Digital Commons Network^™

[Review Of] The New Faces Of American Poverty: A Reference Guide To The Great Recession, Jennifer A. Bartlett

Library Faculty and Staff Publications

No abstract provided.

Family Unity Revisited: Divorce, Separation, And Death In Immigration Law, Albertina Antognini

Law Faculty Scholarly Articles

Families are integral to immigration law and policy, and family-based immigration accounts for the majority of legal entry into the United States. Legislative, judicial, and scholarly discussions that address immigration law's family-based categories rely nearly exclusively on the principle of family unification, which has long been a cornerstone policy of immigration law. Yet the family-based provisions of immigration law do more than unify intact families; understanding families as dynamic entities that experience change reveals an immigration system that acknowledges a flexible family structure in determining status.

The principal aim of this Article is to present a more complete description of …

Novel Image Markers For Non-Small Cell Lung Cancer Classification And Survival Prediction, Hongyuan Wang, Fuyong Xing, Hai Su, Arnold J. Stromberg, Lin Yang

Statistics Faculty Publications

BACKGROUND: Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is one of serious diseases causing death for both men and women. Computer-aided diagnosis and survival prediction of NSCLC, is of great importance in providing assistance to diagnosis and personalize therapy planning for lung cancer patients.

RESULTS: In this paper we have proposed an integrated framework for NSCLC computer-aided diagnosis and survival analysis using novel image markers. The entire biomedical imaging informatics framework consists of cell detection, segmentation, classification, discovery of image markers, and survival analysis. A robust seed detection-guided cell segmentation algorithm is proposed to accurately …

Thymidylate Synthase Genotype-Directed Chemotherapy For Patients With Gastric And Gastroesophageal Junction Cancers, Laura W. Goff, Nilay Thakkar, Liping Du, Emily Chan, Benjamin R. Tan, Dana B. Cardin, Howard L. Mcleod, Jordan D. Berlin, Barbara Zehnbauer, Chloe Fournier, Joel Picus, Andrea Wang-Gillam, Wooin Lee, A. Craig Lockhart

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking.

METHODS: In this phase II study (NCT00515216 registered through ClinicalTrials.gov, http://clinicaltrials.gov/show/NCT00515216), patients with "good risk" TSER genotypes (at least one TSER*2 allele) were treated with FOLFOX chemotherapy to determine whether prospective patient selection can improve overall response rates (ORR) in patients with gastric and gastroesophageal junction (GEJ) cancers, compared with historical outcomes in unselected patients (estimated 43%).

RESULTS: The ORR in genotype-selected patients was 39.1% (9 partial responses out …

Online Deception In Social Media, Michail Tsikerdekis, Sherali Zeadally

Information Science Faculty Publications

The unknown and the invisible exploit the unwary and the uninformed for illicit financial gain and reputation damage.

Assessing The Relationships Between Perceived Support From Close Others, Goal Commitment, And Persistence Decisions At The College Level, Renee E. Strom, Matthew W. Savage

Communication Faculty Publications

Research on supportive communication was examined in relation to students’ goals of earning a college degree and their intent to persist. Theories of student departure (Bean, 1985; Tinto, 1993) informed research questions assessing the impact of how social support from family members and friends affected commitment to the goal of graduation and how commitment to the goal of graduation influenced intent to persist. First-year college students completed a questionnaire at 2 time points during their first year of college. Results revealed that initial support from family and friends positively impacted initial commitment to the goal of graduation. Subsequent support from …

Comparison Of Isokinetic Hip Abduction And Adduction Peak Torques And Ratio Between Sexes, Dai Sugimoto, Carl G. Mattacola, David R. Mullineaux, Thomas Gerard Palmer, Timothy E. Hewett

Physical Therapy Faculty Publications

OBJECTIVE: To evaluate hip abductor and adductor peak torque outputs and compare their ratios between sexes.

DESIGN: A cross-sectional laboratory-controlled study.

SETTING: Participants visited a laboratory and performed an isokinetic hip abductor and adductor test. All participants performed 2 sets of 5 repetitions of concentric hip abduction and adduction in a standing position at 60 degrees per second. Gravity was determined as a function of joint angle relative to the horizontal plane and was corrected by normalizing the weight of the limb on an individual basis.

PARTICIPANTS: A total of 36 collegiate athletes.

INDEPENDENT VARIABLES: Sex (20 females and 16 …

Global School-Based Childhood Obesity Interventions: A Review, Melinda J. Ickes, Jennifer Mcmullen, Taj Haider, Manoj Sharma

Kinesiology and Health Promotion Faculty Publications

Background: The issue of childhood overweight and obesity has become a global public health crisis. School-based interventions have been developed and implemented to combat this growing concern. The purpose of this review is to compare and contrast U.S. and international school-based obesity prevention interventions and highlight efficacious strategies.

