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Articles 31 - 60 of 128
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Evaluating The Long-Term Metacommunity Dynamics Of Tree Hole Mosquitoes, Alicia M. Ellis, L. Philip Lounibos, Marcel Holyoak
Evaluating The Long-Term Metacommunity Dynamics Of Tree Hole Mosquitoes, Alicia M. Ellis, L. Philip Lounibos, Marcel Holyoak
Dartmouth Scholarship
Four different conceptual models of metacommunities have been proposed, termed “patch dynamics,” “species sorting,” “mass effect,” and “neutral.” These models simplify thinking about metacommunities and improve our understanding of the role of spatial dynamics both in structuring communities and in determining local and regional diversity. We tested whether mosquito communities inhabiting water-filled tree holes in southeastern Florida, USA, displayed any of the characteristics and dynamics predicted by the four models. The densities of the five most common species in 3–8 tree holes were monitored every two weeks during 1978–2003. We tested relationships between habitat variables and species densities, spatial synchrony, …
Transcutaneous Immunization With Toxin-Coregulated Pilin A Induces Protective Immunity Against Vibrio Cholerae O1 El Tor Challenge In Mice, Julianne E. Rollenhagen, Anuj Kalsy, Francisca Cerda, Manohar John
Transcutaneous Immunization With Toxin-Coregulated Pilin A Induces Protective Immunity Against Vibrio Cholerae O1 El Tor Challenge In Mice, Julianne E. Rollenhagen, Anuj Kalsy, Francisca Cerda, Manohar John
Dartmouth Scholarship
Toxin-coregulated pilin A (TcpA) is the main structural subunit of a type IV bundle-forming pilus of Vibrio cholerae, the cause of cholera. Toxin-coregulated pilus is involved in formation of microcolonies of V. cholerae at the intestinal surface, and strains of V. cholerae deficient in TcpA are attenuated and unable to colonize intestinal surfaces. Anti-TcpA immunity is common in humans recovering from cholera in Bangladesh, and immunization against TcpA is protective in murine V. cholerae models. To evaluate whether transcutaneously applied TcpA is immunogenic, we transcutaneously immunized mice with 100 mug of TcpA or TcpA with an immunoadjuvant (cholera toxin [CT], …
Prophylaxis And Therapy Of Inhalational Anthrax By A Novel Monoclonal Antibody To Protective Antigen That Mimics Vaccine-Induced Immunity, Laura Vitale, Diann Blanset, Israel Lowy, Thomas O'Neill, Joel Goldstein, Stephen F. Little, Gerard P. Andrews, Gary Dorough, Ronald K. Taylor, Tibor Keler
Prophylaxis And Therapy Of Inhalational Anthrax By A Novel Monoclonal Antibody To Protective Antigen That Mimics Vaccine-Induced Immunity, Laura Vitale, Diann Blanset, Israel Lowy, Thomas O'Neill, Joel Goldstein, Stephen F. Little, Gerard P. Andrews, Gary Dorough, Ronald K. Taylor, Tibor Keler
Dartmouth Scholarship
The neutralizing antibody response to the protective antigen (PA) component of anthrax toxin elicited by approved anthrax vaccines is an accepted correlate for vaccine-mediated protection against anthrax. We reasoned that a human anti-PA monoclonal antibody (MAb) selected on the basis of superior toxin neutralization activity might provide potent protection against anthrax. The fully human MAb (also referred to as MDX-1303 or Valortim) was chosen from a large panel of anti-PA human MAbs generated using transgenic mice immunized with recombinant PA solely on the basis of in vitro anthrax toxin neutralization. This MAb was effective in prophylactic and postsymptomatic treatment of …
Mobicom Poster Abstract: Bandwidth Reservation Using Wlan Handoff Prediction, Libo Song, Udayan Deshpande, Ulaş C. Kozat, David Kotz, Ravi Jain
Mobicom Poster Abstract: Bandwidth Reservation Using Wlan Handoff Prediction, Libo Song, Udayan Deshpande, Ulaş C. Kozat, David Kotz, Ravi Jain
Dartmouth Scholarship
Many network services may be improved or enabled by successful predictions of users' future mobility. The success of predictions depend on how much accuracy can be achieved on real data and on the sensitivity of particular applications to this achievable accuracy. We investigate these issues for the case of advanced bandwidth reservation using real WLAN traces collected on the Dartmouth College campus.
