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Characterizing Changes In The Colonic Epithelium Of Lrig3 Null Mice, Natalie Pedicino Jan 2020

Characterizing Changes In The Colonic Epithelium Of Lrig3 Null Mice, Natalie Pedicino

Scripps Senior Theses

The lining of the colon, or colonic epithelium, is a very dynamic and highly regulated tissue in the human body. Colonic stem cells are a key component of this tissue, and they make up the stem cell niche, which is found at the base of the colonic crypt. Regeneration of the colonic epithelium, which occurs on a weekly basis, is a complex process, and proteins responsible for directing regeneration are still being discovered. Two critical regulatory proteins, Lrig1 and Lrig3, have been shown to modulate the EGFR pathway, a key signaling pathway for growth, differentiation, and regeneration. Data from the …


Escaping The Snowstorm: Legal Rights And Economics In The Developing World, Zane Tolchinsky Jan 2020

Escaping The Snowstorm: Legal Rights And Economics In The Developing World, Zane Tolchinsky

CMC Senior Theses

In this thesis, I seek to provide a framework for developing nations making policy-decisions about legal rights, as in the realm of Rawlsian ideal theory, prescriptions for governments not living in conditions of moderate scarcity is lacking. I first springboard off Stephen Holmes and Cass R. Sunstein’s conclusion that “all legal rights are positive,” from their book, The Cost of Rights, to argue for the value of considering the economic implications of rights protections. I then propose that Holmes and Sunstein’s conclusion means that we can think of legal rights as goods to be purchased by governments. Next, I …