Methods: A systematic literature review was conducted utilizing five relevant databases. Inclusion criteria were: (1) primary research; (2) overweight or obesity prevention interventions; (3) school-based; (4) studies published between 1 January 2002 through 31 December 2013; (5) published in the English language; (6) child-based interventions, which could include parents; and …

Paternal Incarceration And Children's Food Insecurity: A Consideration Of Variation And Mechanisms, Kristen Turney

University of Kentucky Center for Poverty Research Discussion Paper Series

Despite growing attention to the unintended consequences of paternal incarceration for children’s wellbeing across the life course, little is known about whether and how paternal incarceration is related to food insecurity among children, an especially acute and severe form of deprivation. In this article, I use data from the Fragile Families and Child Wellbeing Study, a cohort of children born to mostly unmarried mothers, to examine the relationship between paternal incarceration and three indicators of food insecurity among young children: current food insecurity (at age five), onset of food insecurity (between ages three and five), and exit from food insecurity …

Sex-Specific Alterations In Nos Regulation Of Vascular Function In Aorta And Mesenteric Arteries From Spontaneously Hypertensive Rats Compared To Wistar Kyoto Rats, Analia S. Loria, Krystal N. Brinson, Brandon M. Fox, Jennifer C. Sullivan

Pharmacology and Nutritional Sciences Faculty Publications

The present study tested the hypothesis that spontaneously hypertensive rats (SHR) have impaired nitric oxide synthase (NOS)-mediated regulation of vascular function versus Wistar-Kyoto rats (WKY). Aorta and small mesenteric arteries were studied from male and female SHR (M SHR and F SHR) and WKY (M WKY and F WKY). Phenylephrine (PE)-induced vasoconstriction was greater in aorta of M SHR versus all others (P < 0.05); there were neither sex nor strain differences in PE contraction in mesenteric arteries. The NOS inhibitor l-Nitro-Arginine Methyl Ester (l-NAME) increased PE-induced vasoconstriction in all rats, although the increase was the least in male SHR (P < 0.05), revealing a blunted vasoconstrictor buffering capacity of NOS. l-NAME increased sensitivity to PE-induced constriction only in mesenteric arteries of SHR, although, the maximal percent increase in contraction was comparable among groups. ACh-induced relaxation was also less in aorta from M SHR versus all others (P < 0.05). ACh relaxation was comparable among groups in mesenteric arteries, although SHR exhibited a greater NOS component to ACh-induced relaxation than WKY. To gain mechanistic insight into sex and strain differences in vascular function, NOS activity and NOS3 protein expression were measured. Aortic NOS activity was comparable between groups and M SHR had greater NOS3 expression than M WKY. In contrast, although vascular function was largely maintained in mesenteric arteries of SHR, NOS activity was less in SHR versus WKY. In conclusion, M SHR exhibit a decrease in NOS regulation of vascular function compared to F SHR and WKY, although this is not mediated by decreases in NOS activity and/or expression.

Developing A Tool To Assess Administrative Evidence-Based Practices In Local Health Departments, Rodrigo S. Reis, Kathleen Duggan, Peg Allen, Katherine A. Stamatakis, Paul C. Erwin, Ross C. Brownson

Frontiers in Public Health Services and Systems Research

There is need for assessing the practices undertaken by local health departments in order to improve the implementation of evidence-based actions. This paper describes the development and testing of a survey instrument for assessing Administrative Evidence-Based Practices (A-EBPs) in Local Health Departments. A-EBPs identified through a review of the literature were used to develop a survey composed of nine sections and tested in a sample of local health department practitioners. The resulting tool showed adequate test-retest reliability and internal consistency. Practitioners and researchers may apply this tool in practice-based and evaluation research.

