesity screening and treatment. This study utilized a quasi-experimental quantitative pre- and postsurvey research design based on Lewin’s change theory. Nurse practitioners were surveyed regarding the provider’s perceptions, attitudes, and beliefs about …

Effects Of Ergothioneine On Endothelial Cell And Macrophage Characteristics, And Markers Of Atherosclerosis Risk Under High Lipid Conditions, Daniel Lam-Sidun

Electronic Thesis and Dissertation Repository

Ergothioneine (EGT) is an antioxidant and potential anti-inflammatory molecule that may have protective effects against the lipid-induced oxidative stress and inflammation that occurs in the vasculature of individuals with obesity and metabolic syndrome. This thesis addresses the hypothesis that EGT supplementation decreases endothelial cell dysfunction and macrophage inflammatory characteristics under high lipid conditions, and markers of atherosclerotic risk in diet-induced obese mice. Results showed that EGT did not influence endothelial tube formation or stability but reduced nitric oxide production in endothelial cells. Moreover, EGT decreased the production of reactive oxygen species, and potentially nitric oxide, by macrophages. In diet-induced obese …

Racial And Socioeconomic Disparities Influencing Obesity Amongst Middle-Aged Women, Morgan Woods

Master of Science in Integrative Biology Theses

Many studies have examined the effects of racial and socioeconomic differences on health-related disparities involving obesity but, few have examined the mental and physical well-being intersection. Obesity is a disease that affects many Americans and has become an epidemic affecting the American population. Obesity, especially morbid obesity, is a risk factor for many other obesity-related diseases such as diabetes, cardiovascular diseases, hypertension, and more. Using the 2018 Healthcare Avoidance Study, differences were found between two racial groups, Caucasian and African-American women. Race was found as a significant factor for both level of physical activity and ideal body image perception

Exploring Β-Cell Function And Heterogeneity In Obese Sm/J Mice, Mario Alejandro Miranda

Arts & Sciences Electronic Theses and Dissertations

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process required to maintain systemic glucose homeostasis. Obesity promotes glycemic and inflammatory stress, causing β-cell death and dysfunction, resulting in diabetes. Efforts to improve β-cell function in obesity have been hampered by observations that β-cells are highly heterogeneous, varying in morphology, function, and gene expression. There is great need to understand the breadth of β-cell heterogeneity in health and obesity to improve diabetic therapies.High fat-fed SM/J mice spontaneously transition from hyperglycemic-obese to normoglycemic-obese with age, providing a unique opportunity to study β-cell adaptation. Here, we show that as they resolve hyperglycemia, obese SM/J …

On The Relationship Of Diabetes And Sleep Apnea: Evolution And Epigenetics, Nancy Wilson

Undergraduate Honors Theses

This thesis gives an overview of the relationship between diabetes, sleep apnea, obesity, and heart disease. It then addresses evidence that the traditional understanding of this relationship is incomplete or misleading. In the process, there is a brief discussion of the evolutionary rationale for the development and retention of sleep apnea in light of blood sugar dysregulation, as an adaptive mechanism in response to environmental stressors, followed by a brief overview of the general concepts of epigenetics. Finally, this paper presents the results of a literature search on the epigenetic marks and changes in gene expression found in sleep apnea …

Effect Of Microbiome Alterations On The Progression & Treatment Of Nonalcoholic Fatty Liver Disease, Rachelle Virgin

Nursing Student Class Projects (Formerly MSN)

Nonalcoholic fatty liver disease (NAFLD) is the presence of hepatic steatosis that is not caused by alcohol consumption, viruses, or medications (Sivell, 2019). Fatty liver can become more inflamed and lead to nonalcoholic steatohepatitis (NASH) and possibly progress to cirrhosis and liver failure (Sheka et al., 2020). As rates of obesity and type 2 diabetes rise, healthcare providers can expect to see this disease more prevalently in practice. It can be difficult to provide timely healthcare because there are usually no signs or symptoms present with NAFLD (Mayo Clinic, 2020). This poster discusses the importance of recognizing comorbidities and risk …

Exploring The Relationship Between The Distance Of Parks And Rates Of Adult Obesity In El Paso, Texas, Shawna Payan

Open Access Theses & Dissertations

Background: In El Paso, areas of the city do not have access to parks within walking distance. The rates of people suffering from obesity and the comorbidities that come with obesity are rising annually. Physical activity has been shown to increase lifespan and provide positive health outcomes for the individual. Increasing physical activity in adults by using the parks can decrease their risk for heart disease and diabetes. Objectives: The overall aim of the procedure is to determine a relationship between park density and distance from residence to the nearest park, adult population density, and the obesity rate density within …

Effect Of Obesity On Knee Joint During Walking And Squatting, Simon Vasquez Iii

Theses and Dissertations

This paper analyzes the effect of obesity on the knee joints during squats. This was performed on 2 different subjects by having each squat 30 times at their decided comfortable depth to display some fatigue and effects on the knee joints. Using the VICON NEXUS and AMTI force plates equipment at The University of Texas at Rio Grande Valley Biomechanics Lab, the center of pressure, knee flexion angles, velocity, and ground reaction forces were calculated. The subjects performed the exercises with and without additional weight using a body vest and kettlebell. The ground reaction forces showed a significant increase in …

