Digital Commons Network^™

Investigating The Role Of Small, Acid-Soluble Spore Proteins (Sasps) In The Resistance Of Clostridium Perfringens Spores To Heat., Deepa Raju, Michael Waters, Peter Setlow, Mahfuzur R Sarker

SoM Articles

BACKGROUND: Clostridium perfringens type A food poisoning is caused by enterotoxigenic C. perfringens type A isolates that typically possess high spore heat-resistance. The molecular basis for C. perfringens spore heat-resistance remains unknown. In the current study, we investigated the role of small, acid-soluble spore proteins (SASPs) in heat-resistance of spores produced by C. perfringens food poisoning isolates.

RESULTS: Our current study demonstrated the presence of all three SASP-encoding genes (ssp1, 2 and 3) in five surveyed C. perfringens clinical food poisoning isolates. beta-Glucuronidase assay showed that these ssp genes are expressed specifically during sporulation. Consistent with these expression results, our …

Variation At Apoe And Sth Loci And Alzheimer's Disease., Lingjun Zuo, Christopher Van Dyck, Xingguang Luo, Henry R. Kranzler, Bao-Zhu Yang, Joel Gelernter

SoM Articles

ABSTRACT: BACKGROUND: The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the APOE gene and AD. Association between AD and the newly discovered saitohin (STH) gene, nested within the intron of the tau gene, has been reported. The present study aimed to elucidate the association between APOE and AD, and between STH and AD in our sample. METHODS: The functional polymorphisms, rs429358 and rs7412, in the APOE gene (which together define the {epsilon}2, {epsilon}3, and {epsilon}4 alleles), and the Q7R SNP in the STH …

Effects Of Study Area Size On Geographic Characterizations Of Health Events: Prostate Cancer Incidence In Southern New England, Usa, 1994-1998., David I Gregorio, Holly Samociuk, Laurie Dechello, Helen Swede

SoM Articles

ABSTRACT : BACKGROUND : We consider how representations of geographic variation in prostate cancer incidence across Southern New England, USA may be affected by selection of study area and/or properties of the statistical analysis.

METHOD : A spatial scan statistic was used to monitor geographic variation among 35,167 incident prostate cancer cases diagnosed in Massachusetts, Connecticut and Rhode Island from 1994 to 1998, in relation to the 1990 populations of men 20+ years of age living in that region. Results from the combined-states analysis were compared to those from single-states. Impact of scanning procedures set to examine up to 50% …

Ayurvedic Concept Of Food And Nutrition, Amala Guha

SoM Articles

Ayurveda places special emphasis on Ahar (diet) and Anna (food) and believes that healthy nutrition nourishes the mind, body and soul. Ayurveda does not discriminate food to be good, or bad, instead it emphasizes various factors that influence food, such as its biological properties, origin, environmental factors, seasons, preparation, freshness, and provides a logical explanation of how to balance food according to one's dosha and physical needs.

Neuroimmune Interactions: A Bidirectional Flow That Leads To Health And Disease, Robert E. Cone

SoM Articles

The Vedic philosophy deals with harmony and balance between the mind and the body as well as interactions with nature. This ancient approach to health and well-being is being more and more appreciated in part as we understand the intimate relationship between the immune system, our major defense mechanism and the nervous system. Like other organ systems, the immune system is dependent on the central nervous system (CNS) and the endocrine system in its role for effective defense against foreign and domestic invaders.