Neuroinflammation And Neurodegeneration In Adult Rat Brain From Binge Ethanol Exposure: Abrogation By Docosahexaenoic Acid, Nuzhath Tajuddin, Kwan-Hoon Moon, Simon Alex Marshall, Kimberly Nixon, Edward J. Neafsey, Hee-Yong Kim, Michael A. Collins

Pharmaceutical Sciences Faculty Publications

Evidence that brain edema and aquaporin-4 (AQP4) water channels have roles in experimental binge ethanol-induced neurodegeneration has stimulated interest in swelling/edema-linked neuroinflammatory pathways leading to oxidative stress. We report here that neurotoxic binge ethanol exposure produces comparable significant effects in vivo and in vitro on adult rat brain levels of AQP4 as well as neuroinflammation-linked enzymes: key phospholipase A2 (PLA2) family members and poly (ADP-ribose) polymerase-1 (PARP-1). In adult male rats, repetitive ethanol intoxication (3 gavages/d for 4 d, ∼ 9 g/kg/d, achieving blood ethanol levels ∼ 375 mg/dl; "Majchrowicz" model) significantly increased AQP4, Ca+2-dependent PLA2 GIVA (cPLA2), phospho-cPLA2 GIVA …

Satire And Stoicism: Pieter Bruegel The Elder's Triumph Of Death, Susan K. Gisselberg

Kaleidoscope

In Bruegel and the Creative Process, 1559 – 1563, Margaret Sullivan explains how the religious and political disorder of the Reformation in the Netherlands influenced Pieter Bruegel’s most original works, including The Triumph of Death. During this period, Bruegel combined classical elements and vernacular traditions. As a result of this process, he was able to depict similar imagery to his contemporaries, yet convey a vastly different concept. In a review, Todd Richardson argued that her claim relied heavily on classical literary sources with inadequate visual evidence in the work itself, and her correlations to antiquity rely solely on the …

A Song Without Music Or Music Without Song: Noise Music And Lexington’S Modern Avant-Garde, Matthew H. Gibson

Kaleidoscope

While Lexington KY appears to be a fairly unassuming college town, it is actually a regional hub for noise, experimental, and improvisational music. This work explores the directions, motivations, and origins of Lexington’s experimental music scene through interviews with its artists, promoters, and participants. What I uncovered was a loose collective of fiercely independent artists who write their own music, create their own visual artwork, and organize their own performances in some of the most unlikely locations. These musicians and artists represent a peculiar contemporary folk art that emerges more from the psyche than the classroom and challenges all artistic …

Biomarkers Of Acute Myocardial Infarction In The Elderly: Troponin And Beyond, Martin G. Rains, Charles A. Laney, Alison L. Bailey, Charles L. Campbell

Gill Heart & Vascular Institute Faculty Publications

In the broadest context, biological markers, or biomarkers, are molecules that characterize a biological system or process. In the setting of cardiovascular disease, a number of biomarkers have become an integral part of diagnostic and risk stratification strategies. In this review, we will discuss classic and emerging biomarkers of cardiovascular disease and the role of these biomarkers in the diagnosis and prognosis of elderly patients presenting with acute myocardial infarction.

Choosing My Avatar & The Psychology Of Virtual Worlds: What Matters?, Jennifer Wu

Kaleidoscope

Avatars and virtual worlds have become commonplace across the Internet in recent years through the development of the gaming industry and social media technology. The technology involved in virtual environments is becoming more accessible to the general public, and software for creating avatars or participating in virtual worlds can be found free online. Virtual worlds are used not only for recreation, but are also increasingly used for other purposes, such as education, marketing, and meeting places. We are finding new ways to represent ourselves online for various purposes. Recent research in psychology has shown that social phenomena in virtual worlds …

Empowering The Oppressed In 20th Century Literature Through Magical Realism, Lindsay Oberhausen

Kaleidoscope

No abstract provided.

Parental Problem Drinking: Its Effect On Child Emotional Security, Stephanie Miskell

Kaleidoscope

No abstract provided.

Gelin’: Membership, Space, And Stylistics In South African Queer Culture, Joseph Mann

Kaleidoscope

No abstract provided.

Oswald Social Sciences First Place: Two Is Company, Three Is An Envious Crowd: Effects Of A Third Party Evaluator On Expressions Of Envy According To Lacanian Psychoanalytic Perspective, Elina Matveeva

Kaleidoscope

The implementation of in vitro results to in vivo applications has limitations due to conventional two-dimensional (2D) in vitro conditions lacking the ability to create a physiologically representative model. This study investigated a three-dimensional (3D) cell culture technique to model lung tumors in vitro. A 3D lung cancer model was created by applying collagen (a semi-non-adhesive material) to a transwell, which allowed for nutrient transfer through the collagen. Two lung cancer cells lines (H358, a bronchioalveolar carcinoma and A549, a lung adenocarcinoma) were seeded on top of the collagen. The non-adhesive collagen allowed the cells to preferentially attach to one …

Will Hiv Vaccination Reshape Hiv Risk Behavior Networks? A Social Network Analysis Of Drug Users' Anticipated Risk Compensation, April M. Young, Daniel S. Halgin, Ralph J. Diclemente, Claire E. Sterk, Jennifer R. Havens

Epidemiology and Environmental Health Faculty Publications

Background

An HIV vaccine could substantially impact the epidemic. However, risk compensation (RC), or post-vaccination increase in risk behavior, could present a major challenge. The methodology used in previous studies of risk compensation has been almost exclusively individual-level in focus, and has not explored how increased risk behavior could affect the connectivity of risk networks. This study examined the impact of anticipated HIV vaccine-related RC on the structure of high-risk drug users' sexual and injection risk network.