The Impact Of Obesity On Covid-19 Outcomes In A High-Risk, Majority Hispanic Community Sample, Maxwell A. Lawlor

Capstone Experience

The novel coronavirus disease 2019 (COVID-19) pandemic has caused over 33.7 million cases and 605,000 deaths in the United States¹. Factors associated with increased odds for hospitalization, death, and other poor outcomes include age, comorbid conditions like cardiovascular disease and lung disease, and obesity. COVID-19 has also disproportionately affected Hispanic communities across the United States and in Omaha. Potential explanations for this disparity include social determinants of health, particularly occupational factors, structural challenges to access healthcare services, and increased medical comorbidities including obesity. In this retrospective cohort study, we used patient data from April to May 2020 (N=1,000) …

Fat Lowering Effects Of Fisetin In Caenorhabditis Elegans, Nikolas J. Rodriguez

Masters Theses

Fisetin, a flavanol with anti-inflammatory, anti-cancer, and anti-aging properties, has shown promise for reducing fat accumulation in tissue culture and animal models. This plant sourced compound has limited studies supporting its effects on fat accumulation. Therefore, this study was completed to determine fisetin’s role in fat reduction along with its mechanism of action using Caenorhabditis elegans. C. elegans is a small roundworm with roughly 65% of its genes being conserved in humans related to disease. In this study, 100 and 200 µM fisetin has shown to reduce fat accumulation in wild-type worms. Body size, locomotion, and pumping rate were …

Household Food Insecurity, Depression, And Disordered Eating Symptoms In Adolescents With Severe Obesity, Meredith Bishop

Psychology Dissertations

As rates of severe pediatric obesity have increased, bariatric surgery has become more common in adolescents. Disordered eating symptoms may interfere with an adolescent’s ability to effectively adhere to dietary requirements and hinder weight loss. The purpose of this study was to examine the relations between household food insecurity, depression, and disordered eating in a sample of adolescents seeking bariatric surgery. Participants (N = 73) were adolescents presenting to the pre-surgical psychological evaluation. Household food insecurity was not related to disordered eating or any disordered eating subscales but was significantly higher in Black households compared to White households. Depression …

The Relationship Of Structured Environments With Children’S Body Composition And Obesogenic Behaviors, Ethan T. Hunt

Theses and Dissertations

Recent nationally representative data show among children and adolescents aged 2 to 19 years, the prevalence of obesity is 17.0% (95CI= 15.5%-18.6%). Further, rates of obesity are disproportionately high among minoritized youth. The prevalence of children and adolescents with obesity is lower among White children compared to Black children (14.7% vs. 19.5%) or Hispanic children (14.7% vs. 21.9%). Disparities by socioeconomic status exist as well. Prevalence of children with obesity from households with an income that is >350% of the federal poverty threshold (after accounting for household size) is significantly less compared to children from households with an income that …

The Healthcare Costs Of Overnutrition, Ryan Hodge

Honors Projects

Obesity is a growing problem globally and domestically. Obesity is related to several chronic and noncommunicable diseases such as hypertension, type II diabetes, coronary heart disease, and some cancers. Both obesity and its related diseases are forms of overnutrition, which is the excess intake of nutrients that causes increased body fat to the point of impaired health. Using data from the Medical Expenditure Panel Survey (MEPS) from 2008-2016, this paper is the first to estimate the causal effect of overnutrition on medical expenditure by examining the effect of overnutrition diseases on health care costs, correcting for the endogeneity bias of …

Implementation Of The Center For Disease Control (Cdc) Prediabetes Risk Test In The Medical Weight Loss Setting, Gabriela Miller, Rn, Bsn

Doctor of Nursing Practice Final Manuscripts

Background: Prediabetes is a serious health condition where blood sugars are higher than normal which increases risk of developing type 2 diabetes mellitus (T2DM), heart disease and stroke. One in three US adults have prediabetes and 90% of them do not know. Losing 5-7% of body weight and regular physical activity can lower the risk of developing T2DM by more than half.

Methods: Screening patients for prediabetes at a medical weight loss clinic using the evidence-based Centers for Disease Control (CDC) Prediabetes Risk Test. A score of five or higher on the screening tool indicates the patient is at risk …

Obesity Prevention Toolkit To Combat Weight Gain Related To Sedentary Behavior And Dietary Habits In College Students: An Evidence-Based Project, Maria Amos, Martha Fuller

Doctor of Nursing Practice Final Manuscripts

Abstract

Background: Forty percent of the US population ages 20-39 are categorized as obese,

their BMI is over 30, and 35% of college age students are obese or overweight. Issues related to obesity cost the US $147 billion annually. Between 40%-50% of college students are reported to be inactive. Inactivity can lead to increased morbidity and mortality related to increased risks of cardiovascular disease, diabetes, hypertension, musculoskeletal issues, and depression. Providing dietary and physical activity education and access to nutritional information promotes behavior change in young adults.

