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Compositions And Methods Of Enhancing Immune Responses To Eimeria, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John R. Barta, Guillermo L. Tellez Feb 2015

Compositions And Methods Of Enhancing Immune Responses To Eimeria, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John R. Barta, Guillermo L. Tellez

Patents Granted

Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites are also provided.


Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton Feb 2015

Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton

Patents Granted

Vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector are provided. Compositions comprising the vaccine vectors and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration are also provided . Methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.


Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton Dec 2014

Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton

Patents Granted

Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB 1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.


Evaluation Of Low-Tannin Grain Sorghum In Broiler Chicken Diets, Samantha Aniecia Shelton Dec 2014

Evaluation Of Low-Tannin Grain Sorghum In Broiler Chicken Diets, Samantha Aniecia Shelton

Graduate Theses and Dissertations

Research trials were conducted to evaluate the effects of different levels of dietary grain sorghum on broiler live performance, carcass yield and shank (leg) and breast skin coloring. Iso-caloric diets were formulated where sorghum replaced corn at rates of 0% (control), 20, 40, 60, 80 and 100% for a total of 6 diets. For each of the two trials, 1500 Cobb 500 male broiler chicks were randomly allocated to 60 pens with 25 birds per pen (10 pens/diet) and grown to 46 days for the first research trial and 41 days for the second. There were no differences (P>.05) …


Compositions And Methods Of Enhancing Immune Responses, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton Dec 2013

Compositions And Methods Of Enhancing Immune Responses, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton

Patents Granted

Salmonella enteritidis 13A strains and compositions comprising these strains are provided. Methods of enhancing an immune response against Influenza A; of reducing morbidity associated with an Influenza A infection; of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40; of developing a bacterial vaccine vector are disclosed, and of generating scarless site-specific mutations in a bacterium are disclosed.


Method For Bacteriophage Delivery And Amplification, Billy M. Hargis, Stacy E. Higgins, Lisa R. Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue Feb 2013

Method For Bacteriophage Delivery And Amplification, Billy M. Hargis, Stacy E. Higgins, Lisa R. Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue

Patents Granted

Methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected are described. In addition to methods of treating a subject infected with a pathogenic bacterium using bacteriophage, of decontaminating objects using bacteriophage, of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are also disclosed.


Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg Dec 2012

Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg

Patents Granted

A concentrated quaternary ammonium compound (QAC) solution with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other …


In Vivo System To Monitor Tissue Responses In Birds, Gisela F. Erf Jul 2012

In Vivo System To Monitor Tissue Responses In Birds, Gisela F. Erf

Patents Granted

Methods of evaluating the tissue response to an agent in birds are provided as well as methods of monitoring exposure to agents in birds and of determining the efficacy of vaccines.


Method For Bacteriophage Delivery And Amplification, Billy M. Hargis, Stacy E. Higgins, Lisa R. Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue May 2011

Method For Bacteriophage Delivery And Amplification, Billy M. Hargis, Stacy E. Higgins, Lisa R. Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue

Patents Granted

Methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods are disclosed. Also disclosed are: methods of treating a subject infected with a pathogenic bacterium using bacteriophage, of decontaminating objects using bacteriophage, and of producing vaccines. In another aspect, methods of determining bacterial viability and of improving the sensitivity of a biosensor using wide host range bacteriophages are also disclosed.


Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg Jun 2009

Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg

Patents Granted

A concentrated quaternary ammonium compound (QAC) solution with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and …


Methods Of Treating Manure, Philip A. Moore Jr. Mar 2006

Methods Of Treating Manure, Philip A. Moore Jr.

Patents Granted

A method of treating animal manure solids comprises contacting the solids with a treatment composition comprising AlCl3.nH2O or Al(NO3)3.mH2O, or the residue of AlCl3.nH2O or Al(NO3)3.mH2O, to form a treated waste product, wherein n is from 0 to 10, and m is from 0 to 12. The treatment amount can be effective to reduce phosphorus solubility in the manure; reduce phosphorus runoff and/or phosphorus leaching from fields fertilized with manure; inhibit ammonia volatilization from the manure; flocculate solids in the manure; reduce pathogens in the manure; increase the nitrogen content in the manure; and/or reduce acid rain and PM-10s associated …


Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg Mar 2005

Concentrated, Non-Foaming Solution Of Quaternary Ammonium Compounds And Methods Of Use, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg

Patents Granted

A concentrated quaternary ammonium compound (QAC) solution with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and …


Intra-Vascular Administration Of Particles To Induce Pulmonary Hypertension, Pulmonary Hypertension Syndrome, And Ascites In Animals, Gisela F. Erf, Robert F. Wideman Jr., Howard L. French Apr 2004

Intra-Vascular Administration Of Particles To Induce Pulmonary Hypertension, Pulmonary Hypertension Syndrome, And Ascites In Animals, Gisela F. Erf, Robert F. Wideman Jr., Howard L. French

Patents Granted

The invention relates to a new process for inducing pulmonary hypertension (elevated blood pressure in the pulmonary arteries) in animals, with the objective of identifying and/or eliminating susceptible individuals or families to achieve genetic improvement in agriculturally important breeds of poultry (broiler chickens and turkeys), and cattle. The invention will also be useful for animal research directed toward understanding pulmonary hypertension and its sequelae in human patients as well as in animals. Sustained pulmonary hypertension leads to pulmonary hypertension syndrome, which adversely impacts poultry production throughout the world, as well as cattle production when cattle are kept at latitudes sufficiently …


Method For The Stimulation Of Sperm Production And Gonadal Development In Animals, Wayne J. Kuenzel, John D. Kirby Jun 2003

Method For The Stimulation Of Sperm Production And Gonadal Development In Animals, Wayne J. Kuenzel, John D. Kirby

Patents Granted

A method to stimulate or enhance sperm development in males and gonadal development in females is disclosed. This is done by administration of an agent which results in a transiently lowered level of a thyroid hormone such as T3 and increased gonadotropin levels in the blood.


Poultry Virus Isolates And Method, John K. Skeeles, Lisa A. Newberry Jun 2002

Poultry Virus Isolates And Method, John K. Skeeles, Lisa A. Newberry

Patents Granted

Infectious bursal disease viruses were isolated from broiler chickens experiencing proventriculitis in, for example, Oklahoma, Texas, West Virginia, and California. Chicken virus isolates Texas RB 3, Texas RB 4, HBS, F57-7, W/L 39, GAR 1, and the like have been isolated. These viruses are some of the major causes of this condition and can be utilized as or in a vaccine to prevent the disease condition. The viruses are a significant finding in the search for a causative agent for proventriculitis in broiler chickens and as such may be utilized in the development of a vaccine or vaccines. The viruses …


Methods Of Treating Animal Waste Slurries, Philip A. Moore Jr. Feb 2002

Methods Of Treating Animal Waste Slurries, Philip A. Moore Jr.

Patents Granted

A method of treating liquid animal manure comprising contacting a manure slurry with a treatment composition comprising a treatment effective amount of AlCl3.nH2O or Al(NO3)3.mH2O, or the residue of AlCl3.nH2O or Al(NO3)3.mH2O, to form a resulting slurry, wherein n is from 0 to 10, and m is from 0 to 12. The treatment effective amount is effective to reduce phosphorus solubility, reduce phosphorus runoff and/or phosphorus leaching from fields fertilized with manure; inhibit ammonia volatilization; flocculate solids; reduce pathogens; increase the nitrogen content; and/or reduce acid rain and PM-10s associated with the manure.


In Ovo Use Of L-Arginine And Salts Thereof In The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians, Robert F. Wideman Jr., Walter G. Bottje Oct 2000

In Ovo Use Of L-Arginine And Salts Thereof In The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians, Robert F. Wideman Jr., Walter G. Bottje

Patents Granted

Describes a method of treating an avian egg, including the step of administering a sufficient amount of an L-arginine compound to prevent pulmonary hypertension syndrome in an avian to be hatched from the egg.


Broad Spectrum Prevention And Removal Of Microbial Contamination Of Food By Quaternary Ammonium Compounds, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien Mar 2000

Broad Spectrum Prevention And Removal Of Microbial Contamination Of Food By Quaternary Ammonium Compounds, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li, Timothy O'Brien

Patents Granted

A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products is described. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin producing Escherichia, and pathogenic toxin-producing Escherichia such as O157:H7, fungi such as Aspergillus flavus and Penicillium chrysogenum, and parasites such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit.


Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorous Solubility In Poultry Litter, Philip A. Moore Jr. Oct 1999

Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorous Solubility In Poultry Litter, Philip A. Moore Jr.

Patents Granted

A method is described for treating poultry litter which inhibits ammonia volatilization and reduces soluble phosphorus levels in the litter. It comprises the addition of alum to litter in an amount sufficient to maintain the litter pH at values low enough to inhibit ammonia volatilization. The addition of alum, iron or calcium compounds to litter also effectively precipitates soluble phosphorus in litter, thereby reducing the amount of soluble phosphorus runoff from fields receiving litter.


Methods For Decreasing Non-Point Source Pollution From Poultry Manure, Philip A. Moore Jr. Jul 1999

Methods For Decreasing Non-Point Source Pollution From Poultry Manure, Philip A. Moore Jr.

Patents Granted

Poultry production is improved by treating poultry manure in the growing location with alum in an amount of from about 0.75 to about 1.5 tons of alum per 10000 birds raised, or at least 0.15 to about 0.25 pounds of alum per bird raised. This improves weight gain and feed conversion and decreases mortality for birds grown on treated manure as compared with birds grown on untreated manure. The alum-treated manure may also be used as an agricultural fertilizer. When used as agricultural fertilizer in agricultural runoff water studies, plots fertilized with alum-treated manure exhibit decreased concentrations of phosphorus and …


Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorus Solubility In Poultry Litter, Philip A. Moore Jr. Jun 1999

Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorus Solubility In Poultry Litter, Philip A. Moore Jr.

Patents Granted

Short term control of ammonia volatilization from animal manures is provided by surface treatment with aluminum sulfate. The aluminum sulfate may be applied to manure or manure receiving surfaces in an animal rearing facility in solid or liquid form. The control of atmospheric ammonia levels in animal rearing facilities to preferably less than about 25 ppm ammonia can be achieved by surface treatment employing amounts of alum as low as 0.5% by weight alum based on manure present.


Method And System For Fecal Detection, Amy L. Waldroup, John D. Kirby Apr 1999

Method And System For Fecal Detection, Amy L. Waldroup, John D. Kirby

Patents Granted

Describes a method of and apparatus for detecting the presence of fecal or ingesta matter contaminants on a poultry or meat item. The poultry or meat is conveyed in front of a UV light transmitter/receiver where UV light is directed onto the poultry or meat item and subsequently light is gathered from the poultry or meat. The gathered light is then compared to a threshold above which indicates contaminants. If contaminants are present the controller can generate a signal and/or send the contaminated items to a wash station.


Use Of L-Arginine And Salts Thereof In Drinking Water For The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians, Robert F. Wideman Jr., Walter G. Bottje, Michael T. Kidd Apr 1999

Use Of L-Arginine And Salts Thereof In Drinking Water For The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians, Robert F. Wideman Jr., Walter G. Bottje, Michael T. Kidd

Patents Granted

Describes a method of treating or preventing pulmonary hypertension syndrome in avians, generally including administering a drinking water containing L-arginine.


Swine Rearing Facility And Method For Reducing Ammonia And Odors Therein, Philip A. Moore Jr. Apr 1999

Swine Rearing Facility And Method For Reducing Ammonia And Odors Therein, Philip A. Moore Jr.

Patents Granted

Atmospheric conditions and environmental impact of swine rearing facilities are improved by adding alum (aluminum sulfate) in a swine manure processing system. In an embodiment, alum is added to flush water used to flush away manure which has temporarily collected on at least a portion of a floor of the facility, such as in a flushing trough. The flushed manure and water are drained and delivered to a holding pond. Preferably, the flush water is then recycled from the holding pond for subsequent flushing. In another method, alum is added to a manure slurry in a manure collection pit disposed …


High-Rise Laying Hen Rearing Facility And Method, Philip A. Moore Jr. Feb 1999

High-Rise Laying Hen Rearing Facility And Method, Philip A. Moore Jr.

