Digital Commons Network^™

Tuscaloosa: University Of Alabama Press, 2011. Xi + 313 Pp. (Paper Us$35.00), Andrew D. Halleran, Morgan Sehdev, Brian A. Rabe, Ryan W. Huyck, Cheyenne C. Williams, Margaret S. Saha

Arts & Sciences Articles

The tweety family of genes encodes large-conductance chloride channels and has been implicated in a wide array of cellular processes including cell division, cell adhesion, regulation of calcium activity, and tumorigenesis, particularly in neuronal cells. However, their expression patterns during early development remain largely unknown. Here, we describe the spatial and temporal patterning of ttyh1, ttyh2, and ttyh3 in Xenopus laevis during early embryonic development. Ttyh1 and ttyh3 are initially expressed at the late neurula stage are and primarily localized to the developing nervous system; however ttyh1 and ttyh3 both show transient expression in the somites. By swimming tadpole stages, …

Kinomic Profiling Of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach For Personalized Medicine, Joshua C. Anderson, Douglas J. Minnich, M. Christian Dobelbower, Alexander J. Denton, Alex M. Dussaq, Ashley N. Gilbert, Timothy Rohrbach, Waleed Arafat, Karim Welaya, James A. Bonner, Christopher D. Willey

Richard Bland Faculty Works

Purpose

Researchers are currently seeking relevant lung cancer biomarkers in order to make informed decisions regarding therapeutic selection for patients in so-called “precision medicine.” However, there are challenges to obtaining adequate lung cancer tissue for molecular analyses. Furthermore, current molecular testing of tumors at the genomic or transcriptomic level are very indirect measures of biological response to a drug, particularly for small molecule inhibitors that target kinases. Kinase activity profiling is therefore theorized to be more reflective of in vivo biology than many current molecular analysis techniques. As a result, this study seeks to prove the feasibility of combining a …

Targeting The Effector Domain Of The Myristoylated Alanine Rich C-Kinase Substrate Enhances Lung Cancer Radiation Sensitivity, Timothy Rohrbach, John S. Jarboe, Joshua C. Anderson, Hoa Q. Trummell, Patricia H. Hicks, Alice N. Weaver, Eddy S. Yang, Robert A. Oster, Jessy S. Deshane, Chad Steele, Gene P. Siegal, James A. Bonner, Christopher D. Willey

Richard Bland Faculty Works

Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kinase substrate (MARCKS) is a protein that has the ability to mitigate this signaling cascade by sequestering the target of PI3K, phosphatidylinositol (4,5)-bisphosphate (PIP2). As such, MARCKS has been implicated as a tumor suppressor, though there is some evidence that MARCKS may be tumor promoting in certain cancer types. Since the MARCKS function depends on its phosphorylation status, which impacts its subcellular …

James City County And City Of Williamsburg, Virginia Shoreline Inventory Report Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kory Angstadt, Alexandra Procopi, David Weiss, Carl Hershner

Reports

The data inventory developed for the Shoreline Inventory is based on a three tiered shoreline assessment approach. This assessment characterizes conditions that can be observed from a small boat navigating along the shoreline or by using observations made remotely at the desktop using high resolution imagery. The three tiered shoreline assessment approach divides the shorezone into three regions:

1) the immediate riparian zone, evaluated for land use; 2) the bank, evaluated for height, stability, cover and natural protection; and 3) the shoreline, describing the presence of shoreline structures for shore protection and recreational purposes.

The 2014 Inventory for James City …

City Of Norfolk, Virginia Shoreline Inventory Report Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kory Angstadt, Alexandra Procopi, David Weiss, Carl Hershner

Reports

The data inventory developed for the Shoreline Inventory is based on a three tiered shoreline assessment approach. This assessment characterizes conditions that can be observed from a small boat navigating along the shoreline or by using observations made remotely at the desktop using high resolution imagery. The three tiered shoreline assessment approach divides the shorezone into three regions:

1) the immediate riparian zone, evaluated for land use; 2) the bank, evaluated for height, stability, cover and natural protection; and 3) the shoreline, describing the presence of shoreline structures for shore protection and recreational purposes.