Aims of Service Change: This evidence-based project proposal aims to provide a toolkit …

Art Therapy With Children And Adolescents Experiencing Obesity: Embracing An Object Relations Approach, Rohan Roberts Goldman

Expressive Therapies Capstone Theses

This thesis looked at how art therapy can help identify problems in attachment between children and adolescents living with obese bodies and their parents. In this literature review, I examined the dynamics of child-parent/caretaker relationships and the way object relations and attachment play a significant role in the child’s mental health development. Incorporating art therapy into the treatment for this population has shown some signs of improving the dynamic between children and their caretaker. Through this research, I concluded that children need a consistent caregiver to be attuned to their needs. If they lack attuned and consistent care, the child …

Better Together? The Effects Of Shared Medical Appointments On Bmi In Obese Adults, Amanda Larson

Evidence-Based Practice Project Reports

The United States (U.S.) is amidst an obesity epidemic, with Indiana ranking as the 15th worst state (Institute of Medicine, 2012; United Health Foundations, 2020). Despite current management strategies, the obesity rate in both the U.S. and Indiana continues to rise (WHO, 2020). Therefore, obesity management must change. The purpose of this evidence-based practice (EBP) project was to determine if the addition of shared medical appointments (SMAs) consisting of informational group sessions by specialists and brief individualized meetings with the provider will result in greater reduction of weight and body mass index (BMI) compared to standard care alone in those …

Predicting Reinforcers To Increase Physical Activity In Young Children With Obesity Using The Six-Minute Walk Test, Jordan D. Lill

Theses & Dissertations

Childhood obesity continues to be a significant public health problem in the United States in which approximately 8% to 12% of American children are obese (Cunningham, Kramer, & Narayan, 2014; Mirza et al., 2018; Ogden et al., 2014). Further, 42% of American children are engaging in less than the recommended 60 minutes of daily physical activity (Troiano et al., 2008). Several treatments have been evaluated that have included goal-setting, self-monitoring, performance feedback, and access to arbitrary tangible rewards (e.g., Hyusti, Normand, & Larson, 2011; Van Camp & Hayes, 2012), but these treatments have often failed Luttikhuis et al., 2009; Nooijan …

Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White

Masters Theses, 2020-current

Fucoxanthin is a carotenoid sourced and extracted mainly from dark orange and brown seaweeds found in the pacific ocean, such as the wakame algae. The allenic bonds and unique oxygen groups give fucoxanthin its unique structure and are thought to be part of the reason fucoxanthin has unique physiological functions. Fucoxanthin has potentially numerous effects on the physiology of human health, ranging from skin health to metabolic health, which have been demonstrated in animal model research. The goal of this review is to examine current literature to discuss fucoxanthin’s potential application as a nutraceutical, treatment for obesity, type 2 diabetes, …

Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White

Masters Theses, 2020-current

Fucoxanthin is a carotenoid sourced and extracted mainly from dark orange and brown seaweeds found in the pacific ocean, such as the wakame algae. The allenic bonds and unique oxygen groups give fucoxanthin its unique structure and are thought to be part of the reason fucoxanthin has unique physiological functions. Fucoxanthin has potentially numerous effects on the physiology of human health, ranging from skin health to metabolic health, which have been demonstrated in animal model research. The goal of this review is to examine current literature to discuss fucoxanthin’s potential application as a nutraceutical, treatment for obesity, type 2 diabetes, …

You Are What You Think: The Impacts Of Body Weight Perception In Young Adolescent Women, Olivia Ceja

DNP Qualifying Manuscripts

While research suggests a multifactorial array of contributors to adolescent obesity including lack of physical activity, dietary behaviors, psychosocial factors including the perception of being overweight and body dissatisfaction have been more recently associated with unhealthy weights, unhealthy behaviors and amplified risk of obesity. At an all girl’s private college preparatory middle and high school in Los Angeles, amid a competitive and rigorous academic environment, students face additional pressure to succeed and strive for perfection. Although body weight perception can be used to identify students who are at risk for eating disorders at the middle and high school levels, the …

Leptin Activation Of Metabolically-Related Hypothalamic Neurons, Kailee Hixon

Undergraduate Honors Theses

Obesity is often associated with multiple other clinical conditions, including hypertension and cardiovascular disease. Currently, more than one-third of the world’s population is classified as obese. Leptin is a neuropeptide that is released from adipose cells and is responsible for reducing appetite and increasing metabolism. Leptin also has a role in the activation of cardiovascular and metabolic pre-sympathetic neurons and has been reported to increase blood pressure and heart rate. Thus, understanding the activation of the autonomic nervous system by leptin has implications in the development and safety of drugs to avoid activation of cardiovascular pre-sympathetic neurons. This is important …