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Articles 1 - 30 of 30
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Regulation Of Melanogenesis At The Sub-Cellular Level In Cloudman Murine Melanoma Cells, Kenneth Rosenzweig
Regulation Of Melanogenesis At The Sub-Cellular Level In Cloudman Murine Melanoma Cells, Kenneth Rosenzweig
Yale Medicine Thesis Digital Library
The decarboxylation of dopachrome to 5,6-dihydroxyindole (DHI) appears to be a major control point in the biosynthesis of melanin, in particular the conversation of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). The recent discovery of a factor, DHICA stablin, that stabilizes DHICA and inhibits its conversion to DHI has added insight into the regulation of this intermediary compound. This study has shown that DHICA stablin activity is present in the melanosomal fraction of Cloudman murine melanoma cells and that this activity was observed by a new method using two complementary decarboxylase assays. When three known decarboxylase stabilizing cofactors (biotin, pyridoxal phosphate, and …
T-Cell Tumor Prevention By Treatments With Psoralen/Uva-Inactivated Tumor Cells, Francis M. Lobo
T-Cell Tumor Prevention By Treatments With Psoralen/Uva-Inactivated Tumor Cells, Francis M. Lobo
Yale Medicine Thesis Digital Library
In the photopheresis therapy for cutaneous T-cell lymphoma, malignant T-cells exposed to 8-methoxypsoralen (8-MOP) activated by ultraviolet A (UVA) light appear to induce an immunologic response against the malignancy. In order to investigate this response, we used T-cell hybridoma 2B4.11 in genetically compatible (AKR X B10 .A) F1 hybrid mice as a murine model for T-cell lymphoma. We compared the ability of cells inactivated by 8-MOP/UVA, mitomycin C (MMC)3 glutaraldehyde, and X-irradiation to immunize against tumor.
[3H]-thymidine-uptake assays determined the doses of 8-MOP/UVA, MMC, glutaraldehyde, and X-irradiation necessary for inactivation of 2B4.11 cells. Mice then were subjected to an immunization …
Cross-Cultural Association Between Dietary Animal Protein And Hip Fracture: An Hypothesis, Benjamin Jac Abelow
Cross-Cultural Association Between Dietary Animal Protein And Hip Fracture: An Hypothesis, Benjamin Jac Abelow
Yale Medicine Thesis Digital Library
Age-adjusted female hip fracture incidence has been noted to be higher in industrialized countries than non-industrialized countries. A possible explanation which has received little attention is that elevated metabolic acid production associated with a high animal protein diet might lead to chronic bone buffering and bone dissolution. In an attempt to examine this hypothesis, cross-cultural variations in animal protein consumption and hip fracture incidence were studied. When female fracture rates derived from 34 published studies in 16 countries were regressed against estimates of dietary animal protein, a strong, positive association was found. This association could not plausibly be explained by …
Characterization Of Pregnancy Induced Changes In Glucose Metabolism, Stacey Ann Berg
Characterization Of Pregnancy Induced Changes In Glucose Metabolism, Stacey Ann Berg
Yale Medicine Thesis Digital Library
Many reports indicate that pregnancy is a diabetogenic state in which there is both insulin resistance and an exaggerated maternal glucose and insulin response to food ingestion. However, the magnitude of these aberrations and their temporal relationship have not been adequately characterized. This study utilizes the hyperglycemic clamp technique to investigate the insulin secretory response and tissue sensitivity to insulin under hyperglycemic conditions in normal and gestational diabetic pregnancies. Our results indicate that third trimester normal pregnancy is characterized by an increased first phase (108.81+/-13.03 uU/ml) and second phase (228.57+/-43.40 microunits/ml) insulin secretory response as compared to non-pregnant controls (72.93+/-15.76, …
Assessment Of Progress Towards The Eradication Of Dracunculiasis In The Afram Plains, Ghana, Gregory A. Engel
Assessment Of Progress Towards The Eradication Of Dracunculiasis In The Afram Plains, Ghana, Gregory A. Engel
Yale Medicine Thesis Digital Library
No abstract provided.
Differential Effects Of Platelet-Derived Growth Factor Isoforms On Large And Small Vessel Endothelial Cells And Vascular Smooth Muscle Cells, Robin Alexandra Perlmutter
Differential Effects Of Platelet-Derived Growth Factor Isoforms On Large And Small Vessel Endothelial Cells And Vascular Smooth Muscle Cells, Robin Alexandra Perlmutter
Yale Medicine Thesis Digital Library
No abstract provided.
