Digital Commons Network^™

Versatility Of Low-Power Wide-Area Network Applications, Dali Ismail

Wayne State University Dissertations

Low-Power Wide-Area Network (LPWAN) is regarded as the leading communication technology for wide-area Internet-of-Things (IoT) applications. It offers low-power, long-range, and low-cost communication. With different communication requirements for varying IoT applications, many competing LPWAN technologies operating in both licensed (e.g., NB-IoT, LTE-M, and 5G) and unlicensed (e.g., LoRa and SigFox) bands have emerged. LPWANs are designed to support applications with low-power and low data rate operations. They are not well-designed to host applications that involve high mobility, high traffic, or real-time communication (e.g., volcano monitoring and control applications).With the increasing number of mobile devices in many IoT domains (e.g., agricultural …

Assessing Midbrain Abnormalities In Parkinson’S Disease Using Magnetic Resonance Imaging, Kiarash Ghassaban

Wayne State University Dissertations

Diagnosing early-stage Parkinson’s disease (PD) and its manifestations is still a clinical challenge. Previous imaging studies using iron, neuromelanin (NM) and the Nigrosome-1 (N1) measures in the substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adopted clinically. In this dissertation, we start by studying idiopathic PD patients at their intermediate stages of the disease to evaluate the role of global and regional iron in the major deep gray matter nuclei. Then, we only focus on the NM complex in the midbrain and how neuronal loss interact with iron overload …

Thermal Atomic Layer Deposition Of Titanium Nitride Films: Synthesis And Characterization Of Novel Titanium Precursors, Anuththara Chalani Upeksha Abesinghe Arachchige

Wayne State University Dissertations

Due to the continuous miniaturization of microelectronic devices, robust deposition techniques are required which can provide continuous and conformal thin films even in high aspect ratio structures. Atomic Layer Deposition (ALD) is an excellent choice of deposition technique as it is capable of providing perfect film coverage. Because of its self-limited growth mechanism, ALD can afford sub-nanometer thickness control. Precursors used in ALD should be volatile, thermally stable at the deposition temperature, and highly reactive towards the co-regent. Traditionally, ALD has been used to grow metal oxide films. However, the microelectronics industry now demands ALD for metals and metal nitrides. …

Health And Nutrition Status Of Hemodialysis Patients During Ramadan In Saudi Arabia., Bayan Mansour Tashkandi

Wayne State University Dissertations

During Ramadan R month, Muslims abstain from eating, drinking, and medication from sunrise to sunset, and this causes some changes in their lifestyle and often eating habits (quantity and quality). These changes could lead to affect their health and nutritional status. Among Hemodialysis (HD) patients, malnutrition is common, and it is associated with mortality. Some HD patients opt to fast R which could have an impact on their nutritional and health status. Thus, the primary objective of this study was to document nutritional changes before, during, and after Ramadan on biochemical and health parameters in HD patients. A prospective cohort …

Medical Surge Capability: Performance Modeling Of Hospital Emergency Departments, Egbe-Etu Emmanuel Etu

Wayne State University Dissertations

Hospitals are faced with significant challenges during and after natural or human-caused disasters. Surge planning is a critical component of every healthcare facility’s emergency plan and response system. The process of managing and allocating scarce resources by tackling the vulnerability inherent to patients means that defining improvement priorities is one of the main challenges healthcare systems face when responding to a medical surge event (e.g., COVID-19). The consequences of these challenges include increased patient mortality, ambulance diversion, long wait times, and unavailability of beds. Previous efforts in hospital operations management have successfully applied operations research techniques in analyzing and optimizing …

Maximizing User Engagement In Short Marketing Campaigns Within An Online Living Lab: A Reinforcement Learning Perspective, Aniekan Michael Ini-Abasi

Wayne State University Dissertations

ABSTRACT

MAXIMIZING USER ENGAGEMENT IN SHORT MARKETING CAMPAIGNS WITHIN AN ONLINE LIVING LAB: A REINFORCEMENT LEARNING PERSPECTIVE

by

ANIEKAN MICHAEL INI-ABASI

August 2021

Advisor: Dr. Ratna Babu Chinnam Major: Industrial & Systems Engineering Degree: Doctor of Philosophy

User engagement has emerged as the engine driving online business growth. Many firms have pay incentives tied to engagement and growth metrics. These corporations are turning to recommender systems as the tool of choice in the business of maximizing engagement. LinkedIn reported a 40% higher email response with the introduction of a new recommender system. At Amazon 35% of sales originate from recommendations, …

