Digital Commons Network^™

Collisional Damping In Plasmonic Wakefield Accelerators, Maxime Pindrys

Honors Scholar Theses

We investigate the previously proposed role of collisional damping in plasmonic wakefield accelerators. Wakefields driven in a doped semi-conductor will exist in differing regimes dependent on the driving beam’s intensity. At low intensities, the mobility of free carrier electrons is limited. Here, wakefields will be small if the mean free path of an electron is short compared to the quiver amplitude of a free electron. After reaching a threshold intensity, conduction electrons in the semiconductor will be driven to such high speeds that their coulomb cross section will drop sharply. Here the resulting wakes will resemble those in a hollow …

Exchangeability And A Model Of Biological Evolution, Renee Haddad

Honors Scholar Theses

A sequence of random variables (RVs) is exchangeable if its distribution is invariant under permutations. For example, every sequence of independent and identically distributed (IID) RVs is exchangeable. The main result on exchangeable sequences of random variables is de Finetti's theorem, which identifies exchangeable sequences as conditionally IID. In this thesis, we explore exchangeability, provide an elementary proof of de Finetti's theorem, and present two applications: the classical Polya's urn model and a toy model for biological evolution.

Identifying Novel Upstream Regulators Of The Hippo Pathway: Forward Genetic Screen In Drosophila Melanogaster, Akshara Iyer

Honors Scholar Theses

The Hippo pathway is an evolutionarily conserved developmental pathway that controls organ size and tissue homeostasis in all metazoan animals. Dysregulated Hippo pathway has been implicated in a wide range of human disorders, including cancer. The physiological function of the Hippo pathway is best understood in Drosophila, where inactivation of the Hippo pathway tumor suppressors, or overexpression of the Yorkie (Yki) oncoprotein, results in tissue overgrowth characterized by excessive cell proliferation and diminished apoptosis, and increased transcription of Hippo pathway target genes such as diap1 and expanded (ex). Despite the well-established Hippo pathway core signaling cascade, the upstream regulation of …

Program Analysis Of C For Conversion To Memory-Safe Rust, Dylan Cassidy

Honors Scholar Theses

C is a memory-unsafe language, which can cause software security issues. Rust is a more recent high-performance language that has memory-safe features, which motivates developers to move software to Rust. However, given the large existing C codebase, this is a tedious task, and current approaches result in memory-unsafe blocks of code remaining unsafe after conversion. We seek to use program analysis techniques to create software that identifies blocks of C code that could be safely converted to memory-safe Rust, despite using seemingly memory- unsafe access patterns. We performed manual translation of functions within the libGeoIP C library to Rust, ensuring …

Cleaner, Green Oxidation Chemistry: Development Of New Oxoammonium- And Nitroxide- Mediated Transformations, Katrina Doherty

Honors Scholar Theses

This work investigates various key oxidation and oxidative functionalization reactions that occur using a bench-stable nitroxide and its oxoammonium nitrate salt congener. Such transformations include amidation of aldehydes to acyl azoles or hexafluoroisopropyl esters and oxidation of alcohols to ketones or aldehydes. These transformations are key, everyday reactions within organic chemistry, and the aim to make them cleaner and greener is essential to the future of chemistry. Novel compounds produced by these green methods will also be discussed, as well as the results of a scale-up protocol showing the efficacy of the reactions on a process chemistry level. As an …

"La Experiencia Universitaria"- Asset-Based Community Needs Assessment For Uconn Waterbury’S Hispanic Community, Ilene Garcia

Honors Scholar Theses

An asset-based community needs assessment for the Hispanic community of the University of Connecticut’s Waterbury campus was conducted. The community needs assessment uncovered assets that support students, as well as the need for additional resources to promote success in higher education. Information was gathered from the campus community regarding current documented practices such as informal or formal support to aid Hispanic students in their college experience relating to their wellbeing, academic success, and career development. A town hall meeting for the community of students on campus was conducted to impart the information gathered and gather further feedback from students. The …

Identifying Key Evolving Residues That Drive Cid/Cal1 Incompatibility In Drosophila Species, Hayden Yuan, Barbara Mellone

