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Exploring The Binding Of Anticancer Drug Bi-3802 With Dna Using Optical Tweezers, Jared Mcauliffe
Exploring The Binding Of Anticancer Drug Bi-3802 With Dna Using Optical Tweezers, Jared Mcauliffe
Honors Program Theses and Projects
BI-3802 is a relatively new anticancer drug known to bind to the transcription repressor BCL6 which can lead to the regression of the most common form of cancer in the lymphatic system, B-cell lymphoma. Based on the structure of BI-3802 we believe this small molecule drug can bind to DNA through intercalation. Intercalators are a special type of molecule which have a flat planar section that can stack between DNA base pairs. In this study, we use Optical tweezers to trap a single DNA molecule in order to explore the binding of BI-3802 with DNA. Once we trap a single …
Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Honors Program Theses and Projects
The integrity of our DNA is constantly under threat from many internal and external factors. If the cell cannot properly protect the integrity of DNA, errors (lesions) in DNA may form which can lead to cancer. Most of these lesions serve as a roadblock to the protein, DNA polymerase (Pol), that replicates the DNA during cell division. The mechanism that is employed to read through these errors is called translesion DNA synthesis (TLS). During this process, a special class of DNA polymerases known as TLS DNA Pols that can tolerate and bypass the lesions in DNA are employed by the …