A Spitzer Space Telescope Study Of Sn 2002hh: An Infrared Echo From A Type Iip Supernova, W. P. S. Meikle, S. Mattila, C. L. Gerardy, R. Kotak, M. Pozzo, S. D. Van Dyk, D. Farrah, R. A. Fesen
A Spitzer Space Telescope Study Of Sn 2002hh: An Infrared Echo From A Type Iip Supernova, W. P. S. Meikle, S. Mattila, C. L. Gerardy, R. Kotak, M. Pozzo, S. D. Van Dyk, D. Farrah, R. A. Fesen
Dartmouth Scholarship
We present late-time (590-994 days) mid-IR photometry of the normal but highly reddened Type IIP supernova SN 2002hh. Bright, cool, slowly fading emission is detected from the direction of the supernova. Most of this flux appears not to be driven by the supernova event but instead probably originates in a cool, obscured star formation region or molecular cloud along the line of sight. We also show, however, that the declining component of the flux is consistent with an SN-powered IR echo from a dusty progenitor CSM. Mid-IR emission could also be coming from newly condensed dust and/or an ejecta/CSM impact, …
Erv26p Directs Pro-Alkaline Phosphatase Into Endoplasmic Reticulum–Derived Coat Protein Complex Ii Transport Vesicles, Catherine A. Bue, Christine M. Bentivoglio, Charles Barlowe
Erv26p Directs Pro-Alkaline Phosphatase Into Endoplasmic Reticulum–Derived Coat Protein Complex Ii Transport Vesicles, Catherine A. Bue, Christine M. Bentivoglio, Charles Barlowe
Dartmouth Scholarship
Secretory proteins are exported from the endoplasmic reticulum (ER) in transport vesicles formed by the coat protein complex II (COPII). We detected Erv26p as an integral membrane protein that was efficiently packaged into COPII vesicles and cycled between the ER and Golgi compartments. The erv26Δ mutant displayed a selective secretory defect in which the pro-form of vacuolar alkaline phosphatase (pro-ALP) accumulated in the ER, whereas other secretory proteins were transported at wild-type rates. In vitro budding experiments demonstrated that Erv26p was directly required for packaging of pro-ALP into COPII vesicles. Moreover, Erv26p was detected in a specific complex with pro-ALP …
Digital Image Ballistics From Jpeg Quantization, Hany Farid
Digital Image Ballistics From Jpeg Quantization, Hany Farid
Computer Science Technical Reports
Most digital cameras export images in the JPEG file format. This lossy compression scheme employs a quantization table that controls the amount of compression achieved. Different cameras typically employ different tables. A comparison of an image's quantization scheme to a database of known cameras affords a simple technique for confirming or denying an image's source. Similarly, comparison to a database of photo-editing software can be used in a forensic setting to determine if an image was edited after its original recording.
Tools And Algorithms To Advance Interactive Intrusion Analysis Via Machine Learning And Information Retrieval, Javed Aslam, Sergey Bratus, Virgil Pavlu
Tools And Algorithms To Advance Interactive Intrusion Analysis Via Machine Learning And Information Retrieval, Javed Aslam, Sergey Bratus, Virgil Pavlu
Computer Science Technical Reports
We consider typical tasks that arise in the intrusion analysis of log data from the perspectives of Machine Learning and Information Retrieval, and we study a number of data organization and interactive learning techniques to improve the analyst's efficiency. In doing so, we attempt to translate intrusion analysis problems into the language of the abovementioned disciplines and to offer metrics to evaluate the effect of proposed techniques. The Kerf toolkit contains prototype implementations of these techniques, as well as data transformation tools that help bridge the gap between the real world log data formats and the ML and IR data …
Lowness And Π Nullsets, Rod Downey, Andre Nies, Rebecca Weber, Liang Yu
Lowness And Π Nullsets, Rod Downey, Andre Nies, Rebecca Weber, Liang Yu
Dartmouth Scholarship
We prove that there exists a noncomputable c.e. real which is low for weak 2-randomness, a definition of randomness due to Kurtz, and that all reals which are low for weak 2-randomness are low for Martin-Lof randomness.