Honors Scholar Theses

The centromere, an essential locus on the chromosome critically important for faithful chromosome segregation during cell division, requires the incorporation of centromere protein A (CENP-A/CID) orchestrated by the chaperone CAL1. This thesis investigates the structural requirements governing the interaction between CAL1 and CID, with a focus on two diverged Drosophila species. Using a combination of structural analysis prediction and cellular assays, I explored the compatibility between the N-terminal region of CAL1 and the L1 domain of CID. Previous results demonstrate species specific interactions between CAL1 and CID, with endogenous Drosophila melanogaster (mel) CAL1 efficiently depositing Drosophila melanogaster CID …

The Relationship Between Amygdala And Orbitofrontal Cortex Volume In The Context Of Oppositional Defiant Disorder, Rahul Alla

Honors Scholar Theses

Disobedient and rebellious attitude in children is on the rise and this type of behavior is categorized as Oppositional Defiant Disorder (ODD). ODD in children can be identified as a persistent pattern of angry or irritable mood, argumentative or defiant behavior or vindictiveness toward others according to the Diagnostic and Statistical Manual (DSM-5, Fifth Edition) of Mental Disorders.1 Children with ODD typically have difficulty regulating and processing their emotions. Issues with regulating emotions is defined as the process by which individuals “influence which emotions they have, when they have them, and how they experience and express them”.2 Dysregulation of emotions …

The First Draft Genome Of Cold-Water Octocoral Anthothela Grandiflora, The Great Flowerbud Coral, Laurel Humphrey

Honors Scholar Theses

Cold-water corals are important sources of ocean biodiversity, yet populations are increasingly threatened by human activity and climate change. Soft octocorals may endure higher ocean acidification levels in comparison to stony hexacorals, although the mechanisms of octocoral biomineralization are less understood. Building genomic resources for cold-water octocorals could help to close information gaps by elucidating the evolutionary history of octocoral calcification and provide a reference for future studies of adaptation to acidified waters. This report describes the first reference genome for the cold-water octocoral species Anthothela grandiflora found throughout the Atlantic Ocean. Sequencing using Oxford Nanopore Technologies generated 43.6 Gb …

A Contextual Analysis Of Life Stories From Older Adults Participating In A Telephone Reminiscence Program, Eliana Likorama

Honors Scholar Theses

Life satisfaction, loneliness, and mental health & well-being are important factors to consider when working with the older adult population. This population is predisposed to many risk factors for mental health problems such as coping with a serious illness, losing a loved one, living alone, cognitive deficits, and more. Reminiscence is one simple, flexible, and cost-effective intervention that can be utilized to promote the mental health and well-being of older adults. Reminiscence is defined as the cognitive process of recalling the past. Numerous studies have shown beneficial effects of reminiscence in older adults: increased self-esteem, enhanced quality of life, increased …

An Educational Resource For Particle Identification (Pid) In Experimental Particle Physics Data, Richard Dube

Honors Scholar Theses

Although particle physics research is typically reserved for advanced undergraduates, algebra-based physics students can readily develop the foundational skills necessary to conduct particle physics research. Despite this, there is a shortage of educational resources that introduce particle physics to algebra-based physics students. This project, Particle Identification Playground, is a collection of Python-based activities that teach students about several fundamental topics in experimental particle physics research. Through these activities, students will learn about the common detectors used in particle physics, how they work, and how we can use these detectors to identify particles. Students are able to interact with 3D models …

Bim Coordination Post Pandemic, Zachary Marshall

Honors Scholar Theses

The goal of this thesis is to utilize previous research done on virtual meetings and build upon it by conducting new research on the successes and failures of current virtual BIM meetings. This paper starts with a literature review looking into Building Information Modeling (BIM) Coordination and the effects the COVID-19 pandemic has had on the BIM meetings. BIM meetings started to shift virtual due to the nature of the pandemic and this has had effects on the performance and structure of the coordination. This knowledge was then expanded on by looking at virtual BIM meeting case studies. Interviews were …

Analyzing The Impact Of Implicit Bias In Pharmacy And Healthcare-Related Professions, Jessica Bylyku

