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Clinical Features, Eeg Findings And Outcome In Patients With Bilateral Periventricular Nodular Heterotopia And Epilepsy, Aysun Ünal, Serap Saygi
Clinical Features, Eeg Findings And Outcome In Patients With Bilateral Periventricular Nodular Heterotopia And Epilepsy, Aysun Ünal, Serap Saygi
Turkish Journal of Medical Sciences
Aim: To review the clinical, electrophysiological and neuroimaging data of eight adult patients (4F/4M) with epilepsy and bilateral periventricular nodular heterotopia (PNH) after a long duration of follow-up. Materials and Methods: The clinical charts were reviewed for demographic and clinical features, seizure types and frequency, treatment and prognosis of all eight patients who were under follow-up by one of the authors (SS). The recordings of video-EEG monitoring with scalp electrodes in five patients and routine EEGs in all patients were reviewed. Results: The clinical semiology was in accord with seizures originating from temporal lobe region in four patients, while an …
Pregnancy Associated Plasma Protein-A And Epilepsy, Abdurrahman Coşkun, Burcu Özdemi̇rli̇, Ramazan Memi̇şoğullari
Pregnancy Associated Plasma Protein-A And Epilepsy, Abdurrahman Coşkun, Burcu Özdemi̇rli̇, Ramazan Memi̇şoğullari
Turkish Journal of Medical Sciences
In this study, we aimed to investigate the role of pregnancy-associated plasma protein-A (PAPP-A) as insulin-like growth factor binding protein-4 (IGFBP-4) protease in epilepsy patients. We studied 16 epilepsy patients and 10 healthy controls. Serum PAPP-A levels of epilepsy patients (6.8 ± 3.2 mU/L) were higher than of the control group (5.1 ± 1.9 mU/L), but the difference was not statistically significant (P > 0.05). We concluded that PAPP-A may increase the bioavailability of insulin-like growth factors (IGFs) due to decreased neurogenesis and synthesis of IGFs in chronically epilepsy patients.