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The Gene Wars: Science, The Law And The Human Genome, Omid E. Khalifeh

Omid E Khalifeh J.D.

Is there a place for gene patents in the patent act? Since before the ruling in Diamond v. Chakrabarty this issue has stirred much controversy in the legal and scientific communities. Although the scope of patentable subject matter has been defined, whether gene patents fall within the precise limits of the Chakrabarty doctrine remains unclear.

Gene patents have increasingly faced scrutiny from people who often times don’t understand genetics or the complexities of the patent process. A lack of understanding has led them to make emotive and one-sided arguments. In his novels, Michael Crichton warns of dangerous mutated bacteria and …

The Gene Wars: Science, The Law And The Human Genome, Omid E. Khalifeh

Omid E Khalifeh J.D.

Is there a place for gene patents in the patent act? Since before the ruling in Diamond v. Chakrabarty this issue has stirred much controversy in the legal and scientific communities. Although the scope of patentable subject matter has been defined, whether gene patents fall within the precise limits of the Chakrabarty doctrine remains unclear.

Gene patents have increasingly faced scrutiny from people who often times don’t understand genetics or the complexities of the patent process. A lack of understanding has led them to make emotive and one-sided arguments. In his novels, Michael Crichton warns of dangerous mutated bacteria and …

The Gene Wars: Science, The Law And The Human Genome, Omid E. Khalifeh

Omid E Khalifeh J.D.

Is there a place for gene patents in the patent act? Since before the ruling in Diamond v. Chakrabarty this issue has stirred much controversy in the legal and scientific communities. Although the scope of patentable subject matter has been defined, whether gene patents fall within the precise limits of the Chakrabarty doctrine remains unclear. Gene patents have increasingly faced scrutiny from people who often times don’t understand genetics or the complexities of the patent process. A lack of understanding has led them to make emotive and one-sided arguments. In his novels, Michael Crichton warns of dangerous mutated bacteria and …

A Guide To Biotechnology Law And Business* By Robert A. Bohrer, Lawrence M. Sung

Lawrence M. Sung

No abstract provided.

The Unblazed Trail: Bioinformatics And The Protection Of Genetic Knowledge, Lawrence M. Sung

Lawrence M. Sung

No abstract provided.

Optimizing Taq Polymerase Concentration For Improved Signal-To-Noise In The Broad Range Detection Of Low Abundance Bacteria, Rudolph Spangler, Noel L. Goddard, David S. Thaler

Publications and Research

Background PCR in principle can detect a single target molecule in a reaction mixture. Contaminating bacterial DNA in reagents creates a practical limit on the use of PCR to detect dilute bacterial DNA in environmental or public health samples. The most pernicious source of contamination is microbial DNA in DNA polymerase preparations. Importantly, all commercial Taq polymerase preparations inevitably contain contaminating microbial DNA. Removal of DNA from an enzyme preparation is problematical. Methodology/Principal Findings This report demonstrates that the background of contaminating DNA detected by quantitative PCR with broad host range primers can be decreased greater than 10-fold through the …

Leveling The Playing Field In Gmo Risk Assessment: Importers, Exporters And The Limits Of Science, Alison Peck

Alison Peck

The WTO system requires that trade restrictions to protect health and safety be based on a risk assessment supported by “sufficient scientific evidence.” Scholars and international standards organizations have pointed out, however, that science is not capable of providing answers to questions of health and safety without incorporation of value judgments and assumptions by the risk assessors. Before GMO-importing countries conduct risk assessments, GMO-producing and -exporting countries have already conducted separate risk assessments that led to the decision to produce and market the products in the first place. Both risk assessments – of exporting and importing countries – employ science …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

The Upside Of Intellectual Property's Downside, James Gibson

James Gibson

Intellectual property law exists because exclusive private rights provide an incentive to innovate. This is the traditional upside of intellectual property: the production of valuable information goods that society would otherwise never see. In turn, too much intellectual property protection is typically viewed as counterproductive, as too much control in the hands of private rightsholders creates more artificial scarcity and imposes more costs on future innovators than the incentive effect warrants. This is the traditional downside of intellectual property: reduced production and impeded innovation. This article turns the traditional discussion on its head and shows that intellectual property's putative costs …

Best And Brightest Forum On Medical Innovation

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Protozoan Vaccine Candidate Homologues In Tetrahymena Thermophila, Justin Schumacher

Senior Honors Projects

Tetrahymena thermophila is a member of the phylum Ciliophora (the ciliated protozoa) and is currently of great interest due to its unique qualities that make it useful as a model for research directed towards understanding how eukaryotic cells function. Recently, the T. thermophila genome was sequenced, and made available online. Since Tetrahymena is a member of the Alveolata, the major eukaryotic clade that also contains the apicomplexan parasites that cause a number of serious human and animal diseases, we sought to determine whether the genes coding for apicomplexan vaccine candidates were represented in the genome of Tetrahymena. In addition, we …

Plant Vaccines: An Immunological Perspective., Douglas C. Hooper

Department of Cancer Biology Faculty Papers

The advent of technologies to express heterologous proteins in planta has led to the proposition that plants may be engineered to be safe, inexpensive vehicles for the production of vaccines and possibly even vectors for their delivery. The immunogenicity of a variety of antigens of relevance to vaccination expressed in different plants has been assessed. The purpose of this article is to examine the utility of plant-expression systems in vaccine development from an immunological perspective.

