Digital Commons Network^™

Limd1 Is Induced By And Required For Lmp1 Signaling, And Protects Ebv-Transformed Cells From Dna Damage-Induced Cell Death, Ling Wang, Mary E. A. Howell, Brooke Mcpeak, Katrina Riggs, Carissa Kohne, Jether Uel Yohanon, Daniel E. Foxler, Tyson V. Sharp, Jonathon P. Moorman, Zhi Q. Yao, Shunbin Ning

ETSU Faculty Works

LIMD1 (LIM domain-containing protein 1) is considered as a tumor suppressor, being deregulated in many cancers to include hematological malignancies; however, very little is known about the underlying mechanisms of its deregulation and its roles in carcinogenesis. Epstein-Barr Virus (EBV) is associated with a panel of malignancies of lymphocytic and epithelial origin. Using high throughput expression profiling, we have previously identified LIMD1 as a common marker associated with the oncogenic transcription factor IRF4 in EBV-related lymphomas and other hematological malignancies. In this study, we have identified potential conserved IRF4- and NFκB-binding motifs in the LIMD1 gene promoter, and both are …

Prevalence Of And Trends In Diabetes Among Veterans, United States, 2005–2014, Ying Liu, Sonica Sayam, Xiaonan Shao, Kesheng Wang, Shimin Zheng, Ying Li, Liang Wang

ETSU Faculty Works

Diabetes is a highly prevalent chronic disease among US adults, and its prevalence among US veterans is even higher. This study aimed to examine the prevalence of and trends in diabetes in US veterans by using data from the US National Health and Nutrition Examination Survey from 2005 through 2014. The overall prevalence of diabetes and undiagnosed diabetes was 20.5% and 3.4%, respectively, and increased from 15.5% in 2005–2006 to 20.5% in 2013–2014 (P = .04). Effective prevention and intervention approaches are needed to lower diabetes prevalence among US veterans and ultimately improve their health status.

Playing With Biofeedback: A Practical, Playful Approach To Using Biofeedback In Pediatric Health, Jason L. Steadman, Michael E. Feeney

ETSU Faculty Works

No abstract provided.

Loss Of Sympathetic Nerves In Spleens From Patients With End Stage Sepsis, Donald B. Hoover, Thomas Christopher Brown, Madeleine K. Miller, John B. Schweitzer, David L. Williams

ETSU Faculty Works

The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans. Experimental studies using animal models have established that sympathetic innervation of the spleen is essential for cholinergic anti-inflammatory responses evoked by vagal nerve stimulation, and clinical studies are evaluating this approach for treating inflammatory diseases. Most data on sympathetic nerves in spleen derive from rodent studies, and this work has established that remodeling of sympathetic innervation can occur during inflammation. However, little is known about the effects of sepsis on spleen …

2017 December 5 - Information Technology Council Minutes, Information Technology Council, East Tennessee State University

Information Technology Council Agenda and Minutes

No abstract provided.

2017 December 4 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Hallucinations Are Real To Patients With Dementia, R. C. Hamdy, Amber E. Kinser, J. V. Lewis, Rebecca Copeland

ETSU Faculty Works

In this case study, we present a patient with preexistent posttraumatic stress disorder and psychosis who has been recently diagnosed with Dementia with Lewy Bodies. He is experiencing vivid hallucinations. What went wrong between him and his wife as a result of these hallucinations is presented. Alternative actions that could have been used are suggested.

Antidepressant-Like Actions Of Inhibitors Of Poly(Adp-Ribose) Polymerase In Rodent Models, Gregory A. Ordway, Attila Szebeni, Liza J. Hernandez, Jessica D. Crawford, Katalin Szebeni, Michelle J. Chandley, Katherine C. Burgess, Corwin Miller, Erol Bakkalbasi, Russell W. Brown

ETSU Faculty Works

Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1. Given these findings and evidence that drugs that inhibit poly(ADP-ribose) polymerase-1 activity have antiinflammatory and neuroprotective properties, the present study …

Skeletal Muscle Hypertrophy, Maximal Strength, And Rate Of Force Development: Effects Of Resistance Training Loading Strategy, Kevin M. Carroll, Jake R. Bernard, Michael H. Stone

ETSU Faculty Works

Abstract available in the Annual Coaches and Sport Science College.

