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Tumor Necrosis Factor Receptor-Associated Factor (Traf)2 Represses The T Helper Cell Type 2 Response Through Interaction With Nfat-Interacting Protein (Nip45), Rebecca Lieberson, Kerri A. Mowen, Kathryn D. Mcbride, Veronica Leautaud, Xiankui Zhang, Woong-Kyung Suh, Lin Wu, Laurie H. Glimcher
Tumor Necrosis Factor Receptor-Associated Factor (Traf)2 Represses The T Helper Cell Type 2 Response Through Interaction With Nfat-Interacting Protein (Nip45), Rebecca Lieberson, Kerri A. Mowen, Kathryn D. Mcbride, Veronica Leautaud, Xiankui Zhang, Woong-Kyung Suh, Lin Wu, Laurie H. Glimcher
MUSC Faculty Journal Articles
Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription. The provision of NIP45 together with NFAT and the T helper cell type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, such as B cells or Th1 clones, results in substantial IL-4 secretion to levels that approximate those produced by primary Th2 cells. In studies designed to further our understanding of NIP45 activity, we have uncovered a novel facet of IL-4 gene regulation. We present evidence that members of the tumor necrosis factor …