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Virginia Commonwealth University

2013

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Differential Effects Of Endocannabinoid Catabolic Inhibitors On Opioid Withdrawal In Mice, Thomas Gamage Dec 2013

Differential Effects Of Endocannabinoid Catabolic Inhibitors On Opioid Withdrawal In Mice, Thomas Gamage

Theses and Dissertations

The effects of cannabinoids in reducing somatic signs of opioid withdrawal have been known for some time. In morphine dependent rodents, opioid withdrawal following precipitation with the mu opioid antagonist naloxone elicits robust withdrawal behaviors including jumps, paw flutters, head shakes, diarrhea and weight loss. Delta-9-tetrahydrocannabinol has been shown to reduce this opioid withdrawal in mice via activation of the cannabinoid type-1 (CB1) receptor and recently it has been shown that inhibition of the catabolic enzymes for endocannabinoids also reduce somatic signs of opioid withdrawal. Specifically, inhibition the enzyme fatty acid amide hydrolase (FAAH), the catabolic enzyme for the endocannabinoid …

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Environmental Regulation Of Tidal Wetland Microbial Communities And Associated Biogeochemistry, Ember Morrissey Dec 2013

Environmental Regulation Of Tidal Wetland Microbial Communities And Associated Biogeochemistry, Ember Morrissey

Theses and Dissertations

Microbial communities play an essential role in carrying out the biogeochemical cycles that sustain life on Earth, yet we know very little about their ecology. One question of particular interest is how environmental conditions shape microbial community structure (i.e., the types of organisms found in the community and their relative abundance), and whether such changes in structure are related to biogeochemical function. It is the aim of this dissertation to address this question via the examination of carbon (C) and nitrogen (N) cycling in wetland ecosystems, which due to their diverse hydrology have a profound influence on biogeochemical cycles. With …

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“Cause That’S The Only Skills In School You Need” A Qualitative Analysis Of Revenge Goals In Poor Urban Youth, Lena Janina Jäggi Dec 2013

“Cause That’S The Only Skills In School You Need” A Qualitative Analysis Of Revenge Goals In Poor Urban Youth, Lena Janina Jäggi

Theses and Dissertations

Ample research shows that revenge goals are correlated with maladjustment and retaliation is an important factor driving youth violence. Still, in environments with limited institutionalized interventions revenge might be an indispensable tool to maintain social equilibrium. This qualitative secondary analysis of 50 (30 Boys) revenge scenarios from a larger longitudinal study (N=358 dyads of youth/maternal caregiver) expands existing one-dimensional knowledge of revenge from closed-answer vignettes to the rich real world experience of 10-16 year old youth from an urban community sample. Key findings showed significant qualitative differences in both cognition and emotions of revenge scenarios. Ten distinct patterns emerged and …

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Real Time Monitoring Of Surface Chemical Events By Streaming Potentials In Microfluidic Channels, Kenji Nokura Dec 2013

Real Time Monitoring Of Surface Chemical Events By Streaming Potentials In Microfluidic Channels, Kenji Nokura

Theses and Dissertations

Zeta potential is one of the tools to measure the surface charge of materials, and Alvarez et al. have developed a microchannel device to measure zeta potentials in real time for label-free sensing using immobilized receptors on microchannel surfaces. However, the challenge has been the charge interference of surface modifiers on analyte detection. Therefore, it was necessary to find the best strategy to regenerate minimal surface charge after modifying the channel with polymer films that would anchor the affinity groups for the analyte. It was demonstrated that adsorption of positively and negatively charged analytes were monitored via real time zeta …

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Discovering Driver Somatic Mutations, Copy Number Alterations And Methylation Changes Using Markov Chain Monte Carlo, Bokhari Yahya Dec 2013

Discovering Driver Somatic Mutations, Copy Number Alterations And Methylation Changes Using Markov Chain Monte Carlo, Bokhari Yahya

