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Determining Kinetic Parameters Of Cellulose And Lignin Pyrolysis By Gaussian Process Regression (Gpr) Method, Pichayaporn Viriya-Amornkij, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

The ignition and flame-spread processes in the forest and urban fires involve the pyrolysis reactions of biomass materials. One of the most common methods for estimating the fire performance of a material is the evaluation of kinetic parameters, i.e., activation energy (𝐸), pre-exponential factor (𝐴), and reaction model (𝑓(𝛼)), from thermogravimetric analysis (TG) data. Typically, 𝐸 is estimated based on an Arrhenius-type equation such as Kissinger, Kissinger-Akahira-Sunose (KAS), and Friedman equations. Then, its value is adjusted along with other parameters by assuming a reaction model, e.g., the 𝑛-order model. This study proposes a Gaussian process regression (GPR) method to determine …

Surficial Geologic Map Of The Summit 7.5-Minute Quadrangle, Kentucky, Antonia E. Bottoms, Ann Hislop, Matthew A. Massey, Max Hammond Iii, Michelle Mchugh, Emily Morris

Report of Investigations--KGS

The Summit 7.5-minute quadrangle is located south of Louisville and west of Elizabethtown along the boundary between Hardin and Grayson Counties and within the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by the low relief Pennyroyal region that sits at elevations between 560 to 650 ft above sea level, the low relief Mammoth Cave plateau at elevations between 750 to 900 ft, and the steep Dripping Springs escarpment that separates the two plains. Moore (1964) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Mississippian bedrock is exposed throughout the quadrangle and is …

Surficial Geologic Map Of The Big Clifty 7.5-Minute Quadrangle, Kentucky, Maxwell L. Hammond Iii, Antonia E. Bottoms, Ann Hislop, Matthew Massey, Michele Mchugh, Emily Morris

Contract Reports--KGS

The Big Clifty 7.5-minute quadrangle is located south of Louisville and west of Elizabethtown along the boundary between Hardin and Grayson Counties. The quadrangle lies within the Mammoth Cave plateau of the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by a low relief plain sitting at elevations between 650 to 850 ft above sea level, which is dissected and incised by Rough River, Meeting Creek, Clifty Creek, and their tributaries to below 500 ft. Swadley (1962) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Mississippian bedrock is exposed throughout the quadrangle and …

An Exploration Of Service Needs And Preferences Of Dementia Caregivers In Kentucky, Heehyul Moon, Sunshine Rote, Allison Kacmar, Amy Kostelic, Bari Lewis

Family Sciences Faculty Publications

As Americans live longer, the prevalence of Alzheimer’s disease and related dementias will increase. Caregivers are critical to the care and life quality of people with dementia. Yet, dementia caregivers are at increased risk for health issues, social isolation, and financial challenges. To help educators with the University of Kentucky Cooperative Extension Service work with their local Alzheimer’s Association and the University of Louisville to better support dementia families, we explored caregiver needs and service utilization using an online survey. Our findings highlighted the need for counseling/support, care management skills, resource education, self-care strategies, and legal services. Extension Service Educators …

Phase I Activities Of The Earth Mapping Resources Initiative (Earth Mri) In The Western Kentucky Fluorspar District, Georgina Lukoczki, Craig Dietsch, John B. Hickman, Emily Morris, Douglas C. Curl, Carrie Pulliam, Stephanie Vicroy, William M. Andrews Jr.

Report of Investigations--KGS

The Western Kentucky Fluorspar District (WKFD), which comprises the Kentucky portion of the Illinois–Kentucky Fluorspar District, is well known for the occurrence of strategically important critical mineral resources, such as fluorite (fluorspar) and rare earth elements (REEs). Due to technological advances, demand has increased for critical minerals used in cell phones, magnets in wind turbines, batteries for electric vehicles, smart weapons, and other devices and systems. The overall objective of the Earth Mapping Resources Initiative (Earth MRI) program, directed by the U.S. Geological Survey (USGS), is to gather information that will help better understand the distribution of critical minerals in …

