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Western University

2018

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Evaluation Of Perioperative Peripheral Nerve Injury In Cardiac Surgery Using A Novel Automated Ssep Monitoring Device, Satoru Fujii Dec 2018

Evaluation Of Perioperative Peripheral Nerve Injury In Cardiac Surgery Using A Novel Automated Ssep Monitoring Device, Satoru Fujii

Electronic Thesis and Dissertation Repository

INTRODUCTION: The high incidence of peripheral nerve injury (PNI) in conventional cardiac surgery (CCS) is believed to result from mechanical injury during sternotomy and/or retraction of the sternum. Minimally invasive cardiac surgery (MICS) is a newly developed type of cardiac surgery which does not require sternotomy or retraction of the sternum. Since surgery related PNI can lead to serious problems for both the patients and care providers, the incidence and details of PNI in cardiac surgery needs to be investigated. OBJECTIVE: To compare the degree of nerve injury in MICS and CCS using somatosensory evoked potential (SSEP) signals. …


Investigation Of Flow Disturbances And Multi-Directional Wall Shear Stress In The Stenosed Carotid Artery Bifurcation Using Particle Image Velocimetry, Amanda L. Dicarlo Dec 2018

Investigation Of Flow Disturbances And Multi-Directional Wall Shear Stress In The Stenosed Carotid Artery Bifurcation Using Particle Image Velocimetry, Amanda L. Dicarlo

Electronic Thesis and Dissertation Repository

Hemodynamics and shear forces are associated with pathological changes in the vascular wall and its function, resulting in the focal development of atherosclerosis. Flow complexities that develop in the presence of established plaques create environments favourable to thrombosis formation and potentially plaque rupture leading to stroke. The carotid artery bifurcation is a common site of atherosclerosis development. Recently, the multi-directional nature of shear stress acting on the endothelial layer has been highlighted as a risk factor for atherogenesis, emphasizing the need for accurate measurements of shear stress magnitude as well direction. In the absence of comprehensive patient specific datasets numerical …


Pragmatic Holiness In The Early Salvation Army: A Theology Of Holiness As Action, Terence Hale Dec 2018

Pragmatic Holiness In The Early Salvation Army: A Theology Of Holiness As Action, Terence Hale

Electronic Thesis and Dissertation Repository

The notion of holiness and sanctification are central to most Protestant understandings and expressions of religious life. This thesis explores whether a pragmatic understanding of holiness, particularly in the Wesleyan-Arminian stream, can have a meaningful place in the postmodern world.

This thesis endeavours to establish a theological argument for a non-linear pragmatic understanding of holiness in the Wesleyan tradition. The theological argument is supplemented by a substantial case study of the early Salvation Army, focusing on its missiology and theology.

The argument presented is that a pragmatic understanding of sanctification, as seen in the theology and practice of the early …


Effect Of Ultrafiltration During Hemodialysis On Hepatic And Total-Body Water: An Observational Study., Claire J Grant, Trevor P Wade, Charles A Mckenzie, Guido Filler, Christopher W Mcintyre, Huang S. Shih-Han Dec 2018

Effect Of Ultrafiltration During Hemodialysis On Hepatic And Total-Body Water: An Observational Study., Claire J Grant, Trevor P Wade, Charles A Mckenzie, Guido Filler, Christopher W Mcintyre, Huang S. Shih-Han

Paediatrics Publications

Background

The hepatic circulation is involved in adaptive systemic responses to circulatory stress. However, it is vulnerable to both chronic hypervolemia and cardiac dysfunction. The influence of hemodialysis (HD) and ultrafiltration (UF) upon liver water content has been understudied. We conducted a detailed pilot study to characterize the effects of HD upon liver water content and stiffness, referenced to peripheral fluid mobilization and total body water.

Methods

We studied 14 established HD patients without liver disease. Magnetic resonance imaging (MRI) together with ultrasound-based elastography and bioimpedance assessment were employed to measure hepatic water content and stiffness, body composition, and water …


A Randomized Controlled Trial Of A Modified Cystoscopy Technique, Khalil Hetou Dec 2018

A Randomized Controlled Trial Of A Modified Cystoscopy Technique, Khalil Hetou

Electronic Thesis and Dissertation Repository

Introduction

Pain, anxiety and embarrassment are well documented feelings in patients undergoing ambulatory diagnostic cystoscopy. In this study, we explored utilizing Peak-end theory in improving pain perception in patients undergoing diagnostic cystoscopy.