Cd80 And Cd86 Control Antiviral Cd8+ T-Cell Function And Immune Surveillance Of Murine Gammaherpesvirus 68, Shinichiro Fuse, Joshua J. Obar, Sarah Bellfy, Erica K. Leung, Weijun Zhang, Edward J. Usherwood
Cd80 And Cd86 Control Antiviral Cd8+ T-Cell Function And Immune Surveillance Of Murine Gammaherpesvirus 68, Shinichiro Fuse, Joshua J. Obar, Sarah Bellfy, Erica K. Leung, Weijun Zhang, Edward J. Usherwood
Dartmouth Scholarship
The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells serve as an important costimulatory signal in the activation of T cells. Although the simplistic two-signal hypothesis has been challenged in recent years by the identification of different costimulators, this classical pathway has been shown to significantly impact antiviral humoral and cellular immune responses. How the CD80/CD86-CD28 pathway affects the control of chronic or latent infections has been less well characterized. In this study, we investigated its role in antiviral immune responses against murine gammaherpesvirus 68 (MHV-68) and immune surveillance using CD80/CD86−/− mice. In the …
Gammaherpesvirus Persistence Alters Key Cd8 T-Cell Memory Characteristics And Enhances Antiviral Protection, Joshua J. Obar, Shinichiro Fuse, Erica K. Leung, Sarah C. Bellfy, Edward J. Usherwood
Gammaherpesvirus Persistence Alters Key Cd8 T-Cell Memory Characteristics And Enhances Antiviral Protection, Joshua J. Obar, Shinichiro Fuse, Erica K. Leung, Sarah C. Bellfy, Edward J. Usherwood
Dartmouth Scholarship
In herpesvirus infections, the virus persists for life but is contained through T-cell-mediated immune surveillance. How this immune surveillance operates is poorly understood. Recent studies of other persistent infections have indicated that virus persistence is associated with functional deficits in the CD8(+) T-cell response. To test whether this is the case in a herpesvirus infection, we used a mutant murine gammaherpesvirus that is defective in its ability to persist in the host. By comparing the immune response to this virus with a revertant virus that can persist, we were able to dissect the changes in the antiviral CD8(+) T-cell response …
Reduction In Urinary Arsenic With Bottled-Water Intervention, Arun B. Josyula, Hannah Mcclellen, Tracy A. Hysong, Margaret Kurzius-Spencer, Gerald S. Poplin, Stefan Stürup, Jefferey L. Burgess
Reduction In Urinary Arsenic With Bottled-Water Intervention, Arun B. Josyula, Hannah Mcclellen, Tracy A. Hysong, Margaret Kurzius-Spencer, Gerald S. Poplin, Stefan Stürup, Jefferey L. Burgess
Dartmouth Scholarship
The study was conducted to measure the effectiveness of providing bottled water in reducing arsenic exposure. Urine, tap-water and toenail samples were collected from non-smoking adults residing in Ajo (n=40) and Tucson (n=33), Arizona, USA. The Ajo subjects were provided bottled water for 12 months prior to re-sampling. The mean total arsenic (microg/L) in tap-water was 20.3+/-3.7 in Ajo and 4.0+/-2.3 in Tucson. Baseline urinary total inorganic arsenic (microg/L) was significantly higher among the Ajo subjects (n=40, 29.1+/-20.4) than among the Tucson subjects (n=32, 11.0+/-12.0, p<0.001), as was creatinine-adjusted urinary total inorganic arsenic (microg/g) (35.5+/-25.2 vs 13.2+/-9.3, p<0.001). Baseline concentrations of arsenic (microg/g) in toenails were also higher among the Ajo subjects (0.51+/-0.72) than among the Tucson subjects (0.17+/-0.21) (p<0.001). After the intervention, the mean urinary total inorganic arsenic in Ajo (n=36) dropped by 21%, from 29.4+/-21.1 to 23.2+/-23.2 (p=0.026). The creatinine-adjusted urinary total inorganic arsenic and toenail arsenic levels did not differ significantly with the intervention. Provision of arsenic-free bottled water resulted in a modest reduction in urinary total inorganic arsenic.