Rna Editing Of Microtubule-Associated Protein Tau Circular Rnas Promotes Their Translation And Tau Tangle Formation, Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C. Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C. Lee, Alvaro G. Hernandez, Wang-Xia Wang, Jing Di, Pierre De La Grange, Peter T. Nelson, Stefan Stamm

Sanders-Brown Center on Aging Faculty Publications

Aggregation of the microtubule-associated protein tau characterizes tauopathies, including Alzheimer’s disease and frontotemporal lobar degeneration (FTLD-Tau). Gene expression regulation of tau is complex and incompletely understood. Here we report that the human tau gene (MAPT) generates two circular RNAs (circRNAs) through backsplicing of exon 12 to either exon 7 (12→7 circRNA) or exon 10 (12→10 circRNA). Both circRNAs lack stop codons. The 12→7 circRNA contains one start codon and is translated in a rolling circle, generating a protein consisting of multimers of the microtubule-binding repeats R1–R4. For the 12→10 circRNA, a start codon can be introduced by two …

Genetic Expression Changes And Pathologic Findings Associated With Hyperhomocysteinemia In Human Autopsy Brain Tissue, Erica M. Weekman, Zachary Winder, Colin B. Rogers, Erin L. Abner, Tiffany L. Sudduth, Ela Patel, Adam J. Dugan, Shuling X. Fister, Brandi Wasek, Peter T. Nelson, Gregory A. Jicha, Teodoro Bottiglieri, David W. Fardo, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Introduction: Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absorption in aged persons. Studies aimed at identifying neuropathologic features and gene expression profiles associated with HHcy have been lacking.

Methods: A subset of research volunteers from the University of Kentucky Alzheimer’s Disease Research Center longitudinal cohort came to autopsy and had ante mortem plasma homocysteine levels available. Brain tissue and blood plasma drawn closest to death were used to measure …

Exhibit: Documenting The Presence Of Hispanic And Latinx Students At The University Of Kentucky, Ruth E. Bryan, Taylor Leigh

Library Presentations

From December 6-7, 2022, at the request of Hispanic Studies Department faculty Heather Campbell-Speltz, University Archivist Ruth Bryan and Hispanic Studies Librarian Taylor Leigh presented to students in classes SPA 211 and 208 an exhibit of items from the University Archives in the UK Libraries Special Collections Research Center that document the presence of Hispanic and Latinx students at the University of Kentucky. Starting with the first student from Latin America to graduate from the Agricultural and Mechanical College in 1878 (the precursor to today’s university) and going through some of the activities of the Latino Student Union in 2022, …

Apoe Genetics Influence Murine Gut Microbiome, Diana J. Zajac, Stefan J. Green, Lance A. Johnson, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut microbiome. Here, we evaluated effects of APOE heterozygosity and tested whether these overall results extended to mice maintained under ideal conditions for microbiome analyses. To model human APOE alleles, this study used APOE targeted replacement (TR) mice on a C57Bl/6 background. To minimize genetic drift, homozygous APOE3 mice were crossed to homozygous APOE2 or homozygous APOE4 mice prior to the study, and the resulting …

Single Low-Dose Targeted Bevacizumab Infusion In Adult Patients With Steroid-Refractory Radiation Necrosis Of The Brain: A Phase Ii Open-Label Prospective Clinical Trial, Shervin R. Dashti, Robert J. Kadner, Bradley S. Folley, Jason P. Sheehan, Dong Y. Han, Richard J. Kryscio, Mary B. Carter, Lisa B. E. Shields, Brian M. Plato, Renato V. La Rocca, Aaron C. Spalding, Tom L. Yao, Justin F. Fraser

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

METHODS Ten adults with steroid-refractory, imaging-confirmed brain RN were enrolled between November 2016 and January 2018 and followed for 12 months after treatment. Bevacizumab 2.5 mg/kg was administered as a one-time targeted intra-arterial infusion immediately after BBBD. Primary outcomes included safety and > 25% decrease in lesion volume. …

Acute Invasive Fungal Rhinosinusitis Related Orbital Infection Secondary To Odontogenic Infection, Dennis Levy, Melvyn Yeoh