Theses and Dissertations

Nowadays we have tremendous amount of genetic data needing to be interpreted. Somatic mutations, copy number variations and methylation are example of the genetics data we are dealing with. Discovering driver mutations from these combined data types is challenging. Mutations are unpredictable and have broad heterogeneity, which makes our goal hard to accomplish. Many methods have been proposed to solve the mystery of genetics of cancer. In this project we manipulate those above mentioned genetics data types and choose to use and modified an existing method utilizing Markov Chain Monte Carlo (MCMC). The method introduced two properties, coverage and exclusivity. …

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Localization Of Auditory Spatial Targets In Sighted And Blind Subjects, Richard Nuckols Dec 2013

Localization Of Auditory Spatial Targets In Sighted And Blind Subjects, Richard Nuckols

Theses and Dissertations

This research was designed to investigate the fundamental nature in which blind people utilize audible cues to attend to their surroundings. Knowledge on how blind people respond to external spatial stimuli is expected to assist in development of better tools for helping people with visual disabilities navigate their environment. There was also interest in determining how blind people compare to sighted people in auditory localization tasks. The ability of sighted individuals, blindfolded individuals, and blind individuals in localizing spatial auditory targets was assessed. An acoustic display board allowed the researcher to provide multiple sound presentations to the subjects. The subjects’ …

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The Design And Validation Of A Computational Rigid Body Model For Study Of The Radial Head, Cassandra Woodcock Dec 2013

The Design And Validation Of A Computational Rigid Body Model For Study Of The Radial Head, Cassandra Woodcock

Theses and Dissertations

Rigid body modeling has historically been used to study various features of the elbow joint including both physical and computational models. Computational modeling provides an inexpensive, easily customizable, and effective method by which to predict and investigate the response of a physiological system to in vivo stresses and applied perturbations. Utilizing computer topography scans of a cadaveric elbow, a virtual representation of the joint was created using the commercially available MIMICS(TM) and SolidWorks(TM) software packages. Accurate 3D articular surfaces, ligamentous constraints, and joint contact parameters dictated motion. The model was validated against two cadaveric studies performed by Chanlalit et al. …

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The United States Holocaust Memorial Museum’S Multivalent Tower Of Faces, Grace Astrove Dec 2013

The United States Holocaust Memorial Museum’S Multivalent Tower Of Faces, Grace Astrove

Theses and Dissertations

Holocaust survivor Dr. Yaffa Eliach collected over 6,000 photographs depicting residents of Eishyshok, a small Jewish settlement in Eastern Europe, taken between 1890 and 1941. Eliach survived the Nazi-led massacre in 1941 that killed nearly the entire Jewish population of Eishyshok. As a way to commemorate the destroyed town of her youth she began to collect photographs from other survivors and residents who fled Europe prior to the Holocaust. She subsequently selected 1,032 photographs from the Yaffa Eliach Shtetl Collection for display in The Tower of Faces, a permanent exhibition in The United States Holocaust Memorial Museum, located in Washington, …

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Materials And Meaning, Michael Corigliano Dec 2013

Materials And Meaning, Michael Corigliano

Theses and Dissertations

Decisive moments and their fleeting experiences are born from an individual’s interaction within a defined physical space. It is here at the intersection of environment and context that my work in site-specific art begins. I endeavor to create an examination of socio-political and environmental issues through a manipulation of materials, thereby altering one’s private, communal, and cultural response to them. My installations are comprised of slip casted multiples which reference the human form. I place these forms in galleries and specific exterior locations, and incorporate materials that are charged with societal discord, such as used motor oil and post-consumer detritus, …

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Examination Of The Effect Of Different Training Metrics On Performance Of A Minimally Invasive Surgery Transfer Task, Cristofer Madera Dec 2013

Examination Of The Effect Of Different Training Metrics On Performance Of A Minimally Invasive Surgery Transfer Task, Cristofer Madera

Theses and Dissertations

The purpose of this experiment was to determine if there existed techniques to more efficiently train prospective surgeons the skills necessary to capably perform minimally invasive surgical procedures. Also, we wanted to know if trainees could be pushed to cognitively define a laparoscopic environment with a novel hand-eye relationship. To explore these questions, a simulation was setup wherein subjects would perform a laparoscopic transfer task and receive active feedback during training. Different subjects would receive different metrics as feedback and a comparison would be made between subjects with respect to standard metrics. Results of this experiment show that all subjects …