Quantum Entanglement Via Nilpotent Polynomials, Aikaterini Mandilara, Vladimir M. Akulin, Andrei V. Smilga, Lorenza Viola
Quantum Entanglement Via Nilpotent Polynomials, Aikaterini Mandilara, Vladimir M. Akulin, Andrei V. Smilga, Lorenza Viola
Dartmouth Scholarship
We propose a general method for introducing extensive characteristics of quantum entanglement. The method relies on polynomials of nilpotent raising operators that create entangled states acting on a reference vacuum state. By introducing the notion of tanglemeter, the logarithm of the state vector represented in a special canonical form and expressed via polynomials of nilpotent variables, we show how this description provides a simple criterion for entanglement as well as a universal method for constructing the invariants characterizing entanglement. We compare the existing measures and classes of entanglement with those emerging from our approach. We derive the equation of motion …
Binding Of Internalized Receptors To The Pdz Domain Of Gipc/Synectin Recruits Myosin Vi To Endocytic Vesicles, Samia N. Naccache, Tama Hasson, Arie Horowitz
Binding Of Internalized Receptors To The Pdz Domain Of Gipc/Synectin Recruits Myosin Vi To Endocytic Vesicles, Samia N. Naccache, Tama Hasson, Arie Horowitz
Dartmouth Scholarship
Myosin VI (myo6) is the only actin-based molecular motor that translocates along actin filaments toward the minus end. Myo6 participates in two steps of endocytic trafficking; it is recruited to both clathrin-coated pits and to ensuing uncoated endocytic vesicles (UCV). Although there is evidence suggesting that the PDZ adaptor protein GIPC/synectin is involved in the association of myo6 with UCV, the recruitment mechanism is unknown. We show that GIPC/synectin is required for both internalization of cell surface receptors and for coupling of myo6 to UCV. This coupling occurs via a mechanism wherein engagement of the GIPC/synectin PDZ domain by C …
Heliospheric Response To Different Possible Interstellar Environments, Hans-Reinhard Muller, Priscilla C. Frisch, Vladimir Florinski, Gary P. Zank
Heliospheric Response To Different Possible Interstellar Environments, Hans-Reinhard Muller, Priscilla C. Frisch, Vladimir Florinski, Gary P. Zank
Dartmouth Scholarship
At present, the heliosphere is embedded in a warm, low-density interstellar cloud that belongs to a cloud system flowing through the local standard of rest with a velocity near ~18 km s-1. The velocity structure of the nearest interstellar material (ISM), combined with theoretical models of the local interstellar cloud (LIC), suggest that the Sun passes through cloudlets on timescales of ≤103-104 yr, so the heliosphere has been, and will be, exposed to different interstellar environments over time. By means of a multifluid model that treats plasma and neutral hydrogen self-consistently, the interaction of the …
Agswe1p Regulates Mitosis In Response To Morphogenesis And Nutrients In Multinucleated Ashbya Gossypii Cells, Hanspeter Helfer, Amy S. Gladfelter
Agswe1p Regulates Mitosis In Response To Morphogenesis And Nutrients In Multinucleated Ashbya Gossypii Cells, Hanspeter Helfer, Amy S. Gladfelter
Dartmouth Scholarship
Nuclei in the filamentous, multinucleated fungus Ashbya gossypii divide asynchronously. We have investigated what internal and external signals spatially direct mitosis within these hyphal cells. Mitoses are most common near cortical septin rings found at growing tips and branchpoints. In septin mutants, mitoses are no longer concentrated at branchpoints, suggesting that the septin rings function to locally promote mitosis near new branches. Similarly, cells lacking AgSwe1p kinase (a Wee1 homologue), AgHsl1p (a Nim1-related kinase), and AgMih1p phosphatase (the Cdc25 homologue that likely counteracts AgSwe1p activity) also have mitoses distributed randomly in the hyphae as opposed to at branchpoints. Surprisingly, however, …
Metric Measurements On A Plane From A Single Image, Micah K. Johnson, Hany Farid
Metric Measurements On A Plane From A Single Image, Micah K. Johnson, Hany Farid
Computer Science Technical Reports
The past decade has seen considerable advances in the application of principles from projective geometry to problems in image analysis and computer vision. In this paper, we review a subset of this work, and leverage these results for the purpose of forensic analysis. Specifically, we review three techniques for making metric measurements on planar surfaces from a single image. The resulting techniques should prove useful in forensic settings where real-world measurements are required.