Oral Health Science Faculty Publications

A 64-year old male presented to our institution with painful ophthalmoplegia. The initial differential diagnosis included orbital apex disorders, such as orbital apex syndrome (OAS), cavernous sinus thrombosis (CST), and superior orbital fissure syndrome (SOFS). Ultimately, the diagnosis was acute invasive fungal rhinosinusitis (AIFRS) secondary to an odontogenic infection from carious teeth in the maxilla. Significant overlap exists between AIFRS and orbital apex disorders, making it prudent to include AIFRS in the differential diagnosis for painful ophthalmoplegia. The purpose of this review is to detail this specific patient's presentation and hospital course along with a brief review of AIFRS and …

Spf-R Online User Guide, Eric Green, Paul Ross, Christopher Blackden, William Staats, Reginald Souleyrette

Kentucky Transportation Center Research Report

SPF-R Online greatly improves and simplifies the SPF development process. Building on the original SPF-R script, the online tool eliminates many of the technical barriers associated with the original process, allowing for a much larger audience to take advantage of SPF-R’s capabilities. Like the original SPF-R script, SPF-R Online lets users quickly explore the effect of roadway network heterogeneity on SPF development, compare CURE plots , and compare goodness-of-fit measures to decide which SPF is most appropriate for a given dataset.

Forage News [2022-12], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

The Association Of Gabapentin Initiation And Neurocognitive Changes In Older Adults With Normal Cognition, Gyeon Oh, Daniela Claudia Moga, David W. Fardo, Erin L. Abner

Sanders-Brown Center on Aging Faculty Publications

Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults.

Methods: We conducted a retrospective cohort study using the National Alzheimer’s Coordinating Center Uniform Data Set (UDS; September 2005-March 2021 data freeze). From the eligible sample (≥age 65 years), we identified cognitively normal new-users of gabapentin and the visit they initiated gabapentin (i.e., index visit). Initiators were matched to randomly selected nonusers on year …

Examining Four Blood Biomarkers For The Detection Of Acute Intracranial Abnormalities Following Mild Traumatic Brain Injury In Older Adults, Grant L. Iverson, Mira Minkkinen, Justin E. Karr, Ksenia Berghem, Henrik Zetterberg, Kaj Blennow, Jussi P. Posti, Teemu M. Luoto

Psychology Faculty Publications

Blood-based biomarkers have been increasingly studied for diagnostic and prognostic purposes in patients with mild traumatic brain injury (MTBI). Biomarker levels in blood have been shown to vary throughout age groups. Our aim was to study four blood biomarkers, glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilament light (NF-L), and total tau (t-tau), in older adult patients with MTBI. The study sample was collected in the emergency department in Tampere University Hospital, Finland, between November 2015 and November 2016. All consecutive adult patients with head injury were eligible for inclusion. Serum samples were collected from the enrolled patients, …

Effects Of Sowing Date And Phosphorus Fertiliser Application On Winter Survival Of Lucerne Cv. Aohan In The Northern Semi-Arid Region Of China, Z. L. Wang, Q. Zh. Sun, Y. W. Wang, Zh. Y. Li, Sh. F. Zhao

IGC Proceedings (1993-2023)

In the northern semi-arid region of China, winter survival is always a limiting factor for lucerne production, because low temperatures and a dry climate in winter (Zhou et al., 1993; Ma, 2000; Sun & Gui, 2001; Sun et al., 2003). An experiment was conducted to find an appropriate sowing date and P application rate in order to improve lucerne winter survival.

Ear Emergence Of Different Grass Species Under Finnish Growing Conditions, M. Niskanen, O. Niemeläinen, L. Jauhiainen

IGC Proceedings (1993-2023)

Timothy is the most commonly cultivated grass species in Finland. Swards cultivated for silage of hay are of pure timothy or timothy is the dominant species of the mixture. Successful timing of harvesting of the primary growth is very critical in Northern latitudes where the stand develops very rapidly at daylengths of above 18 hours with a daily mean temperature close to 20 °C. The primary growth has to be harvested within a very short period to obtain a yield of high and uniform quality. Short harvesting periods require high capacity harvest machinery which lead to high costs. If it …

Reasons For The Premature Decline In Astragalus Adsurgens Stands In Kerqin Sandy Land, Q. Zh. Sun, Z. L. Wang, J. G. Han, Y. W. Wang, G. R. Liu

IGC Proceedings (1993-2023)

Diseases partly account for reductions in Astragalus adsurgens, stand longevity. The effect of some cultural practices on the control of pests and diseases have been reported (Hou, 1986; Nan, 1996), but few reports have detailed the relationship among soil fertiliser status, diseases and premature stand decline. This study was conducted to investigate these relationships in order to extend the longevity of Astragalus adsurgens stands.

