Digital Commons Network^™

Evaluation Of Fermentation At 40°C And 30°C For Cost Effective Lignocellulose To Lipid Conversion, Kyle M. Macewen

Graduate Masters Theses

As the world population continues to grow, the demand for energy will continue to rise. Biofuels have become an attractive alternative to replace fossil fuels as a clean and renewable source of energy. The six- and five-carbon sugars contained in lignocellulosic plant biomass is the largest carbohydrate source in the world, and a key feedstock for sustainable biofuel production. The conversion of lignocellulose to lipids is done by using oleaginous yeast as a biocatalyst. Recently, Arxula adeninivorans has become a yeast of interest because of its unique properties. These include its unusual metabolic flexibility which allows it to utilize a …

The Rutabaga That Ate Pittsburgh: Federal Regulation Of Free Release Biotechnology, Michael P. Vandenbergh

Michael Vandenbergh

When the Environmental Protection Agency (EPA) first approved a field test of a bioengineered microbe,' one EPA official remarked: "We're not expecting this to be the rutabaga that eats Pittsburgh.' 2 But regulators cannot afford to be wrong. Bioengineered microbes may serve many useful purposes, but they may also cause harm to the environment and to human health.3 Although the risks of an accident stemming from the deliberate release of bioengineered microbes into the environment may be low, the resulting damage could be substantial. This note examines the possible consequences of two recent trends in biotechnology-the development of bioengineered microbes …

Halted Innovation: The Expansion Of Federal Jurisdiction Over Medicine And The Human Body, Myrisha S. Lewis

Faculty Publications

Modern medical innovations are blurring the line between medical practice and medical devices and drugs. Historically, many techniques have been developed in medicine, without any interference from the federal government, as medical practice is (and has historically been) an area of state jurisdiction. Over the past two decades, however, the U.S. Food and Drug Administration (FDA) has been exerting jurisdiction over the human body and the practice of medicine by targeting new medical techniques for oversight and subjecting the continued use of those treatments to onerous and legally questionable regulatory requirements that hinder the use of those treatments in practice. …

Bs In Biotechnology, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Piloting Participatory Arts-Based Methods For Exploring Indonesians’ Experiences In A U.S. Biotechnology Training Program, Jamie Loizzo, Richard E. Goodman, Mary Garbacz

Journal of Applied Communications

Science communication faculty and professionals often train scientists about conveying and delivering critical and sometimes controversial scientific information to public audiences. This qualitative case study was situated in a U.S.-based biotechnology training program funded by the United States Department of Agriculture for connecting Indonesian science fellows with university biotechnology scientists and science communication experts. The researchers piloted a participatory arts-based approach for instructing and researching Indonesian scientists’, professionals’, and educators’ learning and experiences in the program. Participatory and arts-based research has the potential to uncover and bring to light participants’ perceptions. Participants used iPad multimedia kits to demonstrate their learning …

Nonlinear Dynamics With Chaotic Processes In Biotechnology And Genetic Engineering., M.A Ismailov, M. Saidalieva, M.B Hidirova

Chemical Technology, Control and Management

This paper deals with modeling genetic systems activity during manipulation of an organism’s genes using biotechnology. Computational experiments show that at certain values of internal and external cellular conditions there are exist the following regimes: stationary state, auto-oscillations and chaotic behavior of gene regulatory network linkages.

Biotechnology Research Pattern In Four Saarc Countries From 2007 To 2016, Manendra Singh Mr.

