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Immunoglobin And Fcγ Receptor Genes Influence The Control Of Hiv Replication And The Progression Of Hiv Infection, Ray Deepe

MUSC Theses and Dissertations

HIV is an infection affecting approximately 33 million people worldwide especially in Sub-Saharan Africa and Southeastern Asia. HIV infection is marked by the loss of CD4+ T-cells and is the causative agent of AIDS. Host genetic factors have been shown to influence the progression and outcome of HIV infection, but the genes identified thus far account for approximately 15% of the variance observed in viral load and progression, suggesting involvement of additional genes in HIV pathogenesis. FcyRIIa and FcyRIIIa genotypes have been shown to be influential in the transmission, control, and progression of HIV. These receptors contain polymorphisms that influence …