Honors Scholar Theses

American healthcare is a broad, complicated field of study and work. Those who work in healthcare may possess or be affected by implicit biases, which complicates matters more. Implicit bias is the unconscious mental tendency to create automatic associations with a particular group of people.1 As such, implicit biases have the potential to become explicit biases in the form of stereotyping, microaggressions, prejudice, and ultimately discrimination. Researchers believe implicit biases may have a biological basis in human brains, and several theories implicate bias in decision-making processes. The implications of bias have promoted researchers to perform many studies about effects on …

Molecular Mechanisms Of Sensory Post-Acute Sequelae Of Covid-19 Infection: A Comprehensive Literature Review, Maha Siddiqui

Honors Scholar Theses

The COVID-19 pandemic has upended the world in the last few years, bringing with it countless varying physiological effects, some of which extend beyond the acute phase of the infection. Long-term COVID-19, also referred to as "chronic" or “long-haul” COVID, has become an increasingly prevalent health issue in recent years. Long term sensory loss, particularly anosmia and ageusia (loss of smell and taste respectively), are among the biggest concerns to patients suffering from this condition due to the considerable detriment to their quality of life. This literature review aims to provide an overview of the molecular mechanisms associated with sensory …

In Silico Conformation Analysis Of The Disordered Regions Of Proteins Associated With The Β-Catenin Destruction Complex And P53, Clifford Chen

Honors Scholar Theses

Cancer is a class of diseases caused by an accumulation of genetic mutations and abnormalities during cell division. These errors are caused by a variety of factors such as the inhibition of cell cycle control proteins such as p53 that prevent cells with incorrectly replicated chromosomes from segregating as well as genetic and environmental susceptibilities that further cause DNA alteration. Proteins like p53 are tumor suppressor proteins which prevent the growth of cancer cells by regulating the growth of cells as they pass through the cell cycle. Tumor suppressor proteins p53, Axin, Adenomatous polyposis coli (APC), and β-catenin were analyzed …

The Light Scattering Properties Of Amorphous Nanoparticles Formed By Poorly Soluble Drugs, Sarah Casella

Honors Scholar Theses

The research of amorphous drug formulations is an emerging field of study, which offers a promising strategy to improve the oral bioavailability of poorly water-soluble drugs. A critical aspect of amorphous solubility is the measurement of particle size and light diffraction, which is measured using dynamic light scattering (DLS). DLS is a technique used to characterize the size of colloidal dispersions, where a laser beam illuminates a suspension of particles or molecules undergoing Brownian motion. In this experiment, a procedure was developed utilizing DLS to investigate the similarities and differences in light diffraction properties of particles among three different poorly …

Investigating Effects Of Co-Culturing With Vibrio Fischeri On Secondary Metabolite Production Of Hawaiian Bobtail Squid Symbionts, Mariam A. Zedan

Honors Scholar Theses

Microbes are a fruitful source of natural product drug discovery since many of their secondary metabolites show defensive activity and have unique structures. However, extracting and elucidating the structure of those compounds can be challenging in vitro due to particular environmental and nutritional requirements of some bacteria. Those requirements may include proximity to other organisms that the microbes have symbiotic relationships with. Under those conditions, the organism may activate silent biosynthetic gene clusters (BGCs) responsible for production of certain secondary metabolites not typically expressed otherwise. One method of BGC induction is co-culturing with other microbes since this mimics the natural …

Assessing Health Implications Of Monarch Butterfly Populations And Behaviors, Kira Goldman, Kelsey E. Fisher Dr.

Honors Scholar Theses

Pollinator populations have seen massive declines over the past decade due to anthropogenic activity and climate change posing serious threats to the health of humans and ecosystems (Ulyshen & Horn, 2023). As agents responsible for the production of about 35% of micronutrient rich food crops necessary for adequate nutrition to lead healthful lives and prevent nutrition associated diseases, pollinator decline is a public health concern (Aizen et al., 2009). Monarch butterflies (Danaus plexippus) serve as bio indicators for the health of pollinator populations because of their analogous habitat and food resources shared with many other pollinator species, including bees and …

A Cytoarchitectural Analysis Of The Rat Amygdala In Ultrathin Serial Sections, Katrina Schneider