Integrated Optimization And Learning Methods Of Predictive And Prescriptive Analytics, Mehmet Kolcu

Wayne State University Dissertations

A typical decision problem optimizes one or more objectives subject to a set of constraints on its decision variables. Most real-world decision problems contain uncertain parameters. The exponential growth of data availability, ease of accessibility in computational power, and more efficient optimization techniques have paved the way for machine learning tools to effectively predict these uncertain parameters. Traditional machine learning models measure the quality of predictions based on the closeness between true and predicted values and ignore decision problems involving uncertain parameters for which predicted values are treated as the true values.Standard approaches passing point estimates of machine learning models …

Organizational And Financial Considerations Of Inter-District School Of Choice On One Small District In The Detroit Metropolitan Area, Lori Lucas

Wayne State University Dissertations

The research study investigated the organizational and financial structure of a school district that participated in inter-district school of choice. The goal was to see if choice, resident and non-resident, had any influence on these structures. The literature that I reviewed highlighted the various organizational and funding mechanisms that school districts need to account for when considering options such as school of choice. This research study was conducted on a smaller scale compared to studies that have been completed on a grander scale. The goal of this study was to review the organizational and financial changes that districts make to …

High Mobility N-Type Field Effect Transistors Enabled By Wse2/Pdse2 Heterojunctions, Arthur Bowman Iii

Wayne State University Dissertations

Two-dimensional (2D) semiconductors such as transition metal dichalcogenides (TMDs) have emerged as a promising candidate for post-silicon electronics. Few-layer tungsten diselenide (WSe2), a well-studied TMD, has sown high hole mobility and ON/OFF ratio in field effect transistor (FET) devices. But the n-type performance of WSe2 is still quite limited by the presence of a substantial Schottky Barrier. Palladium diselenide, (PdSe2) is a newly discovered TMD that is of interest because of its high electron mobility, and moderate ON/OFF ratios. However, despite its relatively small bandgap, the n-type performance of few-layer PdSe2 FETs has also been limited by a Schottky barrier, …

Substrate Profiling Of The Epigenetic Erasers Hdac1 And Lsd1, Herath Mudiyansela Gedara Kavinda Eranga Herath

Wayne State University Dissertations

Regulators of chromatin structure have emerged as a key driver of transcriptional responses inside the cell. Two such groups of regulators, histone writers and erasers; the proteins, that add or remove histone post translational modifications (PTMs), have become the central players in chromatin structure. Thus, the aberrant expression of writers and erasures is a hallmark in human diseases. For example, overexpression of the erasures histone deacetylase1 (HDAC1) and lysine specific demethylase1 (LSD1) had been reported in many cancers. Currently, HDAC inhibitors have been used successfully for cancer treatment and several inhibitors targeting LSD1 are in clinical trial. To date, apart …

An Investigation Of Uncertainties In Intensity Modulated Radiation Therapy, Cory Knill

Wayne State University Dissertations

Introduction: The treatment of cancer using intensity modulated radiation therapy (IMRT) is complex, involving many sub-processes to commission a treatment platform and treat patients. Uncertainties within the individual sub-process can lead to inaccurate treatments and sub-optimal patient outcomes. This research focused on minimizing uncertainties throughout IMRT commissioning and treatments. Methods: Five sub-processes were selected for uncertainty reduction: 1) optimizing radiation-imaging coincidence of the treatment machine, 2) improving the statistical model used to analyze IMRT commissioning data, 3) reducing the effect of ion recombination in IMRT quality assurance measurements, 4) improving the correlation between IMRT quality assurance results and patient-specific delivery …

Measurement Of The Cross Section Of Top Quark Pairs Produced In Association With A Photon In Lepton + Jets Events At √S = 13 Tev With Full Runii Cms Data, Nabin Poudyal

Wayne State University Dissertations

The inclusive production cross section of top quark pairs in association with a photon is measured in proton-proton collisions at the LHC with 13 TeV energy using the full RunII data collected by CMS in 2016, 2017, and 2018 with a total corresponding integrated luminosity of 137 fb −1 . The relative fraction of ttγ events normalized to inclusive tt production is measured. The cross section measurement provides important information about the electromagnetic coupling of the standard model top quark and is sensitive to physics beyond the standard model. The analysis is carried out in the in semileptonic decay channel …

Exploring And Expanding The Utility Of Cultural Distance: A Multi-National Analysis, Daniel Wiegert

