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Dose-Response, Vol 8, No 4, Table Of Contents
Dose-Response, Vol 8, No 4, Table Of Contents
Dose-Response: An International Journal
No abstract provided.
Dose-Response, Vol 8, No 4, Cover
Dose-Response, Vol 8, No 4, Cover
Dose-Response: An International Journal
No abstract provided.
Tnf-Α And Microglial Hormetic Involvement In Neurological Health & Migraine, Richard P Kraig, Heidi M Mitchell, Barbara Christie-Pope, Phillip E Kunkler, David M White, Ya-Ping Tang, George Langan
Tnf-Α And Microglial Hormetic Involvement In Neurological Health & Migraine, Richard P Kraig, Heidi M Mitchell, Barbara Christie-Pope, Phillip E Kunkler, David M White, Ya-Ping Tang, George Langan
Dose-Response: An International Journal
Environmental enrichment, i.e., increased intellectual, social, and physical activity makes brain more resilient to subsequent neurological disease. The mechanisms for this effect remain incompletely defined, but evidence shows tumor necrosis factor-alpha (TNF- α) is involved. TNF-α, at acutely high levels, possesses the intrinsic capacity to enhance injury associated with neurological disease. Conversely, the effect of TNF-α at low-levels is nutritive over time, consistent with physiological conditioning hormesis. Evidence shows that neural activity triggers low-level pro-inflammatory signaling involving TNF-α. This low-level TNF-α signaling alters gene expression, resulting in an enhanced resilience to disease. Brain-immune signaling may become maladaptive when increased activity …
Mean Cancer Mortality Rates In Low Versus High Elevation Counties In Texas, John Hart
Mean Cancer Mortality Rates In Low Versus High Elevation Counties In Texas, John Hart
Dose-Response: An International Journal
There is controversy as to whether low levels of radiation (i.e., < 5 rem) pose a health risk. This brief inquiry compares archived cancer mortality data in counties having relatively low (0-250 feet above sea level), medium (500-1000 feet above sea level), and high (3000+ feet above sea level) elevations also having corresponding greater natural back- ground levels of radiation respectively. Cancer mortality was found to be lowest in the high elevation counties (mean = 58.2) followed by low elevation counties (67.5) and then medium elevation counties (70.4). Statistically significant differences were found between low –high elevations (p = 0.003), and medium – high elevations (p = 0.010), but not between low and medium elevations (p = 0.5). More rigorous research, with an accounting of con- founding variables, is indicated.
Stochastic Threshold Microdose Model For Cell Killing By Insoluble Metallic Nanomaterial Particles, Bobby R Scott
Stochastic Threshold Microdose Model For Cell Killing By Insoluble Metallic Nanomaterial Particles, Bobby R Scott
Dose-Response: An International Journal
This paper introduces a novel microdosimetric model for metallic nanomaterial-parti- cles (MENAP)-induced cytotoxicity. The focus is on the engineered insoluble MENAP which represent a significant breakthrough in the design and development of new products for consumers, industry, and medicine. Increased production is rapidly occurring and may cause currently unrecognized health effects (e.g., nervous system dysfunction, heart disease, cancer); thus, dose-response models for MENAP-induced biological effects are needed to facilitate health risk assessment. The stochastic threshold microdose (STM) model presented introduces novel stochastic microdose metrics for use in constructing dose- response relationships for the frequency of specific cellular (e.g., cell killing, …
Dose-Dependency Of Resveratrol In Providing Health Benefits, Subhendu Mukherjee, Jocelyn I Dudley, Dipak K Das
Dose-Dependency Of Resveratrol In Providing Health Benefits, Subhendu Mukherjee, Jocelyn I Dudley, Dipak K Das
Dose-Response: An International Journal
This review describes the dose-dependent health benefits of resveratrol, a polyphenolic antioxidant that is found in a variety of foods, especially grape skin and red wine. Resveratrol provides diverse health benefits including cardioprotection, inhibition of low- density lipoprotein, activation of nitric oxide (NO) production, hindering of platelet aggregation [32] A.A.E. Bertelli, D.E. Giovannini, R.L. Caterina, W. Bernini, M. Migliori and M. Fregoni et al., Antiplatelet activity of cis-resveratrol, Drugs Exp Clin Res 22 (1996), pp. 61–63. View Record in Scopus | Cited By in Scopus (111) and promotion of anti-inflammatory effects. Studies have shown that at a lower dose, resveratrol …
Exposure To Nanoparticles And Hormesis, Ivo Iavicoli, Edward J Calabrese, Marc A Nascarella
Exposure To Nanoparticles And Hormesis, Ivo Iavicoli, Edward J Calabrese, Marc A Nascarella
Dose-Response: An International Journal
Nanoparticles are particles with lengths that range from 1 to 100 nm. They are increasingly being manufactured and used for commercial purpose because of their novel and unique physicochemical properties. Although nanotechnology-based products are gener- ally thought to be at a pre-competitive stage, an increasing number of products and mate- rials are becoming commercially available. Human exposure to nanoparticles is therefore inevitable as they become more widely used and, as a result, nanotoxicology research is now gaining attention. However, there are many uncertainties as to whether the unique properties of nanoparticles also pose occupational health risks. These uncertainties arise because …
