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Compositions And Methods Of Enhancing Immune Responses To Flagellated Bacterium, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
Compositions And Methods Of Enhancing Immune Responses To Flagellated Bacterium, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
Patents Granted
Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
Methods Of Selecting And Using Therapeutic And Prophylactic Probiotic Cultures To Reduce Bacterial Pathogen Loads, Daniel J. Donoghue, Ann M. Donoghue
Methods Of Selecting And Using Therapeutic And Prophylactic Probiotic Cultures To Reduce Bacterial Pathogen Loads, Daniel J. Donoghue, Ann M. Donoghue
Patents Granted
Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. It is also capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided.
Methods And Compositions Including Spore-Forming Bacteria For Increasing The Health Of Animals, Billy M. Hargis, Ross Wolfenden, Neil R. Pumford, Marion Morgan, Anita Menconi, Guillermo L. Tellez, Amanda Wolfenden, Srichaitanya Shivaramaiah
Methods And Compositions Including Spore-Forming Bacteria For Increasing The Health Of Animals, Billy M. Hargis, Ross Wolfenden, Neil R. Pumford, Marion Morgan, Anita Menconi, Guillermo L. Tellez, Amanda Wolfenden, Srichaitanya Shivaramaiah
Patents Granted
Describe methods, compositions and bacterial isolates for improving the gastrointestinal health of animals and in particular of poultry are provided herein. The methods include administering an endospore-forming bacteria to an animal. The bacteria are selected for the ability to reduce the growth and presence of bacterial pathogens, such as Salmonella, Clostridium, and Campylobacter, in the gastrointestinal tract of the animal. The bacteria are also selected for the ability to improve at least one production parameter in the animal.
Vaccine And Methods To Reduce Campylobacter Infection, Billy M. Hargis, Neil R. Pumford, Young M. Kwon, Sherryll Layton
Vaccine And Methods To Reduce Campylobacter Infection, Billy M. Hargis, Neil R. Pumford, Young M. Kwon, Sherryll Layton
Patents Granted
Describe vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
Compositions And Methods Of Enhancing Immune Responses To Eimeria, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John R. Barta, Guillermo L. Tellez
Compositions And Methods Of Enhancing Immune Responses To Eimeria, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John R. Barta, Guillermo L. Tellez
Patents Granted
Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites are also provided.
Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton
Vaccine Vectors And Methods Of Enhancing Immune Responses, Luc Berghman, Walter G. Bottje, Billy M. Hargis, Sherryll Layton
Patents Granted
Vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector are provided. Compositions comprising the vaccine vectors and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration are also provided . Methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.