Honors Scholar Theses

This study delves into the cellular composition and functional dynamics of the lateral amygdala (LA), a crucial brain region implicated in emotional and auditory processing/learning. Utilizing IHC, ultrathin serial sectioning (Ultraplex Method), and RNAscope, distinct cell types are characterized within the LA based on calcium-binding proteins (CBPs) and inhibitory markers such as GABA. Despite a modest sample size, a diverse array of cell types are identified, with calbindin-positive neurons prominently emerging in inhibitory cells. Notably, GABA intensity varies depending on cell identity and marker colocalization, hinting at complex regulatory mechanisms involving GABAergic signaling and CBPs. Analysis of vesicular glutamate transporter …

Hilbert Reciprocity Over Number Fields, Dillon Snyder

Honors Scholar Theses

A Hilbert symbol has the value 1 or −1 depending on the existence of solutions to a certain quadratic equation in a local field, R, or C. Hilbert reciprocity states that for a number field F and two nonzero a and b in F, the product of Hilbert symbols associated to a and b at all the places of F is 1. That is, these Hilbert symbols are −1 for a finite, even number of places of F . Hilbert reciprocity when F = Q is equivalent to the classical quadratic reciprocity law, so Hilbert reciprocity in number fields can …

A Ui-Enhanced Approach To Generic Web-Based Scheduling, Tyler Hinrichs

Honors Scholar Theses

Administrative scheduling is a key aspect of a wide variety of systems, but despite being a widespread need, it is not a straightforward task. Organizational uniqueness introduces complexity when attempting to use algorithmic methods to automate scheduling, as individual organizations often have their own ways of determining various details and constraints of a schedule. However, in this paper, we assert that there are relevant commonalities that many different schedules fundamentally possess, allowing us to create a generic scheduling application that can be productively used for as many different scenarios as possible. After devising a schema that captures this generic representation, …

Understanding The Role Of Minor Intron Splicing In Spermatogenesis, Jade Rosado, Kazumasa Takemoto, Rahul Kanadia

Honors Scholar Theses

The minor spliceosome is composed of the unique small nuclear RNAs (snRNA), U11, U12, U4atac, and U6atac, and is necessary for the splicing of less than 0.5% of introns, termed minor introns. Minor intron containing genes (MIGs) regulate diverse processes, one of which is spermatogenesis. Specifically, 111 testis-specific MIGs have been identified, suggesting that minor splicing is necessary for spermatogenesis. To interrogate the role of minor splicing in spermatogenesis, we conditionally ablated the Rnu11 gene, which encodes for the U11 snRNA, in the developing testes via Stra8-iCre, creating a Rnu11^Flx/Flx::Stra8-Cre⁺ mutant. We found, at postnatal …

Analysis Of Antibiotic Sensitivity Patterns In Pasteurellaceae Family Isolates: A Microbial And Molecular Investigation, Jillian Barron

Honors Scholar Theses

Bacteria in the Pasteurellaceae family are known to cause disease in both human and animal species. Like all species of bacteria, the pathogens in the Pasteurellaceae family evolve and acquire antimicrobial-resistant traits. Antimicrobial resistance of bacteria is a significant public health concern, as treatment of resistant pathogens becomes more difficult, if not impossible, with current medical capabilities. In this project, phenotypic and genotypic analyses were performed on Pasteurellaceae family isolates sourced from the Connecticut Veterinary Medical Diagnostic Laboratory. Phenotypic antibiotic sensitivity patterns of each isolate were assessed against a panel of antibiotics through a Kirby-Bauer disk diffusion test. Disk diffusion …

Characterization Of Platinum On Carbon Nanoparticles Selectively Coated With Titanium Nitride (Tin), Matthew Maramo

Honors Scholar Theses

Proton exchange membrane fuel cells are a promising low-carbon technology that still face problems including low durability during their normal operation cycles. At the cathode, the carbon supports of the catalysts may corrode. Atomic layer deposition of titanium nitride is performed on prepared catalyst layer samples. The purpose of the deposition is to create a thin film over the carbon supports to reduce carbon support corrosion and improve the lifespan of the fuel cell. Sheet resistances and contact angles are measured for the samples before and after the deposition, although some samples did not receive the deposition and post-deposition characterization …

