Digital Commons Network^™

Male Circumcision For Hiv Prevention: Current Evidence And Implementation In Sub-Saharan Africa, Richard G. Wamai, Brian J. Morris, Stefan A. Bailis, David Sokal, Jeffrey D. Klausner, Ross Appleton, Nelson Sewankambo, David A. Cooper, John Bongaarts, Guy De Bruyn, Alex D. Wodak, Joya Banerjee

Richard G. Wamai

Heterosexual exposure accounts for most HIV transmission in sub-Saharan Africa, and this mode, as a proportion of new infections, is escalating globally. The scientific evidence accumulated over more than 20 years shows that among the strategies advocated during this period for HIV prevention, male circumcision is one of, if not, the most efficacious epidemiologically, as well as cost-wise. Despite this, and recommendation of the procedure by global policy makers, national implementation has been slow. Additionally, some are not convinced of the protective effect of male circumcision and there are also reports, unsupported by evidence, that non-sex-related drivers play a major …

Examining The Efficacy Of Hiv Risk-Reduction Counseling On The Sexual Risk Behaviors Of A National Sample Of Drug Abuse Treatment Clients: Analysis Of Subgroups, Lauren K. Gooden

Open Access Dissertations

This dissertation sought to evaluate the efficacy of brief, HIV risk-reduction counseling (versus information only) among subgroups of substance abuse treatment clients by conducting a series of post-hoc analyses of data that were collected from the CTN 0032 trial. It was hypothesized that HIV risk-reduction counseling would be associated with decreased sexual risk behaviors in several subgroups as determined by baseline characteristics. Findings of this dissertation suggest that brief, HIV risk-reduction counseling delivered in conjunction with rapid HIV testing is not efficacious in reducing number of risky sex acts among subgroups of substance abuse treatment clients. Findings suggest that brief, …

Living With Hiv: Views Through The Blog, Linda Eastham

Theses and Dissertations

The purpose of this qualitative descriptive study was to develop a greater clarity of how HIV infected individuals live and work within the sphere of HIV infection as represented through unsolicited, personal narratives posted on blogs. Existing, single author, personal blogs were identified via a search engine. Blogs were defined as the blog author's postings and all responses, whether written by the blog author or a reader respondent. Inclusion and exclusion criteria were developed to respect indicators of bloggers' intentions for privacy, e.g., blogs which required a password were excluded. A total of 14 blogs met inclusion criteria. Actions to …

The Effect Of Combined Moderate-Intensity Training On Immune Functioning, Metabolic Variables, And Quality Of Life In Hiv-Infected Individuals Receiving Highly Active Antiretroviral Therapy, Eduard Tiozzo

Open Access Dissertations

Highly-active antiretroviral therapy (HAART) has improved the prognosis of HIV-infected individuals. Unfortunately it has also been associated with impaired functional capacity and development of metabolic perturbations which increases health risk. This study tested the hypothesis that a combined cardiorespiratory and resistance exercise training (CARET) intervention may result in significant health benefits in HIV-infected individuals receiving HAART. Thirty-seven HIV-infected men and women, predominantly of lower socioeconomic status (SES), were recruited and randomly assigned to: 1) a group of moderate-intensity CARET for three months or 2) a control group receiving no exercise intervention for three months. At baseline and following the intervention, …

The Grizzly, December 1, 2011, Liz Kilmer, Nick Pane, Jacquelyn Heikel, Jenna Yaich, Lisa Jobe, Jordan Demcher, James Noebels, Julia Fox, Sara Sherr, Sarah Bollert, Satchel Summers, Julia Glauberman, Eilish Bennett, Rosemary Clark, Shane Eachus

Ursinus College Grizzly Newspaper, 1978 to Present

Former Child Soldier Speaks for Peace • Landscaping Initiative Looks to Keep Campus Fresh • Fulbright Scholar to Join Ursinus This Spring • HIV Couple Speak on Sexual Health in Bomberger Auditorium • FFO Educates Students to Combat Bullying • Whitians' Woman to Watch: Stephanie Nocito, 2012 • Senior Interns with GlaxoSmithKline • UC United Aims to Help with Organization-run Events • Opinion: "Baby Bio" Insults Humanities Majors; Penn State Scandal Could Impact Victims of Sexual Assault; Students Desire an Off-Campus Shuttle Service; UC Provides Alternatives, Prepares for NBA Lockout • Post-Season Honors and Early Season Struggles

A Novel Telecommunications-Based Approach To Mathematical Modeling Of Hiv Infection, Aaron T. Sharp

Computer and Electronics Engineering: Dissertations, Theses, and Student Research