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Synthesis, Characterization, And Functionalization Of Magnetic Iron Nanoparticles For Enhanced Biological Applications, Christopher Warren Dec 2013

Synthesis, Characterization, And Functionalization Of Magnetic Iron Nanoparticles For Enhanced Biological Applications, Christopher Warren

Theses and Dissertations

The transition metal ferrites of composition MFe2O4 where M is Fe, Co, or Ni are well established materials for various biological applications due to their interesting magnetic properties. Their elemental and stochiometric composition can be easily manipulated which allows further tuning of their ferrimagnetic properties. By changing the identity of M and by changing the crystallite size of the ferrites, nanocrystals with diverse magnetic properties can be systematically produced. Furthermore, ferrites are more stable in diverse chemical environments, as compared to metallic nanoparticles, which make ferrites particularly useful for a broad range of biomedical applications, especially in the field of …

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Accelerating Computational Algorithms, Michael Risley Dec 2013

Accelerating Computational Algorithms, Michael Risley

Theses and Dissertations

Mathematicians and computational scientists are often limited in their ability to model complex phenomena by the time it takes to run simulations. This thesis will inform interested researchers on how the development of highly parallel computer graphics hardware and the compiler frameworks to exploit it are expanding the range of algorithms that can be explored on affordable commodity hardware. We will discuss the complexities that have prevented researchers from exploiting advanced hardware as well as the obstacles that remain for the non-computer scientist.

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Tobramycin Disposition In The Lung Following Airway Administration, Min Li Dec 2013

Tobramycin Disposition In The Lung Following Airway Administration, Min Li

Theses and Dissertations

Tobramycin disposition following airway administration was evaluated by meta-analysis of human data in the literature and, experimentally, using a realistic ex vivo model, the isolated perfused rat lung preparation (IPRL). Pulmonary bioavailability of inhaled tobramycin in published studies was re-evaluated separately for CF and healthy adults, with the drug’s intrinsic pharmacokinetic (PK) parameters obtained from intravenous (IV) studies in the literature. While large variations in tobramycin’s clearance precluded accurate assessment of its bioavailability, the results were indicative of substantial pulmonary absorption, in spite of its hydrophilic and poly cationic properties. To explore its disposition kinetics and mechanisms following airway administration, …

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Clostridium Difficile Infection Occurrence In Academic Health Centers: Do Organizational Factors Matter?, Amy Pakyz Dec 2013

Clostridium Difficile Infection Occurrence In Academic Health Centers: Do Organizational Factors Matter?, Amy Pakyz

Theses and Dissertations

Healthcare-associated infections occur commonly in hospitals and have a major impact on patient well-being. The occurrence of the healthcare-associated infection, Clostridium difficile, has been occurring more frequently among hospitalized patients due to an epidemic strain, and is an important cause of antibiotic-associated diarrhea and colitis. This study examined the impact of several organizational factors on the occurrence of C. difficile infection (CDI) in hospitals using an institutional theory perspective. Administrative claims were utilized from University HealthSystem Consortium hospitals to obtain hospital-level data for the calendar year 2011. Data were available for 89 hospitals. Hospital-level analyses, negative binomial regression models, were …

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The Response Of Naive Channel Catfish To Chemical Cues Associated With Predation, Marinda Coulter Dec 2013

The Response Of Naive Channel Catfish To Chemical Cues Associated With Predation, Marinda Coulter

Theses and Dissertations

The chemosensory abilities of fishes, are important in order to understand how prey can perceive and avoid predators. Predator-naïve Channel catfish were exposed to four extracts over eight sessions (naïve bass water (NBW), bass that were fed catfish water (BFCW), catfish skin extract (CS), and naïve bass water paired with catfish skin extract (CO)) to determine whether they have an innate predator response to potential chemical cues indicating possible predation risk. Movement was quantified as grid squares crossed, directional changes, and tail beats. Response increased during the first minute following stimulus injection and decreased during the second minute. Channel catfish …