Materials and Methods

We conducted a randomized clinical trial at the London Health Sciences Center for patients undergoing an ambulatory diagnostic cystoscopy for the first time. Males and females as well as allocation ratios were 1:1. The control arm received a standard cystoscopy. In the intervention arm the cystoscope was left for additional 2 minutes without further manipulation in the bladder before scope removal. The primary outcome was …


Corrosion Dynamics Of Carbon Steel In Used Fuel Container Environments, Dan Guo Dec 2018

Corrosion Dynamics Of Carbon Steel In Used Fuel Container Environments, Dan Guo

Electronic Thesis and Dissertation Repository

The current Canadian used nuclear fuel container (UFC) design uses a pressure‑grade carbon steel (CS) vessel with its outer surface coated with a thin layer of copper. One concern regarding the structural integrity of the UFC design is the potential internal corrosion of the CS vessel. Moisture trapped inside a UFC could condense within the gap between the hemispherical head and the cylindrical body of the vessel. The internal UFC environment will be exposed to a continuous flux of ionizing radiation arising from the decay of radionuclides trapped in the used UO2 fuel matrix.

This thesis research project investigates …


Complexity Results For Fourier-Motzkin Elimination, Delaram Talaashrafi Dec 2018

Complexity Results For Fourier-Motzkin Elimination, Delaram Talaashrafi

Electronic Thesis and Dissertation Repository

In this thesis, we propose a new method for removing all the redundant inequalities generated by Fourier-Motzkin elimination. This method is based on Kohler’s work and an improved version of Balas’ work. Moreover, this method only uses arithmetic operations on matrices. Algebraic complexity estimates and experimental results show that our method outperforms alternative approaches based on linear programming.


A 10-Minute Single-Bout Of Moderate To Very-Heavy Intensity Aerobic Exercise Improves Executive Function In Older Adults, Andrea F.M. Petrella Dec 2018

A 10-Minute Single-Bout Of Moderate To Very-Heavy Intensity Aerobic Exercise Improves Executive Function In Older Adults, Andrea F.M. Petrella

Electronic Thesis and Dissertation Repository

A 10-minute single-bout of moderate to very-heavy intensity aerobic exercise provides a boost to executive-related oculomotor control in young adults. Furthermore, some evidence shows that older adults (>65 years) can receive similar executive benefits post-exercise. It is, however, unclear if a specific exercise intensity can optimize executive function within this population. This represents an important question given that the population of older adults with executive dysfunction is expected to grow. To that end, this thesis had community-dwelling older adults perform a VO2peak test to determine 10-minute participant-specific moderate, heavy, and very-heavy exercise intensities. Pre- and post- exercise executive …


Retrospective Motion Correction In Magnetic Resonance Imaging Of The Brain, Patricia Johnson Dec 2018

Retrospective Motion Correction In Magnetic Resonance Imaging Of The Brain, Patricia Johnson

Electronic Thesis and Dissertation Repository

Magnetic Resonance Imaging (MRI) is a tremendously useful diagnostic imaging modality that provides outstanding soft tissue contrast. However, subject motion is a significant unsolved problem; motion during image acquisition can cause blurring and distortions in the image, limiting its diagnostic utility. Current techniques for addressing head motion include optical tracking which can be impractical in clinical settings due to challenges associated with camera cross-calibration and marker fixation. Another category of techniques is MRI navigators, which use specially acquired MRI data to track the motion of the head.

This thesis presents two techniques for motion correction in MRI: the first is …


The Effects Of Semantic Priming On Lexical Processing, Alexander Taikh Dec 2018

The Effects Of Semantic Priming On Lexical Processing, Alexander Taikh

Electronic Thesis and Dissertation Repository

The present experiments were designed to investigate the locus of the semantic priming effect, a phenomenon that has received much research attention. Semantically related primes (e.g., cat) might activate the lexical representations of their targets (e.g., DOG) through automatic spreading activation at short stimulus onset asynchronies (SOAs) between the prime and target, or through generation of words expected to follow the prime at long SOAs. Alternately, semantically related primes might be used strategically to aid responding after target identification. The effects of masked orthographic primes (e.g., judpe-JUDGE), in contrast, are assumed to be strictly lexical and automatic. Lexical processing of …


