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Articles 1 - 13 of 13
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Health Literacy, Social Support, And Diabetes Self Care Among Individuals Of Arab Descent, Abeer Aseeri
Health Literacy, Social Support, And Diabetes Self Care Among Individuals Of Arab Descent, Abeer Aseeri
Wayne State University Dissertations
HEALTH LITERACY, SOCIAL SUPPORT, AND DIABETES SELF-CARE AMONG INDIVUDALS OF ARAB DESCENT
BY ABEER ASEERI
August 2020 Advisor: Dr. Joan Visger & Dr. Nancy Hauff
Major: Nursing
Degree: Doctor of Philosophy
Introduction/Objectives: Individuals of Arabic descent who live in the United States are at increased risk of diabetes because the Middle Eastern and North African regions have the second highest global rate of the disease which, is also projected to increase by over 95% by 2035. Diabetes self-care involves seven essential behaviors, including: (1) eating a healthy diet, (2) being physically active, (3) being compliant with medication, (4) monitoring blood …
The Exploration Of Characteristics Of Akkermansia Muciniphila, And Evaluation Of Its Probiotic Effects On Diabetes By Using C57bl/6 Mouse Model, Jiangqi Tang
Wayne State University Dissertations
THE EXPLORATION OF CHARACTERISTICS OF AKKERMANSIA MUCINIPHILA, AND EVALUATION OF ITS PROBIOTIC EFFECTS ON DIABETES BY USING C57BL/6 MOUSE MODEL
by
JIANGQI TANG
December 2018
Advisor: Dr. Kai-Lin Catherine Jen
Major: Nutrition and food science
Degree: Doctor of Philosophy
The prevalence of type 2 diabetes (T2D) is increasing continuously worldwide. The incidence of T2D is highly correlated with poor diet, physical inactivity and occurrence of obesity. Recent studies reported possible interaction between T2D and gut microbiome, which revealed different composition of gut microbiome. A specific strain Akkermansia muciniphila (A. muciniphila) was reported with significantly lower abundance even prior to the …
Remote Preconditioning: Evaluating The Efficacy Of Cardioprotection In Type-2 Diabetes And Exploring The Mechanistic Role Of Exosomes, Joseph Michael Wider
Remote Preconditioning: Evaluating The Efficacy Of Cardioprotection In Type-2 Diabetes And Exploring The Mechanistic Role Of Exosomes, Joseph Michael Wider
Wayne State University Dissertations
Remote preconditioning is a promising and robust treatment for myocardial
ischemia/reperfusion injury that evokes cardioprotection through endogenous neural
and/or humoral signaling. A recent study has reported that protective signaling is
mediated by exosomes through the circulation; however this concept is supported by
limited and inconsistent evidence. Despite overwhelming success in preclinical studies,
the efficacy of remote preconditioning in human studies is inconclusive. Importantly, the
majority of remote preconditioning studies use healthy animal models despite growing
evidence that comorbidities, such as type-2 diabetes, may negatively influence
outcomes. Nonetheless, the efficacy of remote preconditioning in the setting of type-2
diabetes has not …
Human Kinome In Skeletal Muscle Insulin Resistance, Yue Qi
Human Kinome In Skeletal Muscle Insulin Resistance, Yue Qi
Wayne State University Dissertations
Protein kinases play fundamental roles in regulation of biological processes and functions, such as insulin signaling and glucose metabolism. Dysregulation of protein kinases may cause impaired cell signaling and human diseases, such as metabolic syndrome and type 2 diabetes (T2D). Skeletal muscle is the main site responsible for insulin-stimulated glucose disposal, and insulin resistance in skeletal muscle is one of the key features of the pathogenesis of T2D. Therefore, malfunction of protein kinases and their interaction proteins may contribute to the molecular mechanism of insulin resistance in human skeletal muscle. However, no large scale profiling study has been reported to …
Diabetes Interaction Study: Communicating Understanding And Social Support, Dana K. May
Diabetes Interaction Study: Communicating Understanding And Social Support, Dana K. May
Wayne State University Dissertations
The current study evaluated a brief individualized feedback intervention developed to improve communication style of parents with an adolescent with type 1 diabetes. Seventy-nine parent-adolescent dyads (13-18 years) were randomized to receive a single session of brief feedback to target parental person-centered communication skills (n = 39) or to receive an educational comparison group (n = 40). Families were asked to discuss a diabetes related problem. A clinician concurrently rated the parent’s communication skills to identify communication strengths and weaknesses. Parents in the feedback group received feedback on their use of person-centered communication during the conversation using motivational interviewing techniques. …
Mechanisms Of Pancreatic Beta Cell Dysfunction In Diabetes, Vaibhav Sidarala
Mechanisms Of Pancreatic Beta Cell Dysfunction In Diabetes, Vaibhav Sidarala
Wayne State University Dissertations
Diabetes is a serious medical condition characterized by decreased insulin secretion from pancreatic β-cells and decreased insulin sensitivity in the peripheral tissues, resulting in elevated levels of blood glucose. According to the International Diabetes Federation, about 387 million cases have been reported worldwide in the year 2013 and it is estimated that about 500 million people would be affected by 2050. Type 2 diabetes, which accounts for about 90% of the total number of cases, is caused by decreased insulin sensitivity in the peripheral tissues and decreased glucose-stimulated insulin secretion from the pancreatic β-cells. The underlying mechanisms involved in β-cell …
Isolation And Characterization Of Natural Alpha-Glucosidase Inhibitors From Antioxidant Rich Red Wine Grapes (Vitis Vinifera), Hoda Chaouki Kadouh
Isolation And Characterization Of Natural Alpha-Glucosidase Inhibitors From Antioxidant Rich Red Wine Grapes (Vitis Vinifera), Hoda Chaouki Kadouh
Wayne State University Dissertations
Background: Diabetes is currently a global public health problem affecting people at all ages. Dietary antioxidants have been associated with a reduced risk of type 2 diabetes. Grape pomace contains considerable amounts of polyphenols and it has been reported to exhibit an inhibitory activity against alpha- glucosidases. Alpha-glucosidases, in turn, play a major role in controlling starch digestion and therefore postprandial blood glucose, a target for diabetes management.