The Influence Of Fertiliser Application To Strip-Sown Grasslands On Herbage Production And Quality, A. Kohoutek, P. Komárek, V. Odstrčilová, P. Nerušil

IGC Proceedings (1993-2023)

To increase the productivity of dairy cattle in the Czech Republic requires an improvement in herbage quality and an increase in the net energy of herbage. The decrease in cattle numbers by 50 % and the expansion of the grassland area both result in a surplus of feedstuffs of low quality. Introduction of strip-seeding of legumes and grasses into grasslands in interaction with fertilisation provides a possible solution to this problem.

Range-Based Livestock Production In Turkmenistan, R. H. Behnke, G. Davidson

IGC Proceedings (1993-2023)

Turkmenistan retains a centralized system of livestock production in which many critical assets are owned by the state. Though technically in the temperate zone, the country's climate is harsh and unstable. Groundwater resources are unevenly distributed, leaving many potential grazing areas seasonally inaccessible due to lack of drinking water for livestock. This paper summarizes the results of a three-year study of rangelands, livestock production, flock economics and land tenure at two study sites, one in central and the other in eastern Turkmenistan. The results of this study suggest that pastoral communities in Turkmenistan have coped remarkably well with the institutional …

About Private Tommie D. Smith Guy, Wac, Reinette F. Jones

Library Presentations

Tommie D. Smith [Guy], from Lexington, KY, was one of the three African American WACs who were beaten by the local police and charged with disorderly conduct for sitting in the white waiting area of the bus station in Elizabethtown, KY. The three WACs were with the 1550th Service Command Unit, WAC Section II. The three women were eventually found not guilty of any charges.

Scale Modeling Of An Appearance Of Downwash Pattern Of Hot Smoke Ejected From Chimney In The Turbulent Cross Flow, Xangpheuak Inthavideth, Nobumasa Sekishita, Sounthisack Phommachanh, Yuji Nakamura

Progress in Scale Modeling, an International Journal

This study aims to elucidate the scaling law to provide the critical condition on appearance of the downwash pattern of the hot smoke ejected from a chimney in a turbulent cross flow. A specially designed wind tunnel with an active turbulence generator developed by Makita was adopted to offer a quasi-isotropic turbulence field in a lab-scale test facility. A heated jet with smoke is issued into the cross flow from the vertically oriented chimney placed in the test section of the wind tunnel. In this study, the experimental parameters considered are temperature of the heated jet (smoke), jet ejected velocity, …

Green Dairy, A Project For Environmental Friendly And Sustainable Dairy Systems In The Atlantic Area, H. Chambaut, A. Pflimlin, C. Raison

IGC Proceedings (1993-2023)

Green Dairy is an European Interreg III B project which runs over 3 years. It brings together 10 research and development partners from 5 countries and 11 regions of the Atlantic Area which range from Scotland to Portugal. It aims to provide a better understanding of the impact of intensive dairy systems on the quality of the environment in order to develop ways of improving practices in the different regions. This is expected to encourage more rapid responses to the problems of deteriorating water and air quality and a more appropriate response within or between regional contexts that could be …

Management Options To Reduce N-Losses From Ploughed Grass-Clover, J. De Wit, G. J. Van Der Burgt, N. Van Eekeren

IGC Proceedings (1993-2023)

Nitrate (NO₃ -) leaching from grassland can be kept at acceptable levels, but is often high after ploughing for grassland renewal or for silage maize/grain production. In on-farm research with several organic farmers, management options are being explored to save scarce organic manure and to reduce N-losses.

