Digital Commons Network^™

Exploring The Effects Of Christian Worldviews On Heart Rate, Stress, And Adjustment After Loss In Bereaved Individuals, Emma Radini Ratnavel

Honors Scholar Theses

The objective of this study is to investigate the correlation between Christian values, perceptions of God, and physiological stress, assessed through heart rate, among individuals who are experiencing grief due to the loss of a loved one. Previous studies have analyzed various physiological effects on the body. There are very few studies that examine the correlation between Christian values and heart rate in bereaved participants. To explore these topics further, this study analyzes 59 undergraduate students who have recently lost a loved one, identify as a Christian, and are at least 18 years old. The participants' perceptions of God and …

Designing A Mhealth App-Based Intervention To Address The Harm Reduction Needs Of Malaysian Men Who Have Sex With Men (Msm) Who Engage In Chemsex: Findings From A Qualitative Study, Christopher Uyar, Francesca Maviglia, Jeffery Wickersham, Antoine Khati, Olivia Kennedy, Nicholas Copenhaver, Mohd Akbar Ab Halim, Wan Mohd Ikhtiaruddin, Isklander Azwa, Kamal Gautam, Roman Shrestha

Honors Scholar Theses

Background:

Chemsex (the use of drugs by men who have sex with men (MSM) to enhance the sexual experience) is being identified as an increasingly common phenomenon. In Malaysia, where drug use and homosexuality are criminalized, chemsex fosters multiple and simultaneous risk-taking behaviors that endanger MSM's well-being and safety. Exacerbating these risks is the intolerant Malaysian sociopolitical environment that foregoes support and victimizes MSM. Malaysian MSM is thus a hidden and at-risk population.

Objective:

We probed Malaysian MSM's thoughts and opinions to guide the development of a potential chemsex mHealth intervention. This hypothetical app-based intervention could serve as a harm-reduction …

Selfish Genetic Elements In Actinobacteriophages, Catherine Jennings

Honors Scholar Theses

This research studies a methylase family in Actinobacteriophages that has been invaded by three different elements: an intein, an additional homing endonuclease and a domain of unknown function. Selfish genomic elements such as inteins and Homing Endonucleases are often found inserted into the exteins of Actinobacteriophages. These elements can spread through different bacteriophage lineages over time through the mechanisms of homing. The ShiLan domain, a found insertion that was found inserted in the ShiLan phage, an intein, and a Homing Endonuclease domain have been found inserted into a DNA methylase. The evolutionary history of these insertions within the DNA methylase …

Effects Of Creative Movement & Play Based Interventions On Motor Skills Of Children With Autism Spectrum Disorder: Results From A Randomized Controlled Trial, Sharanya Chandu

Honors Scholar Theses

Objective: The purpose of this study was to assess the effects of creative movement, general movement, and seated play interventions on bilateral coordination, balance, and upper limb coordination motor skills of children with autism spectrum disorder.

Methods: This data was collected as a part of a multisite intervention study, Play and Move study, by the University of Connecticut and University of Delaware. Participants were contacted through the SPARK database, UConn Kids, fliers sent to local autism services, schools, community centers and by posting information online or to listservs. Forty-five children agreed to participate in this study and were randomly assigned …

Whole Genome Sequencing Of West Nile Viruses From Animals Submitted To The Connecticut Veterinary Medical Diagnostic Laboratory (Cvmdl), Usa, 2021, Allison Appel

Honors Scholar Theses

West Nile Virus (WNV) causes a zoonotic disease. WNV was first isolated in Uganda in 1937 and has since become an endemic in countries such as North, South, and Central America [1]. According to the Connecticut Department of Public Health, an average of 8 cases of WNV in humans have been reported since the year 2000 [2]. In this study, we focused on the genetic characterization of the viral genomic RNA of WNVs circulating in birds and mammals in the New England region. Following that aim, the complete genome sequence of two WNVs was obtained via next-generation sequencing. One sample …

A Systematic Literature Review Of Telehealth For Health Equity In Pediatric And Women's Health Care: Promise Vs Reality, Sharanya Chandu

Honors Scholar Theses

Background: Telehealth interventions can transform the healthcare system to improve accessibility, quality of care, and outcomes for women’s obstetric health.

