Digital Commons Network^™

Vimos Ultra-Deep Survey (Vuds): Witnessing The Assembly Of A Massive Cluster At Z ~ 3.3, B. C. Lemaux, O. Cucciati, L. A. M. Tasca, O. Le Fèvre, G. Zamorani, P. Cassata, B. Garilli, V. Le Brun, D. Maccagni, L. Pentericci, R. Thomas, E. Vanzella, R. Amorín, S. Bardelli, P. Capak, L. P. Cassarà, M. Castellano, A. Cimatti, J. G. Cuby, S. De La Torre, A. Durkalec, A. Fontana, M. Giavalisco, A. Grazian, N. P. Hathi, O. Ilbert, C. Moreau, S. Paltani, B. Ribeiro, M. Salvato, D. Schaerer, M. Scodeggio, V. Sommariva, M. Talia, Y. Taniguchi, L. Tresse, D. Vergani, P. W. Wang, S. Charlot, T. Contini, S. Fotopoulou, R. R. Gal, Dale D. Kocevski, C. López-Sanjuan, L. M. Lubin, Y. Mellier, T. Sadibekova, N. Scoville

Physics and Astronomy Faculty Publications

Using new spectroscopic observations obtained as part of the VIMOS Ultra-Deep Survey (VUDS), we performed a systematic search for overdense environments in the early universe (z> 2) and report here on the discovery of Cl J0227-0421, a massive protocluster at z = 3.29. This protocluster is characterized by both the large overdensity of spectroscopically confirmed members, δ_gal = 10.5 ± 2.8, and a significant overdensity in photometric redshift members. The halo mass of this protocluster is estimated by a variety of methods to be ~3 × 10¹⁴ℳ_⊙ at z ~ 3.3, which, evolved to z …

Hidden Starbursts And Active Galactic Nuclei At 0 < Z < 4 From The Herschel-Vvds-Cfhtls-D1 Field: Inferences On Coevolution And Feedback, B. C. Lemaux, E. Le Foc'h, O. Le Fèvre, O. Ilbert, L. Tresse, L. M. Lubin, G. Zamorani, R. R. Gal, P. Ciliegi, P. Cassata, Dale D. Kocevski, E. J. Mcgrath, S. Bardelli, E. Zucca, G. K. Squires

Physics and Astronomy Faculty Publications

We investigate of the properties of ~2000 Herschel/SPIRE far-infrared-selected galaxies from 0 < z < 4 in the CFHTLS-D1 field. Using a combination of extensive spectroscopy from the VVDS and ORELSE surveys, deep multiwavelength imaging from CFHT, VLA, Spitzer, XMM-Newton, and Herschel, and well-calibrated spectral energy distribution fitting, Herschel-bright galaxies are compared to optically-selected galaxies at a variety of redshifts. Herschel-selected galaxies are observed to span a range of stellar masses, colors, and absolute magnitudes equivalent to galaxies undetected in SPIRE. Though many Herschel galaxies appear to be in transition, such galaxies are largely consistent with normal star-forming galaxies when rest-frame colors are utilized. The nature of the star-forming “main sequence” is studied and we warn against adopting this …

Focusing On Drug Versus Disease Mechanisms And On Clinical Subgrouping To Advance Personalised Medicine In Psychiatry, Jose De Leon

Psychiatry Faculty Publications

Personalised medicine has finally been featured in psychiatric journals, but psychiatrists have mainly focused on the promise of using disease mechanisms to personalise treatment. Psychiatric disorders such as schizophrenia and depression are not diseases, in the medical sense, and are probably more like syndromes. Instead of spending much time and effort focusing on the mechanisms of diseases that may instead be syndromes, the author believes that psychiatrists should (1) learn more about personalising prescription via drug mechanisms, a pharmacological approach to personalised medicine; and (2) reconsider prior attempts by traditional clinical psychopharmacologists to use sophisticated clinical approaches that try to …

Methods To Expedite And Streamline Utility Relocations For Road Projects, Roy Sturgill, Timothy R.B. Taylor, Seyedmahdi Ghorashinezhad, Jiwen Zhang

Kentucky Transportation Center Research Report

Executive Summary This report describes best practices and tools to streamline and expedite utility relocations when they are required as part of road construction projects. As part of this effort, a research team from the Kentucky Transportation Center (KTC) conducted extensive qualitative research that involved mapping current practices at the Kentucky Transportation Cabinet (KYTC) and reviewing utility manuals from KYTC and other state transportation agencies. The KTC research team also conducted in-depth interviews with KYTC engineers and staff as well as representatives from utility companies (UCs). Based on the data from these investigations, KTC developed a number of recommendations to …