Rangeland Ecological Management Counter-Measures Study Of Xinjiang, H. X. Cui, J. Li, S. Asiya, J. L. Zhang, Jialin

IGC Proceedings (1993-2023)

Xinjiang is located in the hinterland of the Asian-Euro continental area and far from the ocean. It is surrounded by mountains and forms a physiognomic landscape of two basins located in three mountains. This results in an extremely droughty continental climate and a harsh environment in the Temperate Zone. However, the geographical environment is diverse in the Xinjiang Autonomous region, the three high mountains and complicated geographical structure results in changes in ecological conditions with altitude and a diverse ecological environment. Because of the drought characteristics the desert area has developed different types of vegetation, and the complexity of the …

Mechanical Aeration And Liquid Dairy Manure: Application Impacts On Grassland Runoff Water Quality And Yield, T. J. Basden, S. B. Shah, J. L. Miller

IGC Proceedings (1993-2023)

Wet weather on heavy soils reduces oxygen availability in the root zone and reduces forage yields. Mechanical aeration can improve forage yield in these soil conditions. Research has shown that under certain conditions, mechanical aeration can increase yield by improving drainage and aeration (Davies et al., 1989); aeration can also increase depression, storage and infiltration thus reducing surface runoff and improving nutrient distribution in the root zone. Aeration on sloping, fertilised grassland can provide environmental (Douglas et al., 1995) and agronomic benefits. The objectives of this study were to evaluate the runoff water quality and agronomic impacts of …

Nitrogen Dynamics Following The Break-Up Of Grassland On Three Different Sandy Soils, Manfred Kayser, K. Seidel, J. Müller

IGC Proceedings (1993-2023)

Nitrogen (N) is accumulated under grassland depending on factors such as soil type, management, and fertiliser input. Break-up of grassland stimulates mineralisation of organic N and may lead to increased soil mineral N and leaching losses (Lloyd, 1992). The objective of this study was to find out how site factors, e.g. soil, previous management and sward age, the following crop and the new level of N fertiliser affect the amount of inorganic N in autumn and the preceding mineralisation processes when grassland is ploughed in spring.

Fine Colloids ‘Carry’ Diffuse Water Contaminants From Grasslands, P. M. Haygarth, A. L. Heathwaite

IGC Proceedings (1993-2023)

The transport of diffuse pollutants from grassland has traditionally been described by the operationally defined threshold of greater, or smaller than a nominated membrane filter size. Most commonly this has been a 0.45 μm threshold to define ‘solute’ and ‘particulate’ transport. In this paper we shall use phosphorus (P) to help provide an example of the importance of colloid-facilitated transport.

Leaching Losses Of N, P And K From Grazed Legume Based Swards: Some Preliminary Results, E. R. Dixon, A. C. Stone, D. Scholefield, D. J. Hatch

IGC Proceedings (1993-2023)

There is increasing interest in sustainable agricultural systems because of environmental concerns. Animal production which utilises mixed grass and legume swards could be an effective measure in increasing the efficiency of nutrient utilisation, and investigation into different legume species is necessary. Leaching losses of N, P and K from 3 legume species under grazing by sheep were measured using Teflon-coated suction cups. The experiment took place on the UK site of the EU-funded, multi-site experiment – LEGGRAZE.

Soil Aggregate Dynamics, Particulate Organic Matter And Phosphate Under Dryland And Irrigated Pasture, J. T. Scott, L. M. Condron, R. W. Mcdowell

IGC Proceedings (1993-2023)

Soil aggregate formation and turnover affects the rate of occlusion or release of soil organic matter and therefore the availability for mineralisation or stabilisation of soil carbon (C) and phosphorus (P). Furthermore, differences in soil type, management and the quantity and quality of organic inputs can affect aggregate turnover rates (Six et al., 2000). Under pastoral farming the ratio of coarse particulate organic matter (inter-POM) inside macroaggregates but outside microaggregates to fine POM (intra-POM) within microaggregates may provide an indication of physical processes influencing mineralisation and stabilisation of soil C and organic P (Po). Our aim was to determine …