Objective: This literature review seeks to summarize current research to understand the effect of telehealth on women’s obstetrics and gynecology outcomes.

Methods: A literature review was conducted following the PRISMA methodology to identify a set of papers containing information related to obstetrics and maternal health. The search terms used identified telehealth or telemedicine interventions used for obstetric, maternal, or prenatal care from the period 2013-2023. 19 articles were identified and reviewed.

Results: The literature review considered three primary aspects from …

Ethical Considerations Of Clinical Research In Emergency Care Settings: A Review, Adith Velavan

Honors Scholar Theses

Emergency and acute care settings are some of the most volatile and high intensity areas of any healthcare operation. Better understanding of systems and treatments in these spaces are critical to improving outcomes for the high risk patients that are treated there. Clinical research serves as a cornerstone of modern medical research, and is critical to the further improvement of clinical care in these settings. This thesis serves to explore the ethicality of such research given the constraints of emergency medicine settings. Not only does this thesis provide a strong foundation regarding the history and current practices of clinical research, …

Contribution Of Calcium And Vitamin D Supplementation To Nutrient Adequacy Status In Peri- And Postmenopausal Women, Joseph Drossman

Honors Scholar Theses

Adequate calcium and vitamin D intake is necessary for proper bone health in peri- and postmenopausal women. The current study aimed to investigate the effects of calcium and vitamin D supplementation on calcium and vitamin D intakes and adequacy levels in peri- and postmenopausal women. To evaluate this, the current study utilized baseline food records and demographic data from forty-six peri- and early postmenopausal women collected from a 3-arm, randomized, double-blind, placebo-controlled clinical trial which aimed to evaluate the effects of blackcurrant supplementation on prevention of bone loss in peri- and postmenopausal women. Significant differences in the data were determined …

21st Century Political Agronomy: Between Collapse And Apocalypse In The Capitalist World System, Harrison Raskin

Honors Scholar Theses

Examinations of the causal chain between ecological impacts and food shortages reveal significant impending global disturbances. This paper draws a causal link between ecological impacts and low food productivity which will lead to food insecurity and economic crises in the near term. Further, this paper argues that food insecurity may lead to the collapse of the capitalist world system. This threat is contrasted with “business as usual” climate models which, rather than depicting the collapse of the capitalist world system, depict its persistence throughout the collapse of the world ecology.

Automatic Identification Of Jetting Behavior In 3d Printing With Binary Classification And Anomaly Detection, Alexander Chandy

Honors Scholar Theses

Consistently jetting different materials from the print head of a 3D printer is a key, yet challenging task in manufacturing processes. By using active machine learning, we can efficiently predict complex diagrams that illustrate the region of printing conditions under which “desirable jetting”, “jetting”, and “no jetting” of ink occurs for different substances. However, labeling the images of printed ink droplets that are fed to the active learning model can be time intensive. Therefore, it is ideal to use computer vision to automate the classification of this image data. This classification can be broken down into two steps. In the …

Local Field Potentials In The Male Rat Nucleus Accumbens During Effort-Based Behavior, Celine Aliko, John Salamone, Alev Ecevitoglu

Honors Scholar Theses

Major depression is a devastating disorder that consists of multiple symptoms such as low mood and motivational dysfunction. It has been shown that motivational dysfunction can be studied in animal models by using effort-based choice paradigms, which vary in their response requirements. It has been reported that dopamine depletion in the nucleus accumbens decreases ratio-scheduled lever-pressing in a manner related to the size of the ratio requirement. One dopamine depleting agent is tetrabenazine (TBZ), which has been shown to decrease lever-pressing and induce low-effort bias. The current study aims to investigate behavioral and electrophysiological changes that occur with animals performing …

Monitoring Pm2.5 Pollution In The North End Of Hartford, Ct, Jocelyn Phung, Kristina Wagstrom

