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Articles 1201 - 1216 of 1216
Full-Text Articles in Entire DC Network
Impact Of Trem2r47h Variant On Tau Pathology-Induced Gliosis And Neurodegeneration, Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzman
Impact Of Trem2r47h Variant On Tau Pathology-Induced Gliosis And Neurodegeneration, Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzman
Open Access Publications
Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and Aβ, evidence suggests that microglia play an important role in AD pathogenesis. Rare variants in the microglia-expressed triggering receptor expressed on myeloid cells 2 (TREM2) gene increase AD risk 2- to 4-fold. It is likely that these TREM2 variants increase AD risk by decreasing the response of microglia to Aβ and its local toxicity. However, neocortical Aβ pathology occurs many years before neocortical tau pathology in AD. Thus, it will be important to understand the role of TREM2 in …
Development Of A New Macrophage-Specifc Trap Mouse (Mactrap) And Definition Of The Renal Macrophage Translational Signature, Andreas Hofmeister, Maximilian C. Thomaßen, Sabrina Markert, André Marquardt, Mathieu Preußner, Martin Rußwurm, Ralph T. Schermuly, Ulrich Steinhoff, Hermann-Josef Gröne, Joachim Hoyer, Benjamin D. Humphreys, Ivica Grgic
Development Of A New Macrophage-Specifc Trap Mouse (Mactrap) And Definition Of The Renal Macrophage Translational Signature, Andreas Hofmeister, Maximilian C. Thomaßen, Sabrina Markert, André Marquardt, Mathieu Preußner, Martin Rußwurm, Ralph T. Schermuly, Ulrich Steinhoff, Hermann-Josef Gröne, Joachim Hoyer, Benjamin D. Humphreys, Ivica Grgic
Open Access Publications
No abstract provided.
Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury And Preserves Left Ventricular Systolic Function In Rats, As Evaluated By 7t Cardiovascular Magnetic Resonance Imaging, Ziqian Xu, Wei Chen, Ruzhi Zhang, Lei Wang, Ridong Chen, Jie Zheng, Fabao Gao
Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury And Preserves Left Ventricular Systolic Function In Rats, As Evaluated By 7t Cardiovascular Magnetic Resonance Imaging, Ziqian Xu, Wei Chen, Ruzhi Zhang, Lei Wang, Ridong Chen, Jie Zheng, Fabao Gao
Open Access Publications
No abstract provided.
American Society Of Hematology 2020 Guidelines For Sickle Cell Disease: Prevention, Diagnosis, And Treatment Of Cerebrovascular Disease In Children And Adults, M.R. Debaun, L.C. Jordan, A.A. King, J. Schatz, E. Vichinsky, C.K. Fox, R.C. Mckinstry, P. Telfer, M.A. Kraut, L. Daraz, F.J. Kirkham, M.H. Murad
American Society Of Hematology 2020 Guidelines For Sickle Cell Disease: Prevention, Diagnosis, And Treatment Of Cerebrovascular Disease In Children And Adults, M.R. Debaun, L.C. Jordan, A.A. King, J. Schatz, E. Vichinsky, C.K. Fox, R.C. Mckinstry, P. Telfer, M.A. Kraut, L. Daraz, F.J. Kirkham, M.H. Murad
Open Access Publications
No abstract provided.
Structural Basis For Effector Protein Recognition By The Dot/Icm Type Ivb Coupling Protein Complex, Hyunmin Kim, Tomoko Kubori, Kohei Yamazaki, Mi-Jeong Kwak, Suk-Youl Park, Hiroki Nagai, Joseph P. Vogel, Byung-Ha Oh
Structural Basis For Effector Protein Recognition By The Dot/Icm Type Ivb Coupling Protein Complex, Hyunmin Kim, Tomoko Kubori, Kohei Yamazaki, Mi-Jeong Kwak, Suk-Youl Park, Hiroki Nagai, Joseph P. Vogel, Byung-Ha Oh
Open Access Publications
No abstract provided.
On Complement, Memory, And Microglia, Robyn S. Klein
On Complement, Memory, And Microglia, Robyn S. Klein
Open Access Publications
No abstract provided.