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Multi-Column Multi-Layer Computational Model Of Neocortex, Beata Strack Dec 2013

Multi-Column Multi-Layer Computational Model Of Neocortex, Beata Strack

Theses and Dissertations

We present a multi-layer multi-column computational model of neocortex that is built based on the activity and connections of known neuronal cell types and includes activity-dependent short term plasticity. This model, a network of spiking neurons, is validated by showing that it exhibits activity close to biology in terms of several characteristics: (1) proper laminar flow of activity; (2) columnar organization with focality of inputs; (3) low-threshold-spiking (LTS) and fast-spiking (FS) neurons function as observed in normal cortical circuits; and (4) different stages of epileptiform activity can be obtained with either increasing the level of inhibitory blockade, or simulation of …

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Analysis Of Mathematical Models Of The Human Lung, Cooper Racheal Dec 2013

Analysis Of Mathematical Models Of The Human Lung, Cooper Racheal

Theses and Dissertations

The processes of lung ventilation and perfusion, diffusion, and gas transport make up the system of breathing and tissue oxygenation. Here, we present several mathematical formulations of the essential processes that contribute to breathing. These models aid in our understanding and analysis of this complex system and can be used to form treatments for patients on ventilators. With the right analysis and treatment options, patients can be helped and money can be saved. We conclude with the formulation of a mathematical model for the exchange of gasses in the body based on basic reaction kinetics.

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A New Beginning, Nancy Rae Habit Dec 2013

A New Beginning, Nancy Rae Habit

Theses and Dissertations

Artist Statement My artwork reflects elements of simple, everyday life. I find poignancy in people as they go about their daily business, children playing on the beach or an elderly woman at her kitchen stove. And, it’s not just people in whom I find intrigue. The creases and folds of crumpled, brown paper bags; fresh fish lying on crushed ice in outdoor markets; and household objects, such as chairs, irons, and wooden spoons are the types of things that are also evidence of daily life. In my work, I strive to replicate with both accuracy and emotion all of these …

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Who's Your Daddy? A Study Of Extra-Pair Copulation And Mating Behaviors Of Protonotaria Citrea, Morton Catherine Heidrich Dec 2013

Who's Your Daddy? A Study Of Extra-Pair Copulation And Mating Behaviors Of Protonotaria Citrea, Morton Catherine Heidrich

Theses and Dissertations

Mating behavior has a profound impact on reproductive success and the resulting genetic structure of offspring. Extra-pair copulation is a widely observed behavior within avian species. This study explored the genetic effects of mating behaviors of Prothonotary warblers, Protonotaria citrea (Parulidae), using co-dominant microsatellite markers. Prothonotary warblers are migratory songbirds that build nests in cavities, commonly found in wetland habitats. A set of artificial nest boxes were initiated by Dr Robert Reilly in 2002 in Dutch Gap, Chesterfield County Virginia, USA, a tidal tributary off the James River. From this population, 28 nest boxes were surveyed yielding 47 adults and …

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Family Processes As Moderators Of The Impact Of Peer, School, And Neighborhood Influences On Adolescent Aggression, Alison Kramer-Kuhn Dec 2013

Family Processes As Moderators Of The Impact Of Peer, School, And Neighborhood Influences On Adolescent Aggression, Alison Kramer-Kuhn

Theses and Dissertations

Despite theoretical support for the role of the family in providing a foundation to protect youth against risks for aggression, there is little published literature examining a protective influence. This study examined family functioning and perceived parental messages about fighting and nonviolence as moderators of the relation between risk factors and adolescent aggression. The specific risk factors included affiliating with a delinquent group of peers, attending a school with norms that support aggression, and witnessing violence within the community. Secondary analyses were conducted on data collected from a high-risk sample of 537 adolescents in 2 cohorts from 18 schools. Adolescents …

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Dissecting Emotion, Jennifer Lopresti Dec 2013