Top-Down And Bottom-Up Effects On Collembola Communities In Soil Food Webs, Jordan Kustec Dec 2018

Top-Down And Bottom-Up Effects On Collembola Communities In Soil Food Webs, Jordan Kustec

Electronic Thesis and Dissertation Repository

Anthropogenic changes are causing shifts within soil food web communities, which may alter ecosystem processes such as nutrient cycling, carbon storage and decomposition. I quantified ecological stressor effects on the abundance, richness, community composition and body size of a soil-dwelling microarthropod (Collembola: Hexapoda). I quantified the effects of warming and nitrogen deposition in two separate field studies and demonstrated that warming shifts Collembola community structure and decreases community body size. I quantified the interactive effects of top-down and bottom-up forces mediated by warming as ecological stressors in Collembola communities. I found that bottom-up effects of nutrient addition did not affect …


The Effects Of Emotionally Salient Unimodal And Multimodal Stimuli On Low-Level Visual Perception, Stephen Raymond Pierzchajlo Dec 2018

The Effects Of Emotionally Salient Unimodal And Multimodal Stimuli On Low-Level Visual Perception, Stephen Raymond Pierzchajlo

Electronic Thesis and Dissertation Repository

Sensory information can both impair and enhance low-level visual feature processing, and this can be significantly modulated depending on the whether this information matches the visual sensory modality. Emotionally significant visual and auditory stimuli can have opposing effects on attention. While task-irrelevant emotionally salient visual stimuli can often impair task attention, task-irrelevant emotionally salient auditory stimuli have been shown to enhance aspects of attention. To date, no study has directly compared how emotionally salient information presented to different sensory modalities can affect low-level vision. Using Gabor patches of differing contrasts to measure the threshold of visual perception, we hypothesized that …


Electroacoustic Assessment Of Hearing Aids And Psaps, Manan Sheel Dec 2018

Electroacoustic Assessment Of Hearing Aids And Psaps, Manan Sheel

Electronic Thesis and Dissertation Repository

Hearing aids and personal sound amplification products (PSAPs) are commonly used assistive devices for treating hearing loss. Due to the diversity in the hardware and signal processing algorithms in these devices, comprehensive verification of their performance is essential. Existing standards for assistive hearing devices are primarily used for quality control purposes and do not quantify their performance in a perceptually-relevant manner. This thesis developed a comprehensive electroacoustic testing toolbox for hearing devices that encompasses both quality control and perceptually-relevant measures. In particular, a test sequence was developed to assess the effectiveness of noise reduction feature in assistive hearing devices. Several …


Sequential Congruency Effects In Monolingual And Bilingual Adults: A Failure To Replicate Grundy Et Al. (2017), Samantha F. Goldsmith, J. Bruce Morton Dec 2018

Sequential Congruency Effects In Monolingual And Bilingual Adults: A Failure To Replicate Grundy Et Al. (2017), Samantha F. Goldsmith, J. Bruce Morton

Brain and Mind Institute Researchers' Publications

Previous research suggests bilingual adults show smaller sequential congruency effects than monolingual adults. Here we re-examined these findings by administering an Eriksen flanker task to monolingual and bilingual adults. The task produced robust conventional and sequential congruency effects. Neither effect differed for monolingual and bilingual adults. Results are discussed in terms of current debates concerning differences in cognitive control between monolingual and bilingual adults.


Jingle, A Jcmt Legacy Survey Of Dust And Gas For Galaxy Evolution Studies - I. Survey Overview And First Results, Amélie Saintonge, Christine D. Wilson, Ting Xiao, Lihwai Lin, Ho Seong Hwang, Tomoka Tosaki, Martin Bureau, Phillip J. Cigan, Christopher J.R. Clark, David L. Clements, Ilse De Looze, Thavisha Dharmawardena, Yang Gao, Walter K. Gear, Joshua Greenslade, Isabella Lamperti, Jong Chul Lee, Cheng Li, Michal J. Michałowski, Angus Mok, Hsi An Pan, Anne E. Sansom, Mark Sargent, Matthew W. Matthew, Thomas Williams, Chentao Yang, Ming Zhu, Gioacchino Accurso, Pauline Barmby Dec 2018

