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Synthesizing Adversarial Examples For Neural Networks, Hasitha Rasineni Jan 2109

Synthesizing Adversarial Examples For Neural Networks, Hasitha Rasineni

Creative Components

As machine learning is being integrated into more and more systems, such as autonomous vehicles or medical devices, they are also becoming entry points for attacks. Many sate-of-the-art neural networks have been proved, to be vulnerable to adversarial examples. These failures of machine learning models demonstrate that even simple algorithms can behave very differently from what their designers intend to. In order to close this gap between what designers intend to and how algorithms behave, there is a huge need for preventing adversarial examples to improve the credibility of the model. This study focuses on synthesizing adversarial examples using two ...


Surge And Stall Detection Using Acoustic Analysis For Gas Turbine Hybrid Cycles, Keishaly Cabrera Cruz, Paolo Pezzini, Lawrence Shadle, Kenneth Bryden Apr 2020

Surge And Stall Detection Using Acoustic Analysis For Gas Turbine Hybrid Cycles, Keishaly Cabrera Cruz, Paolo Pezzini, Lawrence Shadle, Kenneth Bryden

Ames Laboratory Accepted Manuscripts

Compressor dynamics were studied in a gas turbine—fuel cell hybrid power system having a larger compressor volume than traditionally found in gas turbine systems. This larger compressor volume adversely affects the surge margin of the gas turbine. Industrial acoustic sensors were placed near the compressor to identify when the equipment was getting close to the surge line. Fast Fourier transform (FFT) mathematical analysis was used to obtain spectra representing the probability density across the frequency range (0–5000 Hz). Comparison between FFT spectra for nominal and transient operations revealed that higher amplitude spikes were observed during incipient stall at ...


The Soybean Aphid Suction Trap Network: Sampling The Aerobiological “Soup”, Doris Lagos-Kutz, David J. Voegtlin, David Onstad, David Hogg, David Ragsdale, Kelley Tilmon, Erin Hodgson, Christina Difonzo, Russell Groves, Christian Krupke, Joseph Laforest, Nicholas J. Selter, Emily Duerr, Benjamin Bradford, Glen L. Hartman Apr 2020

The Soybean Aphid Suction Trap Network: Sampling The Aerobiological “Soup”, Doris Lagos-Kutz, David J. Voegtlin, David Onstad, David Hogg, David Ragsdale, Kelley Tilmon, Erin Hodgson, Christina Difonzo, Russell Groves, Christian Krupke, Joseph Laforest, Nicholas J. Selter, Emily Duerr, Benjamin Bradford, Glen L. Hartman

Entomology Publications

The initiation of the soybean aphid suction trap network (STN) in 2001 marked the beginning of a rich and fruitful collaborative effort that has produced a wealth of data about the soybean aphid, other insect species, and other organisms that make up the aerobiological “soup.” Collaboration among researchers, extension specialists, and agriculturalists has provided information about seasonal migration patterns of the soybean aphid and monitoring of other insect species. The physical collections of the “soup” have been stored and used for past research, and will serve as a foundation for future research.


Observations Show That Wind Farms Substantially Modify The Atmospheric Boundary Layer Thermal Stratification Transition In The Early Evening, Daniel A. Rajewski, Eugene S. Takle, Andy Vanloocke, Samantha L. Purdy Mar 2020

Observations Show That Wind Farms Substantially Modify The Atmospheric Boundary Layer Thermal Stratification Transition In The Early Evening, Daniel A. Rajewski, Eugene S. Takle, Andy Vanloocke, Samantha L. Purdy

Agronomy Publications

Single wind turbines and large wind farms modify local scales of atmospheric boundary layer (ABL) turbulence through different mechanisms dependent on location within the wind farm. These changes in turbulence scales would most likely have notable influence on surface fluxes and microclimate during the afternoon and early evening stability transition. Profiles of Richardson number and shear and buoyancy from 1‐Hz tall tower measurements in and near a wind farm in an agricultural landscape were used to quantify departures in stability characteristics during the fallow seasons. A single turbine wake decoupled turbulent connection between the surface and above the wind ...


