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Two New Resorcinarenes: A Pyridine & Acetic Acid Ligand For Metal Coordination And A Deep-Cavity Nitroquinoxaline Resorcinarene, Samantha Sizemore Vernetti
Two New Resorcinarenes: A Pyridine & Acetic Acid Ligand For Metal Coordination And A Deep-Cavity Nitroquinoxaline Resorcinarene, Samantha Sizemore Vernetti
Theses and Dissertations
Functionalizing the upper rim of resorcinarene-based cavitands allows a variety of compounds to be synthesized from a single scaffold. Using the upper-rim moieties as ligands for a variety of transition metal ions further increases the versatility of this class of host compounds. A new resorcinarene-based molecule functionalized with four pyridine and acetic acid ligands has been successfully prepared to explore the properties of metal-assembled complexes. To synthesize this compound, tetra(bromomethyl)cavitand was reacted with N-(2-pyridylmethyl)-N-ethylacetate amine to give ethyl acetate pyridine resorcinarene. Hydrolysis of the ester gave acetic acid pyridine resorcinarene (APRes) in good yield. Complexes with Cu2+, Co2+, and Zn2+ …
Statistical Methods And Experimental Design For Inference Regarding Dose And/Or Interaction Thresholds Along A Fixed-Ratio Ray, Sharon Dziuba Yeatts
Statistical Methods And Experimental Design For Inference Regarding Dose And/Or Interaction Thresholds Along A Fixed-Ratio Ray, Sharon Dziuba Yeatts
Theses and Dissertations
An alternative to the full factorial design, the ray design is appropriate for investigating a mixture of c chemicals, which are present according to a fixed mixing ratio, called the mixture ray. Using single chemical and mixture ray data, we can investigate interaction among the chemicals in a particular mixture. Statistical models have been used to describe the dose-response relationship of the single agents and the mixture; additivity is tested through the significance of model parameters associated with the coincidence of the additivity and mixture models.It is often assumed that a chemical or mixture must be administered above an unknown …