The 2014 Inventory for the City …

Northumberland County, Virginia Shoreline Inventory Report Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, David Stanhope, Kory Angstadt, Christine Tombleson, Alexandra Procopi, David Weiss, Carl Hershner

Reports

The data inventory developed for the Shoreline Inventory is based on a three tiered shoreline assessment approach. This assessment characterizes conditions that can be observed from a small boat navigating along the shoreline or by using observations made remotely at the desktop using high resolution imagery. The three tiered shoreline assessment approach divides the shorezone into three regions:

1 ) the immediate riparian zone, evaluated for land use; 2 ) the bank, evaluated for height, stability, cover and natural protection; and 3 ) the shoreline, describing the presence of shoreline structures for shore protection and recreational purposes.

The 2014 Inventory …

Shoreline Evolution: Fairfax County, Virginia Potomac River Shoreline, Donna A. Milligan, Christine A. Wilcox, C. Scott Hardaway Jr.

Reports

Fairfax County is situated along the upper reaches of the Potomac River (Figure 1). Because the County’s shoreline is continually changing, determining where the shoreline was in the past, how far and how fast it is moving, and what factors drive shoreline change will help define where the shoreline will be going in the future. These rates and patterns of shore change along Chesapeake Bay’s estuarine shores will differ through time as winds, waves, tides and currents shape and modify coastlines by eroding, transporting and depositing sediments.

The purpose of this report is to document how the shore zone of …

Summary Tables: Northumberland County, Virginia Shoreline Inventory Report, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, David Stanhope, Kory Angstadt, Christine Tombleson, Alexandra Procopi, David Weiss, Carl Hershner

Reports

The Shoreline Inventory Summary Tables quantify observed conditions based on river systems, such as the combined length of linear features (e.g. shoreline miles surveyed, miles of bulkhead and revetment), the total number of point features (e.g. docks, boathouses, boat ramps) & total acres of polygon features (tidal marshes).

Virginia Accomplishments Since The 2008 Climate Action Plan Release, Center For Coastal Resources Management, Virginia Institute Of Marine Science

Reports

Virginia has undertaken a variety of actions to mitigate the emission of greenhouse gasses and adapt to climate related changes to our weather, wildlife, and sea level. However, these changes have not been undertaken in a coordinated fashion, nor have they been in clear response to the recommendations of any entity that has approached the problem of climate change as a whole. Greenhouse gas mitigation has taken place in the form of a few policies to capture landfill gas, encourage limited energy efficiency, encourage growth of some renewable energy, and reduce vehicle miles traveled. Additionally, good progress has been made …

Gifted Education In Ireland: Educators' Beliefs And Practices, Jennifer R. Cross, Tracy L. Cross, Colm O'Reilly, Sakhavat Mammadov, Center For Gifted Education, William & Mary

Center for Gifted Education Reports

The Irish Centre for Talented Youth has been the sole provider of enrichment programs for gifted children in the country since its foundation in 1992. From a desire to advocate for gifted students in the schools, this study was undertaken in collaboration with the Center for Gifted Education at the College of William & Mary to better understand the state of gifted education across the country. While high-ability students can be found in every Irish school, it is unclear to what extent they are understood by teachers and administrators, nor how much attention their exceptional abilities have received in the …

Scaling Ecosystem Services To Reef Development : Effects Of Oyster Density On Nitrogen Removal And Reef Community Structure, M. Lisa Kellogg, Jeffrey C. Cornwell, Michael S. Owens, Mark Luckenbach, Paige G. Ross, Thomas A. Leggett, Jennifer C. Dreyer C. Dreyer, Bowdoin Lusk, Alan Birch, Edward Smith