Library Philosophy and Practice (e-journal)

The study presents the trends in authorship pattern and author collaborative in the Biotechnology research field with the sample of 18119 articles which collected from Scopus database for the year 2007 to 2016. The search string used for data download is same for all country and all data downloaded for each country. The three scientometric tools; Collaboration Coefficient, Authorship pattern and Activity Index have been used for the data analysis. The multi- authorship articles are greater than single authorship. The study found that the researchers in Biotechnology move towards team research or group research rather than solo research. The average …

Applications Of Magnetotactic Bacteria, Magnetosomes And Magnetosome Crystals In Biotechnology And Nanotechnology: Mini-Review, Gabriele Vargas, Jefferson Cypriano, Tarcisio Correa, Pedro Leão, Dennis A. Bazylinski, Fernanda Abreu

Life Sciences Faculty Research

Magnetotactic bacteria (MTB) biomineralize magnetosomes, which are defined as intracellular nanocrystals of the magnetic minerals magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a phospholipid bilayer membrane. The synthesis of magnetosomes is controlled by a specific set of genes that encode proteins, some of which are exclusively found in the magnetosome membrane in the cell. Over the past several decades, interest in nanoscale technology (nanotechnology) and biotechnology has increased significantly due to the development and establishment of new commercial, medical and scientific processes and applications that utilize nanomaterials, some of which are biologically derived. One excellent example of a biological nanomaterial …

A Prescription For Biopharmaceutical Patents: A Cure For Inter Partes Review Ailments, Alex A. Jurisch

Seattle University Law Review

The patent system in the United States was forever changed with the introduction of the Leahy-Smith America Invents Act (AIA) in September of 2011. The AIA brought sweeping changes to American patent law in order to align the U.S. with much of the rest of the world by changing the invention priority from a “first to invent” to a “first to file” system. The first section of this note will provide a brief overview of the substance of inter partes reviews and some of the most critical negatives that have become apparent since 2013. The second section of this Note …

Compact Gene Regulatory Cassettes Support Hallmark Features Of T-Cell Receptor (Tcr)-Alpha Gene Locus Control Region (Lcr) Activity, Jordana Lovett

Dissertations, Theses, and Capstone Projects

Despite the promise of emerging stem cell transplant gene therapy strategies, there remains a gap in the ability to predictably generate robust, temporally controlled long-lasting, therapeutic gene expression in specific target cell lineages following stem cell differentiation. There exists a locus control region (LCR) in the mouse T-cell receptor (TCR)-α locus that confers an ab TCR-like spatiotemporal expression pattern upon a linked transgene, regardless of its site of integration in the genome. These properties are well suited to direction of high-level, physiological expression of therapeutic antigen receptor genes to the T cell progeny of vector-transduced stem cells. The endogenous LCR …

The Social Construction Of Understanding & Neoliberal Multiculturalism: Analysis And Critique Of The Peruvian Moratorium Gmos, T. W. Dondanville

Stevenson Center for Community and Economic Development—Student Research

No abstract provided.

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …

Emerging Governance Of Mitochondrial Replacement Therapy: Assessing Coherence Between Scientific Evidence And Policy Outcomes, Katherine Drabiak

DePaul Journal of Health Care Law

In the fall of 2016, media headlines reported news of several births of children born through “three parent IVF” or mitochondrial replacement therapy (MRT). MRT refers to an experimental procedure that entails removing the nuclear DNA from the mother’s egg or fertilized zygote and transferring it to a donor’s egg or fertilized zygote. This procedure constitutes a modification of the human germline, which has been prohibited by numerous declarations, directives, and laws promulgated by the United Nations, the Council of Europe, and other nations. In 2016, the Human Fertilisation and Embryology Authority in the United Kingdom was the first nation …

State Biotechnology Oversight: The Juncture Of Technology, Law, And Public Policy, Christine C. Vito Ph.D.

Maine Law Review

In a 1980 landmark decision, the Supreme Court of the United States ruled that genetically engineered lifeforms such as bacteria were patentable. The significance of this decision to the emerging biotechnology industry—an industry predicated on intellectual property rights—was incalculable. The characteristically research-intensive, capital-intensive biotechnology industry now had the economic incentive to push the technology of genetic engineering to previously unimagined extremes. The genetic engineering and recombinant DNA applications pursued by the biotechnology industry over the past ten years have engendered a spectrum of perplexing inquiries concerning ethical and moral values; agricultural, ecological and environmental matters; global competitiveness and economic priorities; …

The Detriments Of Factory Farming, Carrie Williams

Undergraduate Honors Theses

This thesis discusses the detrimental effects that industrialized farming practices have on public health, animal welfare, and ecological systems and includes factual support. It also provides practical application of this information as well as possible solutions and a detailed description of a related art exhibition.