It is well known that biological systems utilize communication in some form, one prolific example of this is the propagation of HIV (Human Immunodeficiency Virus) in the human body. By modeling HIV infection as a communication system, we hope to gain a unique insight into HIV and biological communication systems in general. Such a model would provide researchers a platform for experimenting and simulating various biological communication systems. We have previously developed a layered communication protocol for interpreting biological communication systems using telecommunications paradigms and will apply said model to HIV proliferation. We will also demonstrate the effectiveness of the …

Pepfar’S Declining Investment In Treatment, Matthew Kavanagh, Marguerite Thorp

Matthew M. Kavanagh

Since its inception in 2003, the President’s Emergency Plan for AIDS Relief (PEPFAR) has saved millions of lives through providing anti-retroviral (ARV) treatment to people living with HIV/AIDS. However, our analysis of publicly available PEPFAR operational plans shows that funding to AIDS treatment has actually fallen significantly since 2008 in both absolute dollars and as a portion of total budgets—just at a pivotal moment when investment could change the course of the epidemic.

Functional Recovery Of Untreated Human Immunodeficiency Virus-Associated Guillain-Barré Syndrome: A Case Report, Adam L. Schreiber, John W. Norbury Iii, Eduardo A. De Sousa

Department of Rehabilitation Medicine Faculty Papers

HIV-associated Guillain-Barré Syndrome is a well-documented phenomenon, typically occurring at seroconversion. GBS may result in functional impairment treated with a combination of medications, plasmapheresis, and rehabilitation. The quantified functional recovery of HIV-associated GBS with or without HIV treatment is not well-described. Utilizing serial FIM scoring, we describe a patient’s recovery from HIV-associated GBS after treatment with IVIg and acute inpatient rehabilitation without HIV treatment.

Adolescent Sexual Behavior: Examining Data From Texas And The Us, Christine Markham, Melissa Peskin, Belinda F. Hernandez, Kimberly Johnson, Robert C. Addy, Paula Cuccaro, Ross Shegog, Susan Tortolero

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: The US has higher rates of teen births and sexually transmitted infections (STI) than other developed countries. Texas youth are disproportionately impacted. Purpose: To review local, state, and national data on teens’ engagement in sexual risk behaviors to inform policy and practice related to teen sexual health. Methods: 2009 middle school and high school Youth Risk Behavior Survey (YRBS) data, and data from All About Youth, a middle school study conducted in a large urban school district in Texas, were analyzed to assess the prevalence of sexual initiation, including the initiation of non-coital sex, and the prevalence of sexual …

Hiv In South African Youth: Relations With Parenting Quality And Executive Functioning, Christina H. Salama

Psychology Theses

Black South Africans account for a majority of HIV cases in South Africa, highlighting the need for greater understanding of risks specific to this group. Within the HIV prevention and risk literature, little information exists regarding the familial and neuropsychological contributions to HIV risk in youth. The current study addressed this gap. In a group of black South African parent-child dyads, the researchers investigated the independent and interactive contributions of parenting quality and executive functioning in the prediction of HIV risk. Child report of relationship quality was negatively associated with risky sexual attitudes and externalizing behaviors. Parent report of parental …

Dha Supplemented In Peptamen Diet Offers No Advantage In Pathways To Amyloidosis: Is It Time To Evaluate Composite Lipid Diet?, Zareen Amtul, Mary Keet, Peter Merrifield, David Westaway, Richard F. Rozmahel

Anatomy and Cell Biology Publications

Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD). However, none of these studies have examined and compared DHA, in combination with other dietary nutrients, for its effects on plaque pathogenesis. Potential interactions of DHA with other dietary nutrients and fatty acids are conventionally ignored. Here we investigated DHA with two dietary regimes; peptamen (pep+DHA) and low fat diet (low fat+DHA). Peptamen base liquid diet is a standard sole-source nutrition for patients with gastrointestinal dysfunction. Here we demonstrate that a robust AD transgenic mouse model shows an increased tendency to …

Follicular Dendritic Cells, Resting Cd4+ T Cells And Human Immunodeficiency Virus Expression, Changna Wang

Theses and Dissertations

Many events associated with Human Immunodeficiency Virus (HIV) infection/replication occur in and around the germinal centers (GCs) of secondary lymphoid tissues where follicular dendritic cells (FDCs) reside, suggesting that this microenvironment may contribute unique signaling that is important to viral progression. My research focused on characterizing signaling, both positive and negative, contributed by FDCs that affects HIV infection and replication. Specifically, I determined if FDC signals could induce the expression of latent HIV in T cells and if so, to characterize the signaling pathways involved. Moreover, I also examined the ability of FDCs to produce inhibitory signals that might block …

