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Cobalamin Deficiency During Pregnancy Expressed As Elevated Urine Methylmalonic Acid Levels Determined By A Photometric Assay, Osman Meti̇n İpçi̇oğlu, Mustafa Gültepe, Ömer Özcan
Cobalamin Deficiency During Pregnancy Expressed As Elevated Urine Methylmalonic Acid Levels Determined By A Photometric Assay, Osman Meti̇n İpçi̇oğlu, Mustafa Gültepe, Ömer Özcan
Turkish Journal of Medical Sciences
Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We aimed to evaluate cobalamin state in pregnancy by using urine MMA levels determined by an economic spectrophotometric method. Materials and Methods: For this cross-sectional study, plasma total homocysteine (tHcy), serum folate and vitamin B12, and urine MMA levels were measured in …
How To Manage Triquetrum And Hamate Fractures In Unusual Patterns: A Case Report, Vuslat Sema Ünal, Fuad Öken, Özgür Yildirim, Murat Gülcek, Zafer Soydan, Ahmet Uçaner
How To Manage Triquetrum And Hamate Fractures In Unusual Patterns: A Case Report, Vuslat Sema Ünal, Fuad Öken, Özgür Yildirim, Murat Gülcek, Zafer Soydan, Ahmet Uçaner
Turkish Journal of Medical Sciences
The 3-dimensional alignment of the carpal bones should be intact to ensure functional integrity of the hand. The treatment of fractures of the carpal bones is challenging and may differ according to localization. A patient with closed carpal injury and his treatment are presented in this report. After his wrist was crushed between a smooth hammer and a workbench during an occupational accident, the patient had multiple carpal bone fractures and remarkable swelling. The type of the injury was regarded to be a sort of capitate-hamate diastasis, although it did not correspond to any type that had been previously described. …
Supernumerary Tooth In The Nose, Cengi̇z Öztürk, Keri̇m Eryilmaz, Bi̇nali̇ Çakur
Supernumerary Tooth In The Nose, Cengi̇z Öztürk, Keri̇m Eryilmaz, Bi̇nali̇ Çakur
Turkish Journal of Medical Sciences
The presence of a supernumerary tooth in the nose is an unusual phenomenon and a rare form of ectopic tooth eruption in the maxillofacial region. In this case, the patient was referred to the hospital with the complaint of severe headache. In the endoscopic examination, the supernumerary tooth crown was not covered with mucosa or granulation tissue. In the present study, the clinical and radiological diagnosis of a supernumerary tooth located in the nose is reported.
Diagnostic Neglect Regarding Ureter Ligation After Hysterectomy, Yaşar Bi̇lge
Diagnostic Neglect Regarding Ureter Ligation After Hysterectomy, Yaşar Bi̇lge
Turkish Journal of Medical Sciences
Complications following cesarean and hysterectomy operations can occur, one of which is ureter ligation. Aims: Urological injuries that occur during hysterectomy are rare but important causes of morbidity. It was aimed to investigate in this case report whether there was any evidence to support malpractice in Court. Case Report: The patient was a woman in her 34^3 week of pregnancy with familial Mediterranean fever (FMF) and nephrotic syndrome with renal amyloidosis. Preterm operational diagnosis was placenta previa totalis and repeat cesarean section was performed with confirmed consent. When the placenta spontaneously ruptured, hysterectomy was undertaken. Ureter ligation with acute renal …
How Should Glucocorticoids Be Used?, Şi̇nasi̇ Özsoylu
How Should Glucocorticoids Be Used?, Şi̇nasi̇ Özsoylu
Turkish Journal of Medical Sciences
No abstract provided.
