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University of Windsor

Electronic Theses and Dissertations

Theses/Dissertations

2003

Molecular.

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Parallel Stochastic Context-Free Grammar Training For Trna Secondary Structure Prediction., Kaiyuan. Shi Jan 2003

Parallel Stochastic Context-Free Grammar Training For Trna Secondary Structure Prediction., Kaiyuan. Shi

Electronic Theses and Dissertations

In this thesis, parallel computing methods are used to construct a stochastic context-free grammar for analyzing the secondary structure of tRNA molecules. Stochastic context-free grammars are basically probabilistic languages that parse a sequence/molecule and output its probability of whether or not it belongs to the sequence family modeled by the grammar and at the same time predict the molecule's secondary structure. Stochastic context-free grammars can be converted from corresponding context-free grammars, by assigning probabilities to the grammar's production rules. The use of stochastic context-free grammars to analyze the secondary structure of RNA molecules was limited due to time and space …


Electron-Cluster Interactions: Excitation Of Neutral Fragments In Rare Gases And Simple Molecules., Charles Patrick Malone Jan 2003

Electron-Cluster Interactions: Excitation Of Neutral Fragments In Rare Gases And Simple Molecules., Charles Patrick Malone

Electronic Theses and Dissertations

The presented work on electron-cluster interactions utilizes mass and translational spectroscopic techniques that have traditionally been applied to atomic and molecular targets.


The Impacts Of Polycyclic Aromatic Hydrocarbons On Brown Bullhead (Ameiurus Nebulosus) Apoptosis Regulation., Christopher Ronald Lindholm Busch Jan 2003

The Impacts Of Polycyclic Aromatic Hydrocarbons On Brown Bullhead (Ameiurus Nebulosus) Apoptosis Regulation., Christopher Ronald Lindholm Busch

Electronic Theses and Dissertations

In this study, it is hypothesized that the apoptotic pathways in the brown bullhead are altered by the presence of PAHs with a final outcome of elevated tumor formation. To evaluate the impact of PAHs on the apoptotic process, three separate, but related, studies were completed to characterise apoptosis in brown bullhead. First, the impact of known apoptotic inducers (staurosporine, cycloheximide, and TNF-alpha) on cell death in brown bullhead fibroblasts was characterized (Chapter 1). Secondly, fibroblasts were exposed to PAHs to examine how exposure to an environmentally relevant genotoxic substance alters the apoptotic pathway (Chapter 2). Finally, bullheads from various …