Enhancing The Conductivity Of Cell-Laden Alginate Microfibers With Aqueous Graphene For Neural Applications, Marilyn C. Mcnamara, Amir Ehsan Niaraki-Asli, Jingshuai Guo, Jasmin Okuzono, Reza Montazami, Nicole N. Hashemi Mar 2020

Enhancing The Conductivity Of Cell-Laden Alginate Microfibers With Aqueous Graphene For Neural Applications, Marilyn C. Mcnamara, Amir Ehsan Niaraki-Asli, Jingshuai Guo, Jasmin Okuzono, Reza Montazami, Nicole N. Hashemi

Mechanical Engineering Publications

Microfluidically manufacturing graphene-alginate microfibers create possibilities for encapsulating rat neural cells within conductive 3D tissue scaffolding to enable the creation of real-time 3D sensing arrays with high physiological relavancy. Cells are encapsulated using the biopolymer alginate, which is combined with graphene to create a cell-containing hydrogel with increased electrical conductivity. Resulting novel alginate-graphene microfibers showed a 2.5-fold increase over pure alginate microfibers, but did not show significant differences in size and porosity. Cells encapsulated within the microfibers survive for up to 8 days, and maintain ~20% live cells over that duration. The biocompatible aqueous graphene suspension used in this ...


Impact Of Spontaneous Haploid Genome Doubling In Maize Breeding, Nicholas A. Boerman, Ursula K. Frei, Thomas Lubberstedt Mar 2020

Impact Of Spontaneous Haploid Genome Doubling In Maize Breeding, Nicholas A. Boerman, Ursula K. Frei, Thomas Lubberstedt

Agronomy Publications

Doubled haploid (DH) technology has changed the maize-breeding landscape in recent years. Traditionally, DH production requires the use of chemical doubling agents to induce haploid genome doubling and, subsequently, male fertility. These chemicals can be harmful to humans and the plants themselves, and typically result in a doubling rate of 10%–30%. Spontaneous genome doubling and male fertility of maize haploids, without using chemical doubling agents, have been observed to a limited extent, for nearly 70 years. Rates of spontaneous haploid genome doubling (SHGD) have ranged from less than 5% to greater than 50%. Recently, there has been increased interest ...


Minecraft As A Tool For Engaging Children In Urban Planning: A Case Study In Tirol Town, Brazil, Bruno De Andrade, Alenka Poplin, Ítalo Sousa De Sena Mar 2020

Minecraft As A Tool For Engaging Children In Urban Planning: A Case Study In Tirol Town, Brazil, Bruno De Andrade, Alenka Poplin, Ítalo Sousa De Sena

Community and Regional Planning Publications

The purpose of this paper is to explore the potential of Minecraft’s game environment for urban planning with older and younger children in a public school in Tirol town, Brazil. Minecraft is employed as an innovative tool to tackle the present lack of engagement and involvement of key societal actors such as children and young people in urban planning. Thus, how can games support children to co-design their future city? Which heritage values do they represent graphically in the game environment? Geogames are games that provide a visualization of a real spatial context and in this study, Minecraft is ...


Genetic And Genomic Characterization Of Vulva Size Traits In Yorkshire And Landrace Gilts, Flor-Anita Corredor, Leticia P. Sanglard, Richard J. Leach, Jason W. Ross, Aileen F. Keating, Nick V. L. Serão Mar 2020

Genetic And Genomic Characterization Of Vulva Size Traits In Yorkshire And Landrace Gilts, Flor-Anita Corredor, Leticia P. Sanglard, Richard J. Leach, Jason W. Ross, Aileen F. Keating, Nick V. L. Serão

Animal Science Publications

Background: Reproductive performance is critical for efficient swine production. Recent results indicated that vulva size (VS) may be predictive of reproductive performance in sows. Study objectives were to estimate genetic parameters, identify genomic regions associated, and estimate genomic prediction accuracies (GPA) for VS traits.

Results: Heritability estimates of VS traits, vulva area (VA), height (VH), and width (VW) measurements, were moderately to highly heritable in Yorkshire, with 0.46 ± 0.10, 0.55 ± 0.10, 0.31 ± 0.09, respectively, whereas these estimates were low to moderate in Landrace, with 0.16 ± 0.09, 0.24 ± 0.11, and 0 ...