Dissecting Emotion, Jennifer Lopresti

Theses and Dissertations

My art making approach has enabled me to focus on the connection between our anatomical makeup and the inner workings of the mind. It has been a journey to personally bridge the gap between the two and to make sense of the overlapping functions. Anatomical imagery has lent itself to my exploration into the topics of transformation and social interaction, and the emotions that are tied to these concepts. My body of work consists of mixed media and sculptural pieces. I make use of found objects such as vinyl records, rotary phones, and old black and white photographs. These items …

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Transcriptional Crosstalk Between Helper Bacteriophages And Staphylococcal Aureus Pathogenicity Islands, Kristin Lane Dec 2013

Transcriptional Crosstalk Between Helper Bacteriophages And Staphylococcal Aureus Pathogenicity Islands, Kristin Lane

Theses and Dissertations

Acquisition of a superantigen pathogenicity island (SaPI) significantly increases virulence in Staphylococcus aureus. Horizontal transfer of SaPIs occurs at high frequency and depends upon a helper bacteriophage, either through direct infection or SOS-mediated induction of a lysogen. SaPIs hijack the packaging machinery of the helper phage, leading to the formation of SaPI-containing transducing particles that can introduce the pathogenicity island into neighboring SaPI-negative cells. All SaPIs contain a conserved core of genes, some of which are co-transcribed as an operon and encode functions involved in helper exploitation. The goal of this study was to more fully understand the intricate relationships …

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Forced Kinship, Lauren Leake Dec 2013

Forced Kinship, Lauren Leake

Theses and Dissertations

My oil paintings, glass works, and mixed media are abstract meditations on familial relationships and their boundaries. The interaction between colors and layers of pigment reference human interaction. I apply veils of colors, which obscure, alter, or blend into previous layers of color. These layers metaphorically reference how family relationships affect the person we are and influence who we become. I approach my oil paintings serially and often refer to them as sisters or a family. I often work on two or more canvases at a time allowing each painting to share palettes and a similar language of shapes. When …

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Patient-Specific Modeling Of Adult Acquired Flatfoot Deformity Before And After Surgery, Edward Meade Spratley Dec 2013

Patient-Specific Modeling Of Adult Acquired Flatfoot Deformity Before And After Surgery, Edward Meade Spratley

Theses and Dissertations

The use of computational modeling is an increasingly commonplace technique for the investigation of biomechanics in intact and pathological musculoskeletal systems. Moreover, given the robust and repeatable nature of computer simulation and the prevalence of software techniques for accurate 3-D reconstructions of tissues, the predictive power of these models has increased dramatically. However, there are no patient-specific kinematic models whose function is dictated solely by physiologic soft-tissue constraints, articular shape and contact, and without idealized joint approximations. Moreover, very few models have attempted to predict surgical effects combined with postoperative validation of those predictions. Given this, it is not surprising …

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Effects Of Thoracic Spinal Manipulative Therapy On Thoracic Spine And Shoulder Kinematics, Thoracic Spine Flexion/Extension Excursion, And Pressure Pain Sensitivity In Patients With Subacromial Pain Syndrome, Joseph Kardouni Dec 2013

Effects Of Thoracic Spinal Manipulative Therapy On Thoracic Spine And Shoulder Kinematics, Thoracic Spine Flexion/Extension Excursion, And Pressure Pain Sensitivity In Patients With Subacromial Pain Syndrome, Joseph Kardouni

Theses and Dissertations

EFFECTS OF THORACIC SPINAL MANIPULATIVE THERAPY ON THORACIC SPINE AND SHOULDER KINEMATICS, THORACIC SPINE FLEXION/EXTENSION EXCURSION, AND PRESSURE PAIN SENSITIVITY IN PATIENTS WITH SUBACROMIAL PAIN SYNDROME By Joseph R. Kardouni, Ph.D., PT A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy, at Virginia Commonwealth University. Virginia Commonwealth University, 2013. Major Director: Lori A. Michener, PhD, PT, ATC, Professor, Department of Physical Therapy In patients with shoulder pain, the use of manual therapy directed at the spine and shoulder have been reported to provide superior outcomes to exercise based interventions or usual care without …

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The Journal Of Elizabeth Maxwell Alsop Wynne, 1862-1878, Andrew Talkov Dec 2013