Wayne State University Dissertations

In the current study, I utilized multiple cultural constructs to create and compare the utility of various forms of cultural distance as a predictor of national-culture-level outcomes, aggregated across multiple countries (i.e., a novel term: “Aggregated Cultural Distance”, hereafter ACD). ACD was first conceptualized in the current study by utilizing the nine Global Leader and Organizational Behavior Effectiveness (hereafter Project GLOBE) Societal Values dimensions in the calculation of ACD. I incrementally added and compared Project GLOBE’s Societal Practices and Tightness-Looseness scores (i.e., norms) to the Values ACD construct in predicting self-isolationist leadership behaviors (i.e., Project GLOBE’s Autonomous and Self-Protective leadership …

The Advanced Applications For Optical Coherence Tomography In Skin Imaging, Qiuyun Xu

Wayne State University Dissertations

Optical coherence tomography (OCT), based on the principle of interferometry, is a fast and non-invasive imaging modality, which has been approved by FDA for dermatologic applications. OCT has high spatial resolution up to micrometer scale compared to traditional ultrasound imaging. In addition, OCT can provide real-time cross-sectional images with 1 to 2 mm penetration depth, which makes it an ideal imaging technique to assess the skin micro-morphology and pathology without any tissue removal. Many studies have investigated the possibilities of using OCT to evaluate dermatologic conditions, such as skin cancer, dermatitis, psoriasis, and skin damages. Hence, OCT has tremendous potential …

A Review Of Sample Size And Design Efficacy In Crossover Design In Peer-Reviewed Psychology Research, Kyle Moxley

Wayne State University Dissertations

A REVIEW OF SAMPLE SIZE AND DESIGN EFFICACY IN CROSSOVER DESIGN IN PEER-REVIEWED PSYCHOLOGY RESEARCHby KYLE C. MOXLEY November 2021 Advisor: Dr. Shlomo S. Sawilowsky Major: Education Evaluation and Research Degree: Doctor of Philosophy The present study seeks to investigate the efficacy of crossover research designs, and the application of crossover designs, in the field of behavioral sciences. Under ideal conditions, crossover designs are assumed to be more efficacious than parallel studies in that participants are given both treatments. However, the presence of carryover effects from treatments may influence outcomes (Jones & Kenward, 2014). To prevent carryover effects, researchers frequently …

Framework For Effective Resilience Managmenet Of Complex Supply Networks, Elham Taghizadeh

Wayne State University Dissertations

In today's environment with high global and complex supply chains for engineered products, the ability to assess and manage the resilience of supply chains is not a luxury but a fundamental prerequisite for business continuity and success. This is particularly true for firms with deep-tier supply chains, such as the automotive original equipment manufacturers (OEMs) and their suppliers. Automotive supply networks are particularly facing growing challenges due to their complexity, globalization, economic volatility, rapidly changing technologies, regulations, and environmental/political shocks. These risks and challenges can disrupt and halt operations in any section of the supply network. Given that supply chains …

Taxation, Liberty, And Property Rights: A Libertarian Defense Of Universal Health Coverage, Graeme Bradley Cave

Wayne State University Dissertations

Today, the United States is widely recognized as the only developed country without universal health coverage. Unfortunately for the United States, that is problematic. Despite lacking universal health coverage, the United States spends more on health care than any other country. In return, it has a large uninsured population, a large underinsured population, and overall comparatively poor health outcomes. Unsurprisingly, then, everyone in the philosophical literature on health care justice—for one reason or another—says the United States should join every other developed country and get universal health coverage. Everyone, that is, except for libertarians.In my dissertation, I argue that libertarians …

Pre-Pregnancy Drinking Among A Sample Of High-Risk Women And The Association Of Social Networks, Sandra Lee King

Wayne State University Dissertations

ABSTRACTPRE-PREGNANCY DRINKING AMONG A SAMPLE OF HIGH-RISK WOMEN AND THE ASSOCIATION OF SOCIAL NETWORKS

Background: Characteristics of drinking alcohol can include drinking contemporaneously; at the same time as others, and concordantly; when individuals exhibit identical traits or characteristics. The purpose of this quantitative study was to examine the association of pre-pregnancy drinking among a unique sample of high-risk women and to investigate the association of their social network members as predictors of alcohol consumption during the 3-month preconceptional period. Analysis was conducted on the patterns of alcohol consumption among study participants who were recruited from the Healthy Families Indiana (HFI) …

Therapeutic Dual-Targeting Of Cytosolic And Mitochondrial One-Carbon Metabolism, Aamod Sanjeev Dekhne