Reports

Eighteen native oyster experimental reefs (16-m2 each) were restored using six oyster densities (0, 10, 25, 50, 100 and 250 adult oysters m-2) with three replicates of each density at each of two sites: one subtidal site in Onancock Creek, Virginia and one intertidal site in Hillcrest Oyster Sanctuary within The Nature Conservancy’s Virginia Coast Reserve. A science-based monitoring program explored quantitative relationships between structural and functional characteristics of these restored reefs. Structural parameters examined included oyster abundance, oyster size/biomass, surface shell volume, reef topographic complexity and sediment characteristics. Functional parameters included denitrification rates and macrofaunal abundance and biomass. Data …

Evaluation Of Striped Bass Stocks In Virginia, Monitoring And Tagging Studies, 2010-2014 Progress Report, 1 September 2013 - 31 August 2014, Philip W. Sadler, Matthew W. Smith, John M. Hoenig, Robert E. Harris, Lydia M. Goins

Reports

This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2013 through 31 August 2014. It includes an assessment of the biological characteristics of striped bass taken from the 2014 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. Also included is information on gear selectivity of recreational anglers for striped bass and on impacts of dermal mycobacteriosis on striped bass. The information contained …

Accidental Agent Of Change: George Ticknor's Study Abroad In 1815 Germany, Leslie Bohon

The William & Mary Educational Review

The historian Herbst (1965) posited that “scholarship . . . like most human endeavors, [is] given [its] distinguishing character by the specific time and place in which [it is] pursued” (p. vii). The distinguishing character of U.S. higher education at the turn of the nineteenth century was transition. Indeed, in the early 1800s, U.S. educators were struggling to determine the future of higher education in the United States, igniting discussions and disagreements concerning everything from the purpose of education, to curriculum and pedagogy, and to student life (Herbst, 1965). Yet, answers did not appear to be forthcoming from within the …

Conceptualizations Of Substance Use, Abuse, Dependence, And Treatment: A Qualitative Comparison Of Experiences Of Italian And American Counselors-In-Training, Amy Elizabeth Williams

The William & Mary Educational Review

The present study is a qualitative exploration of the conceptualizations of substance use, abuse, dependence, and treatment from the perspectives of Italian and American counselors-in-training. The researcher conducted semi- structured interviews with two Italian and two American graduate-level counseling students. Thematic elements identified based upon collected data include differential attitudes toward alcohol and marijuana compared to illicit drug use in both Italy and the United States, consequences experienced as a result of problematic substance use, and the impact of stigma on opportunities following treatment. Differences in treatment practices and standards and differences in vocational opportunities following treatment in Italy and …

Letter From The Editor, Julie Marsh

The William & Mary Educational Review

No abstract provided.

Up For Debate: Acknowledging Diversity At The School Of Education, Clare Merlin

The William & Mary Educational Review

No abstract provided.

The Education Of Young Thomas Jefferson, Nicholas Marsella

The William & Mary Educational Review

No abstract provided.

The University Of Cicerone & Matthew College, Giovanna Bertulu, Sharon Kim, Sara Santilli, Valentina Sestu, Will Taylor, Bianca Waechter, Amy Elizabeth Williams

The William & Mary Educational Review

No abstract provided.

The Burden Of Historical Representation: The Case Of/For Indigenous Film, Jeremy Stoddard, Alan Marcus, David Hicks

Articles

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Case Study: A View To The Future, Giulia Artico, Molly Basehore, Debra Butler, Diana Hernandez, Sara G. Pomini, Tiffany N. F. Pugh

The William & Mary Educational Review

No abstract provided.

Matter, Energy, And Heat Transfer In A Classical Ballistic Atom Pump, Tommy A. Byrd, Kunal K. Das, Kevin Mitchell, Seth Aubin, John B. Delos

Arts & Sciences Articles

A ballistic atom pump is a system containing two reservoirs of neutral atoms or molecules and a junction connecting them containing a localized time-varying potential. Atoms move through the pump as independent particles. Under certain conditions, these pumps can create net transport of atoms from one reservoir to the other. While such systems are sometimes called “quantum pumps,” they are also models of classical chaotic transport, and their quantum behavior cannot be understood without study of the corresponding classical behavior. Here we examine classically such a pump's effect on energy and temperature in the reservoirs, in addition to net particle …

How Teacher Professional Development Can Improve Stem Education In A Standards-Based Classroom, Elise Buckley

The William & Mary Educational Review

No abstract provided.

