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Adolescence, Alcohol, And Astrocytes: The Impact Of Adolescent Alcohol Use On Astrocyte-Synaptic Interactions, Structure, Function, And Behavior, Christopher Douglas Walker

Theses, Dissertations and Capstones

Alcohol is the third leading cause of preventable death in the United States and has substantial social and economic burdens. Excessive alcohol consumption in the form of binge drinking is highly prevalent among adolescents and emerging adults. Binge drinking is a form of excessive drinking, defined as consuming enough alcohol on a single occasion to result in blood alcohol concentrations above 0.08%. Approximately 55% of full-time college students aged 18- 22 years old have reported consuming alcohol in a binge manner. Furthermore, studies have shown that approximately 20% of college students meet the criteria for an alcohol use disorder (AUD). …

The Effects Of Community Type And Sexual Orientation On Adolescent Alcohol Abuse: A Retrospective Exploration, Karla Beth Moore

Theses, Dissertations and Capstones

Considerable research has demonstrated that adolescents, as a whole, are experimenting with alcohol at alarming rates (Biddle, Bank, & Marlin, 1980; Donath, et al., 2011;King, Chassin, & Molina, 2009). However, research is very mixed on findings identifying which groups of adolescents tend to be most at risk for using alcohol, as well as the reasons these groups identify for such experimentation (Carlo, Crockett, Wilkinson, & Beal, 2011; Coomber, Toumbourou, Miller, Staiger, Hemphill, & Catalano, 2011). The current study examined participants from various community types and sexual orientations, in a retrospective manner. Participants (ages 18 and over) answered questions on a …

Effects Of Acute Or Chronic Ethanol Exposure During Adolescence On Behavioral Inhibition And Efficiency In A Modified Water Maze Task, Shawn K. Acheson, Craig Bearison, Mary-Louise Risher, Sabri H. Abdelwahab, Wilkie A. Wilson, H. Scott Swartzwelder

Biomedical Sciences

Ethanol is well known to adversely affect frontal executive functioning, which continues to develop throughout adolescence and into young adulthood. This is also a developmental window in which ethanol is misused by a significant number of adolescents. We examined the effects of acute and chronic ethanol exposure during adolescence on behavioral inhibition and efficiency using a modified water maze task. During acquisition, rats were trained to find a stable visible platform onto which they could escape. During the test phase, the stable platform was converted to a visible floating platform (providing no escape) and a new hidden platform was added …

Long-Term Effects Of Chronic Intermittent Ethanol Exposure In Adolescent And Adult Rats: Radial-Arm Maze Performance And Operant Food Reinforced Responding, Mary-Louise Risher, Rebekah L. Fleming, Nathalie Boutros, Svetlana Semenova, Wilkie A. Wilson, Edward D. Levin, Athina Markou, H. Scott Swartzwelder, Shawn K. Acheson

Biomedical Sciences

Background: Adolescence is not only a critical period of late-stage neurological development in humans, but is also a period in which ethanol consumption is often at its highest. Given the prevalence of ethanol use during this vulnerable developmental period we assessed the long-term effects of chronic intermittent ethanol (CIE) exposure during adolescence, compared to adulthood, on performance in the radial-arm maze (RAM) and operant food-reinforced responding in male rats.

Methodology/Principal Findings: Male Sprague Dawley rats were exposed to CIE (or saline) and then allowed to recover. Animals were then trained in either the RAM task or an operant task using …