Digital Commons Network^™

Did The Adoption Of Ifrs Affect Corporate Tax Avoidance?, Oliver Nnamdi Okafor, Akinloye Akindayomi, Hussein Warsame

Economics and Finance Faculty Publications and Presentations

This article investigates whether the adoption of international financial reporting standards (IFRS) affected corporate tax avoidance in Canada. Based on a 3,200 firm-year data set of 400 publicly listed Canadian firms that adopted IFRS and 400 listed US firms, matched one-to-one using propensity score matching, the authors’ regression results show that IFRS adoption was followed by a decrease in corporate tax avoidance in Canada, at least in the short run. The study finds a significant increase in cash tax paid in the post-adoption period by Canadian firms that adopted IFRS compared to US firms that used US generally accepted accounting …

Blockchain Based Access Control For Enterprise Blockchain Applications, Lei Xu, Isaac Markus, Subhod I, Nikhil Nayab

Computer Science Faculty Publications and Presentations

Access control is one of the fundamental security mechanisms of IT systems. Most existing access control schemes rely on a centralized party to manage and enforce access control policies. As blockchain technologies, especially permissioned networks, find more applicability beyond cryptocurrencies in enterprise solutions, it is expected that the security requirements will increase. Therefore, it is necessary to develop an access control system that works in a decentralized environment without compromising the unique features of a blockchain. A straightforward method to support access control is to deploy a firewall in front of the enterprise blockchain application. However, this approach does not …

“If It Hadn’T Been For Writing, I Think I Would Have Lost My Mind:” Resilient Dwelling And Rhetorical Agency In Prison Writing, Maggie Shelledy

Writing and Language Studies Faculty Publications and Presentations

No abstract provided.

Liver Cancer: Current And Future Trends Using Biomaterials, Sue Anne Chew, Stefania Moscato, Sachin George, Bahareh Azimi, Serena Danti

Health & Biomedical Sciences Faculty Publications and Presentations

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review summarizes the current biomaterial-based approaches for systemic delivery and implantable tools …

Ssa Positivity As Predictor Of Relapse In Patients With Neuromyelitis Optica Spectrum Disorder, Roberto A. Cruz, Alexander B. Ramos, Bridget A. Bagert, Jesus F. Lovera

School of Medicine Publications and Presentations

No abstract provided.

Teaching In A Multicultural And Demanding Society, Khalid Aada

Writing and Language Studies Faculty Publications and Presentations

What does involve leading a new experience of teaching and learning under the new paradigm of a true knowledge society? Is it about mastering the teaching experience through critical reflection, or knowing the natural and social environment in its multiple interactions? Isn’t it about favoring an educational environment where students are not only limited to participate in a traditional way, but expect to find meaning to their learning experience and be able to build the acquired knowledge? This article allows to identify different stages in the new educational models within a multicultural environment. In other words, a field where teachers …

How To Promote Education For Sustainable Development? Vision Of The Educational Situation And Its Contribution To Sustainable Development., Khalid Aada

Writing and Language Studies Faculty Publications and Presentations

During the last decade, the importance of leaving a rational paradigm, debtor of functionalist and utilitarian models, towards another more congruent with the preservation of natural resources, and therefore of life, has been widely discussed. In the same way, different voices have been raised, pointing out the urgency of inserting these precepts into the educational field, hoping to achieve the true cultural transformation that is needed to consolidate the change. Multiple International Entities promote sustainability in Education as an initiative that should be ambitious, complex and reforming character, given the global scope of the social, economic and environmental situation affecting …

Experimental Study Of Condensation In A Thermoacoustic Cooler With Various 3d Printed Regenerators Using Water Vapor As The Working Fluid, Aibek Bekkulov, Andrew Luthen, Ben Xu

Mechanical Engineering Faculty Publications and Presentations

Thermoacoustics (TA) deals with the conversion of heat into sound and vice versa. The device that transfers energy from a low temperature reservoir to a high temperature one by utilizing acoustic work is called TA cooler (TAC). The main components of a typical TAC are a resonator, a porous regenerator (e.g. stack of parallel plates) and two heat exchangers. The thermoacoustic phenomenon takes place in the regenerator where a nonzero temperature gradient is imposed, and interacts with the sound wave. The low temperature at the cold end of TAC can be used to condense water from the humid air and …

Diet-Induced Leukocyte Telomere Shortening In A Baboon Model For Early Stage Atherosclerosis, Genesio M. Karere, Michael C. Mahaney, Deborah E. Newman, Angelica M. Riojas, Clint Christensen, Shifra Birnbaum, John L. Vandeberg, Laura Cox