Predictors Of Home Health Care Use In The Post-Hospitalized Elderly, Daniel H. Solomon
Predictors Of Home Health Care Use In The Post-Hospitalized Elderly, Daniel H. Solomon
Yale Medicine Thesis Digital Library
No abstract provided.
Influences Of The Lateral Geniculate Nucleus In The Specification Of Primary Visual Cortex In Macaca Mulatta, Ivan Jose Suner
Influences Of The Lateral Geniculate Nucleus In The Specification Of Primary Visual Cortex In Macaca Mulatta, Ivan Jose Suner
Yale Medicine Thesis Digital Library
No abstract provided.
Malondialdehyde Levels In Uterine Washing In Fertile And Infertile Women Throughout The Menstrual Cycle, Laura Michelle Drabkin
Malondialdehyde Levels In Uterine Washing In Fertile And Infertile Women Throughout The Menstrual Cycle, Laura Michelle Drabkin
Yale Medicine Thesis Digital Library
No abstract provided.
Storage Of Platelet Concentrates Following Ultraviolet-B Irradiation, Robert B. Johnson
Storage Of Platelet Concentrates Following Ultraviolet-B Irradiation, Robert B. Johnson
Yale Medicine Thesis Digital Library
No abstract provided.
An Inhibitor Of Angiogenesis Isolated From Bovine Cornea, Elizabeth Anne Mullen
An Inhibitor Of Angiogenesis Isolated From Bovine Cornea, Elizabeth Anne Mullen
Yale Medicine Thesis Digital Library
No abstract provided.
A Comparison Of Polymerase Chain Reaction, Elisha, And Western Blot In Detecting Evidence Of Hiv-1 Infection In The Needles Of Injecting Drug Users, Samuel Skipworth Myers
A Comparison Of Polymerase Chain Reaction, Elisha, And Western Blot In Detecting Evidence Of Hiv-1 Infection In The Needles Of Injecting Drug Users, Samuel Skipworth Myers
Yale Medicine Thesis Digital Library
No abstract provided.
The Left Ventricular Pressure-Thickening Loop : A Potential Approach To The Assessment Of Transmural Myocardial Work, Mitchell Todd Saltzberg
The Left Ventricular Pressure-Thickening Loop : A Potential Approach To The Assessment Of Transmural Myocardial Work, Mitchell Todd Saltzberg
Yale Medicine Thesis Digital Library
No abstract provided.
Extraction Of Single Channel Current From Correlated Noise Via A Hidden Markov Model, John Leclerc Walsh
Extraction Of Single Channel Current From Correlated Noise Via A Hidden Markov Model, John Leclerc Walsh
Yale Medicine Thesis Digital Library
No abstract provided.
The Postoperative Incidence Of Small Bowel Obstruction Following Various Abdominal Procedures : A Six Year Retrospective Cohort Study At Yale-New Haven Hospital, Ross Ian Zbar
Yale Medicine Thesis Digital Library
No abstract provided.
Expression Of Axonal Gaba A Receptors In Rat Dorsal Root During Development, Sean Peter Roddy
Expression Of Axonal Gaba A Receptors In Rat Dorsal Root During Development, Sean Peter Roddy
Yale Medicine Thesis Digital Library
No abstract provided.
Hormonal Symptomatic And Neuropsychologic Responses To Sugar Intake In Children With Attention Deficit Disorder, Nancy Lynn Dingott
Hormonal Symptomatic And Neuropsychologic Responses To Sugar Intake In Children With Attention Deficit Disorder, Nancy Lynn Dingott
Yale Medicine Thesis Digital Library
No abstract provided.
Effects Of Air And Saline Inflation On The Stress Relaxation Of The Lungs In Developing Piglets, Joseph A. La Rocca
Effects Of Air And Saline Inflation On The Stress Relaxation Of The Lungs In Developing Piglets, Joseph A. La Rocca
Yale Medicine Thesis Digital Library
No abstract provided.
Regulation Of Cytokine Production In The Rat Osteoblast By Transforming Growth Factor-Beta, John L. Phillips
Regulation Of Cytokine Production In The Rat Osteoblast By Transforming Growth Factor-Beta, John L. Phillips
Yale Medicine Thesis Digital Library
No abstract provided.