Phytotoxic Antibiotic Sulfadimethoxine Elicits A Complex Hormetic Response In The Weed Lythrum Salicaria L., Luciana Migliore, Alice Rotini, Nadia L Cerioli, Salvatore Cozzolino, Maurizio Fiori
Phytotoxic Antibiotic Sulfadimethoxine Elicits A Complex Hormetic Response In The Weed Lythrum Salicaria L., Luciana Migliore, Alice Rotini, Nadia L Cerioli, Salvatore Cozzolino, Maurizio Fiori
Dose-Response: An International Journal
In order to evaluate the hormetic response of the weed Lythrum salicaria to drug expo- sure we investigated the effects of the antibiotic Sulfadimethoxine by growing Lythrum plants for 28 days on culture media containing different drug concentrations (between 0.005 and 50 mg.L-1). The antibiotic was absorbed by plants and can be found in plant tissue. The plant response was organ-dependent: roots, cotyledons and cotyledon petioles, were always affected by a toxic effect, whilst internodes and leaves length, showed a variable dose-depending response, with an increased growth at the lower drug concentrations and toxic effects at the higher …
Hormetic Electric Field Theory Of Pattern Formation, Egil Fosslien
Hormetic Electric Field Theory Of Pattern Formation, Egil Fosslien
Dose-Response: An International Journal
The hormetic morphogen theory of curvature (Fosslien 2009) proposes that hormetic morphogen concentration gradients modulate the synthesis of adenosine triphosphate (ATP) by cells along the gradients (field cells) and thus regulate their proliferation and induce curvature such as vascular wall curvature; however, it is unclear whether such morphogen gradients can also determine the histological pattern of the walls. Here, I propose that the ATP gradients modulate export of H+ by vacuolar H+-ATPase (V-ATPase) located on the surface of field cells and generate extracellular ion concentration gradients, ion currents and electrical fields along the paths of morphogen gradients. …
Low-Dose Pretreatment For Radiation Therapy, Richard Blankenbecler
Low-Dose Pretreatment For Radiation Therapy, Richard Blankenbecler
Dose-Response: An International Journal
In radiotherapy, a large radiation dose must be applied to both cancer and neighboring healthy cells. Recent experiments have shown that a low dose of ionizing radiation turns on certain protective mechanisms that allow a cell to better survive a subsequent high dose of radiation. This adaptive response can have important and positive consequences for radiotherapy. This paper describes a simple change in treatment procedures to make use of these beneficial effects. A low dose applied only to the healthy cells will probably produce some damage. However, it will also start the adaptive response which will yield increased protection when …
Effects Of Ethanol On The Shoaling Behavior Of Zebrafish (Danio Rerio), Anastasia Kurta, Brian G. Palestis
Effects Of Ethanol On The Shoaling Behavior Of Zebrafish (Danio Rerio), Anastasia Kurta, Brian G. Palestis
Dose-Response: An International Journal
Ethanol (EtOH) often has stimulatory effects at low doses and inhibitory effects at high doses, affecting behavior and physiology of many organisms in a non-linear manner suggestive of hormesis. Zebrafish (Danio rerio) shoaling was studied in adult fish exposed to one of five different EtOH concentrations (v/v): 0.0% control, 0.125%, 0.25%, 0.5%, and 1.0%. Digital photographs of groups of four fish were taken every 2 min, with each trial lasting a total of 12 min. The median nearest neighbor distance and shoal area were calculated for each photograph. Exposure to 1.0% EtOH inhibited shoaling. In contrast, as predicted …
Modeling Dose-Response At Low Dose: A Systems Biology Approach For Ionization Radiation, Yuchao Zhao, Paolo F Ricci
Modeling Dose-Response At Low Dose: A Systems Biology Approach For Ionization Radiation, Yuchao Zhao, Paolo F Ricci
Dose-Response: An International Journal
For ionization radiation (IR) induced cancer, a linear non-threshold (LNT) model at very low doses is the default used by a number of national and international organizations and in regulatory law. This default denies any positive benefit from any level of exposure. However, experimental observations and theoretical biology have found that both linear and J-shaped IR dose-response curves can exist at those very low doses. We develop low dose J-shaped dose-response, based on systems biology, and thus justify its use regarding expo- sure to IR. This approach incorporates detailed, molecular and cellular descriptions of biological/toxicological mechanisms to develop a dose-response …
A Community Of Households: Early 19th-Century Enslaved Landscapes At James Madison's Montpelier, Matthew Reeves
A Community Of Households: Early 19th-Century Enslaved Landscapes At James Madison's Montpelier, Matthew Reeves
African Diaspora Archaeology Newsletter
No abstract provided.
