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Recent Advances In Managing Brain Metastasis, Rupesh Kotecha, Minesh Mehta
Recent Advances In Managing Brain Metastasis, Rupesh Kotecha, Minesh Mehta
Minesh Mehta
Brain metastases are the most common malignancy encountered in the central nervous system (CNS), with up to 30-40% of cancer patients developing brain metastases at some point during the course of their disease. The management of brain metastasis is rapidly evolving and the roles of local therapies such as whole-brain radiation therapy, stereotactic radiosurgery, and resection along with systemic therapies are in flux. An emphasis on the neurocognitive side effects associated with treatment has gained prominence. Novel molecular studies have demonstrated important evolutionary patterns underpinning the development of brain metastasis and leptomeningeal disease, which may be key to unlocking new …
A Comparative Study Of Gene-Expression Data Of Basal Cell Carcinoma And Melanoma Reveals New Insights About The Two Cancers, Kun Xu, Xizeng Mao, Minesh Mehta, Juan Cui, Chi Zhang, Ying Xu
A Comparative Study Of Gene-Expression Data Of Basal Cell Carcinoma And Melanoma Reveals New Insights About The Two Cancers, Kun Xu, Xizeng Mao, Minesh Mehta, Juan Cui, Chi Zhang, Ying Xu
Minesh Mehta
A comparative analysis of genome-scale transcriptomic data of two types of skin cancers, melanoma and basal cell carcinoma in comparison with other cancer types, was conducted with the aim of identifying key regulatory factors that either cause or contribute to the aggressiveness of melanoma, while basal cell carcinoma generally remains a mild disease. Multiple cancer-related pathways such as cell proliferation, apoptosis, angiogenesis, cell invasion and metastasis, are considered, but our focus is on energy metabolism, cell invasion and metastasis pathways. Our findings include the following. (a) Both types of skin cancers use both glycolysis and increased oxidative phosphorylation (electron transfer …
Estimating Survival For Renal Cell Carcinoma Patients With Brain Metastases: An Update Of The Renal Graded Prognostic Assessment Tool, Minesh Mehta
Minesh Mehta
No abstract provided.
Control Versus Cognition: The Changing Paradigm Of Adjuvant Therapy For Resected Brain Metastasis, Minesh Mehta
Control Versus Cognition: The Changing Paradigm Of Adjuvant Therapy For Resected Brain Metastasis, Minesh Mehta
Minesh Mehta
No abstract provided.
The Evolving Role Of Tumor Treating Fields In Managing Glioblastoma: Guide For Oncologists, Minesh Mehta
The Evolving Role Of Tumor Treating Fields In Managing Glioblastoma: Guide For Oncologists, Minesh Mehta
Minesh Mehta
No abstract provided.
What Is The Evidence For The Clinical Value Of Sbrt In Cancer Of The Cervix?, Minesh Mehta
What Is The Evidence For The Clinical Value Of Sbrt In Cancer Of The Cervix?, Minesh Mehta
Minesh Mehta
No abstract provided.
Postoperative Management Of Resected Brain Metastases: When Can Radiotherapy Be Deferred?, Minesh Mehta, Rupesh Kotecha
Postoperative Management Of Resected Brain Metastases: When Can Radiotherapy Be Deferred?, Minesh Mehta, Rupesh Kotecha
Minesh Mehta
No abstract provided.
Low-Grade Glioma Radiotherapy Treatment And Trials, Minesh Mehta
Low-Grade Glioma Radiotherapy Treatment And Trials, Minesh Mehta
Minesh Mehta
No abstract provided.
Prognostic Models For Patients With Brain Metastases After Stereotactic Radiosurgery With Or Without Whole Brain Radiotherapy: A Validation Study, Minesh Mehta
Minesh Mehta
No abstract provided.
Mgmt Promoter Methylation Status Testing To Guide Therapy For Glioblastoma: Refining The Approach Based On Emerging Evidence And Current Challenges, Minesh Mehta
Minesh Mehta
No abstract provided.
Pencil Beam Scanning Versus Passively Scattered Proton Therapy For Unresectable Pancreatic Cancer, Michael Chuong, Man Yam, Minesh Mehta
Pencil Beam Scanning Versus Passively Scattered Proton Therapy For Unresectable Pancreatic Cancer, Michael Chuong, Man Yam, Minesh Mehta
Minesh Mehta
No abstract provided.
Omitting Radiosurgery In Melanoma Brain Metastases: A Drastic And Dangerous De-Escalation, Minesh Mehta
Omitting Radiosurgery In Melanoma Brain Metastases: A Drastic And Dangerous De-Escalation, Minesh Mehta
Minesh Mehta
No abstract provided.
Onco-Metabolism: Defining The Prognostic Significance Of Obesity And Diabetes In Women With Brain Metastases From Breast Cancer, Minesh Mehta
Minesh Mehta
No abstract provided.
Treatment Recommendations For Elderly Patients With Newly Diagnosed Glioblastoma Lack Worldwide Consensus, Minesh Mehta
Treatment Recommendations For Elderly Patients With Newly Diagnosed Glioblastoma Lack Worldwide Consensus, Minesh Mehta
Minesh Mehta
No abstract provided.
Consolidative Whole-Brain Radiation Therapy Versus Autologous Stem Cell Transplant For Primary Central Nervous System Lymphoma: A Large Dose Of Perspective And Perhaps A Lower Dose Of Radiation Are In Order, Minesh Mehta
Minesh Mehta
No abstract provided.