Pauline Oliveros And The Quest For Musical Utopia, Hannah Christina Mclaughlin

Theses and Dissertations

This thesis discusses music's role in utopian community-building by using a case study of a specific composer, Pauline Oliveros, who believed her work could provide a positive "pathway to the future" resembling other utopian visions. The questions of utopian intent, potential, and method are explored through an analysis of Oliveros's untraditional scores, as well as an exploration of Oliveros's writings and secondary accounts from members of the Deep Listening community. This document explores Oliveros's utopian beliefs and practices and outlines important aspects of her utopian vision as they relate to three major utopian models: the traditional "end-state" model, the anarchical …

Red Abalone Hemocyanin As An Alternative Hapten-Carrier For Vaccine Production, Isaiah N. Mansour

Honors College

Vaccines protect millions of human lives per year from otherwise fatal illnesses. Vaccination promotes immunity by simulating infection with a non-pathogenic representative of the disease, an antigen, to prepare and train an immune response. Vaccine-safe antigens are often too small to elicit an immune response. These non-immunogenic molecules are referred to as haptens and are introduced to the immune system by hapten-carriers, large immune-stimulating proteins. Keyhole Limpet Hemocyanin (KLH), a respiratory protein of the giant keyhole limpet (Megathura crenulata), is the industry standard hapten-carrier. KLH is a potent yet safe immune-stimulant relied upon in research, available human medications, and emerging …

Where Trying To Conceive Becomes A Community Effort: A Digital Ethnography Of Online Infertility Forums, Megan Burns

Sociology Honors Papers

Online forums for women using in vitro fertilization (IVF), or similar assisted reproductive technologies (ARTs), provide a useful setting to further evaluate and understand women’s expectations of motherhood, the relationship infertile women have with physicians and biomedicine, and their interactions on the forums. Some critics of ARTs consider them a tool of oppression in a pronatalist state. The pressure and desire to become a biological mother leads the women with access to these technologies to use them regardless. Through digital ethnographic research on four online ART forums, this research examines the intersection of altruism and self-interest in the ways forum-users …

Intellectual Property, Surrogate Licensing, And Precision Medicine, Jacob S. Sherkow, Jorge L. Contreras

IP Theory

The fruits of the biotechnology revolution are beginning to be harvested. Recent regulatory approvals of a variety of advanced therapies—Keytruda (pembrolizumab), Kymriah (tisagenlecleucel), and patisiran—have ushered in an age of “precision medicine” treatments that target patients’ specific genetic, physiological, and environmental profiles rather than generalized diagnoses of disease. Therapies like these may soon be supplemented by gene editing technologies such as CRISPR, which could enable the targeted eradication of deleterious genetic variants to improve human health. But the intellectual property (IP) surrounding precision therapies and their foundational technology remain controversial. Precision therapies ultimately rely—and are roughly congruent with—basic scientific information …

Top 10 Indian Academic/Research Organizations: A Scientometric Analysis Of Research In Biotechnology, Manendra Kumar Singh, Prof. Aditya Tripathi

Library Philosophy and Practice (e-journal)

Scientometric study is an effective assessment tool for ongoing researches in a given field. It applies mathematical and statistical methods to study the use of documents and patterns of publication. Present work attempts to describe the patterns of publication by top ten Indian Academic/Research Organizations in the field of Biotechnology. Overall, 5423 articles were related to the field in Scopus database during 2001-2016. The applied scientometric tools are Collaboration Coefficient, Co-authorship Index and Activity Index to study the trend of authorship and collaborative research activities in the given domain. The activity Index formula has been modified for the mapping of …

