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Porous Scaffold And Soft Hydrogel Composite For Biomedical Applications, Matthew Dicerbo
Porous Scaffold And Soft Hydrogel Composite For Biomedical Applications, Matthew Dicerbo
Theses and Dissertations
Biophysical signals including stiffness and dimensionality influence a myriad of stem cell behaviors including morphology, mechanosensing, and differentiation. 2D stiff environments cause increased cellular spreading and induce osteogenic differentiation whereas 3D soft environments favor rounder cell morphologies attributed to a chondrogenic phenotype. The goal of this study is to create a composite that integrates these divergent biophysical signals within one system. This composite consists of a stiff and porous polycaprolactone (PCL) backbone that provides mechanical stiffness and a 2D environment. The PCL backbone is then perfused with mesenchymal stem cells (MSCs) and a soft methacrylated gelatin (GelMe) hydrogel to provide …
In Situ Characterization Of Fiber-Matrix Interface Debonding Via Full-Field Measurements, Robert Livingston
In Situ Characterization Of Fiber-Matrix Interface Debonding Via Full-Field Measurements, Robert Livingston
Theses and Dissertations
Macroscopic mechanical and failure properties of fiber-reinforced composites depend strongly on the properties of the fiber-matrix interface. For example, transverse cracking behavior and interlaminar shear strength of composites can be highly sensitive to the characteristics of the fiber-matrix interface. Despite its importance, experimental characterization of the mechanical behavior of the fiber-matrix interface under normal loading conditions has been limited. This work reports an experimental approach that uses in situ full-field digital image correlation (DIC) to quantify the mechanical and failure behaviors at the fiber-matrix interface. Single fiber model composite samples are fabricated from a proprietary epoxy embedding a single glass …