Crispr-Cas12a Has Widespread Off-Target And Dsdna-Nicking Effects, Karthik Murugan, Arun S. Seetharam, Andrew J. Severin, Dipali G. Sashital Mar 2020

Crispr-Cas12a Has Widespread Off-Target And Dsdna-Nicking Effects, Karthik Murugan, Arun S. Seetharam, Andrew J. Severin, Dipali G. Sashital

Office of Biotechnology Publications

Cas12a (Cpf1) is an RNA-guided endonuclease in the bacterial type V-A CRISPR-Cas anti-phage immune system that can be repurposed for genome editing. Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it an ideal candidate for expanding the arsenal of enzymes used in precise genome editing. However, this reported high specificity contradicts Cas12a’s natural role as an immune effector against rapidly evolving phages. Here, we employed high-throughput in vitro cleavage assays to determine and compare the native cleavage specificities and activities of three different natural Cas12a orthologs (FnCas12a, LbCas12a, and AsCas12a). Surprisingly, we observed pervasive ...


Pyrpipe: A Python Package For Rna-Seq Workflows, Urminder Singh, Jing Li, Arun Seetharam, Eve Syrkin Wurtele Mar 2020

Pyrpipe: A Python Package For Rna-Seq Workflows, Urminder Singh, Jing Li, Arun Seetharam, Eve Syrkin Wurtele

Genetics, Development and Cell Biology Publications

Implementing RNA-Seq analysis pipelines is challenging as data gets bigger and more complex. With the availability of terabytes of RNA-Seq data and continuous development of analysis tools, there is a pressing requirement for frameworks that allow for fast and efficient development, modification, sharing and reuse of workflows. Scripting is often used, but it has many challenges and drawbacks. We have developed a python package, python RNA-Seq Pipeliner (pyrpipe) that enables straightforward development of flexible, reproducible and easy-to-debug computational pipelines purely in python, in an object-oriented manner. pyrpipe provides high level APIs to popular RNA-Seq tools. Pipelines can be customized by ...


High-Throughput Synthesis And Screening Of Rapidly-Degrading Polyanhydride Nanoparticles, Adam S. Mullis, Sarah J. Jacobson, Balaji Narasimhan Mar 2020

High-Throughput Synthesis And Screening Of Rapidly-Degrading Polyanhydride Nanoparticles, Adam S. Mullis, Sarah J. Jacobson, Balaji Narasimhan

Chemical and Biological Engineering Publications

Combinatorial techniques can accelerate the discovery and development of polymeric nanodelivery devices by pairing high-throughput synthesis with rapid materials characterization. Biodegradable polyanhydrides demonstrate tunable release, high cellular internalization, and dose sparing properties when used as nanodelivery devices. This nanoparticle platform shows promising potential for small molecule drug delivery, but the pace of understanding and rational design of these nanomedicines is limited by the low throughput of conventional characterization. This study reports the use of a high-throughput method to synthesize libraries of a newly synthesized, rapidly-eroding polyanhydride copolymer based on 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and sebacic acid (SA) monomers ...


Survival Of White-Tailed Deer Fawns In Central Iowa, Patrick G. Mcgovern, Stephen J. Dinsmore, Julie A. Blanchong Mar 2020

Survival Of White-Tailed Deer Fawns In Central Iowa, Patrick G. Mcgovern, Stephen J. Dinsmore, Julie A. Blanchong

Natural Resource Ecology and Management Publications

Understanding demographic parameters such as survival is important for scientifically sound wildlife management. Survival can vary by region, sex, age-class, habitat, and other factors. White-tailed deer fawn survival is highly variable across the species’ range. While recent studies have investigated fawn survival in several Midwestern states, there have been no published estimates from Iowa for 30 years. We radio-collared 48 fawns in central Iowa from 2015–2017 to estimate survival, home range size, and habitat composition and identity causes of mortality. Estimated fawn survival (± SE) was similar to other Midwest studies at 30 (0.78 ± 0.07)) and 60 days ...