Litigating Against An Epidemic: Hiv/Aids And The Promise Of Socioeconomic Rights In South Africa, Nathaniel Bruhn

Michigan Journal of Race and Law

With one of the highest incidence rates in the world, the HIV/AIDS epidemic has taken a large toll on South Africa. Despite medical advances that have made the disease more manageable, many South Africans still do not have access to the medicines needed to control the disease. At the same time, the Constitution of South Africa grants individuals far-reaching socioeconomic rights, including the right to access health care. This Comment explores the intersection of the socioeconomic rights and the HIV/AIDS crisis. Although the Constitutional Court has developed a deferential approach to enforcing socioeconomic rights, substantial room remains to litigate on …

Hiv And Concurrent Sexual Partnerships: Modelling The Role Of Coital Dilution, Larry Sawers, Alan G. Isaac, Eileen Stillwaggon

Economics Faculty Publications

Background: The concurrency hypothesis asserts that high prevalence of overlapping sexual partnerships explains extraordinarily high HIV levels in sub-Saharan Africa. Earlier simulation models show that the network effect of concurrency can increase HIV incidence, but those models do not account for the coital dilution effect (nonprimary partnerships have lower coital frequency than primary partnerships).

Methods: We modify the model of Eaton et al (AIDS and Behavior, September 2010) to incorporate coital dilution by assigning lower coital frequencies to non-primary partnerships. We parameterize coital dilution based on the empirical work of Morris et al (PLoS ONE, December …

Married And Cohabiting Men's Extra-Dyadic Relationships In Sub-Saharan Africa: Assessing Two Health Behavior Models, Jared L. Ulschmid

Master's Theses - Sociology and Anthropology

Sixty percent of all individuals with HIV live in sub-Saharan Africa. HIV is primarily transmitted through sexual activity; having multiple congruent sexual partners is one significant source of HIV transmission in sub-Saharan African. Men are primarily the individuals to go outside of a relationship because of various social and cultural influences. The purpose of this study is to examine married and cohabiting men’s extra-dyadic affairs. Two models were used to examine men’s extra-dyadic behavior: The Health Belief Model (HBM) and Theory of Planned Behavior (TPB). These models can show if beliefs, attitudes, and norms about HIV/AIDS and the risks of …

Profile Of Systemic Treatment With The Antiviral Lectin Griffithsin In Guinea Pigs., Christopher Lynn Barton 1976-

Electronic Theses and Dissertations

Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is currently unknown what impact systemic GRFT administration may have upon a biological system. For initial in vivo testing, we introduced GRFT into guinea pigs (Cavia Parcel/us) via subcutaneous injection. Based on histological, serological, and biochemical data derived from these experiments, GRFT is well tolerated and maintained at physiologically relevant concentrations while retaining its potent antiviral activity. Follow up in vitro testing included a …

Growing Out Of Adolescence: Conceptions Of Adulthood, Close Relationships, And Health Behaviors Of Emerging Adults With Hiv, Olivia Hsin

Open Access Dissertations

Objective: The current study examined conceptions of adulthood, close personal relationships, and health behaviors (dietary intake, substance use, sexual behaviors) of emerging adults aged 18-30 with horizontally-infected HIV. Emerging adults were expected to differ in levels of achievement of adulthood tasks. The quality of close relationships, and perceptions of close friends’ behaviors were hypothesized to be associated with health behaviors. Method: Utilizing a cross-sectional design, 48 emerging adults with HIV (64.6% female; M age = 22.59, SD = 3.17) from a youth-based clinic serving most of Miami-Dade County were recruited. Participants completed measures on markers of adulthood, close friend and …

Emotional Expression And Depth Processing In Trauma Writing: Impact On Hiv/Aids-Targeted Quality Of Life, Rachel A. Ruffin

Open Access Dissertations

Expressive writing has been linked to positive psychological and health outcomes in general and medical populations, but research examining this intervention in HIV is limited. Higher levels of emotional expression (EE) and depth processing (DP) during writing have been linked to better health status in HIV. Expressive writing has been shown to improve health-related quality of life (HRQoL) in other populations, but has not been examined in HIV. HRQoL is often compromised in HIV+ individuals and therefore improvements in this area are an appropriate goal of psychosocial interventions. This longitudinal study used HLM analyses to examine the relationship between levels …

Collection Development Of Hiv/Aids Information Resources In American Libraries, Joseph G. Andrews Jr