Cathepsin S And Protease-Activated Receptor-2 Drive Alloimmunity And Immune Regulation In Kidney Allograft Rejection, Yutian Lei, Benjamin Ehle, Santhosh V Kumar, Susanne Müller, Solange Moll, Andrew F Malone, Benjamin D Humphreys, Joachim Andrassy, Hans-Joachim Anders
Cathepsin S And Protease-Activated Receptor-2 Drive Alloimmunity And Immune Regulation In Kidney Allograft Rejection, Yutian Lei, Benjamin Ehle, Santhosh V Kumar, Susanne Müller, Solange Moll, Andrew F Malone, Benjamin D Humphreys, Joachim Andrassy, Hans-Joachim Anders
Open Access Publications
Alloantigen presentation is an essential process in acute allorejection. In this context, we speculated on a pathogenic role of cathepsin S (Cat-S), a cysteine protease known to promote antigenic peptide loading into MHC class II and to activate protease-activated receptor (PAR)-2 on intrarenal microvascular endothelial and tubular epithelial cells. Single-cell RNA sequencing and immunostaining of human kidney allografts confirmed Cat-S expression in intrarenal mononuclear phagocytes.
Prostate Cancer Theranostics - An Overview, Diane Abou, Nadia Benabdallah, Wen Jiang, Lu Peng, Hanwen Zhang, Alexandria Villmer, Mark S Longtine, Daniel L J Thorek
Prostate Cancer Theranostics - An Overview, Diane Abou, Nadia Benabdallah, Wen Jiang, Lu Peng, Hanwen Zhang, Alexandria Villmer, Mark S Longtine, Daniel L J Thorek
Open Access Publications
Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. This review article summarized clinically translated approaches to detect, characterize, and treat disease in this rapidly expanding field.
Effects Of Early Life Exposure To Traffic-Related Air Pollution On Brain Development In Juvenile Sprague-Dawley Rats, Kelley T. Patten, Eduardo A. González, Anthony Valenzuela, Elizabeth Berg, Christopher Wallis, Joel R. Garbow, Jill L. Silverman, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein
Effects Of Early Life Exposure To Traffic-Related Air Pollution On Brain Development In Juvenile Sprague-Dawley Rats, Kelley T. Patten, Eduardo A. González, Anthony Valenzuela, Elizabeth Berg, Christopher Wallis, Joel R. Garbow, Jill L. Silverman, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein
Open Access Publications
No abstract provided.
Residual Endotoxin Induces Primary Graft Dysfunction Through Ischemia/Reperfusion-Primed Alveolar Macrophages, Mahzad Akbarpour, Daniel Kreisel, Wenjun Li, Et Al
Residual Endotoxin Induces Primary Graft Dysfunction Through Ischemia/Reperfusion-Primed Alveolar Macrophages, Mahzad Akbarpour, Daniel Kreisel, Wenjun Li, Et Al
Open Access Publications
Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics and is associated with neutrophil infiltration and PGD. In mouse models, depletion of tissue-resident alveolar macrophages (TRAMs) attenuated neutrophil recruitment in response to endotoxin as shown by compartmental staining and intravital imaging. Bone marrow chimeric mice revealed that neutrophils were recruited by TRAM through activation of TLR4 in a MyD88-dependent manner. Intriguingly, low levels of endotoxin, insufficient to cause donor …
Induced Remission Of Metastatic Squamous Cell Carcinoma With An Immune Checkpoint Inhibitor In A Patient With Recessive Dystrophic Epidermolysis Bullosa, Karam Khaddour, Emily S. Gorell, Farrokh Dehdashti, Jean Y. Tang, George Ansstas
Induced Remission Of Metastatic Squamous Cell Carcinoma With An Immune Checkpoint Inhibitor In A Patient With Recessive Dystrophic Epidermolysis Bullosa, Karam Khaddour, Emily S. Gorell, Farrokh Dehdashti, Jean Y. Tang, George Ansstas
Open Access Publications
No abstract provided.
Top Ten Tips Palliative Care Clinicians Should Know About Amyotrophic Lateral Sclerosis, Elyse A. Everett, Elizabeth Pedowitz, Samuel Maiser, Joss Cohen, Jessica Besbris, Ambereen K. Mehta, Luqi Chi, Christopher A. Jones
Top Ten Tips Palliative Care Clinicians Should Know About Amyotrophic Lateral Sclerosis, Elyse A. Everett, Elizabeth Pedowitz, Samuel Maiser, Joss Cohen, Jessica Besbris, Ambereen K. Mehta, Luqi Chi, Christopher A. Jones
Open Access Publications
No abstract provided.