Railway/Highway At-Grade Crossing Surface Management: An Overview, Brett R. Malloy, Jerry G. Rose

Kentucky Transportation Center Research Report

This report draws on data from around the United States to describe the features of a successful railway/highway at-grade crossing management program; it emphasizes the highway/trackbed structures and crossing surfaces. Developing a structurally adequate crossing system is imperative, as this will produce a smooth surface and a stable highway/trackbed that prolongs crossings’ lifespans while keeping maintenance costs low and minimizing the number of disruptions encountered by highway and railway traffic. An overview of the guidance issued by several transportation agencies and organizations to facilitate the design and construction of railway/highway at-grade crossings is included here. Equally important to developing a …

Railway/Highway At-Grade Crossing Surface Rehabilitation Manual: Recommendations And Guides, Brett R. Malloy, Macy L. Purcell, Jerry G. Rose

Kentucky Transportation Center Research Report

This Railway/Highway At-Grade Crossing Surface Rehabilitation Manual offers guidance to engineers and project planners for designing, constructing, and managing railway/highway crossing rehabilitation projects. The manual includes information on pre-project administration, project execution, and post-project management and oversight. Suggestions are provided for determining the most cost-effective rehabilitation procedure, techniques to insure the appropriate installation procedures are followed onsite, and instructions for post-project administration and inspection procedures. The primary goal of this manual is to aid with the implementation of a crossing rehabilitation program; all of its guidance underscores the importance of achieving costeffective solutions through the use of best practices to …

Effect Of Enhanced Trackbed Support On Railway/Highway At-Grade Crossing Performance, Jerry G. Rose, Brett R. Malloy

Kentucky Transportation Center Research Report

This report documents the long-term performance of 89 railway/highway at-grade crossings in Kentucky and adjacent states that contain asphalt underlayment underneath the ballast. Asphalt underlayment increases load carrying capacity for trains and highway vehicles while enhancing the support structure’s waterproofing and confinement. The asphalt underlayment crossings studied were installed at sites that had historically exhibited poor performance and short service lives. Most of the crossing sites evaluated were 10-15 years old; however, their ages ranged up to 30 years. All of the crossings investigated have shown excellent performance since the installation of asphalt underlayments. No crossing failures, such as excessive …

Testing A Risky Sex Behavior Intervention Pilot Website For Adolescents, Randall Starling, Don Helme, Jessica A. Nodulman, Angela D. Bryan, David B. Buller, Robert Lewis Donohew, W. Gill Woodall

Communication Faculty Publications

BACKGROUND AND PURPOSE: Each year, teenagers account for about one-fifth of all unintended pregnancies in the United States. As such, delivering sexual risk reduction educational materials to teens in a timely fashion is of critical importance. Web-based delivery of these materials shows promise for reaching and persuading teens away from risky sexual and substance abuse behaviors. The purpose of this study was to pilot test a web-based program aimed at reducing risky sexual behavior and related outcomes among adolescents in a high school setting.

METHODS: A beta-test of the website was conducted in three public schools in New Mexico, USA …

De La Reina-Madre De La Nación A La Tarasca: Para Un Análisis De Los Discursos De Juramentación Las Presidentas Electas Latinoamericanas, Yanira B. Paz

Hispanic Studies Faculty Publications

El propósito de este trabajo es estudiar desde la perspectiva del análisis crítico del discurso (ACD), los discursos de juramentación al cargo de las presidentas electas latinoamericanas. Se parte de la idea de que estos discursos constituyen la plataforma filosófica-política que, basada sobre las expectativas que llevaron al poder a estas líderes, constituirá el motor de acción del gobierno, así como también un criterio para valorar su implementación y efectividad. Desde la perspectiva de los estudios de género constituyen un proceso para la construcción de la identidad de la imagen de la líder.

This is a study from the perspective …

The Effects Of Temperature And Seasons On Subcutaneous White Adipose Tissue In Humans: Evidence For Thermogenic Gene Induction, Philip A. Kern, Brian S. Finlin, Beibei Zhu, Neda Rasouli, Robert E. Mcgehee Jr., Philip M. Westgate, Esther E. Dupont-Versteegden

Clinical and Translational Science Faculty Publications

Context: Although brown adipose tissue (BAT) activity is increased by a cold environment, little is known of the response of human white adipose tissue (WAT) to the cold.