A Copper Determination Method Based On The Reaction Between 2-(5-Nitro-2-Pyridylazo)-5-(N-Propyl-N- Sulfopropylamino) Phenol (Nitro-Paps) And Copper For Use In Urine Copper Measurement And Application To Automation, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe
A Copper Determination Method Based On The Reaction Between 2-(5-Nitro-2-Pyridylazo)-5-(N-Propyl-N- Sulfopropylamino) Phenol (Nitro-Paps) And Copper For Use In Urine Copper Measurement And Application To Automation, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe
Turkish Journal of Medical Sciences
Aim: To develop a sensitive automated colorimetric urine copper determination method using a water soluble compound, 2-(5-nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino) phenol (nitro-PAPS), as a ligand. Materials and Methods: The new photometric method using sodium dodecyl sulfate (SDS)-ascorbic acid to dissociate copper from proteins in acetate buffer (pH 3.2) and nitro-PAPS as ligand was also adapted to an automated analyzer. Copper concentrations were determined by atomic absorption spectrophotometric method and by photometric method in 24 h urine samples of patients (n = 100) with various types of diseases including Wilson's disease (n = 12), diabetes mellitus (n = 34), osteoporosis (n = 27), nephrotic …
Ghrelin May Be A Universal Peptide In All Living Organisms, Süleyman Aydin
Ghrelin May Be A Universal Peptide In All Living Organisms, Süleyman Aydin
Turkish Journal of Medical Sciences
No abstract provided.
Intussusception Due To Inflammatory Fibroid Polyp Located At Ileum: Report Of Two Cases, Özgür Korkmaz, Hati̇ce Gülşen Yilmaz, Fahri̇ Yilmaz
Intussusception Due To Inflammatory Fibroid Polyp Located At Ileum: Report Of Two Cases, Özgür Korkmaz, Hati̇ce Gülşen Yilmaz, Fahri̇ Yilmaz
Turkish Journal of Medical Sciences
Inflammatory fibroid polyps are uncommon gastrointestinal tract lesions. The stomach and ileum are the most commonly affected sites. Clinical symptoms depend on the location and size of the lesion. Obstruction or intussusception is the most frequent initial symptom when an inflammatory fibroid polyp is located in the small intestine. We describe two cases of inflammatory fibroid polyps of the small intestine causing ileocecal and ileoileal intussusception.
Excretion Rate And Composition Of Skin Surface Lipids On The Foreheads Of Adult Males With Type Iv Hyperlipoproteinemia, Tayfun Güldür, Ni̇hayet Bayraktar, Özgür Kaynar, Gülçi̇n Beker, Muzaffer Koçer, Hamdi̇ Özcan
Excretion Rate And Composition Of Skin Surface Lipids On The Foreheads Of Adult Males With Type Iv Hyperlipoproteinemia, Tayfun Güldür, Ni̇hayet Bayraktar, Özgür Kaynar, Gülçi̇n Beker, Muzaffer Koçer, Hamdi̇ Özcan
Turkish Journal of Medical Sciences
Aim: Most of the lipids of the skin surface come from the sebaceous glands, which secrete an oily substance called sebum. Some of the sebum lipids are synthesized by sebaceous cells while some are reported to be derived from the plasma. The role of blood lipoproteins in sebum secretion rate and composition is unclear. To this end, excretion rate and composition of skin surface lipids in normo- and type IV hyperlipoproteinemic adult male subjects were compared. Materials and Methods: Quantitative analysis of skin surface lipids of subjects with type IV hyperlipoproteinemia (n:21) and normolipoproteinemia (n:15) was performed by three successive …
Ventilation Tubes In Secretory Otitis Media Associated With Cleft Palate: A Retrospective Analysis, Bi̇rol Ci̇velek, Seli̇m Çelebi̇oğlu, Mustafa Sağit, İstemi̇han Akin
Ventilation Tubes In Secretory Otitis Media Associated With Cleft Palate: A Retrospective Analysis, Bi̇rol Ci̇velek, Seli̇m Çelebi̇oğlu, Mustafa Sağit, İstemi̇han Akin
Turkish Journal of Medical Sciences
Aim: The insertion of ventilation tubes at the time of cleft palate surgery is a controversial issue. We assessed the status of hearing and the middle ear in long-term follow-up after the treatment of cleft palate. Materials and Methods: 56 patients with cleft palate repair at the ages of 15 to 24 months were included in the study. The control group consisted of 15 patients in whom ventilation tubes were inserted previously for secretory otitis media. They all had audiologic analyses. Results: In the control group, only one patient was found to have perforation of tympanic membrane on one side. …
Case Of Tuberous Sclerosis With Pulmonary Involvement, Arzu Balkan, Cantürk Taşci, Carl R. Fuhrman
Case Of Tuberous Sclerosis With Pulmonary Involvement, Arzu Balkan, Cantürk Taşci, Carl R. Fuhrman
Turkish Journal of Medical Sciences
Tuberous sclerosis is a rare genetic disorder. The diagnosis of tuberous sclerosis requires the presence of two major or one major and two minor features. Pulmonary involvement has been reported to occur in less than 1% in patients and carries a poor prognosis. We present a female tuberous sclerosis patient with pulmonary involvement, evaluated for a positive PPD reaction.