School of Medicine Publications and Presentations

Reported associations between leukocyte telomere length (LTL) attrition, diet and cardiovascular disease (CVD) are inconsistent. This study explores effects of prolonged exposure to a high cholesterol high fat (HCHF) diet on LTL in a baboon model of atherosclerosis. We measured LTL by qPCR in pedigreed baboons fed a chow (n = 105) or HCHF (n = 106) diet for 2 years, tested for effects of diet on LTL, and association between CVD risk factors and atherosclerotic lesions with LTL. Though not different at baseline, after 2 years median LTL is shorter in HCHF fed baboons (P < 0.0001). Diet predicts sex- and age-adjusted LTL and LTL attrition (P = 0.0009 and 0.0156, respectively). Serum concentrations of CVD biomarkers are associated with LTL at the 2-year endpoint and LTL accounts approximately 6% of the variance in aortic lesions (P = 0.04). Although heritable at baseline (h2 = 0.27, P = 0.027) and after 2 years (h2 = 0.46, P = 0.0038), baseline LTL does not predict lesion extent after 2 years. Atherogenic diet influences LTL, and LTL is a potential biomarker for early atherosclerosis. Prolonged exposure to an atherogenic diet decreases LTL and increases LTL attrition, and shortened LTL is associated with early-stage atherosclerosis in pedigreed baboons.

Understanding Us Firm Efficiency And Its Asset Pricing Implications, Giovanni Calice, Levent Kutlu, Ming Zeng

Economics and Finance Faculty Publications and Presentations

We investigate the links between firm-level total factor productivity (TFP) growth and technical efficiency change, and their implications on firm-level stock returns. We estimate TFP growth of US firms between 1966 and 2015 and decompose TFP growth into returns to scale, technical progress, and technical efficiency change components. We show that most of the variation in TFP growth is explained by variation in technical efficiency change. Moreover, we examine the effects of important macro- and micro-level factors on inefficiency as well as its asset pricing implications. We find that low-efficiency firms are more vulnerable to a wide class of aggregate …

Quantum-Enhanced Advanced Ligo Detectors In The Era Of Gravitational-Wave Astronomy, M. Tse, Haocun Yu, N. Kijbunchoo, A. Fernandez-Galiana, P. Dupej, L. Barsotti, C. D. Blair, D. D. Brown, S. E. Dwyer, Karla E. Ramirez

Physics and Astronomy Faculty Publications and Presentations

The Laser Interferometer Gravitational Wave Observatory (LIGO) has been directly detecting gravitational waves from compact binary mergers since 2015. We report on the first use of squeezed vacuum states in the direct measurement of gravitational waves with the Advanced LIGO H1 and L1 detectors. This achievement is the culmination of decades of research to implement squeezed states in gravitational-wave detectors. During the ongoing O3 observation run, squeezed states are improving the sensitivity of the LIGO interferometers to signals above 50 Hz by up to 3 dB, thereby increasing the expected detection rate by 40% (H1) and 50% (L1).

Numerical Simulations Of The Hall–Petch Relationship In Aluminium Using Gradient-Enhanced Plasticity Model, Yooseob Song, Jaeheum Yeon, Byoungjoon Na

Civil Engineering Faculty Publications and Presentations

+e Hall-Petch relation in aluminium is discussed based on the strain gradient plasticity framework. +e thermodynamically consistent gradient-enhanced flow rules for bulk and grain boundaries are developed using the concepts of thermal activation energy and dislocation interaction mechanisms. It is assumed that the thermodynamic microstresses for bulk and grain boundaries have dissipative and energetic contributions, and in turn, both dissipative and energetic material length scale parameters are existent. Accordingly, two-dimensional finite element simulations are performed to analyse characteristics of the Hall–Petch strengthening and the Hall–Petch constants. +e proposed flow rules for the grain boundary are validated using the existing experimental …

Veru-111 Suppresses Tumor Growth And Metastatic Phenotypes Of Cervical Cancer Cells Through The Activation Of P53 Signaling Pathway, Vivek Kumar Kashyap, Nirnoy Dan, Neeraj Chauhan, Qinghai Wang, Saini Setua, Prashanth K. B. Nagesh, Shabnam Malik, Vivek Batra, Murali M. Yallapu, Duane D. Miller, Bilal B. Hafeez, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications and Presentations