Objective: This study aims to investigate the anti-diabetes potential of a selection of six grape pomaces and prepare and purify active components in the active variety that specifically inhibit intestinal alpha-glucosidases. The …
Linking Environmental Toxicant Exposure To Diabetes Susceptibility, Jannifer Beth Tyrrell
Linking Environmental Toxicant Exposure To Diabetes Susceptibility, Jannifer Beth Tyrrell
Wayne State University Dissertations
An important and unresolved question in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity.
Previous studies suggested that dioxin exposure increased peripheral insulin resistance but did not appear to cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by the …
Type 2 Diabetes And Insomnia: Impact On Metabolic Control, Cheryl Lee Tannas
Type 2 Diabetes And Insomnia: Impact On Metabolic Control, Cheryl Lee Tannas
Wayne State University Dissertations
Diabetes is one of the most serious health challenges in the United States, affecting nearly 21 million Americans. The goal of diabetes management is to maintain the blood glucose close to normal to prevent diabetic complications and therefore extending life expectancy and improving quality of life. Research now indicates a relationship of the quantity and quality of sleep to glycemic control in type 2 diabetics. No research on the impact of insomnia on diabetes prevention and/or management was found in the literature. The purpose of this 11 week intervention study was to examine the effects of participation in Cognitive Behavioral …
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Wayne State University Dissertations
MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN
ISCHEMIA
by
MONIQUE K. LEWIS
August 2011
Advisor: Dr. Donald DeGracia
Major: Physiology
Degree: Doctor of Philosophy
The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …
The Effect Of Changes In Drug Benefit Design Among Individuals With Diabetes In Large Employer-Sponsored Insurance Plans, Ninee Shoua Yang
The Effect Of Changes In Drug Benefit Design Among Individuals With Diabetes In Large Employer-Sponsored Insurance Plans, Ninee Shoua Yang
Wayne State University Dissertations
THE EFFECT OF CHANGES IN DRUG BENEFIT DESIGN AMONG INDIVIDUALS WITH DIABETES IN LARGE EMPLOYER-SPONSORED INSURANCE PLANS
By
NINEE SHOUA YANG
August 2011
Advisor: Dr. Allen C. Goodman
Major: Economics
Degree: Doctor of Philosophy
With spending for prescription drugs rising so rapidly, employers and insurers are seeking different cost-cutting strategies to stem this tide. Given that prescription drugs have become an indispensable means to treat and manage chronic illnesses, the issues of affordability and trade-offs between medications and other health care services are important for chronically ill patients, particularly for patients with diabetes who typically have more than one comorbidity …
Effects Of Managed Care On The Health And Health-Care Of The Non-Elderly With Diabetes, Meihua Lu
Effects Of Managed Care On The Health And Health-Care Of The Non-Elderly With Diabetes, Meihua Lu
Wayne State University Dissertations
This dissertation attempts to examine the quality effect of managed care plans (as compared with traditional fee-for-service plans, or FFS) on the health outcome and health care use of patients with diabetes. As the number of diabetics is growing rapidly with many of them are relying on managed care plans, knowing better the effects of different plans on health status and health care utilization is of great interest and significance to consumers, employers, and policymakers, especially at a time that universal health care is under being implemented.
Using up-to-date data from MEPS, a nationally representative survey, I compared 484 HMO …
A Social Ecological Perspective On Diabetes Care: Supporting Adolescents And Caregivers, April Marie Idalski Carcone
A Social Ecological Perspective On Diabetes Care: Supporting Adolescents And Caregivers, April Marie Idalski Carcone
Wayne State University Dissertations
The diabetes illness management regimen is complex and demanding, requiring daily motivation and self-control. Adolescents with diabetes face unique risks for which social support may be one protective factor. The importance of social support from family and friends is well documented in the literature. Support for the caregiver and support from the health care provider, conversely, are understudied. These four sources of social support, considered together, span the adolescent's micro-, meso-, and exosystems constituting a social ecological model of social support for diabetes. The primary aim of this study was to test this model. The hypotheses were that each source …