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Sodium Bicarbonate Supplementation And Its Effect On Fatigue In A Maximal Bout Of Exercise, Tony John Ramos Jan 2015

Sodium Bicarbonate Supplementation And Its Effect On Fatigue In A Maximal Bout Of Exercise, Tony John Ramos

MSU Graduate Theses

The purpose of this study was to determine or assess if sodium bicarbonate (NaHCO3) supplementation is a plausible method of delaying fatigue in a maximal effort bout of exercise. Fourteen, college aged, cardiovascular trained males participated in the study (Age- 21.38 +- 1.50y, Height- 180.46 +- 10.12cm, Weight- 79.15 +- 9.28kg). Sodium bicarbonate was compared with sodium chloride and a baseline. Following the initial meeting and tolerance test, participants completed 3 exercise trials which consisted of Day 1: Initial meeting & tolerance testing and Days 2, 3, and 4: Exercise Test Sessions 1-3. Data being collected was run time, RPE, …


Factors Affecting Anterior Knee Pain In Post-Aclr Comparing Patellar Tendon And Hamstring Tendon Autografts, Alexandria Annalicia Jauregui-Dusseau Jan 2015

Factors Affecting Anterior Knee Pain In Post-Aclr Comparing Patellar Tendon And Hamstring Tendon Autografts, Alexandria Annalicia Jauregui-Dusseau

MSU Graduate Theses

Anterior cruciate ligament (ACL) injuries are frequent athletic and non-athletic injuries that impact a person's functional and athletic capability. ACL injuries generally require surgical reconstruction. The most popular graft types include patellar tendon (PT) and hamstring tendon (HT) autografts. PT autografts have been blamed for chronic anterior knee pain (AKP) and extensor mechanism deficits. This study compared the PT and HT autografts and their impact on AKP in subjects who underwent anterior cruciate ligament reconstruction (ACLR). Data were gathered from existing patient data from rehabilitation therapy records. Additional factors were also analyzed to determine the effect on post-ACLR pain. Post-treatment …


Tumor Necrosis Factor Alpha Converting Enzyme Inhibition During Acute Colitis In Mice: A Regional Analysis, Brian Maddox Jan 2015

Tumor Necrosis Factor Alpha Converting Enzyme Inhibition During Acute Colitis In Mice: A Regional Analysis, Brian Maddox

MSU Graduate Theses

Tumor Necrosis Factor-a Converting Enzyme (TACE) induces active TNFa and may contribute to the development of colitis in humans. I hypothesized that pharmacological blockade of TNFa production would improve colitis scoring through decreased expression of inflammatory biomarkers. Acute colitis was induced in wild type BALB/c mice using 5% dextran sulfate sodium (DSS) in drinking water for 7 days. TACE inhibition was accomplished through twice daily intraperitoneal injection of DPC- 333 (10mg/kg; BSM Inc.) To determine the effects of TACE blockade during colitis, the following experimental groups (n=6-7/group) were tested: 1) vehicle; 2) DPC-333; 3) 5% DSS and vehicle; and 4) …