In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the G2/M phase and modulated cell cycle regulatory proteins (cyclin B1, p21 p34cdc2 and pcdk1). Moreover, VERU-111 treatment induced apoptosis and modulated the expression of Bid, Bcl-xl, Survivin, Bax, Bcl2 …

Production Of Biscuits By Substitution With Different Ratios Of Yellow Pea Flour, Jikai Zhao, Xin Liu, Xiang Bai, Fengcheng Wang

School of Earth, Environmental, and Marine Sciences Faculty Publications and Presentations

To promote the commercialization of yellow pea flour (YPF) due to its nutritional benefits. Four biscuits with different YPF ratio (10%–50%) were conducted to explore the optimal addition percentage. The effects of YPF on the rheological and baking performance of biscuits were performed. The results showed that the substitution ratio of YPF and milling methods had a critical impact on the rheological properties of dough. The dough stability decreased gradually while a softening degree increased with YPF ratio increased. In a term of biscuits, the dimensions of length (L), width (W), thickness (T) and color (L*) of biscuits reduced as …

Kcrs: A Blockchain-Based Key Compromise Resilient Signature System, Lei Xu, Lin Chen, Zhimin Gao, Xinxin Fan, Kimberly Doan, Shouhuai Xu, Weidong Shi

Computer Science Faculty Publications and Presentations

Digital signatures are widely used to assure authenticity and integrity of messages (including blockchain transactions). This assurance is based on assumption that the private signing key is kept secret, which may be exposed or compromised without being detected in the real world. Many schemes have been proposed to mitigate this problem, but most schemes are not compatible with widely used digital signature standards and do not help detect private key exposures. In this paper, we propose a Key Compromise Resilient Signature (KCRS) system, which leverages blockchain to detect key compromises and mitigate the consequences. Our solution keeps a log of …

The Shape Of Translation Policy: A Comparison Of Policy Determinants In Bangor And Brownsville, Gabriel Gonzalez Nunez

Writing and Language Studies Faculty Publications and Presentations

RÉSUMÉ L’idée qu’il y a quelque chose que les chercheurs appellent «politique de traduction» existe depuis les tout débuts de ce domaine. Au fur et à mesure que les études avancent, de nouvelles perspectives continuent de contribuer à notre compréhension de l’évolution de la politique de traduction. D’une manière générale, ces études ont tendance à examiner de près le rôle que jouent les autorités dans la définition de la politique de traduction. Une telle approche a permis de dégager des perspectives utiles et, dans un avenir prévisible, elle continuera probablement d’offrir des perspectives enrichissantes. Mais souvent, la politique de traduction …

Converging Space And Producing Place: Social Inequalities And Birth Across Mexico, Rosalynn A. Vega

Anthropology Faculty Publications and Presentations

I combine ethnographic research of the professional midwifery model in Mexico with concepts gleaned from an interdisciplinary literature in order to illustrate how different types of spaces converge in the process of place-making. From October 2010 to November 2013, I conducted twenty-eight months of research, interviewing employees of government bureaus and public health programs, observing how the professional midwifery model unfolds in distinct contexts, performing interviews and participant-observation with casa midwifery students/alumni, and “shadowing” professional midwives and obstetricians as they engage with pregnant women in a hospital setting. Drawing from ethnographic examples, this article points to five different types of …

What’S Out There (Review Of A Portrait Of Assisted Reproduction In Mexico: Scientific, Political, And Cultural Interactions, By Sandra P. González-Santos), Rosalynn A. Vega

Anthropology Faculty Publications and Presentations

González-Santos’ book begins with a poem that likens counting sperm to counting moving stars. She alludes to the significance of the book’s title when she describes the portraits painted by Milanese artist Guiseppe Arcimboldo, and the power of portraits to convey the social position, psychological characteristics, personality, mood, and historical context of the person being depicted. The analogy of painting a portrait is indicative of González-Santos’ methods and the organization of the book. González-Santos paints through words a “repronational portrait” (Franklin and Inhorn, 2016) of Mexico’s system of assisted reproduction. González-Santos began her research in 2007. In the following twelve …

Synergistic Effect Of Nanocoatings For Corrosion And Wear Protection Of Steel Surfaces, Jaime Taha-Tijerina, Laura Peña Parás, Antonio Sánchez Fernández, Demófilo Maldonado Cortés, Pablo Sarmiento Barbosa, Jesús Rolando Adán López