Effects Of Esmolol On Hemodynamic Responses To Laryngoscopy And Tracheal Intubation In Diabetic Versus Non-Diabetic Patients, Taner Taşyüz, İsmet Topçu, Sabri̇ Özaslan, Melek Sakarya
Effects Of Esmolol On Hemodynamic Responses To Laryngoscopy And Tracheal Intubation In Diabetic Versus Non-Diabetic Patients, Taner Taşyüz, İsmet Topçu, Sabri̇ Özaslan, Melek Sakarya
Turkish Journal of Medical Sciences
Aim: We aimed to investigate the efficiency of esmolol, a short-acting ß-blocker, in preventing the hemodynamic response to laryngoscopy and endotracheal intubation in diabetic patients. Materials and Methods: Eighty diabetic or non-diabetic patients with ASA physical status I-II scheduled for noncardiac surgery were included in this study. They were divided randomly into 4 groups (Non-diabetic control: NDC, Non-diabetic esmolol: NDE, Diabetic control: DC, Diabetic esmolol: DE). Blood glucose analyses were measured in the preoperative period and at the 10^{th} min of the study. Prior to anesthetic induction, 1 mg/kg esmolol to Groups NDE and DE and saline to Groups NDC …
Pain In Upper Abdominal Malignancy, Colin Johnson, Jon Birtwistle, Carol Davis
Pain In Upper Abdominal Malignancy, Colin Johnson, Jon Birtwistle, Carol Davis
Turkish Journal of Medical Sciences
No abstract provided.
New Replacement Of A Thrombosed Mitral Valve Via Right Anterolateral Thoracotomy In A Patient With Coronary Artery By-Pass Graft And Functioning Internal Mammary Artery Graft, Münacetti̇n Cevi̇z, Neci̇p Beci̇t, Bi̇lgehan Erkut, Hi̇kmet Koçak
New Replacement Of A Thrombosed Mitral Valve Via Right Anterolateral Thoracotomy In A Patient With Coronary Artery By-Pass Graft And Functioning Internal Mammary Artery Graft, Münacetti̇n Cevi̇z, Neci̇p Beci̇t, Bi̇lgehan Erkut, Hi̇kmet Koçak
Turkish Journal of Medical Sciences
A 49-year-old male, who had undergone mitral valve replacement with mechanical cardiac valve and coronary arterial by-pass grafting six years previously, was admitted to our hospital with acute dyspnea. Transesophageal echocardiography revealed that one of the leaflets of the prosthetic valve was entirely immobilized in the closed position, and an immobile soft tissue mass was detected on the ventricular side of the obstructed leaflet. We performed re-replacement using a 29-mm mechanical prosthetic St. Jude valve under deep hypothermic circulatory arrest via right atrial thoracotomy. Postoperative course was uneventful, and the patient was discharged with oral anticoagulant therapy on day 7 …
An Impulse Control Disorder Case With Penile Fracture And Trichotillomania, Bi̇rgül Elbozan Cumurcu, Burhanetti̇n Kaya, Feryal Çam Çeli̇kel, Ahmet Soylu, Fi̇kret Erdemi̇r
An Impulse Control Disorder Case With Penile Fracture And Trichotillomania, Bi̇rgül Elbozan Cumurcu, Burhanetti̇n Kaya, Feryal Çam Çeli̇kel, Ahmet Soylu, Fi̇kret Erdemi̇r
Turkish Journal of Medical Sciences
Penile fractures are classically described as presenting with rapid detumescence of an erection associated with blunt trauma. This clinical finding is due to a tear in the tunica albuginea surrounding the corpora cavernosum. In this study, we report and discuss a case of trichotillomania and penile bending impulse resulting in penile fracture, which was operated in the urology clinic. The possible psychological and psychiatric problems underlying the impulsive behavior are discussed, and the value of a psychiatric evaluation is emphasized.
