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Articles 1 - 25 of 25
Full-Text Articles in Entire DC Network
23andme Inc.: Patent Law And Lifestyle Genetics, Matthew Rimmer
23andme Inc.: Patent Law And Lifestyle Genetics, Matthew Rimmer
Matthew Rimmer
The venture, 23andMe Inc., raises a host of issues in respect of patent law, policy, and practice in respect of lifestyle genetics and personalised medicine. The company observes: ‘We recognize that the availability of personal genetic information raises important issues at the nexus of ethics, law, and public policy’. 23andMe Inc. has tested the boundaries of patent law, with its patent applications, which cut across information technology, medicine, and biotechnology. The company’s research raises fundamental issues about patentability, especially in light of the litigation in Bilski v. Kappos, Mayo Collaborative Services v. Prometheus Laboratories Inc. and Association for Molecular Pathology …
Understanding Biotechnology: Conceptualizing And Measuring Us Public Concern, Jenna Ann Lamphere
Understanding Biotechnology: Conceptualizing And Measuring Us Public Concern, Jenna Ann Lamphere
Masters Theses
Biotechnology has had a short but rather conflict-ridden history. The technology was commercialized in 1995 and since has become a volatile topic for international debate. Arguably, the United States is the biggest supporter of this technology. The United States conducted the first study using recombinant DNA, grows more biotech crops than any other country, and houses the vast majority of the largest biotech corporations. Proponents frequently claim that biotech crops are a way to improve crop production, lower food prices, decrease the need for petrochemical inputs, and alleviate international food security problems. Others see them as accelerating the loss of …
“The Problem Of Science” In Nietzsche And Heidegger, Babette Babich
“The Problem Of Science” In Nietzsche And Heidegger, Babette Babich
Babette Babich
Nietzsche and Heidegger pose important philosophical questions to science and its technological projects. The resultant contributes to what may be called a continental philosophy of science and I argue that only such a rigorously critical approach to the question of science permits a genuinely philosophical reflection on science. The resultant contributes to what may be called a continental philosophy of science and I argue that only such a rigorously critical approach to the question of science permits a genuinely philosophical reflection on science. More than a thoughtful reflection on science, however, the heart of philosophy is also at stake in …
Politicizing Patents - Patenting Biotechnology In The Wake Of Section 33, Prometheus, And Cls Bank, Jonathan R. K. Stroud
Politicizing Patents - Patenting Biotechnology In The Wake Of Section 33, Prometheus, And Cls Bank, Jonathan R. K. Stroud
Articles in Law Reviews & Journals
Tucked into the America Invents Act is the first statutory exemption for any patentable subject matter. Section 33 renders unpatentable all claims “encompassing a human being.” By recognizing a vague subject matter – exception for human beings despite the fact that internal policies had long militated against such patent claims, Congress has politicized the patent law to an unheard-of degree. While textually consistent with internal USPTO policy, the passage of § 33 should not be seen as an invitation to litigators to expand § 101 unpatentable-subject-matter challenges to validity by including arguments that medical methods, genetic tests, biological chimeras, or …
Integrated Analysis Of Hydrothermal Flow Through Pretreatment, Veronique Archambault-Leger, Xiongjun Shao, Lee R. Lynd
Integrated Analysis Of Hydrothermal Flow Through Pretreatment, Veronique Archambault-Leger, Xiongjun Shao, Lee R. Lynd
Dartmouth Scholarship
Background:
The impact of hydrothermal flowthrough (FT) pretreatment severity on pretreatment and solubilization performance metrics was evaluated for three milled feedstocks (corn stover, bagasse, and poplar) and two conversion systems (simultaneous saccharification and fermentation using yeast and fungal cellulase, and fermentation by Clostridium thermocellum).
Results:
Compared to batch pretreatment, FT pretreatment consistently resulted in higher XMG recovery, higher removal of non-carbohydrate carbon and higher glucan solubilization by simultaneous saccharification and fermentation (SSF). XMG recovery was above 90% for FT pretreatment below 4.1 severity but decreased at higher severities, particularly for bagasse. Removal of non-carbohydrate carbon during FT pretreatment increased …
Expanding Horizons: Scientific Frontiers, Legal Regulation And Globalization, Belinda Bennett
Expanding Horizons: Scientific Frontiers, Legal Regulation And Globalization, Belinda Bennett
Indiana Journal of Global Legal Studies
In the six decades since the discovery of the double helix structure of DNA by Watson and Crick in 1953, developments in genetic science have transformed our understanding of human health and disease. These developments, along with those in other areas such as computer science, biotechnology, and nanotechnology, have opened exciting new possibilities for the future. In addition, the increasing trend for technologies to converge and build upon each other potentially increases the pace of change, constantly expanding the boundaries of the scientific frontier. At the same time, however, scientific advances are often accompanied by public unease over the potential …
A Growing Concern, William Munro
A Growing Concern, William Munro
Illinois Wesleyan University Magazine, 2002-2017
Though it holds promise to help alleviate world hunger, agricultural biotechnology has been rejected by millions who might benefit from it. Is there a way to bridge the gap?