Intermetallic Nanocatalysts From Heterobimetallic Group 10–14 Pyridine-2-Thiolate Precursors, Carena L. Daniels, Megan Knobeloch, Philip Yox, Marquix A. S. Adamson, Yunhua Chen, Rick W. Dorn, Hao Wu, Guoquan Zhou, Huajun Fan, Aaron J. Rossini, Javier Vela Mar 2020

Intermetallic Nanocatalysts From Heterobimetallic Group 10–14 Pyridine-2-Thiolate Precursors, Carena L. Daniels, Megan Knobeloch, Philip Yox, Marquix A. S. Adamson, Yunhua Chen, Rick W. Dorn, Hao Wu, Guoquan Zhou, Huajun Fan, Aaron J. Rossini, Javier Vela

Chemistry Publications

Intermetallic compounds are atomically ordered inorganic materials containing two or more transition metals and main-group elements in unique crystal structures. Intermetallics based on group 10 and group 14 metals have shown enhanced activity, selectivity, and durability in comparison to simple metals and alloys in many catalytic reactions. While high-temperature solid-state methods to prepare intermetallic compounds exist, softer synthetic methods can provide key advantages, such as enabling the preparation of metastable phases or of smaller particles with increased surface areas for catalysis. Here, we study a generalized family of heterobimetallic precursors to binary intermetallics, each containing a group 10 metal and ...


An Assessment Use Argument For Spanish For The Professionals, Cristina Pardo-Ballester Mar 2020

An Assessment Use Argument For Spanish For The Professionals, Cristina Pardo-Ballester

World Languages and Cultures Conference Papers, Posters and Proceedings

This study focuses on reflective practice journal entries and compares intermediate Spanish learners’ journals of their own oral performance through two different opportunities - an Oral Proficiency Interview (OPI) and a Virtual Oral Interview Classroom/based Exam (VOICES) - within the framework of a Spanish for the Professions course. Students’ journals reveal that both types of assessment have their advantages in the learning process, which results in more autonomous and more efficient learners (Ziegler, 2014). Moreover, data from the two focus groups reveals information about sufficiency, relevance, beneficence, and usefulness about the Spanish speaking activities used in the Spanish for the Professions ...


The Surface Termination Of Cspbbr3 Perovskite Quantum Dots Determined By Solid-State Nmr Spectroscopy, Yunhua Chen, Sara R. Smock, Anne H. Flintgruber, Frederic A. Perras, Richard L. Brutchey, Aaron J. Rossini Mar 2020

The Surface Termination Of Cspbbr3 Perovskite Quantum Dots Determined By Solid-State Nmr Spectroscopy, Yunhua Chen, Sara R. Smock, Anne H. Flintgruber, Frederic A. Perras, Richard L. Brutchey, Aaron J. Rossini

Chemistry Publications

Cesium lead halide perovskite quantum dots (QDs) have gained significant attention as next-generation optoelectronic materials; however, their properties are highly dependent on their surface chemistry. The surfaces of cuboidal CsPbBr3 QDs have been intensively studied by both theoretical and experimental techniques, but fundamental questions still remain about the atomic termination of the QDs. The binding sites and modes of ligands at the surface remain unproven. Herein, we demonstrate that solid-state NMR spectroscopy allows the unambiguous assignments of organic surface ligands via 1H, 13C, and 31P NMR. Surface-selective 133Cs solid-state NMR spectra show the presence of an additional 133Cs NMR signal ...


Comparison Of Three Similarity Scores For Bullet Lea Matching, Susan Vanderplas, Melissa Nally, Tylor Klep, Cristina Cadevall, Heike Hofmann Mar 2020

Comparison Of Three Similarity Scores For Bullet Lea Matching, Susan Vanderplas, Melissa Nally, Tylor Klep, Cristina Cadevall, Heike Hofmann

CSAFE Publications

Recent advances in microscopy have made it possible to collect 3D topographic data, enabling more precise virtual comparisons based on the collected 3D data as a supplement to traditional comparison microscopy and 2D photography. Automatic comparison algorithms have been introduced for various scenarios, such as matching cartridge cases[1],[2] or matching bullet striae[3],[4],[5]. One key aspect of validating these automatic comparison algorithms is to evaluate the performance of the algorithm on external tests, that is, using data which were not used to train the algorithm. Here, we present a discussion of the performance of the matching ...


Inclusive Environments: Legislative Framework, Julie E.N. Irish Mar 2020

Inclusive Environments: Legislative Framework, Julie E.N. Irish

Open Course Materials

No abstract provided.


Inclusive Environments: Access Audits Lesson, Julie E.N. Irish Mar 2020

Inclusive Environments: Access Audits Lesson, Julie E.N. Irish

Open Course Materials

No abstract provided.