School of Information Student Research Journal

HIV/AIDS remains an incurable epidemic in the United States that disproportionately affects men who have sex with men (MSM) and African Americans. Library and information science (LIS) professionals can play a vital role in keeping these higher risk groups informed about preventing HIV/AIDS and living with the disease, through a variety of current information resources that addresses their specific questions. This paper reviews collection development policies proposed by LIS professionals and library agencies since the late 1980s, and evaluates how such policies took higher-risk user groups into consideration. The findings of this paper are that collection development policies have become …

The Implications Of Male Circumcision On Hiv Transmission, Aliciamarie Hurlburt

Pell Scholars and Senior Theses

Human immunodeficiency virus (HIV) is one of the world’s biggest health threats. In 2010, 33.3 million adults and children were predicted to be living with HIV/AIDS. Although prevention methods such as abstinence, condoms, and fewer sexual partners will help to lower the number of people infected by HIV, they are not enough. Male circumcision may provide an extra prevention method to acquiring HIV. A correlation between male circumcision and HIV transmission was first discovered in areas in western and northern Africa where the male circumcision prevalence rates tend to be high and HIV prevalence tends to be low. The foreskin …

Treatment Outcome Of Multi-Drug Resistant Tuberculosis Treated As Outpatient In A Tertiary Care Center, Zeeshan Waheed, Muhammad Irfan, Ahmed Suleman Haque, Muhammad Owais Khan, Atif Zubairi, Noor Ul Ain, Javaid A. Khan

Section of Pulmonary & Critical Care

INTRODUCTION: Community-based out-patient treatment for multidrug-resistant tuberculosis (MDR TB) is relatively new concept with reported successful outcomes.

OBJECTIVE: To assess the treatment outcomes of HIV negative multidrug-resistant tuberculosis (MDR TB) patients treated as outpatient at a tertiary care center in Karachi, Pakistan.

METHODS: A retrospective observational study of 53 consecutive, culture proven HIV negative MDR TB patients (resistant at least to both Isoniazid (H) and Rifampin(R) treated at Aga Khan University Hospital, Karachi between August 1999 and March 2007. Data were collected on predesigned performa regarding patient’s demography, clinical features, radiological findings, drug sensitivity, treatment and outcome.

RESULTS: A total …

Demographic Factors Associated To Survival Of Hiv/Aids Patients In Southernmost Province Of Thailand, B Chaimay, S Woradet, K. Sukkasem

Chulalongkorn Medical Journal

Introduction : HIV/AIDS is a serious public health problem that has globally caused severe illnesses and deaths within the past two decades. However, a little is known about the impact on demographic factors which is changed over time. Objective : To investigate the demographic factors associated to survival of HIV/AIDS patients. Setting : Provincial and community hospitals. Research design : A prospective, hospital-based cohort study. Patients : HIV/AIDS patients registered in both provincial and community hospitals between January 1992 and April 2010. Methods : In total, 1,575 patients with HIV/AIDS infection were observed and followed-up in one regional and other …

Roles Of Autophagy In Hiv-1 Infection, Christina Dinkins

Biomedical Sciences ETDs

Human immunodeficiency virus type 1 (HIV-1) chronically infects approximately 30 million people worldwide. HIV-1 has become one of the most difficult viral infections to treat due to its high mutability and emerging drug resistance. Critical to our development of more effective therapeutic treatments, we must better understand the HIV life cycle in order to reveal better targets for drug development. Thus, the purpose of this work was to investigate the role of autophagy, a cellular homeostatic mechanism capable of eliminating intracellular pathogens, in HIV-1 infection of two relevant hosts, the human and the Old World non-permissive primate, the rhesus macaque. …

Analysis Of Hiv/Aids Incidents In Sudan With Reference To Khartoum State, Professor Issam A.W. Mohamed

Professor Issam A.W. Mohamed

The present paper introduces results of an analysis conducted on data collected from Khartoum state for the yea 2009. It aims to apply statistical models for the HIV/AIDS data in Khartoum state centers of testing blood and counseling. AIDS is recognized as an emerging disease only in the early 1980s, AIDS has rapidly established itself throughout the world, and is likely to endure and persist well into the 21s century. AIDS has evolved from a mysterious illness to a global pandemic which has infected tens of millions less than 20 years. The importance of the study is to emphasize that …

U.S. Cultural Involvement And Its Association With Co-Occurring Substance Abuse And Sexual Risk Behaviors Among Youth In The Dominican Republic, Elián P. Cabrera-Nguyen, Juan B. Peña

Elián P. Cabrera-Nguyen

We examined the relationship of US cultural involvement with substance abuse and sexual risk behavior profiles from our nationally representative sample of public high school students in the Dominican Republic. Using a novel methodological approach to control for selection bias, we examined explanations for the so-called Latino or Hispanic immigrant paradox. A latent class regression analysis with manifest and latent covariates found that US cultural involvement indicators were independent and robust predictors of increased risk of co-ocurring substance abuse and sexual risk behaviors. Implications for prevention efforts targeting risk behaviors among Latino/a adolescents in the US and abroad are considered.