Honors Scholar Theses

Particulate matter (PM) or particle pollution is one of the six criteria air pollutants that can cause harm to human health and the environment; yet, there is a lack of data in many areas of the United States. Particulate matter is a mixture of solid particles and liquid droplets suspended in the air (EPA). Exposure to PM2.5 has been linked to respiratory and cardiovascular conditions. People who live in urban areas are more likely to be exposed to particulate matter as many urban areas are known to have poor air quality. Our goal is to determine how particulate matter levels …

Cenabis Bene: A Culinary Odyssey Through Apicius, Kathryn Atkinson

Honors Scholar Theses

Apicius is the sole surviving cookbook from classical antiquity; as such it is invaluable for what it tells us about ancient feasting customs. Yet the gluttony typically associated with classical antiquity has no place in Apicius beyond the art that is inherently associated with food; we are not so much given a seat at the cena (dinner) as we are led into the kitchen, handed an apron, and instructed to cook. This critical analysis explores each recipe not only on the surface—i.e., examining the ingredients and recreating selected recipes—but also on a deeper level, lifting food above its concrete reality …

Elucidating The Impact Of Sos-Response Timing In On Escherichia Coli Survival Following Treatment With Fluoroquinolone Topoisomerase Inhibitors, Stephanie Schofield

Honors Scholar Theses

Antibiotic treatment failure is a public health crisis, with a 2019 report stating that roughly 35,000 deaths occur in the United States yearly due to bacterial infections that are unresponsive to antibiotics (1). One complication in the treatment of bacterial infection is antibiotic persistence which further compromises our battle to effectively treat infection. Bacterial persisters can exist in clonal bacterial cultures and can tolerate antibiotic treatment by undergoing reversible phenotypic changes. They can survive drug concentrations that their genetically identical kin cannot. Some persisters remain in a slow growing state and are difficult to target with current antibiotics. A specific …

Assessing Leadership In Business: A Critical Investigation Of Warren Buffett, Jack Tubridy

Honors Scholar Theses

The world knows Warren Buffett as one of the greatest value investors of all time. He is the CEO of Berkshire Hathaway, a multinational conglomerate holding company, and over the years his company has seen unimaginable returns under his leadership. Though he possesses superior investment knowledge, it is not just his intelligence that has lead to his company's success. Warren Buffett is an incredibly effective leader on account of his personal integrity, relationship building skills, wise business approach, and commitment to his responsibilities. This paper examines what sets Warren Buffett's leadership style apart from other CEOs.

Understanding The Relationship Between B Chromosomes And Nondisjunction In Drosophila Melanogaster, Ayushi Patel

Honors Scholar Theses

B chromosomes are supernumerary, heterochromatic genetic elements that are found in hundreds of different plant and animal species. Recently, B chromosomes were discovered in a stock of Drosophila melanogaster and are carried at a high copy number of 10-12 B chromosomes per cell. B chromosomes are not known to carry any active genes, but when placed in a wild-type genetic background, they cause a significant increase in the frequency of chromosome 4 missegregation during meiosis. This project aimed to understand the relationship between a female’s B chromosome copy number and how often she passes on too many (or too few) …

Oncolytic Virus Immunotherapy: Development And Potential For Cancer Treatment, Olivia Guinness

Honors Scholar Theses

The American Cancer Society estimates that in 2023, 1,958,310 new cancer cases and 609,820 cancer deaths will occur in the United States [16]. A promising therapeutic option that has been supported by recent clinical trials is the use of oncolytic viruses to treat malignant tumors. The mechanism of action of existing treatments, such as chemotherapy, radiotherapy, and surgery, differs from that of oncolytic virus therapy because oncolytic viruses are able to affect cancer cells with specificity, minimizing side effects. When infecting a normal, non-cancerous cell, oncolytic viruses do not replicate, leaving healthy cells unaffected. In tumor cells, oncolytic viruses will …

Healthcare Experiences By Race, Sex, And Weight Status In A Sample Of Low Wage Workers Before And During The Covid-19 Pandemic, Michael Ampofo