Design: We examined both abdominal and thigh subcutaneous (SC) WAT from 71 subjects who were biopsied in the summer or winter, and adipose expression was assessed after an acute cold stimulus applied to the thigh of physically active young subjects.

Results: In winter, UCP1 and PGC1 α mRNA were increased 4 to 10-fold (p<0.05) and 1.5 to 2-fold, respectively, along with beige adipose markers, and UCP1 protein was 3-fold higher in the winter. The seasonal increase in abdominal SC WAT UCP1 mRNA was considerably diminished in subjects with a BMI > 30 kg/m², suggesting that dysfunctional WAT in obesity inhibits adipose thermogenesis. After applying an acute …

Transcription Of The Streptococcus Pyogenes Hyaluronic Acid Capsule Biosynthesis Operon Is Regulated By Previously Unknown Upstream Elements, Marina Falaleeva, Oliwia W. Zurek, Robert L. Watkins, Robert W. Reed, Hadeel Ali, Paul Sumby, Jovanka M. Voyich, Natalia Korotkova

Molecular and Cellular Biochemistry Faculty Publications

The important human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]) produces a hyaluronic acid (HA) capsule that plays critical roles in immune evasion. Previous studies showed that the hasABC operon encoding the capsule biosynthesis enzymes is under the control of a single promoter, P1, which is negatively regulated by the two-component regulatory system CovR/S. In this work, we characterize the sequence upstream of P1 and identify a novel regulatory region controlling transcription of the capsule biosynthesis operon in the M1 serotype strain MGAS2221. This region consists of a promoter, P2, which initiates transcription of a novel small RNA, HasS, an …

“Danger Is My Business”: The Right To Manufacture Unsafe Products, Richard C. Ausness

Law Faculty Scholarly Articles

While no one would dispute that safety is a desirable objective, it may not always be an absolute priority. Rather, in some cases, other societal interests such as personal autonomy, consumer choice, product cost, and performance may trump legitimate safety goals. This is reflected in some of the doctrines and defenses that have evolved to protect the producers of unsafe products against tort liability. Some of these doctrines, such as those determining liability for the producers of optional safety equipment, inherently dangerous products, products with obvious hazards, and prescription drugs and medical devices, are part of the law of products …

Recommendations For Kytc’S Railway/Highway At-Grade Crossing Surface Management Practices, Brett R. Malloy, Jerry G. Rose, Macy L. Purcell

Kentucky Transportation Center Research Report

An ideal Railway/Highway At-Grade Crossing Management program involves selecting costeffective practices when designing new crossings and rehabilitating existing crossings. This report outlines two strategies to enhance KYTC’s existing program. First, it describes a process that uses decision-option diagrams to optimize the assessment and implementation of engineering solutions in order to restore desired smoothness, minimize settlement in the postconstruction phase, and foster acceptable long-term performance of crossings following their rehabilitation. Decision-option diagrams rely on assessments that are site-specific and based on historical performance, the present observed performance and condition, and the measureable parameters specific to particular crossings. To supplement this process, …

Simplified Post Processing Of Cine Dense Cardiovascular Magnetic Resonance For Quantification Of Cardiac Mechanics, Jonathan D. Suever, Gregory J. Wehner, Christopher M. Haggerty, Linyuan Jing, Sean M. Hamlet, Cassi M. Binkley, Sage P. Kramer, Andrea C. Mattingly, David K. Powell, Kenneth C. Bilchick, Frederick H. Epstein, Brandon K. Fornwalt

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: Cardiovascular magnetic resonance using displacement encoding with stimulated echoes (DENSE) is capable of assessing advanced measures of cardiac mechanics such as strain and torsion. A potential hurdle to widespread clinical adoption of DENSE is the time required to manually segment the myocardium during post-processing of the images. To overcome this hurdle, we proposed a radical approach in which only three contours per image slice are required for post-processing (instead of the typical 30-40 contours per image slice). We hypothesized that peak left ventricular circumferential, longitudinal and radial strains and torsion could be accurately quantified using this simplified analysis.