Informatics and Engineering Systems Faculty Publications and Presentations

The purpose of this paper is to evaluate the corrosion and wear protection of a steel substrate by epoxy vinyl ester nanocomposite coatings with Zn and TiO2 nanoparticle fillers. Steel substrates were coated with epoxy vinyl ester nanocomposites, varying Zn and TiO2 nanofiller concentrations and combinations of both nanoparticles. Corrosion resistance was evaluated by salt spray fog test during 480 h, according to ASTM B-117. The degree of damage was obtained quantitatively by measuring the enhancement in corroded area compared to the scribe mark. Tribological evaluation was performed with a ball-on-disk tribotester, according to ASTM G-99. Results showed that the …

Investigation Of Constant Volume And Constant Flux Initial Conditions On Bidensity Particle-Laden Slurries On An Incline, Dominic Diaz, Jessica Bojorque, Joshua Crasto, Margaret Koulikov, Tameez Lati, Aviva Prins, Andrew Shapiro, Clover Ye, David Arnold, Michael R. Lindstrom

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Particle-laden slurries are pervasive in both natural and industrial settings, whenever particles are suspended or transported in a fluid. Previous literature has investigated the case of a single species of negatively buoyant particles suspended in a viscous fluid. On an incline, three distinct regimes emerge depending on the particle concentration and inclination angle: settled (where particles settle and there is a pure fluid front), well-mixed (where particle concentration is constant throughout), and ridged (where a particle-rich ridge leads the flow). Recently, the same three regimes were also found for constant volume two species bidensity slurries. We extend the literature on …

Full Recovery From Cocaine-Induced Toxic Leukoencephalopathy: Emphasizing The Role Of Neuroinflammation And Brain Edema, Edward C. Mader Jr., Alexander B. Ramos, Roberto A. Cruz, Lionel A. Branch

School of Medicine Publications and Presentations

Toxic leukoencephalopathy (TL) is characterized by white matter disease on magnetic resonance imaging (MRI) and evidence of exposure to a neurotoxic agent. We describe a case of cocaine-induced TL in which extensive white matter disease did not preclude full recovery. A 57-year-old man with substance abuse disorder presented with a 5-day history of strange behavior. On admission, he was alert but had difficulty concentrating, psychomotor retardation, and diffuse hyperreflexia. Brain MRI revealed confluent subcortical white matter hyperintensities with restricted diffusion in some but not in other areas. Electroencephalography (EEG) showed mild diffuse slowing. Blood tests were normal except for mild …

Optical Detection Of The Structural Properties Of Tumor Tissue Generated By Xenografting Of Drug-Sensitive And Drug-Resistant Cancer Cells Using Partial Wave Spectroscopy (Pws), Prakash A. Adhikari, Prashanth K.B. Nagesh, Fatemah Alharthi, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu, Prabhakar Pradhan

School of Medicine Publications and Presentations

A mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having 2D structures, are studied. The results show that the 3D xenografted tissues maintain a similar hierarchy of the degree of structural disorder properties as that of the 2D original drug-sensitive and …

Opposing Age-Related Trends In Absolute And Relative Risk Of Adverse Health Outcomes Associated With Out-Of-Office Blood Pressure, Yan Li, Lutgarde Thijs, Zhen-Yu Zhang, Kei Asayama, Tine W. Hansen, José Boggia, Kristina Björklund-Bodegård, Wen-Yi Yang, Gladys E. Maestre

School of Medicine Publications and Presentations

Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (≤60, 61-70, 71-80, and >80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher …

Reck Suppresses Interleukin-17/Traf3ip2-Mediated Mmp-13 Activation And Human Aortic Smooth Muscle Cell Migration And Proliferation, Srinivas Mummidi, Nitin A. Das, Andrea J. Carpenter, Tadashi Yoshida, Manjunath Yariswamy, Ricardo Mostany, Reza Izadpanah, Yusuke Higashi, Sergiy Sukhanov, Makoto Noda, Ulrich Siebenlist, Randy S. Rector, Bysani Chandrasekar

School of Medicine Publications and Presentations

Sustained inflammation and matrix metalloproteinase (MMP) activation contribute to vascular occlusive/proliferative disorders. Interleukin-17 (IL-17) is a proinflammatory cytokine that signals mainly via TRAF3 Interacting Protein 2 (TRAF3IP2), an upstream regulator of various critical transcription factors, including AP-1 and NF-κB. Reversion inducing cysteine rich protein with kazal motifs (RECK) is a membrane-anchored MMP inhibitor. Here we investigated whether IL-17A/TRAF3IP2 signaling promotes MMP-13-dependent human aortic smooth muscle cell (SMC) proliferation and migration, and determined whether RECK overexpression blunts these responses. Indeed, IL-17A treatment induced (a) JNK, p38 MAPK, AP-1, NF-κB, and CREB activation, (b) miR-21 induction, (c) miR-27b and miR-320 inhibition, (d) …

Dexamethasone As Abortive Treatment For Refractory Seizures Or Status Epilepticus In The Inpatient Setting, Alexander B. Ramos, Roberto A. Cruz, Nicole R. Villemarette-Pittman, Piotr W. Olejniczak, Edward C. Mader Jr.