Patents Granted

Atmospheric growing conditions in high-rise animal rearing facilities are improved by spraying liquid alum periodically over the manure collection area. This results in improved high rise animal rearing facilities provided with a liquid alum treatment delivery system for misting or spraying the liquid alum over the manure collection area to strip ammonia gas from the air and to apply a chemical coating on a surface of the accumulated manure which reduces or prevents ammonia volatilization. The liquid chemical treatment comprises an aqueous alum solution containing 1 to about 50% by weight alum, applied at a rate of about 50-250 g …


Method For The Broad Spectrum Prevention And Removal Of Microbial Contamination Of Poultry And Meat Products By Quaternary Ammonium Compounds, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li Jan 1999

Method For The Broad Spectrum Prevention And Removal Of Microbial Contamination Of Poultry And Meat Products By Quaternary Ammonium Compounds, Cesar M. Compadre, Philip J. Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael F. Slavik, Yanbin Li

Patents Granted

A composition and a method of using the composition for removal and prevention of broad spectrum foodborne microbial contamination in meat products is described. The method uses quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from poultry and meat products. For example, removing Escherichia coli O157:H7 contamination from meat and poultry products. One of the treatment methods is spraying quaternary ammonium compounds on the poultry and meat products to prevent broad spectrum foodborne microbial contamination. The treatment methods can contact the meat products with the quaternary ammonium compounds for less than 10 …


Method And System For Fecal Detection, Min Xiao, Da Kui Zhuang, Guolu Zheng, Michael F. Slavik Oct 1998

Method And System For Fecal Detection, Min Xiao, Da Kui Zhuang, Guolu Zheng, Michael F. Slavik

Patents Granted

A method of and apparatus for detecting the presence of fecal or ingesta matter contaminants on a poultry or meat item is described. The poultry or meat is exposed to excitation light of a selected bandwidth(s) and certain bandwidth(s) is(are) measured and compared to a threshold, above which indicates contaminants. Suitable excitation bandwidth and measuring bandwidth are selected such that the ratio of or difference between the resulting sample fluorescence and contamination fluorescence are greater than a certain ratio or difference. If contaminants are present, a controller can generate a signal and/or send the contaminated items to a wash station.


Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorus Solubility In Poultry Litter, Philip A. Moore Jr. Apr 1997

Use Of Alum To Inhibit Ammonia Volatilization And To Decrease Phosphorus Solubility In Poultry Litter, Philip A. Moore Jr.

Patents Granted

A method for treating poultry litter which inhibits ammonia volatilization and reduces soluble phosphorus levels in the litter. The method comprises the addition of alum to litter in an amount sufficient to maintain the litter pH at values low enough to inhibit ammonia volatilization. The addition of alum, iron or calcium compounds to litter also effectively precipitates soluble phosphorus in litter, thereby reducing the amount of soluble phosphorus runoff from fields receiving litter.


Method And System For Fecal Detection, Amy L. Waldroup, John D. Kirby Apr 1997

Method And System For Fecal Detection, Amy L. Waldroup, John D. Kirby

Patents Granted

Describes a method of and apparatus for detecting the presence of fecal or ingesta matter contaminants on a poultry or meat item. The poultry or meat is conveyed in front of a UV light transmitter/receiver where UV light is directed onto the poultry or meat item and subsequently light is gathered from the poultry or meat. The gathered light is then compared to a threshold above which indicates contaminants. If contaminants are present the controller can generate a signal and/or send the contaminated items to a wash station.


Use Of Quaternary Ammonium Compounds To Remove Salmonella Contamination From Meat Products, Danny L. Lattin, Philip J. Breen, Cesar M. Compadre, E. Kim Fifer, Michael F. Slavik, Hamid Salari, Phillip V. Engler Nov 1994

Use Of Quaternary Ammonium Compounds To Remove Salmonella Contamination From Meat Products, Danny L. Lattin, Philip J. Breen, Cesar M. Compadre, E. Kim Fifer, Michael F. Slavik, Hamid Salari, Phillip V. Engler

Patents Granted

A composition and method for removing and preventing Salmonella contamination of meat products, in particular poultry, is disclosed. The composition comprises an effective amount of a quaternary ammonium compound in an aqueous solution. The quaternary ammonium compound are selected from the group consisting of alkylpyridinium, tetra-alkylammonium, and alkylalicyclic ammonium salts. Preferably, the quaternary ammonium compounds are cetylpyridinium chloride and cetylpyridinium bromide. Mutagenicity studies are also disclosed.