Methods

A sample of 433 rural drug users in the US provided data on their risk relationships (i.e., those involving recent unprotected sex …

The Safety Of Women On College Campuses: Implications Of Evolving Paradigms In Postsecondary Education [July 2014], Carol E. Jordan

Psychology Faculty Publications

No abstract provided.

Frontal White Matter Integrity In Adults With Down Syndrome With And Without Dementia, David K. Powell, Allison Caban-Holt, Greg A. Jicha, William C. Robertson, Roberta Davis, Brian T. Gold, Frederick A. Schmitt, Elizabeth Head

Magnetic Resonance Imaging and Spectroscopy Center Faculty Publications

Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with dementia (DSAD n = 10) and age matched non-DS subjects (CTL n = 10) would show differential levels of FA and an association with scores from the Brief Praxis Test and the Severe Impairment Battery. WM integrity differences in DS compared with CTL were found predominantly …

Global Kentucky (Summer 2014), University Of Kentucky International Center

Global Kentucky

No abstract provided.

Southeastern Law Librarian Summer 2014, Seaall

Newsletters

No abstract provided.

An Exploration Of Sexual Victimization And Academic Performance Among College Women, Carol E. Jordan, Jessica L. Combs, Gregory T. Smith

Office for Policy Studies on Violence Against Women Publications

The literature has documented the widespread nature of sexual assault victimization among college women. While the aftermath of violence against university women has also received focus, that is, documenting trauma-related sequelae; risk factors; reporting patterns; and legal interventions, the impact on academic performance has not received adequate attention in the literature. The primary purpose of this study was to explore the association of rape and sexual assault with academic performance among college women. Its specific aims included the following: to compare high school and college sexual assault experiences with collegiate grade point averages (GPAs) at key points in time; to …

Individual Differences In Personality Predict Externalizing Versus Internalizing Outcomes Following Sexual Assault, Jessica L. Combs, Carol E. Jordan, Gregory T. Smith

Office for Policy Studies on Violence Against Women Publications

For some women, the experience of being sexually assaulted leads to increases in externalizing behaviors, such as problem drinking and drug use; for other women, the experience of being assaulted leads to increases in internalizing distress, such as depression or anxiety. It is possible that preassault personality traits interact with sexual assault to predict externalizing or internalizing distress. We tested whether concurrent relationships among personality, sexual assault, and distress were consistent with such a model. We surveyed 750 women just prior to their freshman year at a large public university. Consistent with our hypotheses, at low levels of negative urgency …

Epidemiology Of Pediatric Rapid Response Calls In Children Less Than Two Years Old, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

Poster presentation of original research at Pediatric Hospital Medicine 2014 Lake Buena Vista, FL

A Common Law Constitutionalism For The Right To Education, Scott R. Bauries

Law Faculty Scholarly Articles

This Article makes two claims, one descriptive and the other normative. The descriptive claim is that individual rights to education have not been realized under state constitutions because the currently dominant structure of education reform litigation prevents such realization. In state constitutional education clause claims, both pleadings and adjudication generally focus on the equality or adequacy of the system as a whole, rather than on any particular student's educational resources or attainment. The Article traces the roots of the currently dominant systemic approach, and finds these roots in federal institutional reform litigation. This systemic focus leads to a systemic, rather …

A 2-Step Penalized Regression Method For Family-Based Next-Generation Sequencing Association Studies, Xiuhua Ding, Shaoyong Su, Kannabiran Nandakumar, Xiaoling Wang, David W. Fardo

Biostatistics Faculty Publications

Large-scale genetic studies are often composed of related participants, and utilizing familial relationships can be cumbersome and computationally challenging. We present an approach to efficiently handle sequencing data from complex pedigrees that incorporates information from rare variants as well as common variants. Our method employs a 2-step procedure that sequentially regresses out correlation from familial relatedness and then uses the resulting phenotypic residuals in a penalized regression framework to test for associations with variants within genetic units. The operating characteristics of this approach are detailed using simulation data based on a large, multigenerational cohort.