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Genetic Markers Involved In Macrocyclic Lactone Resistance In Dirofilaria Immitis And Estimation Of Heartworm Prevalence In Resident Canine Populations Of The Cumberland Gap Region Of Kentucky, Tennessee, And Virginia., Hailey Watlington, Charles T. Faulkner
Genetic Markers Involved In Macrocyclic Lactone Resistance In Dirofilaria Immitis And Estimation Of Heartworm Prevalence In Resident Canine Populations Of The Cumberland Gap Region Of Kentucky, Tennessee, And Virginia., Hailey Watlington, Charles T. Faulkner
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Infection with heartworm (Dirofilaria immitis), is a significant cause of disease in companion animals worldwide. Macrocyclic lactones (MLs) have been the standard treatment for heartworm prevention for the last 25 years. Although widely used and highly effective, recent studies have shown a potential loss of efficacy. Investigations suggest the involvement of a single-nucleotide polymorphisms (SNPs) of a gene encoding a fragment of P-glycoprotein (P-gp) within the Dirofilaria. immitis genome. This reveals a potential relationship between SNP frequencies within the P-gp gene and ML resistance. The prevalence of heartworm infection in the Cumberland Gap Region (CGR) is reported to …