Measuring Cmi Responses Using The Primeflow Rna Assay: A New Method Of Evaluating Bvdv Vaccination Response In Cattle, Shollie M. Falkenberg, Rohana P. Dassanayake, John D. Neill, Paul H. Walz, Eduardo Casas, Julia F. Ridpath, James A. Roth Mar 2020

Measuring Cmi Responses Using The Primeflow Rna Assay: A New Method Of Evaluating Bvdv Vaccination Response In Cattle, Shollie M. Falkenberg, Rohana P. Dassanayake, John D. Neill, Paul H. Walz, Eduardo Casas, Julia F. Ridpath, James A. Roth

Veterinary Microbiology and Preventive Medicine Publications

Current methods for evaluating bovine viral diarrhea virus (BVDV) vaccination response typically rely on measurement of humoral responses as determined by virus neutralizing antibody titers (VNT) against BVDV. While VNT are correlated with increased protection, research has also shown that cell mediated immunity (CMI) is an important component of a protective response against BVDV. For example, improved protection against BVDV by modified-live viral (MLV) vaccines as compared to killed vaccines is thought to be due to better CMI induced by the MLV. The goal of this work was to evaluate the cell mediated response in vaccinated calves using a novel ...


A Brief Report On A Facilitated Approach To Connect Cooperative Extension Southern Region State-Level Health Specialists, Samantha M. Harden, Lisa Washburn, Alison Berg, Ninfa Pena-Purcell, Heather Norman-Burgdolf, Nancy K. Franz Mar 2020

A Brief Report On A Facilitated Approach To Connect Cooperative Extension Southern Region State-Level Health Specialists, Samantha M. Harden, Lisa Washburn, Alison Berg, Ninfa Pena-Purcell, Heather Norman-Burgdolf, Nancy K. Franz

Education Publications

Improving the nation’s health will require collaboration among many stakeholders and systems, including representatives from Cooperative Extension Services (CES). This paper describes the process of establishing a multi state collaboration and discusses initial outcomes of a third-party facilitated participatory planning meeting. State-level specialists with expertise and responsibilities in“health”promotion participated. Satisfaction with meeting format;feasibility, acceptability, and appropriateness of the proposed approach to public health impact;and general meeting feedback were collected through a survey and cultural artifacts (e.g., notes, worksheets). Preparation and attendance costs were captured. Seventeen of the 20 attendees (85%) responded to the survey ...


Similarity Evaluation Of Topography Measurement Results By Different Optical Metrology Technologies For Additive Manufactured Parts, Yi Zheng, Xiao Zhang, Shaodong Wang, Qing Li, Hantang Qin, Beiwen Li Mar 2020

Similarity Evaluation Of Topography Measurement Results By Different Optical Metrology Technologies For Additive Manufactured Parts, Yi Zheng, Xiao Zhang, Shaodong Wang, Qing Li, Hantang Qin, Beiwen Li

Industrial and Manufacturing Systems Engineering Publications

The surface topographic measurements can be used by the additive manufacturing (AM) industry for in-situ quality inspection. However, disagreements may arise when we use different technologies to measure the topography of the same sample surface due to noise, sampling or optical properties of the sample surface, which may cause miscommunications or confusions between manufacturers. Thus, proposing methods for rating the similarities to match surface topographic data measured by various optical techniques is of crucial importance. This research investigates similarity evaluation methods for three-dimensional point-cloud topography data acquired by different technologies. Two different optical techniques (focus variation microscopy and structured light ...


Design Of Attack-Resilient System For Wide-Area Monitoring, Protection, And Control In Smart Grid, Vivek Kumar Singh, Manimaran Govindarasu Mar 2020

Design Of Attack-Resilient System For Wide-Area Monitoring, Protection, And Control In Smart Grid, Vivek Kumar Singh, Manimaran Govindarasu

Electrical and Computer Engineering Publications

Can you imagine that a simple cyber-attack can turn your lights off? Do you know more than a dozen U.S. utilities have been constantly targeted through cyber-attacks within the past year? The solution - an attack-resilient grid infrastructure that can quickly detect stealthy cyber-attacks and provide an intelligent incident response to restore the normal grid condition.