Effects Of Diet Versus Gastric Bypass On Metabolic Function In Diabetes, Mihoko Yoshino, Brandon D. Kayser, Jun Yoshino, Richard I. Stein, Dominic Reeds, J. Christopher Eagon, Shaina R. Eckhouse, Jeramie D. Watrous, Mohit Jain, Rob Knight, Kenneth Schechtman, Bruce W. Patterson, Samuel Klein
Effects Of Diet Versus Gastric Bypass On Metabolic Function In Diabetes, Mihoko Yoshino, Brandon D. Kayser, Jun Yoshino, Richard I. Stein, Dominic Reeds, J. Christopher Eagon, Shaina R. Eckhouse, Jeramie D. Watrous, Mohit Jain, Rob Knight, Kenneth Schechtman, Bruce W. Patterson, Samuel Klein
Open Access Publications
No abstract provided.
Effects Of Remote Limb Ischemic Conditioning On Muscle Strength In Healthy Young Adults: A Randomized Controlled Trial, Swati M. Surkar, Marghuretta D. Bland, Anna E. Mattlage, Ling Chen, Jeffrey M. Gidday, Jin-Moo Lee, Tamara Hershey, Catherine E. Lang
Effects Of Remote Limb Ischemic Conditioning On Muscle Strength In Healthy Young Adults: A Randomized Controlled Trial, Swati M. Surkar, Marghuretta D. Bland, Anna E. Mattlage, Ling Chen, Jeffrey M. Gidday, Jin-Moo Lee, Tamara Hershey, Catherine E. Lang
Open Access Publications
Remote limb ischemic conditioning (RLIC) is a clinically feasible method in which brief, sub-lethal bouts of ischemia protects remote organs or tissues from subsequent ischemic injury. A single session of RLIC can improve exercise performance and increase muscle activation. The purpose of this study, therefore, was to assess the effects of a brief, two-week protocol of repeated RLIC combined with strength training on strength gain and neural adaptation in healthy young adults. Participants age 18-40 years were randomized to receive either RLIC plus strength training (n = 15) or sham conditioning plus strength training (n = 15). Participants received RLIC …
Experiences From The Missouri Antimicrobial Stewardship Collaborative: A Mixed Methods Study, Sena J Sayood, Chinmayi Venkatram, Jason G Newland, Hilary M Babcock, David K Warren, George Turabelidze, Virginia R Mckay, Erin C Rachmiel, Kate Peacock, Tracey Habrock-Bach, Kevin Hsueh, Michael J Durkin
Experiences From The Missouri Antimicrobial Stewardship Collaborative: A Mixed Methods Study, Sena J Sayood, Chinmayi Venkatram, Jason G Newland, Hilary M Babcock, David K Warren, George Turabelidze, Virginia R Mckay, Erin C Rachmiel, Kate Peacock, Tracey Habrock-Bach, Kevin Hsueh, Michael J Durkin
Open Access Publications
We performed a mixed-methods study to evaluate antimicrobial stewardship program (ASP) uptake and to assess variability of program implementation in Missouri hospitals. Despite increasing uptake of ASPs in Missouri, there is wide variability in both the scope and sophistication of these programs.
Macrophages Respond Rapidly To Ototoxic Injury Of Lateral Line Hair Cells But Are Not Required For Hair Cell Regeneration, Mark E Warchol, Angela Schrader, Lavinia Sheets
Macrophages Respond Rapidly To Ototoxic Injury Of Lateral Line Hair Cells But Are Not Required For Hair Cell Regeneration, Mark E Warchol, Angela Schrader, Lavinia Sheets
Open Access Publications
The sensory organs of the inner ear contain resident populations of macrophages, which are recruited to sites of cellular injury. Such macrophages are known to phagocytose the debris of dying cells but the full role of macrophages in otic pathology is not understood. Lateral line neuromasts of zebrafish contain hair cells that are nearly identical to those in the inner ear, and the optical clarity of larval zebrafish permits direct imaging of cellular interactions. In this study, we used larval zebrafish to characterize the response of macrophages to ototoxic injury of lateral line hair cells. Macrophages migrated into neuromasts within …