METHODS …

Quantitative Neuropathological Assessment To Investigate Cerebral Multi-Morbidity, Johannes Attems, Janna H. Neltner, Peter T. Nelson

Pathology and Laboratory Medicine Faculty Publications

The aging brain is characterized by the simultaneous presence of multiple pathologies, and the prevalence of cerebral multi-morbidity increases with age. To understand the impact of each subtype of pathology and the combined effects of cerebral multi-morbidity on clinical signs and symptoms, large clinico-pathological correlative studies have been performed. However, such studies are often based on semi-quantitative assessment of neuropathological hallmark lesions. Here, we discuss some of the new methods for high-throughput quantitative neuropathological assessment. These methods combine increased quantitative rigor with the added technical capacity of computers and networked analyses. There are abundant new opportunities - with specific techniques …

Catechol Oxidation By Ozone And Hydroxyl Radicals At The Air-Water Interface, Elizabeth A. Pillar, Robert C. Camm, Marcelo I. Guzman

Chemistry Faculty Publications

Anthropogenic emissions of aromatic hydrocarbons promptly react with hydroxyl radicals undergoing oxidation to form phenols and polyphenols (e.g., catechol) typically identified in the complex mixture of humic-like substances (HULIS). Because further processing of polyphenols in secondary organic aerosols (SOA) can continue mediated by a mechanism of ozonolysis at interfaces, a better understanding about how these reactions proceed at the air–water interface is needed. This work shows how catechol, a molecular probe of the oxygenated aromatic hydrocarbons present in SOA, can contribute interfacial reactive species that enhance the production of HULIS under atmospheric conditions. Reactive semiquinone radicals are quickly produced upon …

Selection Of Reference Genes For Expression Analysis Using Quantitative Real-Time Pcr In The Pea Aphid, Acyrthosiphon Pisum (Harris) (Hemiptera, Aphidiae), Chunxiao Yang, Huipeng Pan, Yong Liu, Xuguo Zhou

Entomology Faculty Publications

To facilitate gene expression study and obtain accurate qRT-PCR analysis, normalization relative to stable expressed housekeeping genes is required. In this study, expression profiles of 11 candidate reference genes, including actin (Actin), elongation factor 1 α (EF1A), TATA-box-binding protein (TATA), ribosomal protein L12 (RPL12), β-tubulin (Tubulin), NADH dehydrogenase (NADH), vacuolar-type H+-ATPase (v-ATPase), succinate dehydrogenase B (SDHB), 28S ribosomal RNA (28S), 16S ribosomal RNA (16S), and 18S ribosomal RNA (18S) from the pea aphid Acyrthosiphon pisum, …

Deficiency Of Kruppel-Like Factor Klf4 In Myeloid-Derived Suppressor Cells Inhibits Tumor Pulmonary Metastasis In Mice Accompanied By Decreased Fibrocytes, Y. Shi, L. Ou, S. Han, M. Li, M. M. O. Pena, E. A. Pena, Chunming Liu, M. Nagarkatti, D. Fan, W. Ai

Molecular and Cellular Biochemistry Faculty Publications

The importance of immunosuppressive myeloid-derived suppressor cells (MDSCs) bearing monocyte markers in tumor metastasis has been well established. Recently, it was reported that these cells possess phenotypic plasticity and differentiate into fibrocytes, very distinct cells that are precursors of tumorigenic myofibroblasts. However, the importance of this transdifferentiation in tumor metastasis has not been explored. Here, we describe the role of MDSC-derived fibrocytes in tumor metastasis that is regulated by Kruppel-like factor 4 (KLF4), a transcription factor that is critical to monocyte differentiation and to promotion of cancer development. Using mouse metastasis models of melanoma and breast cancer, we found that …

Line-Driven Radiative Outflows In Luminous Quasars, Rebecca A. A. Bowler, Paul C. Hewett, James T. Allen, Gary J. Ferland

Physics and Astronomy Faculty Publications

An analysis of ≃19 500 narrow ( ≲ 200 km s⁻¹) C iv λλ1548.2,1550.8 absorbers in ≃34 000 Sloan Digital Sky Survey quasar spectra is presented. The statistics of the number of absorbers as a function of outflow velocity shows that in approximately two-thirds of outflows, with multiple C iv absorbers present, absorbers are line-locked at the 500 km s⁻¹ velocity separation of the C iv absorber doublet; appearing as ‘triplets’ in the quasar spectra. Line-locking is an observational signature of radiative line-driving in outflowing material, where the successive shielding of ‘clouds’ of material in the outflow …