The Journal Of Elizabeth Maxwell Alsop Wynne, 1862-1878, Andrew Talkov

Theses and Dissertations

The experiences of Southern women during the American Civil War are often represented through the publication of their journals, diaries, and memoirs. This project consists of the transcription and annotation of the journal of Elizabeth (“Lizzie”) Maxwell Alsop Wynne, written from March 4, 1862, through March 20, 1878. During her most intense period of writing from 1862 to 1866, Lizzie Alsop recorded the effects of the American Civil War on an extensive network of friends and family in the Confederate capital at Richmond, Virginia, and at her home in Fredericksburg, Virginia. Lizzie’s journal offers valuable insight into the wartime politicization …

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Dead Virginians: The Corpse And Its Uses In Early Virginia, David Roettger Dec 2013

Dead Virginians: The Corpse And Its Uses In Early Virginia, David Roettger

Theses and Dissertations

The thesis traces the history of colonial Virginia in an attempt to uncover the origins of several peculiarities in Virginia death-ways. Elite Virginians buried at home more often than not (where they could protect the dead from animal desecration), while avoided death’s heads, reapers, and bone based tomb and mourning jewelry iconography even though such was popular throughout the British Atlantic. Research done for this thesis reveals a fear on the part of elite Virginias regarding questions of both corpse desecration and natural putrefaction. The cause of this cultural obsession lie in two facts: The blackening of the early colony’s …

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Metabolic Remodeling And Mitochondrial Dysfunction In Maladaptive Right Ventricular Hypertrophy Secondary To Pulmonary Arterial Hypertension, Jose Gomez-Arroyo Dec 2013

Metabolic Remodeling And Mitochondrial Dysfunction In Maladaptive Right Ventricular Hypertrophy Secondary To Pulmonary Arterial Hypertension, Jose Gomez-Arroyo

Theses and Dissertations

Right ventricular dysfunction is the most frequent cause of death in patients with pulmonary arterial hypertension. Although abnormal energy substrate use has been implicated in the development of chronic left heart failure, data describing such metabolic remodeling in failing right ventricular tissue remain incomplete. In the present dissertation we sought to characterize metabolic gene expression changes and mitochondrial dysfunction in functional and dysfunctional RV hypertrophy. Two different rat models of RV hypertrophy were studied. The model of right ventricular failure (SU5416/hypoxia) exhibited a significantly decreased gene expression of peroxisome proliferator-activated receptor- coactivator-1α, peroxisome proliferator- activated receptor-α and estrogen-related receptor-α. The …

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Richard Wagner's Jesus Von Nazareth, Matthew Giessel Dec 2013

Richard Wagner's Jesus Von Nazareth, Matthew Giessel

Theses and Dissertations

In addition to his renowned musical output, Richard Wagner produced a logorrhoeic prose oeuvre, including a dramatic sketch of the last weeks of the life of Jesus Christ entitled Jesus von Nazareth. Though drafted in 1848-1849, it was published only posthumously, and has therefore been somewhat neglected in the otherwise voluminous Wagnerian literature. This thesis first examines the origins of Jesus von Nazareth amidst the climate of revolution wherein it was conceived, ascertaining its place within Wagner’s own internal development and amongst the radical thinkers who influenced it. While Ludwig Feuerbach has traditionally been seen as the most prominent of …

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Speech In America: Tracking The Evolution Of Speech Pedagogy In Theatre Training, Zachary Campion Dec 2013

Speech In America: Tracking The Evolution Of Speech Pedagogy In Theatre Training, Zachary Campion

Theses and Dissertations

Speech work, as it relates to actor training, has undergone many important changes since its formal introduction to the field over a century ago by Edith Skinner. Unfortunately, there are many who hold on to antiquated, misinformed and often harmful approaches to this kind of training. This thesis questioned the traditional models of speech pedagogy by creating a narrative for its development, questioning its efficacy, and exploring the alternatives that have developed over the years. I looked at the texts and approaches of Edith Skinner, Patricia Fletcher, Louis Coliaini, and Dudley Knight/Phil Thompson. I acknowledge that each practitioner has made …

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