A Submission To The Senate Community Affairs Committee Inquiry Into Gene Patents, Matthew Rimmer

Matthew Rimmer

I am a senior lecturer and the associate director for research at the Australian National University College of Law based in Canberra, Australia. I am also an associate director of the Australian Centre for Intellectual Property in Agriculture (ACIPA). I have a BA (Hons) and a University Medal in literature, and a LLB (Hons) from the Australian National University, and a PhD in law from the University of New South Wales. I am a member of the Copyright and Intellectual Property Advisory Group of the Australian Library and Information Association, and a director of the Australian Digital Alliance. I am …

Of Mice And Men: Why An Anticommons Has Not Emerged In The Biotechnological Realm, Chester J. Shiu

Chester J Shiu

In 1998 Michael Heller and Rebecca Eisenberg posited that excessive patenting of fundamental biomedical innovations might create a “tragedy of the anticommons.” A decade later, their dire predictions have not come to pass, an outcome which calls much of the legal scholarship on the topic into question. This Article proposes that legal commentators’ theoretical arguments have largely ignored two very important factors. First, the National Institutes of Health (NIH)—the single most important actor in the biomedical research industry—has played an active role in keeping the biomedical research domain open. In particular, regardless of what the current patent regime may theoretically …

Two Approaches For Cell Retention In Perfusion Culture Systems, Zhaowei Wang

ETD Archive

A lack of efficient, economical, and reliable cell retention devices has limited the application of perfusion culture systems in the biopharmaceutical industry. Two types of cell retention devices were developed in this work for long-term perfusion culture systems: a modification of an inclined gravity settler and a variation of an ultrasonic filter. Both bench-top and large-scale tests showed that the gravity settler can effectively retain viable cells and preferentially remove nonviable cells in perfusion culture systems. The viable cell retention rate can be maintained well above 90 during long-term perfusion culture period while the nonviable cell retention rate is 20-30 …

Biotechnology For Immune Cell Detection And Evaluation : Devices Specifically Designed To Capture, Detect Or To Evaluate Alterations In Leukocyte Structure And Function, Thomas Joseph Zieziulewicz

Legacy Theses & Dissertations (2009 - 2024)

The advent of Nano-biotechnology has opened a whole new area of biological study that has allowed us to pattern, manipulate, separate, evaluate and detect biological structures and functions that were previously not possible. This dissertation will describe different types of micro-fabricated devices that were designed to quantify and/or evaluate the functional activities of cells of the immune system. The micro-fabricated devices were developed in collaboration with our colleagues at Princeton University as part of our Cellular Micro-dynamics Program of the Nanobiotechnology Center (NBTC) at Cornell University.

Combined Effects Of Hyperglycemic Conditions And Hiv-1 Nef: A Potential Model For Induced Hiv Neuropathogenesis., Edward A Acheampong, Cassandra Roschel, Muhammad Mukhtar, Alagarsamy Srinivasan, Mohammad Rafi, Roger J Pomerantz, Zahida Parveen

Department of Neurology Faculty Papers

Hyperglycemic conditions associated with diabetes mellitus (DM) or with the use of antiretroviral therapy may increase the risk of central nervous system (CNS) disorders in HIV-1 infected patients. In support of this hypothesis, we investigated the combined effects of hyperglycemic conditions and HIV-1 accessory protein Nef on the CNS using both in vitro and in vivo models. Astrocytes, the most abundant glial cell type required for normal synaptic transmission and other functions were selected for our in vitro study. The results show that in vitro hyperglycemic conditions enhance the expression of proinflammatory cytokines including caspase-3, complement factor 3 (C3), and …

A Semiotic Analysis Of Biotechnology And Food Safety Images In Time, Newsweek, And U.S. News & World Report, Jenn Norwood Tolbert, Tracy Rutherford

Journal of Applied Communications

This study examined the photographs and photo illustrations used in Time, Newsweek, and U.S. News & World Report biotechnology and food safety stories in 2000 and 2001. Semiotic theory provided a conceptual framework for interpreting data collected through a quantitative content analysis. The evaluation of 45 images indicated that the news magazines had relatively balanced coverage of the issues. Five categories of images were determined to be used by the news magazines: food, animals, scientists or food handlers, producers, and foreign. These results are consistent with journalism research in relationship to the use of images to create perceptions and support …

Learning From Litigation: What Can Lawsuits Teach Us About The Role Of Human Gene Patents In Research And Innovation, Christopher M. Holman

Faculty Works

In 2007, I published an article entitled "The Impact of Human Gene Patents on Innovation and Access: A Survey of Human Gene Patent Litigation," in which I reported the results of a project to identify and characterize all instances in which a human gene patent was asserted in a lawsuit. For the purposes of this study, I essentially treated any US patent claiming a product or process involving one or more specific human genes as a "human gene patent."

In the present article I explore in greater depth some of the implications of the 2007 study, and discuss some general …

Who Owns Your Body? A Study In Literature And Law, Lori B. Andrews

Lori B. Andrews

No abstract provided.