Cogstate Computerized Memory Tests In Patients With Brain Metastases: Secondary Endpoint Results Of Nrg Oncology Rtog 0933., Chip Caine, Snehal Deshmukh, Vinai Gondi, Minesh Mehta, Wolfgang Tomé, Benjamin W. Corn, Andrew Kanner, Howard Rowley, Vijayananda Kundapur, Albert Denittis, Jeffrey Noah Greenspoon, Andre A. Konski, Glenn S. Bauman, Adam Raben, Wenyin Shi, Merideth Wendland, Lisa Kachnic
Cogstate Computerized Memory Tests In Patients With Brain Metastases: Secondary Endpoint Results Of Nrg Oncology Rtog 0933., Chip Caine, Snehal Deshmukh, Vinai Gondi, Minesh Mehta, Wolfgang Tomé, Benjamin W. Corn, Andrew Kanner, Howard Rowley, Vijayananda Kundapur, Albert Denittis, Jeffrey Noah Greenspoon, Andre A. Konski, Glenn S. Bauman, Adam Raben, Wenyin Shi, Merideth Wendland, Lisa Kachnic
Minesh Mehta
Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre- and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning …
Short Delay In Initiation Of Radiotherapy For Patients With Glioblastoma- Effect Of Concurrent Chemotherapy: A Secondary Analysis From The Nrg Oncology/Radiation Therapy Oncology Group Database, Minesh Mehta
Minesh Mehta
No abstract provided.
Temozolomide, Sirolimus And Chloroquine Is A New Therapeutic Combination That Synergizes To Disrupt Lysosomal Function And Cholesterol Homeostasis In Gbm Cells, Minesh Mehta
Minesh Mehta
Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and endogenous cholesterol. We hypothesized that three already approved drugs, the autophagy inducer, sirolimus (rapamycin, Rapa), the autophagy inhibitor, chloroquine (CQ), and DNA alkylating chemotherapy, temozolomide (TMZ) could synergize against GBM. This repurposed triple therapy combination induced GBM apoptosis in vitro and inhibited GBM xenograft growth in vivo. Cytotoxicity is caused by induction of lysosomal membrane permeabilization and release of hydrolases, …
Preoperative Vs Postoperative Radiosurgery For Resected Brain Metastases: A Review, Minesh Mehta
Preoperative Vs Postoperative Radiosurgery For Resected Brain Metastases: A Review, Minesh Mehta
Minesh Mehta
No abstract provided.
Association Of Mgmt Promoter Methylation Status With Survival Outcomes In Patients With High-Risk Glioma Treated With Radiotherapy And Temozolomide: An Analysis From The Nrg Oncology/Rtog 0424 Trial, Minesh Mehta
Minesh Mehta
No abstract provided.
Repeat Reirradiation Of The Spinal Cord: Multi-National Expert Treatment Recommendations, Minesh Mehta
Repeat Reirradiation Of The Spinal Cord: Multi-National Expert Treatment Recommendations, Minesh Mehta
Minesh Mehta
No abstract provided.
Influence Of Residual Disease Following Surgical Resection In Newly Diagnosed Glioblastoma On Clinical, Neurocognitive, And Patient Reported Outcomes, Minesh Mehta
Minesh Mehta
No abstract provided.
Effect Of Targeted Therapies On Prognostic Factors, Patterns Of Care, And Survival In Patients With Renal Cell Carcinoma And Brain Metastases, Minesh Mehta
Minesh Mehta
No abstract provided.
Prognostic And Predictive Factors In Patients With Brain Metastases From Solid Tumors: A Review Of Published Nomograms, Minesh Mehta
Prognostic And Predictive Factors In Patients With Brain Metastases From Solid Tumors: A Review Of Published Nomograms, Minesh Mehta
Minesh Mehta
No abstract provided.
Minimal Increase In Contrast Enhancement After Chemo-Radiotherapy (Crt) For Glioblastoma Predicts Worse Survival And Progression-Free Survival, Sameer Aggarwal, Jason Molitoris, Cecelia Gzell, Minesh Mehta
Minimal Increase In Contrast Enhancement After Chemo-Radiotherapy (Crt) For Glioblastoma Predicts Worse Survival And Progression-Free Survival, Sameer Aggarwal, Jason Molitoris, Cecelia Gzell, Minesh Mehta
Minesh Mehta
No abstract provided.
Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta
Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta
Minesh Mehta
No abstract provided.
The Neurologic Assessment In Neuro-Oncology (Nano) Scale: A Tool To Assess Neurologic Function For Integration Into The Response Assessment In Neuro-Oncology (Rano) Criteria, Minesh Mehta
Minesh Mehta
No abstract provided.
Reirradiation Of Recurrent Node-Positive Non-Small Cell Lung Cancer After Previous Stereotactic Radiotherapy For Stage I Disease : A Multi-Institutional Treatment Recommendation, Minesh Mehta
Minesh Mehta
No abstract provided.
The Role Of Radiation In Treating Glioblastoma: Here To Stay, Minesh Mehta
The Role Of Radiation In Treating Glioblastoma: Here To Stay, Minesh Mehta
Minesh Mehta
No abstract provided.
Reply To M.C. Chamberlain, Minesh Mehta