Arsenic Exposure Is Associated With Decreased Dna Repair In Vitro And In Individuals Exposed To Drinking Water Arsenic, Angeline S. Andrew, Jefferey L. Burgess, Maria M. Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, Margaret R. Karagas
Arsenic Exposure Is Associated With Decreased Dna Repair In Vitro And In Individuals Exposed To Drinking Water Arsenic, Angeline S. Andrew, Jefferey L. Burgess, Maria M. Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, Margaret R. Karagas
Dartmouth Scholarship
The mechanism(s) by which arsenic exposure contributes to human cancer risk is unknown; however, several indirect cocarcinogenesis mechanisms have been proposed. Many studies support the role of As in altering one or more DNA repair processes. In the present study we used individual-level exposure data and biologic samples to investigate the effects of As exposure on nucleotide excision repair in two study populations, focusing on the excision repair cross-complement 1 (ERCC1) component. We measured drinking water, urinary, or toenail As levels and obtained cryopreserved lymphocytes of a subset of individuals enrolled in epidemiologic studies in New Hampshire (USA) and Sonora …
Exact Casimir Interaction Between Eccentric Cylinders, D. A. R. Dalvit, F. C. Lombardo, F. D. Mazzitelli, R. Onofrio
Exact Casimir Interaction Between Eccentric Cylinders, D. A. R. Dalvit, F. C. Lombardo, F. D. Mazzitelli, R. Onofrio
Dartmouth Scholarship
The Casimir force is the ultimate background in ongoing searches for extragravitational forces in the micrometer range. Eccentric cylinders offer favorable experimental conditions for such measurements as spurious gravitational and electrostatic effects can be minimized. Here we report on the evaluation of the exact Casimir interaction between perfectly conducting eccentric cylinders using a mode summation technique, and study different limiting cases of relevance for Casimir force measurements, with potential implications for the understanding of mechanical properties of nanotubes.
Salicylic Acid Activates Sigma Factor B By Rsbu-Dependent And -Independent Mechanisms, Marco Palma, Arnold Bayer, Leon I. Kupferwasser, Tammy Joska, Michael R. Yeaman, Ambrose Cheung
Salicylic Acid Activates Sigma Factor B By Rsbu-Dependent And -Independent Mechanisms, Marco Palma, Arnold Bayer, Leon I. Kupferwasser, Tammy Joska, Michael R. Yeaman, Ambrose Cheung
Dartmouth Scholarship
Salicylic acid (SAL) may impact Staphylococcus aureus virulence by activating the sigB operon (rsbU-V-W-sigB), thus leading to reductions in alpha-toxin production and decreased fibronectin binding (L. I. Kupferwasser et al., J. Clin. Investig. 112:222-233, 2003). As these prior studies were performed in strain RN6390 (an rsbU mutant) and its rsbU-repaired variant, SH1000, the current investigation was designed to determine if the SAL effect occurs via rsbU- and/or rsbV-dependent pathways in an rsbU-intact S. aureus strain (FDA486). We thus quantified the transcription from two sigB-dependent promoters (asp23 and sarA P3) in FDA486 in response to SAL exposure in vitro, using isogenic …
Circadian Rhythmicity By Autocatalysis, Arun Mehra, Christian I. Hong, Mi Shi, Jennifer J. Loros, Jay C. Dunlap, Peter Ruoff
Circadian Rhythmicity By Autocatalysis, Arun Mehra, Christian I. Hong, Mi Shi, Jennifer J. Loros, Jay C. Dunlap, Peter Ruoff
Dartmouth Scholarship
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
A Subset Of Arabidopsis Ap2 Transcription Factors Mediates Cytokinin Responses In Concert With A Two-Component Pathway, Aaron M. Rashotte, Michael G. Mason, Claire E. Hutchison, Fernando J. Ferreira, G. Eric Schaller, Joseph J. Kieber
A Subset Of Arabidopsis Ap2 Transcription Factors Mediates Cytokinin Responses In Concert With A Two-Component Pathway, Aaron M. Rashotte, Michael G. Mason, Claire E. Hutchison, Fernando J. Ferreira, G. Eric Schaller, Joseph J. Kieber