Clay Minerals For Nanocomposites And Biotechnology: Surface Modification, Dynamics And Responses To Stimuli, Hendrik Heinz
Clay Minerals For Nanocomposites And Biotechnology: Surface Modification, Dynamics And Responses To Stimuli, Hendrik Heinz
College of Polymer Science and Polymer Engineering
Clay minerals find a wide range of application in composites, paints, drilling liquids, cosmetics, and medicine. This article reviews chemical and physical properties of natural and organically modified clay minerals to understand the nanometre-scale structure, surface characteristics, and application in functional materials. The relation between fundamental properties and materials design is emphasized and illustrated by examples. The discussion comprises the following: an overview; surface structure and cation density; solubility and solubility reversal by surface modification; the degree of covalent and ionic bonding represented by atomic charges; the distribution of metal substitution sites; measurements and simulations of interfacial properties at the …
Biological Strategies And Mathematical Approaches For Limiting Bacterial Contaminants And Chemical Pollutants In Bioethanol Fermentations, Alia Chahed Ep Limayem
Biological Strategies And Mathematical Approaches For Limiting Bacterial Contaminants And Chemical Pollutants In Bioethanol Fermentations, Alia Chahed Ep Limayem
Graduate Theses and Dissertations
During the most recent decades increased interest in fuel from biomass in the United States and worldwide has emerged each time petroleum derived-gasoline registered well publicized spikes in price. The willingness of the U.S. government to face the issues of more heavily high-priced foreign oil and climate change has led to more investment on plant-derived sustainable biofuel sources. Biomass derived from corn has become one of the primary feedstocks for bioethanol production for the past several years in the U.S. However, the argument of whether to use food as biofuel has led to a search for alternative non-food sources. Consequently, …
Cloning And Characterization Of The Cell Wall Acting Enzyme Cd1034 From The Pathogen Clostridium Difficile, Zachary Suter
Cloning And Characterization Of The Cell Wall Acting Enzyme Cd1034 From The Pathogen Clostridium Difficile, Zachary Suter
Honors Projects in Science and Technology
The manifestation of multidrug resistance in bacteria over the past several decades has resulted in one of the foremost challenges in the management of infectious diseases. The question arises, “How do we address this growing problem?” One solution to stem the growing rise in antimicrobial resistance is to investigate new targets, while another approach is to re-examine classical antibacterial targets with a fresh perspective. The aim of this paper is to begin the process of antibacterial development for the pathogen Clostridium difficile by characterizing the cell wall acting glucosaminidase CD1034. It is inunderstanding how CD1034 functions biochemically that it can …
Patents And Regulatory Exclusivity, Rebecca S. Eisenberg
Patents And Regulatory Exclusivity, Rebecca S. Eisenberg
Book Chapters
This article reexamines the sources of exclusivity for drugs, considers their limitations, and evaluates exclusivity under the new biologics legislation in light of these limitations. The current overlapping legal protections for exclusivity in the pharmaceutical marketplace reflect a series of political compromises, repeatedly renegotiated to correct for unintended consequences in the previous version of the rules. Patents and patent challenges play a central role in this system of protection, and many of the patents at stake are ultimately held invalid in litigation. It is not easy to untangle a complex legal regime that allocates billions of dollars of profits. But …
Human-Capital-Centred Regionalism In Economic Development: A Case Of Analytics Outpacing Institutions?, Laura Wolf-Powers
Human-Capital-Centred Regionalism In Economic Development: A Case Of Analytics Outpacing Institutions?, Laura Wolf-Powers
Laura Wolf-Powers
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
George J. Pappas
Gene regulatory networks capture interactions between genes and other cell substances, resulting in various models for the fundamental biological process of transcription and translation. The expression levels of the genes are typically measured in mRNA concentrations in micro-array experiments. In a so called genetic perturbation experiment, small perturbations are applied to equilibrium states and the resulting changes in expression activity are measured. This paper develops a novel algorithm that identifies a sparse stable genetic network that explains noisy genetic perturbation experiments obtained at equilibrium. Our identification algorithm can also incorporate a variety of possible prior knowledge of the network structure, …
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
George J. Pappas