Sequential Dependence Of In-Vitro Freeze-Drying And Irradiation On The Biomechanical Properties Of Rat Bone, Robert Lawrence Randall
Sequential Dependence Of In-Vitro Freeze-Drying And Irradiation On The Biomechanical Properties Of Rat Bone, Robert Lawrence Randall
Yale Medicine Thesis Digital Library
No abstract provided.
Regulation Of Melanogenesis At The Sub-Celluar Level In Cloudman Murine Melanoma Cells, Kenneth E. Rosenzweig
Regulation Of Melanogenesis At The Sub-Celluar Level In Cloudman Murine Melanoma Cells, Kenneth E. Rosenzweig
Yale Medicine Thesis Digital Library
No abstract provided.
A Prospective Study Assessing Patients After Anterior Cruciate Ligament Reconstruction With Serial Magnetic Resonance Imaging, Genucom, Kincom And Subjective Evaluation, Ann Marion Smith
Yale Medicine Thesis Digital Library
No abstract provided.
In Utero Detection Of Fetal Alcohol Syndrome Using Ultrasonography, Chloe Lynne Thio
In Utero Detection Of Fetal Alcohol Syndrome Using Ultrasonography, Chloe Lynne Thio
Yale Medicine Thesis Digital Library
No abstract provided.
A Comparsion Of Clonidine, Clonidine/Naltrexone And Buprenorphine In Primary Care-Based Outpatient Opiate Detoxification, Edward Paul Weiss
A Comparsion Of Clonidine, Clonidine/Naltrexone And Buprenorphine In Primary Care-Based Outpatient Opiate Detoxification, Edward Paul Weiss
Yale Medicine Thesis Digital Library
No abstract provided.
Regulation Of Potassium Transport In Rat Mesangial Cells : A Fluorescent Analysis Using The Potassium Sensitive Dye, Pbfi, Scott Eric Kasner
Regulation Of Potassium Transport In Rat Mesangial Cells : A Fluorescent Analysis Using The Potassium Sensitive Dye, Pbfi, Scott Eric Kasner
Yale Medicine Thesis Digital Library
No abstract provided.
Molecular Mechanisms Of Lithium Action : Chronic Lithium Regulates The Expression Of Adenylate Cyclase And Gi-Protein Alpha Subunit In Rat Cerebral Cortex, Samuel F. Colin
Yale Medicine Thesis Digital Library
No abstract provided.
The Hormonal And Humoral Regulators Of Myocardial Protein Metabolism : The In Vivo Measurement Of The Physiologic Role Of Insulin And Amino Acids In Cardiac Protein Kinetics, Douglas Middleton Dahl
The Hormonal And Humoral Regulators Of Myocardial Protein Metabolism : The In Vivo Measurement Of The Physiologic Role Of Insulin And Amino Acids In Cardiac Protein Kinetics, Douglas Middleton Dahl
Yale Medicine Thesis Digital Library
No abstract provided.
Anencephalics As Organ Donors : An Analysis And Application Of The Original Intent Of The Ad Hoc Committee On Brain Death, Neely Anne Egan
Anencephalics As Organ Donors : An Analysis And Application Of The Original Intent Of The Ad Hoc Committee On Brain Death, Neely Anne Egan
Yale Medicine Thesis Digital Library
No abstract provided.
Hepatic Insulin Receptor Tyrosine Kinase Activity In Diabetes: Modulation By Assorted Adenosine Triphosphatases/Phosphatases Which Copurify In Partially Purified Preparations Of The Insulin Receptor, Darrick James Alaimo
Hepatic Insulin Receptor Tyrosine Kinase Activity In Diabetes: Modulation By Assorted Adenosine Triphosphatases/Phosphatases Which Copurify In Partially Purified Preparations Of The Insulin Receptor, Darrick James Alaimo
Yale Medicine Thesis Digital Library
No abstract provided.
Comparison Of Precorneal Tear Film Stability And Basal Tear Secretion Rates In Contact Lens Wearers Versus Non-Wearers, Jivin Gerard Tantisira
Comparison Of Precorneal Tear Film Stability And Basal Tear Secretion Rates In Contact Lens Wearers Versus Non-Wearers, Jivin Gerard Tantisira
Yale Medicine Thesis Digital Library
No abstract provided.