School of Medicine Publications and Presentations

Refractory seizures or status epilepticus (RS/SE) continues to be a challenge in the inpatient setting. Failure to abort a seizure with antiepileptic drugs (AEDs) may lead to intubation and treatment with general anesthesia exposing patients to complications, extending hospitalization, and increasing the cost of care. Studies have shown a key role of inflammatory mediators in seizure generation and termination. We describe 4 patients with RS/SE that was aborted when dexamethasone was added to conventional AEDs: a 61-year-old female with temporal lobe epilepsy who presented with delirium, nonconvulsive status epilepticus, and oculomyoclonic status; a 56-year-old female with history of traumatic left …

Genome-Wide Meta-Analysis Of Macronutrient Intake Of 91,114 European Ancestry Participants From The Cohorts For Heart And Aging Research In Genomic Epidemiology Consortium, Jordi Merino, Hassan S. Dashti, Sherly X. Li, Chloé Sarnowski, Anne E. Justice, Misa Graff, Constantina Papoutsakis, Caren E. Smith, George V. Dedoussis, John Blangero

School of Medicine Publications and Presentations

Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10-6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.

Diverse Effects Of Diversity: Disaggregating Effects Of Diversity In Global Virtual Teams, Vas Taras, Daniel Baack, Dan Caprar, Douglas Dow, Fabian Froese, Alfredo Jimenez, Peter Magnusson

Marketing Faculty Publications and Presentations

Global Virtual Team (GVT) member diversity provides many advantages but also poses many challenges. Diversity comes in different forms that each has different effects on GVT dynamics and performance. Past research typically explored the effect of only one type of diversity at a time. Using multi-source, multi-wave data from 5728 individuals working in 804 consulting project GVTs, the present study is unique in that it explores and compares the effects of different forms of team member diversity on different aspects of GVT effectiveness in a single sample. It proposes a refined theoretical model that differentiates between the effects of personal …

Mind, Brain, And Behavior: An Integrative Approach To Teaching Neuroscience To Medical Students, Arden D. Dingle, Annelyn Torres-Reveron, Mario Gil, Francisco Fernandez, Ignacio Martinez Escobedo, Valerie Terry, Gladys E. Maestre, Gabriel A. De Erausquin

School of Medicine Publications and Presentations

Disorders related to neuroscience, psychiatry, and neurology cause significant disease burdens impacting medical practice [1, 2]. Teaching medical students these subjects remains challenging as many consider neuroscience and neurology too difficult to adequately learn [3] and psychiatry to be irrelevant [4–7]. Developing and implementing curricular initiatives to effectively teach these subjects so that students can utilize these knowledge and skills in practice is essential.

Interactive educational methods offer new approaches to improve student learning, especially within current educational initiatives that emphasize integration of basic and clinical science and incorporation of social …

Crossover Interference And Sex-Specific Genetic Maps Shape Identical By Descent Sharing In Close Relatives, Madison Caballero, Daniel N. Seidman, Ying Qiao, Jens Sannerud, Thomas D. Dyer, Donna M. Lehman, Joanne E. Curran, Ravindranath Duggirala, John Blangero, Shai Carmi, Amy L. Williams

School of Medicine Publications and Presentations

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a method for simulating relatives that can utilize either sex-specific or sex averaged genetic maps and also either a model of crossover interference or the traditional Poisson model for inter-crossover distances. To characterize the impact of previously ignored mechanisms, we simulated data for all four combinations of these factors. We found that modeling crossover interference decreases the …

Novel Mechanistic Insight Into The Anticancer Activity Of Cucurbitacin D Against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer), Mohammed Sikander, Shabnam Malik, Sheema Khan, Sonam Kumari, Neeraj Chauhan, Parvez Khan, Fathi T. Halaweish, Bhavin Chauhan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications and Presentations

Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is gemcitabine, but its success is poor due to the emergence of drug resistance. Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. However, there is no report on the therapeutic effect of Cuc D in PanCa. In the present study, we investigated the effects of the Cuc D on PanCa cells in vitro and in vivo. Cuc D inhibited …