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A Role For Nanoparticles In Treating Traumatic Brain Injury, Badrul Alam Bony, Forrest M. Kievit

Department of Biological Systems Engineering: Papers and Publications

Traumatic brain injury (TBI) is one of the main causes of disability in children and young adults, as well as a significant concern for elderly individuals. Depending on the severity, TBI can have a long-term impact on the quality of life for survivors of all ages. The primary brain injury can result in severe disability or fatality, and secondary brain damage can increase the complexities in cellular, inflammatory, neurochemical, and metabolic changes in the brain, which can last decades post-injury. Thus, survival from a TBI is often accompanied by lifelong disabilities. Despite the significant morbidity, mortality, and economic loss, there …

Time-Domain And Frequency-Domain Reflectometry Type Soil Moisture Sensor Performance And Soil Temperature Effects In Fine- And Coarse-Textured Soils, Y. Zhu, S. Irmak, A. J. Jhala, M. C. Vuran, A. Diotto

Department of Biological Systems Engineering: Papers and Publications

The performances of six time-domain reflectometry (TDR) and frequency-domain reflectometry (FDR) type soil moisture sensors were investigated for measuring volumetric soil-water content (θ_v) in two different soil types. Soil-specific calibration equations were developed for each sensor using calibrated neutron probe-measured θ_v. Sensors were also investigated for their performance response in measuring θ_v to changes in soil temperature. The performance of all sensors was significantly different (P<0.05) than the neutron probe-measured θ_v, with the same sensor also exhibiting variation between soils. In the silt loam soil, the 5TE sensor had the lowest root mean squared error (RMSE) of 0.041 …

Isotopic Composition Of Groundwater And Precipitation In Nebraska, Usa, Mikaela L. Cherry, Troy E. Gilmore, Aaron R. Mittelstet, Didier Gastmans, John Gates

School of Natural Resources: Faculty Publications

Groundwater is vital worldwide for water supply, agriculture and industry. Nearly 60% of all water use in Nebraska is from groundwater. Over 90% of groundwater is used for irrigation in Nebraska, which has the largest area of irrigated land in the United States. Many Nebraskans depend on groundwater for drinking water, both from private wells and municipal wells. The sustainability of groundwater resources is dependent on groundwater recharge. The recharge processes, as well as climatic patterns, influence the stable isotope signatures.

Based on weekly samples collected at two monitoring stations managed by the National Atmospheric Deposition Program (NADP), Harvey (2001) …

Performance Of Saudi Universities In Global Rankings And Appropriate Strategies For Its Improvement, Ahmed Al Kuwaiti Phd, Kevin Downing Phd, Arun Vijay Subbarayalu Phd

Library Philosophy and Practice (e-journal)

Saudi universities are utilizing various university ranking systems to publicize their academic and research performance to the students and their parents. This study aimed to describe the ranking position of top ten Saudi universities across Quacquarelli Symonds (QS) and Times Higher Education (THE) world university rankings based on the ranking results established in 2019. Based on results, the leading position observed among such universities were King Fahd University of Petroleum & Minerals (KFUPM) in QS and King Abdulaziz University (KAU) in THE. This study is not only provided an analysis of rankings of top ten Saudi universities; but also highlighted …

Radiomic Feature Stability Across 4d Respiratory Phases And Its Impact On Lung Tumor Prognosis Prediction, Qian Du, Michael Baine, Kyle Bavitz, Josiah Mcallister, Xiaoying Liang, Hongfeng Yu, Jeffrey Ryckman, Lina Yu, Hengle Jiang, Sumin Zhou, Sumin Zhou, Chi Zhang, Dandan Zheng

School of Biological Sciences: Faculty Publications

Radiomic analysis has recently demonstrated versatile uses in improving diagnostic and prognostic prediction accuracy for lung cancer. However, since lung tumors are subject to substantial motion due to respiration, the stability of radiomic features over the respiratory cycle of the patient needs to be investigated to better evaluate the robustness of the interpatient feature variability for clinical applications, and its impact in such applications needs to be assessed. A full panel of 841 radiomic features, including tumor intensity, shape, texture, and wavelet features, were extracted from individual phases of a four-dimensional (4D) computed tomography on 20 early-stage non-small-cell lung cancer …

Comparative Kinetic Modeling Of Growth And Molecular Hydrogen Overproduction By Engineered Strains Of Thermotoga Maritima, Raghuveer Singh, Rahul Tevatia, Derrick White, Yaşar Demirel, Paul H. Blum

Department of Chemical and Biomolecular Engineering: Faculty Publications

Thermotoga maritima is an anaerobic hyperthermophilic bacterium known for its high amounts of hydrogen (H₂) production. In the current study, the kinetic modeling was applied on the engineered strains of T. maritima that surpassed the natural H₂ production limit. The study generated a kinetic model explaining H₂ overproduction and predicted a continuous fermentation system. A Leudking-Piret equation-based model predicted that H₂ production by Tma200 (0.217 mol-H₂ g^–1-biomass) and Tma100 (0.147 mol-H₂ g^–1-biomass) were higher than wild type (0.096 mol-H₂ g^–1 -biomass) with reduced rates of maltose utilization. …

Alcohol Metabolism Potentiates Hiv-Induced Hepatotoxicity: Contribution To End-Stage Liver Disease, Murali Ganesan, Moses New-Aaron, Raghubendra Singh Dagur, Edward Makarov, Weimin Wang, Kusum K. Kharbanda, Srivatsan Kidambi, Larisa Y. Poluektova, Natalia A. Osna

Department of Chemical and Biomolecular Engineering: Faculty Publications

In an era of improved survival due to modern antiretroviral therapy, liver disease has become a major cause of morbidity and mortality, resulting in death in 15–17% of human immunodeficiency virus (HIV)-infected patients. Alcohol enhances HIV-mediated liver damage and promotes the progression to advanced fibrosis and cirrhosis. However, the mechanisms behind these events are uncertain. Here, we hypothesize that ethanol metabolism potentiates accumulation of HIV in hepatocytes, causing oxidative stress and intensive apoptotic cell death. Engulfment of HIV-containing apoptotic hepatocytes by non-parenchymal cells (NPCs) triggers their activation and liver injury progression. This study was performed on primary human hepatocytes and …

Depletion Of Mitochondrial Protease Oma1 Alters Proliferative Properties And Promotes Metastatic Growth Of Breast Cancer Cells, Amita Daverey, Roman M. Levytskyy, Kimberly M. Stanke, Martonio Ponte Viana, Samantha Swenson, Stephen Hayward, Madhusudhanan Narasimhan, Oleh Khalimonchuk, Srivatsan Kidambi

Department of Chemical and Biomolecular Engineering: Faculty Publications

Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis. While it is generally accepted that mitochondria play important roles in tumorigenesis, the respective molecular events that regulate aberrant cancer cell proliferation remain to be clarified. Therefore, understanding the mechanisms underlying the role of mitochondria in cancer progression has potential implications in the development of new therapeutic strategies. We show that low expression of mitochondrial quality control protease OMA1 correlates with poor overall survival in breast cancer patients. Silencing OMA1 in vitro in patientderived metastatic breast cancer cells isolated …