Serum Vitamin B12, And Related Mtrr And Cubilin Genotypes, Predict Neural Outcomes Across The Ad Spectrum, K. E. Mcliman, A. D. Collazo Martinez, Jonathan P. Mochel, Karin D. Allenspach, Auriel A. Willette Mar 2020

Serum Vitamin B12, And Related Mtrr And Cubilin Genotypes, Predict Neural Outcomes Across The Ad Spectrum, K. E. Mcliman, A. D. Collazo Martinez, Jonathan P. Mochel, Karin D. Allenspach, Auriel A. Willette

Biomedical Sciences Publications

Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p


Generalized Instrumental Inequalities: Testing The Instrumental Variable Independence Assumption, Desire Kedagni, Ismael Mourifié Feb 2020

Generalized Instrumental Inequalities: Testing The Instrumental Variable Independence Assumption, Desire Kedagni, Ismael Mourifié

Economics Publications

This paper proposes a new set of testable implications of the instrumen- tal variable (IV) independence assumption: generalized instrumental inequalities. In our leading case with a binary outcome, we show that the generalized instrumen- tal inequalities are necessary and sufficient to detect all observable violations of the IV independence assumption. To test the generalized instrumental inequalities, we propose an approach combining a sample splitting procedure and intersection bounds inferential methods. This idea allows one to easily implement the test using the Stata package of Chernozhukov, Kim, Lee, and Rosen (2015).We apply our pro- posed strategy to assess the validity ...


The Effect Of Intravenous Maropitant On Blood Pressure In Healthy Awake And Anesthetized Dogs, Ting-Ting Chi, Bonnie L. Hay Kraus Feb 2020

The Effect Of Intravenous Maropitant On Blood Pressure In Healthy Awake And Anesthetized Dogs, Ting-Ting Chi, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Objective To evaluate the effects of intravenous maropitant on arterial blood pressure in healthy dogs while awake and under general anesthesia.

Design Experimental crossover study.

Animals Eight healthy adult Beagle dogs.

Procedure All dogs received maropitant (1 mg kg-1) intravenously under the following conditions: 1) awake with non-invasive blood pressure monitoring (AwNIBP), 2) awake with invasive blood pressure monitoring (AwIBP), 3) premedication with acepromazine (0.005 mg kg-1) and butorphanol (0.2 mg kg-1) intramuscularly followed by propofol induction and isoflurane anesthesia (GaAB), and 4) premedication with dexmedetomidine (0.005 mg kg-1) and butorphanol (0.2 mg kg-1) intramuscularly followed ...


An Environmental And Economic Analysis Of Flocculation Technology Applied To A Corn-Based Ethanol Plant, Maria C. T. B. Oliveira, Kurt A. Rosentrater Feb 2020

An Environmental And Economic Analysis Of Flocculation Technology Applied To A Corn-Based Ethanol Plant, Maria C. T. B. Oliveira, Kurt A. Rosentrater

Agricultural and Biosystems Engineering Publications

The stimulation of renewable fuel production is related to the environmental issues resulting from the extraction and utilization of fossil fuels. Although corn-based ethanol is one of the leading renewable fuels and promises to mitigate these environmental impacts, it generates large volumes of wastewater with high concentrations of organic material (CODcr > 30,000 mg/L) and low pH (3.5–4.5), which leads to serious environmental concerns. A common method of treatment of distillery wastewater is the Dry Distilled Grain Soluble (DDGS) process, which separates liquid and solid fractions; however, a disadvantage of this process is its high ...


Evaluation Of The Functional Role Of The Maize Glossy2 And Glossy2-Like Genes In Cuticular Lipid Deposition, Liza Esther Alexander, Yozo Okazaki, Michael A. Schelling, Aeriel Davis, Xiaobin Zheng, Ludmila Rizhsky, Marna D. Yandeau-Nelson, Kazuki Saito, Basil J. Nikolau Feb 2020

Evaluation Of The Functional Role Of The Maize Glossy2 And Glossy2-Like Genes In Cuticular Lipid Deposition, Liza Esther Alexander, Yozo Okazaki, Michael A. Schelling, Aeriel Davis, Xiaobin Zheng, Ludmila Rizhsky, Marna D. Yandeau-Nelson, Kazuki Saito, Basil J. Nikolau

Genetics, Development and Cell Biology Publications

Plant epidermal cells express unique molecular machinery that juxtapose the assembly of intracellular lipid components and the unique extracellular cuticular lipids that are unidirectionally secreted to plant surfaces. In maize (Zea mays L.), mutations at the glossy2 (gl2) locus affect the deposition of extracellular cuticular lipids. Sequence-based genome scanning identified a novel gl2 homolog in the maize genome, Gl2-like. Sequence homology identifies that both the Gl2-like and Gl2 genes are members of the BAHD superfamily of acyltransferases, with close sequence homology to the Arabidopsis CER2 gene. Transgenic experiments demonstrate that Gl2-like and Gl2 functionally complement the Arabidopsis cer2 mutation, with ...


