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Protein Concentration Elevations In Mouse Lungs Following Sudden Transient Cephalad (+Gz) Acceleration, Charles J. Gutierrez
Protein Concentration Elevations In Mouse Lungs Following Sudden Transient Cephalad (+Gz) Acceleration, Charles J. Gutierrez
Retrospective Theses and Dissertations
Laboratory and feral lineages of mice were subjected to cephalad (+GZ) accelerations, for 1.8 seconds, aboard a solid fuel rocket. Spectrophotometric analysis of bronchoalveolar lavage retrieved post launch revealed significant (p < .001) elevations of protein in the lungs of experimental mice. Sudden transient imposition of a mean +GZ acceleration of 6.22 ± .47 (SD) G, at lift-off, may have induced hypervolemia of basilar pulmonary microvasculature with concomitant migration of fluid and protein from intravascular to juxta-alveolar perivascular compartments. Exudates may have entered bronchiolar airways subsequently gravitating toward alveoli.