Determining Detection Limits Of Aqueous Anions Using Electrochemical Impedance Spectroscopy, Dane W. Scott, Yahya Alseiha

ETSU Faculty Works

Background: Pulsed amperometric detection is a relatively new method for detection of ions and especially non-electrolytes such as carbohydrates in aqueous solutions. Pulsed amperometric detection relies on a redox reaction while electrochemical impedance simply measures the real and capacitive resistant of the solution. There is a correlation between the real impedance of a solution and the ionic strength of the solution. Method: This work explores measuring real impedance of pure water as a function of temperature from 25.0 to 60.0 °C to determine the relationship between impedance and temperature. Maintaining temperature at 25.0 °C, solutions of sodium chloride, potassium carbonate, …

Associations Between General And Central Obesity And Hypertension Among Children: The Childhood Obesity Study In China Mega-Cities, Yaling Zhao, Liang Wang, Bo Xue, Youfa Wang

ETSU Faculty Works

In this study, we examined the associations of general and central obesity and hypertension among Chinese children. Data was collected from 1626 children aged 7-16 years and their parents in four mega-cities across China. Mixed effect models examined associations of general and central obesity with hypertension, and between body mass index (BMI), waist circumference (WC), waist-To-height ratio (WHtR), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The prevalence of general obesity, central obesity, and hypertension among the children was 11.1%, 19.7%, and 9.0%, respectively. More boys had general and central obesity than girls (15.2% vs. 6.9%; 27.4% vs. 11.7%, …

Midbrain Circuit Regulation Of Individual Alcohol Drinking Behaviors In Mice, Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edward, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming Hu Han

ETSU Faculty Works

Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There is substantial individual variability in alcohol drinking behaviors in the population, the neural circuit mechanisms of which remain elusive. Utilizing in vivo electrophysiological techniques, we find that low alcohol drinking (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst activity. Unexpectedly, VTA dopamine neuron activity in high alcohol drinking (HAD) mice does not differ from alcohol naive mice. Optogenetically enhancing VTA dopamine neuron burst activity in HAD mice decreases alcohol drinking behaviors. Circuit-specific recordings reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons …

The Influence Of The Social And Cultural Environment On Maternal Mortality In Nigeria: Evidence From The 2013 Demographic And Health Survey, Oluwatosin Ariyo, Ifeoma D. Ozodiegwu, Henry V. Doctor

ETSU Faculty Works

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction Reducing maternal mortality remains a priority for global health. One in five maternal deaths, globally, are from Nigeria. Objective This study aimed to assess the sociocultural correlates of maternal mortality in Nigeria. Methods We conducted a retrospective analysis of nationally representative data from the 2013 Nigeria Demographic and Health Survey. The analysis was based on responses from the core women’s questionnaire. Maternal mortality was categorized …

Patients With Dementia Are Easy Victims To Predators, Ronald C. Hamdy, J. V. Lewis, Rebecca Copeland, Audrey Depelteau, Amber E. Kinser, T. Kendall-Wilson, Kathleen Whalen

ETSU Faculty Works

Patients with dementia, especially Alzheimer’s disease and particularly those in early stages, are susceptible to become victims of predators: Their agnosia (see Case 1) prevents them from detecting and accurately interpreting subtle signals that otherwise would have alerted them that they are about to fall for a scam. Furthermore, their judgment is impaired very early in the disease process, often before other symptoms manifest themselves and usually before a diagnosis is made. Patients with early stages of dementia are therefore prime targets for unscrupulous predators, and it behooves caregivers and health care professionals to ensure the integrity of these patients. …

Resting Hormone Alterations And Injuries: Block Vs “Daily Undulating Periodization” Weight-Training Among Division I Track And Field Athletes, Keith B. Painter, Gregory N. Haff, Travis Triplett, Charles A. Stuart, Guy Hornsby, Michael W. Ramsey, Caleb D. Bazyler, Michael H. Stone

ETSU Faculty Works

No abstract provided.

Validation Of The Short Recovery Stress Scale Questionnaire During Women’S Volleyball In-Season Training, Asher Flynn, Joseph Walters, Henry Lang, Alec Perkins, Jacob Goodin, Caleb D. Bazyler

ETSU Faculty Works

No abstract provided.