Dartmouth Scholarship
The plant hormone cytokinin regulates numerous growth and developmental processes. A signal transduction pathway for cytokinin has been elucidated that is similar to bacterial two-component phosphorelays. In Arabidopsis, this pathway is comprised of receptors that are similar to sensor histidine kinases, histidine-containing phosphotransfer proteins, and response regulators (ARRs). There are two classes of response regulators, the type-A ARRs, which act as negative regulators of cytokinin responses, and the type-B ARRs, which are transcription factors that play a positive role in mediating cytokinin-regulated gene expression. Here we show that several closely related members of the Arabidopsis AP2 gene family of …
Saccharomyces Cerevisiae-Based Molecular Tool Kit For Manipulation Of Genes From Gram-Negative Bacteria, Robert M. Q. Shanks, Nicky C. Caiazza, Shannon M. Hinsa, Christine M. Toutain, George A. O'Toole
Saccharomyces Cerevisiae-Based Molecular Tool Kit For Manipulation Of Genes From Gram-Negative Bacteria, Robert M. Q. Shanks, Nicky C. Caiazza, Shannon M. Hinsa, Christine M. Toutain, George A. O'Toole
Dartmouth Scholarship
A tool kit of vectors was designed to manipulate and express genes from a wide range of gram-negative species by using in vivo recombination. Saccharomyces cerevisiae can use its native recombination proteins to combine several amplicons in a single transformation step with high efficiency. We show that this technology is particularly useful for vector design. Shuttle, suicide, and expression vectors useful in a diverse group of bacteria are described and utilized. This report describes the use of these vectors to mutate clpX and clpP of the opportunistic pathogen Pseudomonas aeruginosa and to explore their roles in biofilm formation and surface …
Critical Computational Aspects Of Near Infrared Circular Tomographic Imaging: Analysis Of Measurement Number, Mesh Resolution And Reconstruction Basis, Phaneendra K. Yalavarthy, Hamid Dehghani, Brian W. Pogue, Keit D. Paulsen
Critical Computational Aspects Of Near Infrared Circular Tomographic Imaging: Analysis Of Measurement Number, Mesh Resolution And Reconstruction Basis, Phaneendra K. Yalavarthy, Hamid Dehghani, Brian W. Pogue, Keit D. Paulsen
Dartmouth Scholarship
The image resolution and contrast in Near-Infrared (NIR) tomographic image reconstruction are affected by parameters such as the number of boundary measurements, the mesh resolution in the forward calculation and the reconstruction basis. Increasing the number of measurements tends to make the sensitivity of the domain more uniform reducing the hypersensitivity at the boundary. Using singular-value decomposition (SVD) and reconstructed images, it is shown that the numbers of 16 or 24 fibers are sufficient for imaging the 2D circular domain for the case of 1% noise in the data. The number of useful singular values increases as the logarithm of …
Sampled: Shared Anonymous Music Playback Using Wireless Devices, Constantinos Neophytou
Sampled: Shared Anonymous Music Playback Using Wireless Devices, Constantinos Neophytou
Computer Science Technical Reports
Recent advances in mobile computing enable many new applications, yet at the same time create privacy implications caused by the increasing amount of data that becomes available. This thesis will explore the possibilities of wireless-enabled portable devices and their attending privacy implications. We will describe how such a device containing personal information about the musical preferences of its user can help improve the user's experience in a social setting where music is played for all, and at the same time preserve each user's privacy.