Gene regulatory networks capture interactions between genes and other cell substances, resulting in various models for the fundamental biological process of transcription and translation. The expression levels of the genes are typically measured in mRNA concentrations in micro-array experiments. In a so called genetic perturbation experiment, small perturbations are applied to equilibrium states and the resulting changes in expression activity are measured. This paper develops a novel algorithm that identifies a sparse stable genetic network that explains noisy genetic perturbation experiments obtained at equilibrium. Our identification algorithm can also incorporate a variety of possible prior knowledge of the network structure, …
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
Identification Of Stable Genetic Networks Using Convex Programming, Michael M. Zavlanos, A. Agung Julius, Stephen P. Boyd, George J. Pappas
George J. Pappas
Gene regulatory networks capture interactions between genes and other cell substances, resulting in various models for the fundamental biological process of transcription and translation. The expression levels of the genes are typically measured in mRNA concentrations in micro-array experiments. In a so called genetic perturbation experiment, small perturbations are applied to equilibrium states and the resulting changes in expression activity are measured. This paper develops a novel algorithm that identifies a sparse stable genetic network that explains noisy genetic perturbation experiments obtained at equilibrium. Our identification algorithm can also incorporate a variety of possible prior knowledge of the network structure, …
Could A Hub And Spoke, Homegrown Ceo Strategy Boost The Success Of University Start-Ups?, Brendan O. Baggot, Martin R. Graf Phd
Could A Hub And Spoke, Homegrown Ceo Strategy Boost The Success Of University Start-Ups?, Brendan O. Baggot, Martin R. Graf Phd
Brendan O. Baggot
How can universities make more money with their spinout company (SpinCo)‐suitable technologies? By “growing” their own CEOs to improve both the quality and quantity of startup company leaders available, that’s how. Surprisingly, however, at most universities little or no effort is made to interweave this critical need into tech transfer efforts.
Will Gene Patents Derail The Next-Generation Of Genetic Technologies?: A Reassessment Of The Evidence Suggests Not, Christopher M. Holman
Will Gene Patents Derail The Next-Generation Of Genetic Technologies?: A Reassessment Of The Evidence Suggests Not, Christopher M. Holman
UMKC Law Review
Judge Bryson recently asserted in Association for Molecular Pathology v. US Patent and Trademark Office (dissenting-in-part) that human gene patents "present a significant obstacle to the next generation of innovation in genetic medicine — multiplex tests and whole-genome sequencing." His concern over the impact of gene patents on genetic testing, which coincides with his position that certain gene patents should be declared patent ineligible, reflects a widely held misperception that 20% of human genes are patented in a manner that would necessarily result in infringement by whole genome sequencing and other forms of genetic testing. In fact, the myth that …
Silkworms Transformed With Chimeric Silkworm/Spider Silk Genes Spin Composite Silk Fibers With Improved Mechanical Properties, Florence Joe Teulé, Yun-Gen Miao, Bong-Hee Sohn, Young-Soo Kim, J. Hull, Malcolm J. Fraser, Randolph V. Lewis, Donald L. Jarvis
Silkworms Transformed With Chimeric Silkworm/Spider Silk Genes Spin Composite Silk Fibers With Improved Mechanical Properties, Florence Joe Teulé, Yun-Gen Miao, Bong-Hee Sohn, Young-Soo Kim, J. Hull, Malcolm J. Fraser, Randolph V. Lewis, Donald L. Jarvis
Biology Faculty Publications
The development of a spider silk-manufacturing process is of great interest. However, there are serious problems with natural manufacturing through spider farming, and standard recombinant protein production platforms have provided limited progress due to their inability to assemble spider silk proteins into fibers. Thus, we used piggyBac vectors to create transgenic silkworms encoding chimeric silkworm/spider silk proteins. The silk fibers produced by these animals were composite materials that included chimeric silkworm/spider silk proteins integrated in an extremely stable manner. Furthermore, these composite fibers were, on average, tougher than the parental silkworm silk fibers and as tough as native dragline spider …
Expression Of Lipase From Mycobacterium Tuberculosis In Nicotiana Tobacum And Lactuca Sativa Chloroplasts, Bethany Lloyd
Expression Of Lipase From Mycobacterium Tuberculosis In Nicotiana Tobacum And Lactuca Sativa Chloroplasts, Bethany Lloyd
Electronic Theses and Dissertations
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis), is a global threat and the leading cause of death among individuals infected with HIV. TB treatment requires multi-drug cocktails, due to the increasing rates of drug resistance of the bacterium. With multi-drug cocktails, strains have been documented to be resistant to all major drugs in the fight against TB. Since the strains are drug resistant, it calls for an increasing need for vaccine and treatment development for the purpose of preventing and managing the disease. The most widely distributed vaccine against TB is Bacillus Calmette-Gue´rin (BCG). Apart from being …
Trait Stacking For Biotech Crops: An Essential Consideration For Agbiotech Development Projects For Building Trust., Obidimma Ezezika, Nadira Saleh, Abdallah S. Daar