Environment And Affect: Toward An Emotional Geography Of Student Persistence, Jamison R. Miller, Michael Donlan

The William & Mary Educational Review

Student persistence is a perennial problem for higher education. From lost revenue for colleges and universities to lost opportunity and development for students, educational scholars have had much incentive to examine the problem. In this paper, we review some of the prominent assessments of student persistence in research from various theoretical perspectives. Further, we explore how scholars have studied environmental factors in persistence and to a lesser extent student affect, yet we find the relationship between these two to be only lightly engaged in the literature. The emerging discipline of emotional geography offers to draw out new insights at the …

A Regional Approach To School Diversity: The Possibility, Feasibility, And Desirability, Damon Richardson, Brian Maltby, Joseph Koontz, Ram Bhagat

The William & Mary Educational Review

The growing opportunity and achievement gaps between and within school divisions in the Richmond, Virginia area are a concern of late. Educational experts and researchers attribute these disparities in part to factors such as less- qualified teachers, poor curricula, and inferior school facilities that are linked to racially and socioeconomically isolated schools. To help reverse the widening student opportunity and achievement gaps that are related to economic and racial isolation, there is a need to explore ways to advance educational equity and excellence in Richmond area schools.

The Effect Of Brand And Caloric Information On Flavor Perception And Food Consumption In Restrained And Unrestrained Eaters, Kevin V. Cavanagh, Blina Kruja, Catherine A. Forestell

Arts & Sciences Articles

The goal of the current study was to determine whether provision of brand and caloric information affects sensory perception and consumption of a food in restrained (n = 84) and unrestrained eaters (n = 104). Using a between-subjects 2 × 2 × 3 design, female restrained and unrestrained eaters were asked to taste and rate a cookie that was labeled with a brand associated with healthful eating (Kashi®) or one associated with unhealthful eating (Nabisco®). Additionally, some participants were presented with a nutrition label alongside the brand name indicating that one serving contained 130 calories (Low-Calorie Condition), or …

Isotope Shifts In Francium Isotopes Fr206-213 And Fr-221, R. Collister, G. Gwinner, M. Tandecki, Seth Aubin

Arts & Sciences Articles

We present the isotope shifts of the 7s(1/2) to 7p(1/2) transition for francium isotopes Fr206-213 with reference to Fr-221 collected from two experimental periods. The shifts are measured on a sample of atoms prepared within a magneto-optical trap by a fast sweep of radio-frequency sidebands applied to a carrier laser. King plot analysis, which includes literature values for 7s(1/2) to 7p(3/2) isotope shifts, provides a field shift constant ratio of 1.0520(10) and a difference between the specific mass shift constants of 170(100) GHz amu between the D-1 and D-2 transitions, of sufficient precision to differentiate between ab initio calculations.

Developing Talent Among Low-Income Gifted Learners: A Review Of Recent Research, Jennifer Riedl Cross, Darlene Wiggins Dockery

Arts & Sciences Articles

No abstract provided.

Economic Activity Associated With Commercial Fisheries And Shellfish Aquaculture In Northampton County, Virginia, Thomas J. Murray

Reports

No abstract provided.

Identification Of Low-Income Gifted Learners: A Review Of Recent Research, Jennifer Riedl Cross, Darlene Wiggins Dockery

Arts & Sciences Articles

No abstract provided.

Cruise: Yr130618, Stations: S5139- S5152, York River Estuary And Pamunkey River, Virginia, Mudbed Longitudinal Profiler Station Survey Bracketing An Ebb Tide., Kelsey A. Fall, Grace M. Cartwright, Carl T. Friedrichs, David G. Bowers

Data

Dataset consists of profile and water column burst Data collected as part of a longitudinal profiler station survey at approximately 20 km, 25 km, 35 km, 45 km, 56 km and 62 km upriver from the mouth of the York River Estuary.