Imaging Breast Adipose And Fibroglandular Tissue Molecular Signatures By Using Hybrid Mri-Guided Near-Infrared Spectral Tomography, Ben Brooksby, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Christine Kogel, Tor D. Tosteson, John Weaver, Steven P. Poplack, Keith D. Paulsen
Imaging Breast Adipose And Fibroglandular Tissue Molecular Signatures By Using Hybrid Mri-Guided Near-Infrared Spectral Tomography, Ben Brooksby, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Christine Kogel, Tor D. Tosteson, John Weaver, Steven P. Poplack, Keith D. Paulsen
Dartmouth Scholarship
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
Genetic And Maternal Determinants Of Effective Dispersal: The Effect Of Sire Genotype And Size At Birth In Side-Blotched Lizards, Barry Sinervo, Ryan Calsbeek, Tosha Comendant, Christiaan Both
Genetic And Maternal Determinants Of Effective Dispersal: The Effect Of Sire Genotype And Size At Birth In Side-Blotched Lizards, Barry Sinervo, Ryan Calsbeek, Tosha Comendant, Christiaan Both
Dartmouth Scholarship
We assessed genetic factors on progeny dispersal due to sire color morph genotypes in a field pedigree and lab crosses, and we measured maternal effects by studying both natural and experimentally induced egg size variation. Progeny were released into nature upon hatching, but we recorded dispersal distance at maturity, which reflects effective dispersal after viability selection has run its course. Progeny dispersal was significantly affected by sire genotype. Progeny from orange sires dispersed the farthest. Progeny from blue sires dispersed intermediate distances. Progeny from yellow sires were the most philopatric. Sire genotype effects interacted with egg size. In particular, enlarged …
Wait-Free And Obstruction-Free Snapshot, Khanh Do Ba
Wait-Free And Obstruction-Free Snapshot, Khanh Do Ba
Dartmouth College Undergraduate Theses
The snapshot problem was first proposed over a decade ago and has since been well-studied in the distributed algorithms community. The challenge is to design a data structure consisting of $m$ components, shared by upto $n$ concurrent processes, that supports two operations. The first, $Update(i,v)$, atomically writes $v$ to the $i$th component. The second, $Scan()$, returns an atomic snapshot of all $m$ components. We consider two termination properties: wait-freedom, which requires a process to always terminate in a bounded number of its own steps, and the weaker obstruction-freedom, which requires such termination only for processes that eventually execute uninterrupted. First, …
Computation Reuse In Statics And Dynamics Problems For Assemblies Of Rigid Bodies, Anne Loomis
Computation Reuse In Statics And Dynamics Problems For Assemblies Of Rigid Bodies, Anne Loomis
Dartmouth College Master’s Theses
The problem of determining the forces among contacting rigid bodies is fundamental to many areas of robotics, including manipulation planning, control, and dynamic simulation. For example, consider the question of how to unstack an assembly, or how to find stable regions of a rubble pile. In considering problems of this type over discrete or continuous time, we often encounter a sequence of problems with similar substructure. The primary contribution of our work is the observation that in many cases, common physical structure can be exploited to solve a sequence of related problems more efficiently than if each problem were considered …
Coexistence Of The Niche And Neutral Perspectives In Community Ecology, Mathew A. Leibold, Mark A. Mcpeek
Coexistence Of The Niche And Neutral Perspectives In Community Ecology, Mathew A. Leibold, Mark A. Mcpeek
Dartmouth Scholarship
The neutral theory for community structure and biodiversity is dependent on the assumption that species are equivalent to each other in all important ecological respects. We explore what this concept of equivalence means in ecological communities, how such species may arise evolutionarily, and how the possibility of ecological equivalents relates to previous ideas about niche differentiation. We also show that the co-occurrence of ecologically similar or equivalent species is not incompatible with niche theory as has been supposed, because niche relations can sometimes favor coexistence of similar species. We argue that both evolutionary and ecological processes operate to promote the …