Comparison Of Conventional Cytogenetic And Fluorescence In Situ Hybridization Results Of Prenatal Aneuploidy Screening, Zerri̇n Yilmaz, Özge Özalp, Ebru Tarim, Ayla Üçkuyu, Vural Dağli, Feri̇de İffet Şahi̇n
Comparison Of Conventional Cytogenetic And Fluorescence In Situ Hybridization Results Of Prenatal Aneuploidy Screening, Zerri̇n Yilmaz, Özge Özalp, Ebru Tarim, Ayla Üçkuyu, Vural Dağli, Feri̇de İffet Şahi̇n
Turkish Journal of Medical Sciences
Background and Aim: Prenatal diagnosis of chromosome abnormalities is usually performed on amniotic fluid samples. Aneuploidy screening by fluorescence in situ hybridization (FISH), although not an alternative for conventional cytogenetics, has become a useful tool. Materials and Methods: We compared the results of FISH and conventional cytogenetic analysis applied on 51 amniotic fluid samples between January 2002 and December 2005, in our Cytogenetics Laboratory. Amniocytes were extracted using 5 cc of the sample, and direct FISH was applied using an AneuVysion Assay Kit (Vysis). The remaining fluid samples were used for chromosome analysis by conventional methods after long-term cell cultures. …
Increased Lipid Peroxidation And Decreased Antioxidant Response In Serum And Cerebrospinal Fluid In Acute Ischemic Stroke, Abdulkadi̇r Yildirim, Di̇lcan Kotan, Serap Yildirim, Recep Aygül, Fati̇h Akçay
Increased Lipid Peroxidation And Decreased Antioxidant Response In Serum And Cerebrospinal Fluid In Acute Ischemic Stroke, Abdulkadi̇r Yildirim, Di̇lcan Kotan, Serap Yildirim, Recep Aygül, Fati̇h Akçay
Turkish Journal of Medical Sciences
Background and Aim: The pathogenesis of brain damage in ischemic stroke is highly complex. The aim of the present study was to investigate the presence of oxidative stress in ischemic stroke and to determine whether the measured oxidative stress markers in serum and cerebrospinal fluid (CSF) were associated with infarction volume, and the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS). Materials and Methods: The study included 32 patients with acute ischemic stroke within 48 h of onset and 18 suitable controls. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity, glutathione (GSH) and malondialdehyde (MDA) level, and total antioxidant …
Ultrasonographic Mapping Reduces The Complications Of Diagnostic Laparoscopy For Abdominal Tuberculosis, Müjdat Balkan, Arzu Balkan, Taner Yi̇ği̇t, Mutlu Sağlam, Yüksel Ateş, Ahmet Tüzün
Ultrasonographic Mapping Reduces The Complications Of Diagnostic Laparoscopy For Abdominal Tuberculosis, Müjdat Balkan, Arzu Balkan, Taner Yi̇ği̇t, Mutlu Sağlam, Yüksel Ateş, Ahmet Tüzün
Turkish Journal of Medical Sciences
Background and Aim: Diagnostic laparoscopy is of great value in the early diagnosis of abdominal tuberculosis and to help improve bed turnover. Diagnostic laparoscopy, however, is subject to all the risks and complications inherent to any invasive procedure. Our aim was to evaluate the role of ultrasonography in the prevention of complications when using diagnostic laparoscopy, and to present its efficacy in the monitoring of response to therapy. Materials and Methods: Nineteen male patients who had ascites with unknown etiology or with suspected abdominal tuberculosis were recruited. In order to analyze the potential role of ultrasonographic mapping as an aid …