How We Close The Gaps: Our Interprofessional Team Approach To Meeting Quality Measures, Peter Blockhurst, William Buselmeier, Mckenzie Calhoun, Paige Gilbert-Green, Jesse Gilbreath, Erin Harris, Amy Lawrence

ETSU Faculty Works

• Define the role/function of an interprofessional team in the management of complex outpatients.
• Identify the types of patients that would benefit most from a team-based approach.
• Implement elements of our team-based patient care model into individual practices.

Acute Kidney Injury, Immune Thrombocytopenic Purpura, And The Infection That Binds Them Together: Disseminated Histoplasmosis, Pooja Sethi, Jennifer Treece, Chidinma Onweni, Vandana Pai, Sowminya Arikapudi, Lakshmi Kallur, Varun Kohli, Jonathan Moorman

ETSU Faculty Works

Untreated human immunodeficiency virus (HIV) can be complicated by opportunistic infections, including disseminated histoplasmosis (DH). Although endemic to portions of the United States and usually benign, DH can rarely act as an opportunistic infection in immunocompromised patients presenting with uncommon complications such as acute kidney injury and idiopathic thrombocytopenic purpura. We report a rare presentation of DH presenting with acute kidney injury and immune thrombocytopenic purpura in an immunocompromised patient with HIV.

Dental Caries In The Fossil Record: A Window To The Evolution Of Dietary Plasticity In An Extinct Bear, Borja Figueirido, Alejandro Pérez-Ramos, Blaine W. Schubert, Francisco Serrano, Aisling B. Farrell, Francisco J. Pastor, Aline A. Neves, Alejandro Romero

ETSU Faculty Works

During the late Pleistocene of North America (≈36,000 to 10,000 years ago), saber-toothed cats, American lions, dire wolves, and coyotes competed for prey resources at Rancho La Brea (RLB). Despite the fact that the giant short-faced bear (Arctodus simus) was the largest land carnivoran present in the fauna, there is no evidence that it competed with these other carnivores for prey at the site. Here, for the first time, we report carious lesions preserved in specimens of A. simus, recovered from RLB. Our results suggest that the population of A. simus from RLB was more omnivorous than the highly carnivorous …

Too Many Choices Confuse Patients With Dementia, R. C. Hamdy, J. V. Lewis, Amber Kinser, A. Depelteau, Rebecca Copeland, T. Kendall-Wilson, K. Whalen

ETSU Faculty Works

Choices are often difficult to make by patients with Alzheimer Dementia. They often become acutely confused when faced with too many options because they are not able to retain in their working memory enough information about the various individual choices available. In this case study, we describe how an essentially simple benign task (choosing a dress to wear) can rapidly escalate and result in a catastrophic outcome. We examine what went wrong in the patient/caregiver interaction and how that potentially catastrophic situation could have been avoided or defused.

An X-Ray Study Of Two B+B Binaries: Ah Cep And Cw Cep, Richard Ignace, K. T. Hole, Lidia M. Oskinova, J. P. Rotter

ETSU Faculty Works

AH Cep and CW Cep are both early B-type binaries with short orbital periods of 1.8 days and 2.7 days, respectively. All four components are B0.5V types. The binaries are also double-lined spectroscopic and eclipsing. Consequently, solutions for orbital and stellar parameters make the pair of binaries ideal targets for a study of the colliding winds between two B stars. Chandra ACIS-I observations were obtained to determine X-ray luminosities. AH Cep was detected with an unabsorbed X-ray luminosity at a 90% confidence interval of erg s−1, or , relative to the combined Bolometric luminosities of the two components. While formally …

2017 November 20 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Intracellular S100a9 Promotes Myeloid-Derived Suppressor Cells During Late Sepsis, Jun Dai, Ajinkya Kumbhare, Dima Youssef, Charles E. Mccall, Mohamed El Gazzar

ETSU Faculty Works

Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1+CD11b+ MDSCs after pro-inflammatory sepsis transitions to the later chronic anti-inflammatory and immunosuppressive phenotype. The purpose of this study was to determine whether intracellular S100A9 protein might sustain Gr1+CD11b+ MDSC repressor cell reprogramming during sepsis. We used a chronic model of sepsis in mice to show that S100A9 release from MDSCs and circulating phagocytes decreases after early sepsis and that targeting the S100a9 gene improves survival. …