Honors Scholar Theses

There is longstanding evidence of racial, sex-based, weight-based, and socioeconomic status (SES) disparities in the quality of healthcare. These disparities can result from provider bias and discrimination in the healthcare system and can contribute to disparities in health outcomes. The emergence of the COVID-19 pandemic may have exacerbated differential treatment in healthcare due to the strain it placed on the healthcare system. The purpose of this study was to examine the impact of the COVID-19 pandemic on U.S. healthcare experiences among low SES non-Hispanic Black and non-Hispanic White patients. This secondary analysis utilized survey measures from 225 low-wage workers, ages …

Stringency In Occupational Licensing Requirements: Explanations And Effects, Nicholas Hall

Honors Scholar Theses

In this paper, I explore explanations for and effects of variation in stringency in occupational licensing requirements across states. Focusing on data on cosmetology, I first analyze the effect of characteristics of the professional licensing board, including its membership composition and department within the state government, on the regulations the board implements. I find evidence that the department of a board impacts its licensing fees, with health-based departments requiring lower fees than commerce- and general licensing-based departments. I then examine the effects of stringency on wages and the number of practitioners in an area. I find evidence that the number …

Cues Guiding Postnatal Neuron Migration In Mouse And Human, Sarah Bellizzi

Honors Scholar Theses

This project is the first step in identifying the molecular mechanisms that support movement and distribution of neural stem cells that migrate from the lateral ventricles to the olfactory bulb (OB) and ventral medial prefrontal cortex (VMPFC, humans). In rodents, the forebrain rostral migratory stream (RMS) is the only postnatal long-range pathway involved in neuroblast cell migration. It consists of fasciculated chains of neuroblasts that migrate through a dense meshwork of astrocytes to finally integrate within the olfactory bulb. What exactly guides new neuron distribution and coordinates this extensive migration still remains unclear.

Ephs/ephrins are well known for coordinating and …

Control And Design Of A Passive Solar Lumber Drying Kiln, Peter Chardavoyne

Honors Scholar Theses

The passive solar lumber drying kiln design, developed by EE Senior Design Team 2317 is presented, tested, and discussed. The design incorporates solar power and a custom control system to dry 12’ lumber boards inside a shipping container much faster than air-drying methods, which can take up to a year for thorough drying, though this can be extended due to the unpredictability of weather events and conditions. This work presents the design as in the final report provided by the team, but provides a more detailed explanation and analysis of the microcontroller system, testing methods and outcomes, alternate solutions and …

The Effects Of The Covid-19 Pandemic On Mergers And Acquisitions, Goodwill, And Goodwill Impairment In The Technology Industry, Dee Webster

Honors Scholar Theses

I explore associations between COVID-19 and changes in mergers and acquisitions (M&As), goodwill valuation, and goodwill impairments in the technology industry. Prior literature explores the pandemic’s effects on the dynamics of M&As, goodwill, and goodwill impairment, but are not specific to the pandemic’s impact on the technology industry. This study references prior literature to provide conceptual support as well as research findings to examine the overall changes in technology companies of interest in this study. First, I find that M&A activity before COVID-19 and during COVID-19 was not substantially different when averaged. Second, I find that there was a significant …

Acute Kidney Injury In The Elderly, Zachary Palanza

Honors Scholar Theses

Acute kidney injury (AKI) is a significant clinical concern in the elderly, marked by heightened incidence rates, increased morbidity and mortality, and impaired kidney repair mechanisms. AKI often has severe consequences, including extended hospital stays, heightened rates of chronic kidney disease, and elevated healthcare costs. The vulnerability of elderly individuals to AKI is amplified by age-related structural and functional changes in the kidneys, reduced physiological reserve, and increased exposure to nephrotoxic agents. The impaired kidney repair mechanisms observed in the elderly pose further complexities in AKI management. With age, the regenerative capacity of the kidneys diminishes, resulting in incomplete recovery …

Assessing The Effects Of Pergolide On The Motivational Aspects Of Depression In Rats Using Operant Conditioning, Theresa Marciano

Honors Scholar Theses

Pergolide is an ergot derivative dopamine agonist which acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine receptors. It was previously used as a treatment for the symptoms of Parkinson’s disease, but was taken off of the market as a result of causing increased risk of heart disease. As a dopamine agonist, pergolide stimulates D2 receptors, which are associated with improvement of symptoms of movement disorders. This link exists because the highest concentration of D2 receptors in the brain is in the basal ganglia, which is involved in motor control. Given the connection between pergolide, dopamine, and …