Editorial, M. Mahi̇r Özmen
A Role Of Leptin In Psoriasis?, Şebnem Aktan, Si̇mi̇n Rota, Berna Şanli Erdoğan, Şeni̇z Ergi̇n, Bünyami̇n Kaptanoğlu, Mehmet Bostanci
A Role Of Leptin In Psoriasis?, Şebnem Aktan, Si̇mi̇n Rota, Berna Şanli Erdoğan, Şeni̇z Ergi̇n, Bünyami̇n Kaptanoğlu, Mehmet Bostanci
Turkish Journal of Medical Sciences
Aim: Although there is evidence of a positive association between psoriasis and body mass index (BMI) and leptin is known to play a part in the regulation of the immune system, the relationship between psoriasis and leptin is still not well known. The aim of this study was to evaluate the possible relation between leptin and psoriasis. Materials and Methods: Serum leptin concentrations and BMI in 20 patients with psoriasis were compared to 20 age- and sex-matched healthy volunteers. Results: There was no difference between serum leptin levels of psoriatic patients (32.3 ± 24.9 ng/ml) and controls (36.8 ± 28.2 …
Evaluation Of The Ehrlich-Ziehl-Neelsen (Ezn) And Amplified Mycobacterium Tuberculosis Direct Test According To The Bactec Method In Respiratory And Nonrespiratory Samples, Tuncer Özeki̇nci̇, Sevi̇m Meşe, Selahatti̇n Atmaca, Nezahat Akpolat, Kadri̇ Gül
Evaluation Of The Ehrlich-Ziehl-Neelsen (Ezn) And Amplified Mycobacterium Tuberculosis Direct Test According To The Bactec Method In Respiratory And Nonrespiratory Samples, Tuncer Özeki̇nci̇, Sevi̇m Meşe, Selahatti̇n Atmaca, Nezahat Akpolat, Kadri̇ Gül
Turkish Journal of Medical Sciences
Aim: Tuberculosis remains a significant and threatening disease, particularly in developing countries. Mycobacterium tuberculosis should be detected and identified as soon as possible to ensure the prevention of the spread of the disease. For this purpose, use of fast and reliable laboratory diagnostic methods with high sensitivity and specificity was initiated in recent years. Materials and Methods: In this study, 107 respiratory and 198 nonrespiratory (305 in total) samples submitted to Dicle University Faculty of Medicine Clinical Microbiology Laboratory were examined using the Ehrlich-Ziehl-Neelsen (EZN), BACTEC 460 TB (Becton and Dickinson Diagnostic Instrument System, Towson, MD), and MTD (Amplified Mycobacterium …
A Rare Side Effect Of Metformin: Metformin-Induced Hepatotoxicity, Ersi̇n Aksay, Sedat Yanturali, Başak Bayram, Ni̇l Hocaoğlu, Selahatti̇n Kiyan
A Rare Side Effect Of Metformin: Metformin-Induced Hepatotoxicity, Ersi̇n Aksay, Sedat Yanturali, Başak Bayram, Ni̇l Hocaoğlu, Selahatti̇n Kiyan
Turkish Journal of Medical Sciences
Metformin is an oral hypoglycemic agent that is commonly used in the treatment of type 2 diabetes mellitus. While metformin-associated metabolic acidosis is a widely recognized side effect of this drug, metformin-induced hepatotoxicity has been rarely reported in the literature. We present herein the case of a 52-year-old male in whom metformin-associated lactic acidosis and metformin-induced hepatotoxicity developed.