Jingle, A Jcmt Legacy Survey Of Dust And Gas For Galaxy Evolution Studies - I. Survey Overview And First Results, Amélie Saintonge, Christine D. Wilson, Ting Xiao, Lihwai Lin, Ho Seong Hwang, Tomoka Tosaki, Martin Bureau, Phillip J. Cigan, Christopher J.R. Clark, David L. Clements, Ilse De Looze, Thavisha Dharmawardena, Yang Gao, Walter K. Gear, Joshua Greenslade, Isabella Lamperti, Jong Chul Lee, Cheng Li, Michal J. Michałowski, Angus Mok, Hsi An Pan, Anne E. Sansom, Mark Sargent, Matthew W. Matthew, Thomas Williams, Chentao Yang, Ming Zhu, Gioacchino Accurso, Pauline Barmby

Physics and Astronomy Publications

JINGLE is a new JCMT legacy survey designed to systematically study the cold interstellar medium of galaxies in the local Universe. As part of the survey we perform 850 μm continuum measurements with SCUBA-2 for a representative sample of 193 Herschel-selected galaxies with M* > 109 M⊙, as well as integrated CO(2-1) line fluxes with RxA3m for a subset of 90 of these galaxies. The sample is selected from fields covered by the Herschel-ATLAS survey that are also targeted by the MaNGA optical integral-field spectroscopic survey. The new JCMT observations combined with the multiwavelength ancillary data will allow for the robust …


Tension Analysis In Survivor Interviews: A Computational Approach, Jumayel Islam Dec 2018

Tension Analysis In Survivor Interviews: A Computational Approach, Jumayel Islam

Electronic Thesis and Dissertation Repository

Tension is an emotional experience that can occur in different contexts. This phenomenon can originate from a conflict of interest or uneasiness during an interview. In some contexts, such experiences are associated with negative emotions such as fear or distress. People tend to adopt different hedging strategies in such situations to avoid criticism or evade questions.

In this thesis, we analyze several survivor interview transcripts to determine different characteristics that play crucial roles during tension situation. We discuss key components of tension experiences and propose a natural language processing model which can effectively combine these components to identify tension points …


Objective Assessment Of Machine Learning Algorithms For Speech Enhancement In Hearing Aids, Krishnan Parameswaran Dec 2018

Objective Assessment Of Machine Learning Algorithms For Speech Enhancement In Hearing Aids, Krishnan Parameswaran

Electronic Thesis and Dissertation Repository

Speech enhancement in assistive hearing devices has been an area of research for many decades. Noise reduction is particularly challenging because of the wide variety of noise sources and the non-stationarity of speech and noise. Digital signal processing (DSP) algorithms deployed in modern hearing aids for noise reduction rely on certain assumptions on the statistical properties of undesired signals. This could be disadvantageous in accurate estimation of different noise types, which subsequently leads to suboptimal noise reduction. In this research, a relatively unexplored technique based on deep learning, i.e. Recurrent Neural Network (RNN), is used to perform noise reduction and …


True North Strong Canada 150: Canadian Identity And Its Contribution To Doping Free Sport, Helena A. Hlas Dec 2018

True North Strong Canada 150: Canadian Identity And Its Contribution To Doping Free Sport, Helena A. Hlas

Electronic Thesis and Dissertation Repository

This thesis, a reflective piece inspired by “Canada 150” events, explores the psychosocial and sociocultural factors surrounding the ongoing evolution of the clean sport movement in Canada. A literature review recounts the critical events in the history of doping, viz. the Ben Johnson scandal, which resulted in a call to overhaul sport culture and realign it with fair play values. Theories in sports philosophy and psychology provide a further understanding of the meaning of sport, and psychosocial factors that are inextricably linked to doping behavior, respectively. The autoethnographic method provides insight into current Canadian values to compare with those in …


On The Space/Time Of Information Literacy, Higher Education, And The Global Knowledge Economy, Karen Patricia Nicholson Dec 2018

On The Space/Time Of Information Literacy, Higher Education, And The Global Knowledge Economy, Karen Patricia Nicholson

FIMS Publications

Local sites and practices of information work become embroiled in the larger imperatives and logics of the global knowledge economy through social, technological, and spatial networks. Drawing on human geography’s central claim that space and time are dialectically produced through social practices, in this essay I use human/critical geography as a framework to situate the processes and practices—the space and time—of information literacy within the broader social, political, and economic environments of the global knowledge economy. As skills training for the knowledge economy, information literacy lies at the intersection of the spatial and temporal spheres of higher education as the …


Bastard Reasoning: A "Preposterous" History Of Walter Benjamin's Ideas, Vladimir Cristache Dec 2018