Exploring Emotion Regulation And Social Support As Moderators Of The Relationship Between Sleep Disturbance And High Cortisol Levels In Cancer Survivors, Rose Karvandi

Honors Scholar Theses

Stress is a constant, ongoing occurrence in our lives, and research has given us further understanding of the health implications it has. Cortisol has been explored as a biomarker of stress, and high levels of it can lead to further health problems. Cancer is a life-changing disease and can have varying impacts on one’s emotional and physical health. Cancer diagnosis and treatment is a stressful experience, and stress is known to impact other aspects of health, such as sleep. The importance of sleep quality on our proper bodily functioning is well known. Given how essential sleep is to our health, …

The Dreamwalker: A Novella In Progress, Camryn Johnson

Honors Scholar Theses

The DreamWalker is a fantasy novella based in the near future city of Nova where beings with extraordinary powers exist alongside "normal" humans. One night there was a mass raid on the homes of extras and they were thrown into the Centrum, a specially curated holding facility that keeps extras and their powers indefinitely imprisoned. Aybis, a Dreamwalker, is one of these beings, though she managed to escape this prison. Now she works for Marco, a handler of sorts, in the underground, using her ability to enter and sometimes manipulate dreams of the wealthy and elite clientele of Nova who …

Quantitative Analysis Of The Proteomic Selectivity Of Acidic Reductive Alkylation Of Peptides, Connor Jewell

Honors Scholar Theses

Proteome quantification is a complicated process which takes on many methods, usually involving peptide derivatization and complex mass spectral analysis. Scores of techniques have been utilized to address issues of incomplete quantification. The implementation of IPTL labeling, or isobaric peptide terminal labeling, is a recent addition to the literature, which exploits the supposedly selective labeling of N-termini of tryptic peptides from the C-termini of lysine residues due to differences in basicity. This method has been shown to improve quantitation by reducing spectral complexity and provide more accurate and reproducible results on peptide abundance. Investigations into the selectivity of terminal derivatization …

Investigating Microbial Metabolism Of Garcinia Mangostana By The Human Gut Bacterium Clostridium Sporogenes, Anna Liu

Honors Scholar Theses

The human gut microbiome is a burgeoning field of research due to recent recognition of its profound impact on the human hosts’ homeostasis, physiology and metabolism, and disease. Botanical natural products have been utilized for disease prevention and medical treatment since ancient times. Increased consumption of botanical natural products for their health benefits have led researchers to investigate interactions between the gut microbiome and botanical natural products. Garcinia mangostana, also known as mangosteen, is a fruit from Southeast Asia that is known for its health benefits such as anti-inflammatory, antihypertensive, and anticancer properties. Its benefits have been linked to bioactive …

Uconn Baseball Batting Order Optimization, Gavin Rublewski, Gavin Rublewski

Honors Scholar Theses

Challenging conventional wisdom is at the very core of baseball analytics. Using data and statistical analysis, the sets of rules by which coaches make decisions can be justified, or possibly refuted. One of those sets of rules relates to the construction of a batting order. Through data collection, data adjustment, the construction of a baseball simulator, and the use of a Monte Carlo Simulation, I have assessed thousands of possible batting orders to determine the roster-specific strategies that lead to optimal run production for the 2023 UConn baseball team. This paper details a repeatable process in which basic player statistics …

Probabilistic Machine Learning For Battery State Of Health Prognostics, Charli Zaretsky

Honors Scholar Theses

The ability to understand and predict the state of health (SOH) of lithium-ion batteries is an integral component of their widespread commercial use. There are various methods through which SOH can be analyzed and predicted, and this paper discusses these different methods, and the strengths and weaknesses of each. This paper also details an analysis of lithium-ion battery SOH through two data-driven machine learning methods: XGBoost and Gaussian process regression. A comparison is made between each method’s accuracy in predicting next-cycle discharge capacity using electrochemical impedance spectroscopy (EIS) readings and battery charge and discharge rates, from a dataset given in …