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A Combined Phase I And Ii Open Label Study On The Effects Of A Seaweed Extract Nutrient Complex On Osteoarthritis, Stephen P. Myers, Joan O'Connor, J Helen Fitton, Lyndon O. Brooks, Margaret Rolfe, Paul A. Connellan, Hans Wohlmuth, Phillip A. Cheras, Carol A. Morris
A Combined Phase I And Ii Open Label Study On The Effects Of A Seaweed Extract Nutrient Complex On Osteoarthritis, Stephen P. Myers, Joan O'Connor, J Helen Fitton, Lyndon O. Brooks, Margaret Rolfe, Paul A. Connellan, Hans Wohlmuth, Phillip A. Cheras, Carol A. Morris
Dr Lyndon O Brooks
Background: Isolated fucoidans from brown marine algae have been shown to have a range of anti-inflammatory effects. Purpose: This present study tested a Maritech® extract formulation, containing a blend of extracts from three different species of brown algae, plus nutrients in an open label combined phase I and II pilot scale study to determine both acute safety and efficacy in osteoarthritis of the knee. Patients and methods: Participants (n = 12, five females [mean age, 62 ± 11.06 years] and seven males [mean age, 57.14 ± 9.20 years]) with a confirmed diagnosis of osteoarthritis of the knee were randomized to …
Synthesis And In Vitro Binding Of N,N-Dialkyl-2-Phenylindol-3-Ylglyoxylamides For The Peripheral Benzodiazepine Binding Sites, T. P. Homes, F. Mattner, Paul A. Keller, A. Katsifis
Synthesis And In Vitro Binding Of N,N-Dialkyl-2-Phenylindol-3-Ylglyoxylamides For The Peripheral Benzodiazepine Binding Sites, T. P. Homes, F. Mattner, Paul A. Keller, A. Katsifis
Paul Keller
A series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides bearing the halogens iodine and bromine were synthesised and their binding affinity for the peripheral benzodiazepine binding sites (PBBS) in rat kidney mitochondrial membranes were evaluated using [3H]-PK11195. Central benzodiazepine receptor (CBR) affinities were also evaluated in rat cortices using 3H-flumazenil to determine their selectivity for PBBS over CBR. The tested compounds had PBBS binding affinities (IC50) ranging from 7.86 nM to 618 nM, with all compounds showing high selectivity over the CBR (CBR IC50 > 5000 nM). Among the 12 compounds tested, those with a diethylamide group were the most potent. The highest affinity iodinated PBBS …
Marital Behavior, Oxytocin, Vasopressin, And Wound Healing, Jean-Phillipe Gouin, Jeffrey R. Stowell, C. Sue Carter, Hossein Pournajafi-Nazarloo, Ronald Glasser, William B. Malarkey, Timothy J. Loving, Janice K. Kiecoltglaser
Marital Behavior, Oxytocin, Vasopressin, And Wound Healing, Jean-Phillipe Gouin, Jeffrey R. Stowell, C. Sue Carter, Hossein Pournajafi-Nazarloo, Ronald Glasser, William B. Malarkey, Timothy J. Loving, Janice K. Kiecoltglaser
Jeffrey R. Stowell
Animal studies have implicated oxytocin and vasopressin in social bonding, physiological stress responses, and wound healing. In humans, endogenous oxytocin and vasopressin levels covary with perceptions of relationship quality, marital behaviors, and physiological stress responses. To investigate relationships among marital behavior, oxytocin, vasopressin, and wound healing, and to determine the characteristics of individuals with the highest neuropeptide levels, 37 couples were admitted for a 24-hour visit in a hospital research unit. After small blister wounds were created on their forearm, couples participated in a structured social support interaction task. Blister sites were monitored daily following discharge to assess wound repair …
Lifecourse Socioeconomic Trajectories And C-Reactive Protein Levels In Young Adults: Findings From A Brazilian Birth Cohort, Aydin Nazmi, I. O. Oliveira, Bernardo L. Horta, D. P. Gigante, Cesar G, Victora
Lifecourse Socioeconomic Trajectories And C-Reactive Protein Levels In Young Adults: Findings From A Brazilian Birth Cohort, Aydin Nazmi, I. O. Oliveira, Bernardo L. Horta, D. P. Gigante, Cesar G, Victora
Aydin Nazmi
Socioeconomic factors are associated with cardiovascular disease. C-reactive protein (CRP) is increasingly implicated as a candidate linking conventional risk factors and atherosclerosis. The impact of early- and later-life socioeconomic status (SES) on CRP levels has not been widely investigated and a handful of studies from high-income countries are inconsistent. We set out to examine the associations between lifecourse socioeconomic indicators (family income at birth, maternal education, family income at age 23 and own education) on CRP levels in young adults belonging to the 1982 Pelotas (Brazil) Birth Cohort Study (n = 5914). Early-life SES showed significant and graded associations with …