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Control Of Pausing In Rich-Lean Transitions By Spatially Localized And Spatially Diffuse Stimuli, Carson S. Yahrmarkt
Control Of Pausing In Rich-Lean Transitions By Spatially Localized And Spatially Diffuse Stimuli, Carson S. Yahrmarkt
All NMU Master's Theses
Signaled transitions from rich (favorable) to lean (less favorable) schedules of reinforcement (i.e., rich-lean transitions) can disrupt operant behavior. Previous literature suggests that disruptions in these transitions could occur because individuals engage in other behavior that reduces contact with the schedule-correlated stimuli. My thesis project evaluated this possibility by using different stimuli to manipulate the ease by which rats could reduce contact with schedule-correlated stimuli during signaled rich-lean transitions. We arranged a two-component multiple fixed ratio-fixed ratio (FR-FR) schedule to evaluate effects of different types of schedule-correlated stimuli on pausing in rich-lean transitions using rat subjects. Components had equivalent FR …
An Examination Of Affective Blunting In Rodents, Sigrid Crowel
An Examination Of Affective Blunting In Rodents, Sigrid Crowel
All NMU Master's Theses
Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The prevalence of MDD is 12% in men and 20% in women. Antidepressant drugs are the first line of treatment in Major Depressive Disorder and other mood disorders, particularly selective-serotonin reuptake inhibitors. Affective blunting is a potential side effect of chronic SSRI treatment, which can be defined as a diminished response to pleasurable or unpleasant stimuli, and is indicated as a marked indifference towards engagement in activities. The present study looked to examine the effects of chornic fluoxetine (0.16g/L) administration on pre-test and post-test performance of a light aversion …
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
All NMU Master's Theses
The present study sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, the 0.25 mg/kg …