Archaeological Investigations And Lidar Aerial Survey In Edgefield, South Carolina, Christopher Fennell
Archaeological Investigations And Lidar Aerial Survey In Edgefield, South Carolina, Christopher Fennell
African Diaspora Archaeology Newsletter
No abstract provided.
The Old Plantation Painting At Colonial Williamsburg: New Findings And Some Observations, Jerome S. Handler
The Old Plantation Painting At Colonial Williamsburg: New Findings And Some Observations, Jerome S. Handler
African Diaspora Archaeology Newsletter
No abstract provided.
Okra Soup And Earthenware Pots: The Archaeology Of Gullah Communities, Carl Steen, Jodi A. Barnes
Okra Soup And Earthenware Pots: The Archaeology Of Gullah Communities, Carl Steen, Jodi A. Barnes
African Diaspora Archaeology Newsletter
No abstract provided.
Christopher Barton Joins As Adan Newsletter Co-Editor
Christopher Barton Joins As Adan Newsletter Co-Editor
African Diaspora Archaeology Newsletter
No abstract provided.
Cultural Heritage Resources Of The New Oyo Empire, Southwestern Nigeria: Prospects For Sustainability, Titilayo O. Olukole
Cultural Heritage Resources Of The New Oyo Empire, Southwestern Nigeria: Prospects For Sustainability, Titilayo O. Olukole
African Diaspora Archaeology Newsletter
No abstract provided.
Dr. Cheryl Laroche Receives 2011 John L. Cotter Award By Society For Historical Archaeology
Dr. Cheryl Laroche Receives 2011 John L. Cotter Award By Society For Historical Archaeology
African Diaspora Archaeology Newsletter
No abstract provided.
Crossroads And Cosmologies Receives 2010 Gustave O. Arlt Award In The Humanities By Council Of Graduate Schools
African Diaspora Archaeology Newsletter
No abstract provided.
Judith Carney, Siddharth Kara, And Richard Rosomoff Share Frederick Douglass Book Prize
Judith Carney, Siddharth Kara, And Richard Rosomoff Share Frederick Douglass Book Prize
African Diaspora Archaeology Newsletter
No abstract provided.
African And Africanist Archaeologists Voice Their Support Of Anthropology At Howard University, Flordeliz T. Bugarin
African And Africanist Archaeologists Voice Their Support Of Anthropology At Howard University, Flordeliz T. Bugarin
African Diaspora Archaeology Newsletter
No abstract provided.
Racism Plagues Every Society -- Un Reports
Racism Plagues Every Society -- Un Reports
African Diaspora Archaeology Newsletter
No abstract provided.
On Eve Of The International Year For People Of African Descent Un Secretary-General Calls For Final End To Racism
African Diaspora Archaeology Newsletter
No abstract provided.
Transatlantic Slave Trade Visual Record Online: Updated
Transatlantic Slave Trade Visual Record Online: Updated
African Diaspora Archaeology Newsletter
No abstract provided.
Number Of Blacks Earning Doctorates Reached An All-Time High In 2009
Number Of Blacks Earning Doctorates Reached An All-Time High In 2009
African Diaspora Archaeology Newsletter
No abstract provided.
Philadelphia Site Honoring Washington And His Slaves Ready For Dedication, Stephan Salisbury
Philadelphia Site Honoring Washington And His Slaves Ready For Dedication, Stephan Salisbury
African Diaspora Archaeology Newsletter
No abstract provided.
Harsh Life Of Washington's Slaves At Mt. Vernon Revisited, Faiza Elmasry
Harsh Life Of Washington's Slaves At Mt. Vernon Revisited, Faiza Elmasry
African Diaspora Archaeology Newsletter
No abstract provided.
Challenge Of Culture In Africa: From Restoration To Integration, Bernard Nsokika Foulon
Challenge Of Culture In Africa: From Restoration To Integration, Bernard Nsokika Foulon
African Diaspora Archaeology Newsletter
No abstract provided.
Mississippi In Africa: The Saga Of The Slaves Of Prospect Hill Plantation And Their Legacy In Liberia Today, Alan Huffman
Mississippi In Africa: The Saga Of The Slaves Of Prospect Hill Plantation And Their Legacy In Liberia Today, Alan Huffman
African Diaspora Archaeology Newsletter
No abstract provided.