Pleiotrophin, A Multifunctional Cytokine And Growth Factor, Induces Leukocyte Responses Through The Integrin Mac-1, Di Shen, Nataly P. Podolnikova, Valentin P. Yakubenko, Christopher L. Ardell, Arnat Balabiyev, Tatiana P. Ugarova, Xu Wang

ETSU Faculty Works

Pleiotrophin (PTN) is a multifunctional, cationic, glycosaminoglycan- binding cytokine and growth factor involved in numerous physiological and pathological processes, including tissue repair and inflammation-related diseases. PTN has been shown to promote leukocyte responses by inducing their migration and expression of inflammatory cytokines. However, the mechanisms through which PTN mediates these responses remain unclear. Here, we identified the integrin Mac-1 (αMβ2, CD11b/CD18) as the receptor mediating macrophage adhesion and migration to PTN. We also found that expression of Mac-1 on the surface of human embryonic kidney (HEK) 293 cells induced their adhesion and migration to PTN. Accordingly, PTN promoted Mac-1-dependent cell …

The Importance Of Human Population Characteristics In Modeling Aedes Aegypti Distributions And Assessing Risk Of Mosquito-Borne Infectious Diseases, Julie F. Obenauer, T. Andrew Joyner, Joseph B. Harris

ETSU Faculty Works

Background: The mosquito Aedes aegypti has long been a vector for human illness in the Southeastern United States. In the past, it has been responsible for outbreaks of dengue, chikungunya, and yellow fever and, very recently, the Zika virus that has been introduced to the region. Multiple studies have modeled the geographic distribution of Ae. aegypti as a function of climate factors; however, this ignores the importance of humans to the anthropophilic biter. Furthermore, Ae. aegypti thrives in areas where humans have created standing water sites, such as water storage containers and trash. As models are developed to examine the …

Current Research And Statistical Practices In Sport Science And A Need For Change, Jake R. Bernards, Kimitake Sato, G. Gregory Haff, Caleb D. Bazyler

ETSU Faculty Works

Current research ideologies in sport science allow for the possibility of investigators producing statistically significant results to help fit the outcome into a predetermined theory. Additionally, under the current Neyman-Pearson statistical structure, some argue that null hypothesis significant testing (NHST) under the frequentist approach is flawed, regardless. For example, a p-value is unable to measure the probability that the studied hypothesis is true, unable to measure the size of an effect or the importance of a result, and unable to provide a good measure of evidence regarding a model or hypothesis. Many of these downfalls are key questions researchers strive …

Evaluating And Improving The Effectiveness Of Vehicle Inspection And Maintenance Programs: A Cost-Benefit Analysis Framework, Ying Li

ETSU Faculty Works

Motor vehicle inspection and maintenance (I/M) programs are designed to identify high-emitting vehicles and mitigate their impacts on air quality and climate. I/M programs have been traditionally ranked superior among various vehicle emission control measures by the results of cost-benefit analysis, based on the assumption that these programs will achieve the targeted emission reduction outcomes. However, the actual effects of I/M programs may be greatly uncertain and when this uncertainty is taken into account, these programs may become suboptimal. This study develops a new a cost-benefit analysis framework that links various program design consideration, such as program participation rate, identification …

2017 November 13 - University Council Agenda And Minutes, University Council, East Tennessee State University

University Council Agendas and Minutes

No abstract provided.

Beauty And Women's Professional Golf, Kelly Price-Rhea

ETSU Faculty Works

Dr. Kelly Price looks at the research linking perceived attractiveness and prizemoney on the LPGA Tour and asks 'What is Beauty?'

Young Adults With Cleft Lip And Palate: Are They Receiving Team Services?, Sarah Widy, Andrea Bisceglia, Emily Bradley, Sanjana Kumari Vyda Srinivasa Kumar, Andrea Mcdowell, Amanda Murr, Blake Nowicki, Elisha Reed, Alexandria Staples, Brenda Louw

ETSU Faculty Works

It is widely acknowledged that a team approach is preferred practice and contributes to optimizing the surgical, dental, speech and psychosocial outcomes for individuals with CLP. Young adulthood often marks the transition from child-centered interdisciplinary care to adult-centered care. There is a paucity in literature relating to the transition of care for young adults with CLP. The purpose of this survey research is therefore to explore the CLP team practices regarding young adults with CLP.