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Automatic Annotation Of Protein Motif Function With Gene Ontology Terms, Xinghua Lu, Chengxiang Zhai, Vanathi Gopalakrishnan, Bruce G. Buchanan
Automatic Annotation Of Protein Motif Function With Gene Ontology Terms, Xinghua Lu, Chengxiang Zhai, Vanathi Gopalakrishnan, Bruce G. Buchanan
MUSC Faculty Journal Articles
Background: Conserved protein sequence motifs are short stretches of amino acid sequence patterns that potentially encode the function of proteins. Several sequence pattern searching algorithms and programs exist for identifying candidate protein motifs at the whole genome level. However, a much needed and important task is to determine the functions of the newly identified protein motifs. The Gene Ontology (GO) project is an endeavor to annotate the function of genes or protein sequences with terms from a dynamic, controlled vocabulary and these annotations serve well as a knowledge base. Results: This paper presents methods to mine the GO knowledge base …
Tumor Necrosis Factor Receptor-Associated Factor (Traf)2 Represses The T Helper Cell Type 2 Response Through Interaction With Nfat-Interacting Protein (Nip45), Rebecca Lieberson, Kerri A. Mowen, Kathryn D. Mcbride, Veronica Leautaud, Xiankui Zhang, Woong-Kyung Suh, Lin Wu, Laurie H. Glimcher
Tumor Necrosis Factor Receptor-Associated Factor (Traf)2 Represses The T Helper Cell Type 2 Response Through Interaction With Nfat-Interacting Protein (Nip45), Rebecca Lieberson, Kerri A. Mowen, Kathryn D. Mcbride, Veronica Leautaud, Xiankui Zhang, Woong-Kyung Suh, Lin Wu, Laurie H. Glimcher
MUSC Faculty Journal Articles
Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription. The provision of NIP45 together with NFAT and the T helper cell type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, such as B cells or Th1 clones, results in substantial IL-4 secretion to levels that approximate those produced by primary Th2 cells. In studies designed to further our understanding of NIP45 activity, we have uncovered a novel facet of IL-4 gene regulation. We present evidence that members of the tumor necrosis factor …
Immunoglobulin Κ Chain Allotypes (Km) In Onchocerciasis, Janardan P. Pandey, Lynne H. Elson, Susan E. Sutherland, Ronald H. Guderian, Edmundo Araujo, Thomas B. Nutman
Immunoglobulin Κ Chain Allotypes (Km) In Onchocerciasis, Janardan P. Pandey, Lynne H. Elson, Susan E. Sutherland, Ronald H. Guderian, Edmundo Araujo, Thomas B. Nutman
MUSC Faculty Journal Articles
GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups-Afro-Ecuadorians and Amerindians-living in a single restricted geographical area of Ecuador, appear to have different risk factors for acquisition and clinical expression of onchocerciasis, a disease caused by the filarial parasite Onchocerca volvulus. In this study, GM and KM allotypes were determined in 25 Afro-Ecuadorians and 24 Amerindians infected with Onchocerca volvulus (INF) and in putative immune individuals (PI). In Afro-Ecuadorians, the frequency of the homozygous KM 3 phenotype was …
Spontaneous Expression Of The C-Sis Gene And Release Of A Platelet-Derived Growth Factorlike Molecule By Human Alveolar Macrophages, Jean-Francois Mornex, Yves Martinet, Kohei Yamauchi, Peter B. Bitterman, Gary R. Grotendorst, Anna Chytil-Weir, George R. Martin, Ronald G. Crystal
Spontaneous Expression Of The C-Sis Gene And Release Of A Platelet-Derived Growth Factorlike Molecule By Human Alveolar Macrophages, Jean-Francois Mornex, Yves Martinet, Kohei Yamauchi, Peter B. Bitterman, Gary R. Grotendorst, Anna Chytil-Weir, George R. Martin, Ronald G. Crystal
MUSC Faculty Journal Articles
Alveolar macrophages from normal individuals and patients with interstitial lung diseases spontaneously expressed a 4.2-kilobase mRNA complementary to the c-sis gene, a proto-oncogene coding for one of the chains of platelet-derived growth factor (PDGF). Concomitantly, these cells released a mediator with the properties of PDGF, including: (a) chemotactic factor for smooth muscle cells whose activity was resistant to heat and acid, but sensitive to reduction; (b) mitogenic (competence) activity for fibroblasts; (c) ability to compete with PDGF for its receptor, and (d) precipitated by an anti-PDGF antibody. While blood monocytes did not contain c-sis mRNA transcripts, monocytes matured in vitro …
Heterozygosity At Gm Loci Associated With Humoral Immunity To Osteosarcoma, Janardan P. Pandey, Barry T. Shannon, Kwong Y. Tsang, H. Hugh Fudenberg, John G. Camblin
Heterozygosity At Gm Loci Associated With Humoral Immunity To Osteosarcoma, Janardan P. Pandey, Barry T. Shannon, Kwong Y. Tsang, H. Hugh Fudenberg, John G. Camblin
MUSC Faculty Journal Articles
Familial clustering of osteosarcoma suggests the involvement of genetic factors (1, 2), and the demonstration of a high incidence of osteosarcoma-specific antibodies (3, 4), as well as tumor-specific cell-mediated immunity (5) in patients and their relatives, indicates the involvement of immunological factors in the pathogenesis of this disease. Certain Gm allotypes (genetic markers of IgG) have been shown to be associated with a high relative risk of some forms of cancer. For instance, in Caucasians an unusual Gm haplotype--Gm 1,3;5,13,14--has been found to be associated with neuroblastoma (6), and an increased frequency of Gm (2) has been reported in patients …
Immunoglobulin G Heavy Chain (Gm) Allotypes In Multiple Sclerosis, Janardan P. Pandey, Jean-Michel Goust, Jean-Philippe Salier, H. Hugh Fudenberg
Immunoglobulin G Heavy Chain (Gm) Allotypes In Multiple Sclerosis, Janardan P. Pandey, Jean-Michel Goust, Jean-Philippe Salier, H. Hugh Fudenberg
MUSC Faculty Journal Articles
Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.