Wayne State University Dissertations

One-carbon metabolism (1CM) is compartmentalized in the mitochondria and cytosol and generates a host of metabolites critical to tumor propagation. Although drug-targeting of cytosolic 1CM remains a clinically-relevant mainstay, development of clinically-useful agents targeting mitochondrial 1CM remains elusive. Of particular pharmacological interest is the mitochondrial 1CM enzyme, serine hydroxymethyltransferase2 (SHMT2). SHMT2 expression correlates with the oncogenic phenotype in lung, colon, breast, glioma, and liver cancer and, overall, is the fifth-most differentially expressed metabolic enzyme in cancer cell versus normal tissue. Despite the unequivocal oncogenic importance and therapeutic potential of SHMT2, there are no clinically relevant (i.e. active in vivo) inhibitors …

Understanding The Resilient Practices Of Journalists In The Face Of Hostile Sources: An Intersectional Approach, Kelsey Renee Mesmer

Wayne State University Dissertations

After former President Trump began calling the news media “the enemy of the American people,” many scholars and journalism practitioners worried about such anti-media’s trickle-down effect and how it would complicate work for local reporters. Given a growing need to pay attention to hostility toward journalists, this project sought to better understand the ways journalists experience the trickle-down effects of anti-media rhetoric in the form of hostile interactions with sources who vilify journalists; how women and journalists of color experience these effects to different, possibly heightened degrees; and how journalists are resilient in spite of these challenges. Drawing on 38 …

Protein Phosphatase 2a In Metformin’S Action In Primary Human Skeletal Muscle Cells, Aktham H. Mestareehi

Wayne State University Dissertations

Diabetes is a group of metabolic diseases characterized by hyperglycemia caused by defects in insulin secretion, insulin action, or both. Diabetes is associated with damage, dysfunction, and failure of various organs, such as the eyes, heart, kid-neys, and brain. Diabetes is mainly classified into type 1 (T1DM) and type 2 diabetes (T2D). Diabetes affects more than 34 million people in the USA (about 1 in 10) and more than 90% of diabetic patients have type 2 diabetes (T2D). Insulin resistance is a main characteristic feature of type 2 diabetes. Skeletal muscle insulin resistance is con-sidered to be the primary defect …

How Do We Learn To Hope? The Development Of The Parent Report Of Child Hope, Lauren A. Sparks

Wayne State University Dissertations

Hope has been shown to be an important protective factor, with hypothesized origins in early childhood (Snyder, 2002). However, despite the established importance of hope, little research to date has examined its developmental origins. Specifically, a lack of appropriate instrumentation represents a significant barrier to detecting hope in children under the age of eight years old. The current study meets this need by examining the reliability and validity of a novel parent-report measure of hope in early childhood, titled the Parent Report of Child Hope (PRCH). The PRCH represents an initial step towards understanding individual differences in early childhood hope. …

Characterization Of Clostridium Cochlearium As A Potential Probiotic For Obesity Management, Paba Edirisuriya

Wayne State University Dissertations

ABSTRACTCHARACTERIZATION OF CLOSTRIDIUM COCHLEARIUM AS A POTENTIAL PROBIOTIC FOR OBESITY MANAGEMENT

ByPABA EDIRISURIYA MAY 2021 Advisor: Dr. Kequan Zhou Major: Nutrition and food science Degree: Doctor of Philosophy Emerging evidence indicates that manipulation of gut microflora is a potential therapeutic approach for managing obesity. Probiotic effects on host weight reduction have repeatedly been revealed through previous studies. Clostridium cochlearium is a butyrate-producing, spore-forming bacteria that have been reported to present in the mammalian gut. Our simulated Invitro digestion model revealed that C. cochlearium could survive in the unfavorable conditions of the human gastrointestinal tract, including low pH (pH2), high bile …

Cardio-Renal Mechanisms Of Fructose-Induced Salt-Sensitive Hypertension, Peter Eric Levanovich

Wayne State University Dissertations

Dietary consumption of fructose facilitates increased intestinal fluid absorption and renal sodium reabsorption, thereby increasing fluid retention. The net result of this is a sustained increased in extracellular fluid volume that leads to states of hypervolemia and subsequent hypertension. Simultaneously, arterial pressure is being elevated by increased autonomic drive stemming from the sympathetic nervous system and various other endovascular proteins that induce vasoconstriction. Under these conditions, the addition of high dietary sodium promotes hypertension prior to the development of significant metabolic disturbances; the subtlety of which may go unnoticed by patients for prolonged periods. While much is understood regarding the …