Population Modeling Of Tumor Growth Curves And The Reduced Gompertz Model Improve Prediction Of The Age Of Experimental Tumors, Cristina Vaghi, Anne Rodallec, Raphaelle Fanciullin, Joseph Ciccolini, Jonathan P. Mochel, Michalis Mastri, Clair Poignard, John M. L. Ebos, Sebastien Benzekry Feb 2020

Population Modeling Of Tumor Growth Curves And The Reduced Gompertz Model Improve Prediction Of The Age Of Experimental Tumors, Cristina Vaghi, Anne Rodallec, Raphaelle Fanciullin, Joseph Ciccolini, Jonathan P. Mochel, Michalis Mastri, Clair Poignard, John M. L. Ebos, Sebastien Benzekry

Biomedical Sciences Publications

Tumor growth curves are classically modeled by means of ordinary differential equations. In analyzing the Gompertz model several studies have reported a striking correlation between the two parameters of the model, which could be used to reduce the dimensionality and improve predictive power. We analyzed tumor growth kinetics within the statistical framework of nonlinear mixed-effects (population approach). This allowed the simultaneous modeling of tumor dynamics and inter-animal variability. Experimental data comprised three animal models of breast and lung cancers, with 833 measurements in 94 animals. Candidate models of tumor growth included the exponential, logistic and Gompertz models. The exponential and ...


Comparison Of Productivity Losses Between Swine Breeding Herds Adopting Killed Or Attenuated Prrs Virus Vaccination Protocols Following Prrs Outbreaks, Gaurav Rawal, Christopher Rademacher, Daniel Linhares Feb 2020

Comparison Of Productivity Losses Between Swine Breeding Herds Adopting Killed Or Attenuated Prrs Virus Vaccination Protocols Following Prrs Outbreaks, Gaurav Rawal, Christopher Rademacher, Daniel Linhares

Veterinary Diagnostic and Production Animal Medicine Publications

Porcine reproductive and respiratory syndrome virus (PRRSv) has been endemic for more than 30 years in most pig producing countries across the globe, and is still one of the most economically important pathogens affecting swine. The use of modified live vaccines (MLV) on breeding herds has been reported by several investigators and is a common practice in the industry for the control of PRRSv. There is limited published information on efficacy of killed virus (KV) vaccines as part of PRRS control programs in breeding herds. Thus, the objective of this study was to describe productivity losses in breeding herds following ...


Transcriptome And Parasitome Analysis Of Beet Cyst Nematode Heterodera Schachtii, Abdelnaser M. Elashry, Samer S. Habash, Paramasivan Vijayapalani, Nahal Brocke-Ahmadinejad, Roman Blümel, Arun Seetharam, Heiko Schoof, Florian M. W. Grundler Feb 2020

Transcriptome And Parasitome Analysis Of Beet Cyst Nematode Heterodera Schachtii, Abdelnaser M. Elashry, Samer S. Habash, Paramasivan Vijayapalani, Nahal Brocke-Ahmadinejad, Roman Blümel, Arun Seetharam, Heiko Schoof, Florian M. W. Grundler

Office of Biotechnology Publications

Beet cyst nematodes depend on a set of secretory proteins (effectors) for the induction and maintenance of their syncytial feeding sites in plant roots. In order to understand the relationship between the beet cyst nematode H. schachtii and its host, identification of H. schachtii effectors is crucial and to this end, we sequenced a whole animal pre-infective J2-stage transcriptome in addition to pre- and post-infective J2 gland cell transcriptome using Next Generation Sequencing (NGS) and identified a subset of sequences representing putative effectors. Comparison between the transcriptome of H. schachtii and previously reported related cyst nematodes and root-knot nematodes revealed ...