Trait Stacking For Biotech Crops: An Essential Consideration For Agbiotech Development Projects For Building Trust., Obidimma Ezezika, Nadira Saleh, Abdallah S. Daar
Health Studies Publications
The development of agricultural biotechnology humanitarian projects for food security in the last five years has been rapid in developing countries and is expected to rise sharply over the coming years. An extremely critical issue in these projects involves building trust with the community and farmers they aim to serve. For the first time, our social audit engagement with one of these initiatives, the Water Efficient Maize for Africa project, has revealed that a critical but unrecognized component of building trust with farmers involves publicly addressing the concerns surrounding stacked trait crops. As a result, we argue in this article …
Terms Of Perfection, Art Bochner
Terms Of Perfection, Art Bochner
Art Bochner
In this essay, I attempt to think with the story Michael Hyde tells in Perfection: Coming to Terms with Being Human. Viewing the drive for perfection from the perspective of narrative, I focus on the question of how the language game of perfection might lead in the direction of other ways of understanding ourselves, our writing practices, and the unity of our lives. I question the appropriateness of conventions of rhetorical scholarship that inhibit communication scholars from enacting more personal expressions of rhetorical competence, which could give greater urgency to burning issues at the heart of what it can mean …
Rapid, Large-Scale Production Of Full-Length, Human-Like Monoclonal Antibodies, Christopher M. Warner
Rapid, Large-Scale Production Of Full-Length, Human-Like Monoclonal Antibodies, Christopher M. Warner
KGI Theses and Dissertations
Current recombinant protein production systems require several months to develop. Existing systems fail to provide timely, flexible, and cost-effective therapies to protect against emergency mass-casualty infections or poisonings. As the identity of many new biological threat agents are unlikely to be known in advance, pre-emptive manufacturing and stockpiling of countermeasures cannot be performed. Preparedness for a biological catastrophe requires a radical solution to replace the current slow scale-up and manufacture of lifesaving medical countermeasures. Subunit vaccines and antibody fragments may be produced in bacteria, yeast, plant or insect cells. However, generation of full-length, human like glycosylated antibodies requires mammalian cell …
Chapter 1 An Introduction To Agricultural Biotechnology Regulation In The U.S., Chris A. Wozniak, Annabel Fellman Waggoner, Sheryl Reilly
Chapter 1 An Introduction To Agricultural Biotechnology Regulation In The U.S., Chris A. Wozniak, Annabel Fellman Waggoner, Sheryl Reilly
United States Environmental Protection Agency: Publications
The regulation of agricultural plant and microbial biotechnology products in the United States of America has a rich history that re fl ects the challenges the federal government has faced in the development of appropriate rules and standards needed to determine their safety to humans and the environment. Several factors – the insuf fi cient global food supply, loss or curtailment of the use of older chemistries to control pests due to risks and environmental persistence, the rising demand for safer food commodities, and the uncertainty surrounding the sustainability of agriculture in this and other countries – have added to …
Wisdom Of The Ages Or Dead-Hand Control? Patentable Subject Matter For Diagnostic Methods After In Re Bilski, Rebecca S. Eisenberg
Wisdom Of The Ages Or Dead-Hand Control? Patentable Subject Matter For Diagnostic Methods After In Re Bilski, Rebecca S. Eisenberg
Articles
In 1980, the Supreme Court gave a reassuring signal to the then-nascent biotechnology industry about the availability of patent protection for the fruits of its research when it upheld the patentability of a genetically modified living organism in Diamond v. Chakrabarty. Twenty-five years later, the Court seemed poised to reexamine the limits of patentable subject matter for advances in the life sciences when it granted certiorari in Laboratory Corporation v. Metabolite. But the Federal Circuit had not addressed the patentable subject matter issue in Laboratory Corporation, and the Court ultimately dismissed the certiorari p etition as improvidently granted. Five years …
Complete Genome Sequence Of Clostridium Clariflavum Dsm 19732, Javier A. Izquierdo, Lynne Goodwin, Karen W. Davenport, Hazuki Teshima
Complete Genome Sequence Of Clostridium Clariflavum Dsm 19732, Javier A. Izquierdo, Lynne Goodwin, Karen W. Davenport, Hazuki Teshima
Dartmouth Scholarship
Clostridium clariflavum is a Cluster III Clostridium within the family Clostridiaceae isolated from thermophilic anaerobic sludge (Shiratori et al, 2009). This species is of interest because of its similarity to the model cellulolytic organism Clostridium thermocellum and for the ability of environmental isolates to break down cellulose and hemicellulose. Here we describe features of the 4,897,678 bp long genome and its annotation, consisting of 4,131 protein-coding and 98 RNA genes, for the type strain DSM 19732.