Solving And Applications Of Multi-Facility Location Problems, Anuj Bajaj

Wayne State University Dissertations

This thesis is devoted towards the study and solving of a new class of multi-facility location problems. This class is of a great theoretical interest both in variational analysis and optimization while being of high importance to a variety of practical applications. Optimization problems of this type cannot be reduced to convex programming like, the much more investigated facility location problems with only one center. In contrast, such classes of multi-facility location problems can be described by using DC (difference of convex) programming, which are significantly more involved from both theoretical and numerical viewpoints.In this thesis, we present a new …

Clinical Significance, Functional Role And Molecular Mechanism Of 2’-O-Methyltransferase Ftsj3 In Promoting Cancer Progression, Morenci Manning-Powell

Wayne State University Dissertations

2’-O-methylation (2’-O-Me), one of the most common modifications within RNA, has multiple roles in modulating RNA structure, stability, and interactions, as well as gene transcription and translation. We previously performed integrative genomic and transcriptomic analysis of 58 RNA methyltransferases, and identified FTSJ3 (FtsJ RNA 2ʹ-O-methyltransferase 3) as significantly amplified/overexpressed in breast cancer. Knockdown of FTSJ3 inhibits breast cancer cell growth in vitro. However, the clinical significance, functional role, and molecular mechanism of FTSJ3 in human cancer remains to be elucidated. In the present study, we first analyzed the differential mRNA and protein expression of FTSJ3 between tumor and normal tissues …

Intelligent Healthcare Process Discovery And Operational Coordination Using Discrete Event Simulation And Machine Learning, Suleyman Yildirim

Wayne State University Dissertations

The healthcare system in the US is rapidly changing and reshaping to adopt continuously evolving demand for improved operational efficiency and treatment effectiveness from patients and providers in critical health services. Healthcare service systems and clinical treatment operations need to be more predictable to increase operational efficiency through proactive operations management. This research contributes to the literature by discovering clinical processes and calibrating discrete-event simulation models in healthcare service systems using data-driven and process-driven predictive models. Unlike the data-driven predictive approaches such as machine learning and statistical methods, the proposed methodologies in this thesis leverages and focuses on process-based methods …

Mnrr1: Understanding The Role Of A Novel Mitochondrial-Nuclear Regulator, Stephanie L. Gladyck

Wayne State University Dissertations

Mitochondria are complex organelles that generate most of the energy required to sustain life and function in metabolic and signaling pathways required to maintain cellular homeostasis. MNRR1 (mitochondrial nuclear retrograde regulator 1 or CHCHD2) is a small, bi-organellar twin CX9C protein that is emerging as an important regulator of mitochondrial function, apoptosis, and cellular stress by participating in mitochondrial-nuclear crosstalk. Our lab has previously shown that in the mitochondria, MNRR1 regulates complex IV (Cytochrome c oxidase or COX) and is able to finetune the oxidase function through phosphorylation status. We have also shown that during stress, mitochondrial MNRR1 levels deplete, …

Modulation Of Pharyngeal Health In Bacterial Diet-Dependent Survival, Deniz Sifoglu

Wayne State University Dissertations

ABSTRACT

MODULATION OF PHARYNGEAL HEALTH IN BACTERIAL DIET-DEPENDENT SURVIVAL

by

DENIZ SIFOGLU

August 2021

Advisor: Dr. Joy Alcedo Major: Biological Sciences Degree: Doctor of Philosophy Both diet and bacterial microbiome modulate insulin signaling, which regulates key physiological processes that are important for survival. However, the mechanisms through which diet and the microbiome modulate insulin signaling remain unclear. To understand these mechanisms, I turned to the nematode worm C. elegans, whose diet consists of different types of bacteria. Like humans and other animals, C. elegans has to modulate its responses to its diet and to bacteria to optimize its survival. Because …

The Hatcher-Quinn Invariant And Differential Forms, Joshua Lenwood Turner

Wayne State University Dissertations

An intersection problem consists of submanifolds $P, Q \subset M$ having non-empty intersection. In 1974, Hatcher and Quinn introduced a bordism-theoretic obstruction to finding a deformation of $P$ off of $Q$ by an isotopy. This dissertation studies the problem of finding an analytical expression for the Hatcher-Quinn obstruction---one which involves the language of differential forms. We first introduce the notion of a smooth structure on a set by introducing a system of mappings called plots. By generalizing this to the fibered setting, we use the concept to give a model for the homology of the generalized path space $E$ i.e., …