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Antimicrobial Activity Of Silver(I) Cyanoximates Against Streptococcus Mutans Ua159 Planktonic Growth And Biofilm Formation, Sarah Hameer
Antimicrobial Activity Of Silver(I) Cyanoximates Against Streptococcus Mutans Ua159 Planktonic Growth And Biofilm Formation, Sarah Hameer
Honors Program Theses
Streptococcus mutans is identified as the causative agent of human dental caries, with biofilm formation serving as its most important virulence factor. Biofilms are typically more challenging to treat than planktonic or free-floating bacteria, adding to the already challenging issue of antibiotic resistance. This has led to an increased need for the discovery of alternative antibacterial compounds other than antibiotics. Among these compounds, silver(I) cyanoximates have been demonstrated to have antibacterial activity against a variety of microorganisms, specifically those that colonize in-dwelling medical devices. To assess the antibacterial properties of two silver(I) cyanoximate compounds, silver(I) nitrosodicyanomethanide (Ag(ACO)) and silver(I)α-oximido-(2-benzoyl)acetonitrile (Ag(BCO)), …