Horner´S Syndrome Post-Excision Of A Huge Cervical Sympathetic Chain Schwannoma, Sedat Aydin, Ari̇f Şanli, Ömer Taşdemi̇r, Ayli̇n Ege Gül
Horner´S Syndrome Post-Excision Of A Huge Cervical Sympathetic Chain Schwannoma, Sedat Aydin, Ari̇f Şanli, Ömer Taşdemi̇r, Ayli̇n Ege Gül
Turkish Journal of Medical Sciences
Schwannoma of the cervical sympathetic chain is a rare nerve tumor. These lesions typically present as an asymptomatic neck mass and are easily mistaken for a carotid body tumor during the initial work-up. In this report, a rarely seen huge cervical sympathetic chain schwannoma case, who experienced partial Horner´s syndrome postoperatively, is presented. We report a case of schwannoma on the cervical sympathetic chain, which to our knowledge is the largest reported in the current literature.
The Nature Of Medical Evidence And Evidence-Based Practice, John A. Murie
The Nature Of Medical Evidence And Evidence-Based Practice, John A. Murie
Turkish Journal of Medical Sciences
No abstract provided.
Is Serum Prostate Specific Antigen Level Affected By In-And-Out Urethral Catheterization?, Yilmaz Aslan, Altuğ Tuncel, Ümi̇t Tekdoğan, Osman Özergi̇n, Ali̇ Atan
Is Serum Prostate Specific Antigen Level Affected By In-And-Out Urethral Catheterization?, Yilmaz Aslan, Altuğ Tuncel, Ümi̇t Tekdoğan, Osman Özergi̇n, Ali̇ Atan
Turkish Journal of Medical Sciences
Aim: In this study, we aimed to investigate the effect of in-and-out urethral catheterization on serum total and free prostate specific antigen (PSA) levels and free/total PSA ratio. Materials and Methods: This is a prospective study including 24 patients who admitted with lower urinary tract symptoms and underwent in-and-out urethral catheterization with 18 F Foley catheter inserted for postvoiding residual urine measurement. Blood samples were withdrawn to determine serum total and free PSA levels and free/total PSA ratio immediately before, and at 1, 24 and 72 hours after urethral catheterization. Results: There was no alteration in total and free PSA …
An Investigation On The Natural Radioactivity Of Building Materials, Raw Materials And Interior Coatings In Central Turkey, Arman Erkan
Turkish Journal of Medical Sciences
Aim: The aim of this investigation was to measure the amount of g-decay of several building materials (brick and cement), raw materials (fly-ash and soil), interior coating materials (foam [used as a thermal insulator], water-based paints, solvent-based paints and phosphogypsum) from central Turkey, in terms of Bq kg^{-1}, and to calculate the biological damage caused by this radioactivity. Materials and Methods: Gamma-spectrometry technique has been used throughout the research in order to determine the activity of natural radionuclides. Later, annual doses were calculated. Results: The average radioactivity values were 632.2 Bq kg^{-1}for fly-ash, 4.4 Bq kg^{-1} for brick, 73.3 Bq …
Sacral Chondroblastic Osteosarcoma Misdiagnosed As Chondrosarcoma And Chordoma, Nusret Akpolat, Hanefi̇ Yildirim, Kürşat Poyraz
Sacral Chondroblastic Osteosarcoma Misdiagnosed As Chondrosarcoma And Chordoma, Nusret Akpolat, Hanefi̇ Yildirim, Kürşat Poyraz
Turkish Journal of Medical Sciences
Chondroblastic osteosarcoma (COS), a subgroup of intramedullary osteosarcoma, is usually located in the knee region of the body. It is most common in adolescents and early adulthood. COS has similar clinical and radiological features to those of conventional osteosarcomas. A 17-year-old male suffered from walking problems and lower limb pain. CT and MRI revealed a mass with soft tissue density and bone destruction at the level of L5-S1. It was described as \"posttraumatic hematoma\". In cytopathologic examination, initial diagnosis was chordoma in fine-needle aspiration cytology (FNAC), chondrosarcoma in incisional biopsy, and finally COS in total resection specimen. Because sacral location …
Quality Assurance Standards Task Force Global Standards: Route For Accreditation In Medical Education In Europe, İskender Sayek, Hans Karle
Quality Assurance Standards Task Force Global Standards: Route For Accreditation In Medical Education In Europe, İskender Sayek, Hans Karle
Turkish Journal of Medical Sciences
No abstract provided.