Bastard Reasoning: A "Preposterous" History Of Walter Benjamin's Ideas, Vladimir Cristache

Electronic Thesis and Dissertation Repository

This dissertation presents the theory of ideas developed by Walter Benjamin in the “Epistemo-Critical Prologue” of his Trauerspiel book and thereby seeks to fill an existing gap in English-language Benjamin literature. On the one hand, it performs its task by closely reading this thinker’s early, epistemo-linguistic writings up to and including the “Prologue”: most prominently, “On Language as Such,” “The Program of the Coming Philosophy,” “The Concept of Criticism,” and the theoretically inclined sections of “Goethe’s Elective Affinities.” On the other, it does so by positioning Benjamin’s theory of language within existentialist philosophy and by applying his theory of …


Experimental Testing And Modeling Of Partial Nitrification At Different Temperatures, Xiaoguang Liu Dec 2018

Experimental Testing And Modeling Of Partial Nitrification At Different Temperatures, Xiaoguang Liu

Electronic Thesis and Dissertation Repository

Nitrogen in wastewater treatment plant effluents has adverse environmental effects on aquatic systems. Excessive concentrations of nitrogen in water bodies can result in the depletion of dissolved oxygen, deterioration of water quality, and shifts of biotic community. Conventional biological nitrogen removal (BNR) processes consume high energy for nitrification and require external carbon for denitrification. Alternatively, partial nitrification is of interest as an emerging technology for its lower need of organic carbon addition and cost savings in aeration. In this study, the main objectives are: 1- developing a mathematical model involving operational parameters for the determination of successful partial nitrification conditions; …


Multiwavelength, Machine Learning, And Parallax Studies Of X-Ray Binaries In Three Local Group Galaxies, Robin Arnason Dec 2018

Multiwavelength, Machine Learning, And Parallax Studies Of X-Ray Binaries In Three Local Group Galaxies, Robin Arnason

Electronic Thesis and Dissertation Repository

X-ray binary stars are rare systems consisting of a black hole or neutron star and a main-sequence companion star. They are useful probes of galaxy properties and interesting laboratories for extreme physical conditions. In this thesis, I investigated the X-ray binary population of three galaxies in the Local Group.

The Sculptor Dwarf Spheroidal Galaxy offers the chance to study a primordial low-mass X-ray binary (LMXB) population in an isolated, low-metallicity environment. Combining X-ray, optical, and infrared observations, I have studied nine previously-identified and discovered four additional LMXB candidates in this galaxy. Of these candidates, all but one are either background …


Effect Of Bacterial Superantigens On The Magnitude And Breadth Of Influenza-Specific Cd8+ T Cell Responses, Courtney Meilleur Dec 2018

Effect Of Bacterial Superantigens On The Magnitude And Breadth Of Influenza-Specific Cd8+ T Cell Responses, Courtney Meilleur

Electronic Thesis and Dissertation Repository

Severe cases of influenza A virus (IAV) infection are often complicated by concomitant bacterial pneumonia or sepsis. Many bacterial species are capable of producing potent immunomodulators called superantigens (SAgs), which have the potential to interfere with cell-based antiviral immune mechanisms. I asked what effects bacterial SAgs have on both the magnitude and the breadth of antiviral CD8+ T cell (TCD8+) responses. Surprisingly, administration of SAgs to mice shortly before or after vaccination with IAV increased the number of primary TCD8+ responding to select IAV-derived epitopes. T cell receptor staining of these SAg-augmented populations revealed expression of …


Examining Climate Change-Health Nexus In Ghana, Lucia Kafui Hussey Dec 2018

Examining Climate Change-Health Nexus In Ghana, Lucia Kafui Hussey

Electronic Thesis and Dissertation Repository

Climate change is one of today’s most pressing global issues with its physical, biological and social impacts widely recognized. One area of concern is its potential health consequences. The postulated health effects from climate change are far-reaching that climate change induced health risks are signaled as the most pressing problems to public health in the 21st century. Although developing countries such as Ghana had been suggested as a vulnerable hotspot for the health consequences of climate change, there is a paucity of empirical research on climate change and its health linkages in the country.