Fragmented Bodies, Legal Privilege, And Commodification In Science And Medicine, Melissa M. Perry

Maine Law Review

Science and medicine have long possessed a culturally distinct status in American society; however, in the contemporary context of corporate biotechnology and managed health care, this cultural authority has begun to appear to many as increasingly threatening. Science and medicine often are criticized for having become businesses. This recognition becomes more daunting when one considers that a primary object of entrepreneurial pursuits in science and medicine is the commodification of the human body. That is, many scientific and medical practices effectively reduce the body to an object defined by its exchange value in the marketplace. Given the rapid advances of …

Congress Considering Legislation Intended To Reverse The Recent Trend Toward Devaluation Of The Us Patent Right, Christopher M. Holman

Faculty Works

Decisions of the United States Supreme Court spanning the last quarter of a century that have, in the aggregate, substantially devalued the patent right. The Court’s four decisions reinvigorating and substantially raising the patent eligibility bar have probably resulted in the most critical commentary, but a host of other decisions have also served to erode the patent right in multiple dimensions, including the scope of potentially patent-able subject matter as well as the strength and enforce-ability of issued patents. In 2011 Congress joined in when it enacted the America Invents Act (AIA), which includes multiple provisions tending to devalue patents, …

The Uneasy Case For Patent Law, Rachel E. Sachs

Michigan Law Review

A central tenet of patent law scholarship holds that if any scientific field truly needs patents to stimulate progress, it is pharmaceuticals. Patents are thought to be critical in encouraging pharmaceutical companies to develop and commercialize new therapies, due to the high costs of researching diseases, developing treatments, and bringing drugs through the complex, expensive approval process. Scholars and policymakers often point to patent law’s apparent success in the pharmaceutical industry to justify broader calls for more expansive patent rights.

This Article challenges this conventional wisdom about the centrality of patents to drug development by presenting a case study of …

Vanda V. West-Ward Pharmaceuticals: Good News For The Patent Eligibility Of Diagnostics And Personalized Medicine, With Some Important Caveats, Christopher M. Holman

Faculty Works

In Mayo v. Prometheus, decided in 2011, the U.S. Supreme Court invalidated patent claims directed towards diagnostic methods useful in the optimization of drug dosage for the needs of an individual patient, i.e., an example of personalized medicine, based on the Court’s determination that the claims were directed towards a patent ineligible law of nature. Notably, the claims in Mayo did not recite a step of applying the information generated by the test, e.g., a step of administering the drug to a patient at the optimized dosage. Some, including this author, have speculated that inclusion of such a step might …

Praxair V. Mallinckrodt: An Expanded Interpretation Of The Printed Matter Doctrine With Important Implications For Biotechnology, Christopher M. Holman

Faculty Works

Although the “printed matter doctrine” has a long history in U.S. patent law, until recently it has played a relatively minor role in policing patent-ability, so much so that an article published in 1994 essentially wrote it off as nothing more than an “archaic common law has-been.” Although the doctrine is rooted in the concept of patent eligibility, it is never mentioned in recent patent eligibility decisions of the U.S. Supreme Court such as Mayo and Alice, and patent law treatises and casebooks tend to give the doctrine little if any coverage. At its core, the printed matter doctrine has …

Bloodlines – Mammalian Motherhood, Biotechnologies And Other Entanglements, Lynn Mowson

Animal Studies Journal

This paper outlines my current sculptural research project bloodlines focusing on the ways in which dairy cows are entangled with multiple biotechnologies and the wider environment. bloodlines brings extant works such as fleshlumps, boobscape and slink, together with new works, to represent the dairy industry, the environmental impacts of animal agriculture and the biotech innovations of in-vitro meat and bio-fabricated leather. These works are linked together by a web of interconnected fluids: excreta, milk and blood. In this new work, I hope to make the links between the dairy industry and these extended concerns both visceral and visible.