Successful Aging And The Epidemiology Of Hiv, David E. Vance, Teena Mcguinness, Karen Musgrove, Nancy Ann Orel, Pariya L. Fazeli

Gerontology Faculty Publications

By 2015, it is estimated that nearly half of those living with HIV in the US will be 50 years of age and older. This dramatic change in the demographics of this clinical population represents unique challenges for patients, health care providers, and society-at-large. Fortunately, because of highly active antiretroviral therapy (HAART) and healthy lifestyle choices, it is now possible for many infected with HIV to age successfully with this disease; however, this depends upon one’s definition of successful aging. It is proposed that successful aging is composed of eight factors: length of life, biological health, cognitive efficiency, mental health, …

The Prevalence And Factors Associated With Nonadherence With Arv Treatment And Cotrimoxazole Preventive Therapy Among Hiv Infected Adolescents Attending Out-Patient Hiv Clinics In Kenya, Reson Marima

Theses & Dissertations

Background: There is an increase in the burden of HIV infected adolescents, both those perinatally infected as well as those acquiring HIV during adolescence. Female adolescents continue to be at the highest risk for acquiring HIV; in many Southern African countries, they have a three fold risk of acquiring HIV compared to their male counterparts. Adherence to treatment among adolescents has been shown to range between 30-70%, which is unacceptably low for antiretroviral therapy (ART). Psychosocial wellbeing and social support have been shown to be possible contributing factors to adherence to ART. This relationship has not been previously evaluated …

An Exploratory Study: Perceptions Of Power Dynamics And Sexual Decision-Making Among College-Age African American Women, Latisha Oliver

Africana Studies Theses

This qualitative grounded study explores power dynamics and its influence on sexual decision-making amongst college-age African American women. The film All of Us was shown to eighteen African American women to understand how they perceive power dynamics and sexual decision-making. Taking place at Georgia State University‟s main campus in Atlanta, focus groups and one on one interviews were implemented. Much of the research being conducted theorize that the risk factors regarding HIV infection are related to risky sexual decision-making and lack of consistent condom use; however this study concluded that there is a relationship between sexual decision-making and gendered power …

A Methodology For Building Culture And Gender Norms Into Intervention: An Example From Mumbai, India, Kristin M. Kostick,, Stephen L. Schensul, Pertti Pelto

UCHC Articles - Research

This paper responds to the call for culturally relevant intervention research by introducing a methodology for identifying community norms and resources in order to more effectively implement sustainable interventions strategies. Results of an analysis of community norms, specifically attitudes toward gender equity, are presented from an HIV/STI research and intervention project in a low income community in Mumbai, India (2008–2012). Community gender norms were explored because of their relevance to sexual risk in settings characterized by high levels of gender inequity. This paper recommends approaches that interventionists and social scientists can take to incorporate cultural insights into formative assessments and …

Acceptability Of Pre-Exposure Prophylaxis (Prep) As An Hiv Prevention Strategy: Barriers And Facilitators To Prep Uptake Among At-Risk Peruvian Populations, Jerome T. Galea, Janni J. Kinsler, Ximena Salazar, Sung-Jae Lee, Maziel Giron, Jennifer N. Sayles, Carlos Cáceres, William E. Cunningham

Social Work Faculty Publications

This study examined Pre-Exposure Prophylaxis (PrEP) acceptability among female sex workers, male-to-female transgendered persons, and men who have sex with men in Lima, Peru. Focus groups explored social issues associated with PrEP acceptability and conjoint analysis assessed preferences among eight hypothetical PrEP scenarios with varying attribute profiles and their relative impact on acceptability. Conjoint analysis revealed that PrEP acceptability ranged from 19.8 to 82.5 out of a possible score of 100 across the eight hypothetical PrEP scenarios. Out-of-pocket cost had the greatest impact on PrEP acceptability (25.2, p < 0.001), followed by efficacy (21.4, p < 0.001) and potential side effects (14.7, p < 0.001). Focus group data supported these findings, and also revealed that potential sexual risk disinhibition, stigma and discrimination associated with PrEP use, and mistrust of health care professionals were also concerns. These issues will require careful attention when planning for PrEP roll-out if proven efficacious in ongoing clinical trials.