Persuasion As A Function Of Celebrity, Argument Complexity, And Need For Cognition, Stratton Stave, Blair T. Johnson Dr., Lisset Martinez-Berman, Matthew B. Jané

Honors Scholar Theses

With advertising commanding so much money as an industry, it is critical to determine what people like or do not with ads. Our focus was on three main factors within advertising, two dimensions within how the advertisement is presented, one based on the person reading the ad. The two dimensions based on presentation were the complexity of the ad, done the first time by omitting letters from the ad and the second time by swapping letters within words, and celebrity endorsement, comparing popstar Taylor Swift’s to Alicia Steele, an AI-generated celebrity. We also measured Need for Cognition (NFC), the level …

Database And Machine Learning Model For Classifying Autism Spectrum Disorder From Smartphone Based Electroretinography, Rory Harris

Honors Scholar Theses

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that negatively affects a patient’s cognitive and communication aptitude and, therefore, can severely impact that patient’s quality of life. Because of this, early diagnosis is paramount. In recent studies, electroretinography (ERG), which is a measure of the retina’s electrical response to a brief flash of light into the eye, has shown promise in detecting ASD. Access to these scans can provide early diagnosis, improving well-being. Current ERG devices are very expensive due to their on board processing capabilities. This paper aims to create an ERG device using a smartphone as the main …

Comparing The Effectiveness Of Different Forms Of Vitamin E Supplementation (Liquid Vs. Powder) On Serum Alpha-Tocopherol Concentrations In Developing Horses, Emilia Fong-Gallagher

Honors Scholar Theses

Vitamin E is an essential antioxidant in equines that has a significant role in the nutritional requirements of horses to keep bodily systems functioning at optimal levels. Vitamin E deficiency is often associated with serious incurable neuromuscular diseases such as equine motor neuron disease and equine protozoal myeloencephalitis. Many horses stabled in urban areas are often deficient due to the lack of adequate grazing time as their natural source of vitamin E is from grass, and therefore should receive supplementation. This study evaluated the effectiveness of different forms of Elevate vitamin E supplement on the serum alpha-tocopherol concentrations in fourteen …

The Blood Pressure Response To Transcendental Meditation: A Meta-Analytic Review Of Interventions, Lucinda M. Carlos, Blair T. Johnson Ph.D.

Honors Scholar Theses

With hypertension affecting over 1.28 billion individuals globally, its prevalence continues to escalate, placing a formidable burden on public health systems and individuals. While pharmaceutical treatments for managing blood pressure exist, various factors such as cost, adverse effects, and limited accessibility can deter individuals from relying solely on medication. There is a need for nonpharmacological interventions to complement traditional approaches. Transcendental Meditation (TM) is a promising alternative method, offering individuals a holistic approach to blood pressure management that addresses both physiological and psychological factors.

We meta-analyzed 33 primary studies (35 interventions) to determine the effects of TM on blood pressure …

Implementation Of Explainable Ai For Bearing Fault Classification, Mohammad Mundiwala

Honors Scholar Theses

It is difficult to overstate the impact of artificial intelligence (AI) over the past decade. The rapid expansion of machine learning has stimulated a race to deploy AI in all facets of life, one such domain being machine health monitoring. There is no doubt that machine learning excels in prediction accuracy, but oftentimes, these models are cryptic and fail to provide valuable insight into their decisions. This paper presents an overview of a neural network and what it means to learn. Next, two distinct Explainable AI (XAI) techniques will be presented: Gradient Class Activation Mapping and SimplEx . Finally, these …

How Does Hummock Creation In Submerging Salt Marshes Alter Nitrous Oxide Fluxes?, Juliette Doyle

Honors Scholar Theses

Climate change is altering ecosystems and the services they provide. Salt marsh ecosystems typically protect coastal areas and filter nitrogen out of water, but are rapidly submerging due to rising sea levels and human development that prevents landward migration. Recent restoration efforts to preserve salt marshes attempt to build elevation capital and promote vegetation and animal habitat, but it is unclear how such efforts affect salt marsh biogeochemistry and dynamics of nitrous oxide, a potent greenhouse gas. To better understand how adding sediment to submerging salt marshes may alter nitrous oxide fluxes, I leveraged a salt marsh hummock creation experiment …