The purpose of this dissertation …


Conceptual Representation In Bilinguals: A Feature-Based Approach, Eriko Matsuki Dec 2018

Conceptual Representation In Bilinguals: A Feature-Based Approach, Eriko Matsuki

Electronic Thesis and Dissertation Repository

A challenge for bilinguals is that translation equivalent words often do not convey exactly the same conceptual information. A bilingual exhibits a “semantic accent” when they comprehend or use a word in one language in a way that is influenced by knowledge of its translation equivalent. Semantic accents are well-captured by feature-based models, such as the Distributed Conceptual Feature model and the Shared (Distributed) Asymmetrical model, however, few empirical studies have used semantic features to provide direct evidence for these models. The goal of this thesis is to use a feature-based approach to identify conceptual differences in translation equivalent words …


Performance Of Single And Groups Of Hollow Bar Micropiles In Sand, Maged Abdlrahem Dec 2018

Performance Of Single And Groups Of Hollow Bar Micropiles In Sand, Maged Abdlrahem

Electronic Thesis and Dissertation Repository

Micropiles offer an efficient load transfer mechanism, which facilitates carrying considerable load in compression and tension. Recently, hollow bar micropiles (HBMP) have gained wide acceptance due to their fast installation and small installation equipment, which allows installation in sites with limited access. The HBMP is commonly constructed using a drill bit/ hollow bar diameter ratio (Db/Dh) of around 2, and they are typically designed assuming type B micropiles as classified by the Federal Highway Administration (FHWA). However, increasing the drill bit diameter should increase the micropile diameter and hence may enhance its performance and increase its …


Sgps 9105a: United Way Counselling Programs, Ebenezer Narh, Sarah Moroz, Doan Nguyen, Mahshid Nasiri, Tamara Hluchaniuk Dec 2018

Sgps 9105a: United Way Counselling Programs, Ebenezer Narh, Sarah Moroz, Doan Nguyen, Mahshid Nasiri, Tamara Hluchaniuk

Community Engaged Learning Final Projects

In the efforts to build strong communities and promote well-being for community members, three Counselling Programs (Anova, Daya, JHS) were organized by United Way. This report is an assessment of the effectiveness of the program using the Program survey conducted both before and after the counseling sessions. This year, there was an increase in the number of people taking the pre-program survey with 506 people against 462 of last year. In contrast, the number for the post-program survey for 2017/2018 saw a slightly decrease compared to last year. This is partly because some of the participants have not completed the …


Sgps 9105a: United Way Summer Camping Programs, Ebenezer Narh, Tamara Hluchaniuk, Mahshid Nasiri, Doan Nguyen, Sarah Moroz Dec 2018

Sgps 9105a: United Way Summer Camping Programs, Ebenezer Narh, Tamara Hluchaniuk, Mahshid Nasiri, Doan Nguyen, Sarah Moroz

Community Engaged Learning Final Projects

The following report is an analysis of five summer camp programs in partnership with United Way Elgin Middlesex. The data were collected from the following summer camping programs: Boys and Girls Club of London (BGCL); Pearce Williams Summer Camp (PWSC); SARI Therapeutic Riding (SARI) ; Stevenson Children’s Camp (SCC); and YMCA Western Ontario (YMCA). The survey from which the data was gathered from was created to measure outcomes such as: Personal development, Self-confidence, Friendships, Fun and enjoyment The first part of the report combines all the camping programs for quantitative analysis by year – 2016, 2017 and 2018. The second …


Studio Recital, Tina Yanchus, James Hibbard Dec 2018

Studio Recital, Tina Yanchus, James Hibbard

All Don Wright Faculty of Music Concert Programs

No abstract provided.


19f-Mri To Monitor Therapeutic Cell Migration And Distribution, Corby Fink Dec 2018

19f-Mri To Monitor Therapeutic Cell Migration And Distribution, Corby Fink

Electronic Thesis and Dissertation Repository

A major hurdle hindering the advancement of cell-based cancer vaccines is the inability to non-invasively track in vivo therapeutic cell migration. Within cancer immunotherapy, antigen presenting cell-based (APC) immunotherapies can be dendritic cell-based (DC) and elicit de novo anti-tumor immune responses or formulated as mixed APC-based immunotherapy generated from peripheral blood mononuclear cells (PBMC). Mixed APC-based therapies contain monocytes and B cells as APC and can enhance a pre-existing anti-tumor immune response such that objective anti-tumor responses are observed. In either APC-based formulation, the quantity of anti-tumor APC reaching a secondary lymphoid organ post injection is predictive of the magnitude …