Plasma Thrombin Activitable Fibrinolysis Inhibitor Levels In Behçet´S Disease, Mehmet Ali̇ Özcan, Servet Akar, İnci̇ Alacacioğlu, Özden Pi̇şki̇n, Fai̇ze Yüksel, Oğuz Gürler, Nurullah Akkoç, Fati̇h Demi̇rkan, Güner Hayri̇ Özsan, Şebnem Özkan, Fatoş Önen, Bülent Ündar
Plasma Thrombin Activitable Fibrinolysis Inhibitor Levels In Behçet´S Disease, Mehmet Ali̇ Özcan, Servet Akar, İnci̇ Alacacioğlu, Özden Pi̇şki̇n, Fai̇ze Yüksel, Oğuz Gürler, Nurullah Akkoç, Fati̇h Demi̇rkan, Güner Hayri̇ Özsan, Şebnem Özkan, Fatoş Önen, Bülent Ündar
Turkish Journal of Medical Sciences
Aim: The precise pathogenetic mechanisms causing thrombotic complications in Behçet´s disease (BD) are still not known. To explain the pathogenesis with coagulation induction or a defective fibrinolysis superimposed on endothelial dysfunction, various hemostatic parameters were studied. Thrombin activatable fibrinolysis inhibitor (TAFI), downregulating plasmin generation and fibrinolysis, is a novel risk factor for thrombotic disorders. We studied plasma TAFI levels in BD in comparison with healthy controls. Materials and Methods: Twenty-three patients with BD (mean age: 38.3 ± 10.83, M/F: 5/18) diagnosed according to the criteria of the International Study Group and 20 healthy volunteers (mean age: 38.05 ± 6.29, M/F: …
Genetic Variants Account For Differences In Responses In Blood Pressure And Blood Flow Values To Laryngoscopy/Intubation/Extubation, Hülya Gönen, Zeynep Kayhan, Fatma Belgi̇n Ataç, Ayşe Canan Yazici, Feri̇de İffet Şahi̇n
Genetic Variants Account For Differences In Responses In Blood Pressure And Blood Flow Values To Laryngoscopy/Intubation/Extubation, Hülya Gönen, Zeynep Kayhan, Fatma Belgi̇n Ataç, Ayşe Canan Yazici, Feri̇de İffet Şahi̇n
Turkish Journal of Medical Sciences
Aim: There is a variation in drug response among individuals. In this study, we determined angiotensin-converting enzyme (ACE) insertion/deletion (I/D), beta2-adrenergic receptor (ADRB2) Arg16Gly and dopamine D1 receptor (DRD1) -48 G/A polymorphisms, which are presumed to be related to the transient hypertension induced by the mechanical stimulation of laryngoscopy and tracheal intubation/extubation. Materials and Methods: One hundred American Society of Anesthesiologists (ASA) class I patients were enrolled in this study. Heart rate and blood pressure were recorded before induction (T_0), after induction (T_1), during laryngoscopy/intubation (T_i) and 1, 2, 3, 4 and 5 min thereafter (T_{i-1}-T_{i-5}), before extubation (T_e) and …