Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Treatment Of Brain Tumors In Children Is Associated With Abnormal Mrs Ratios In Brain Tissue Remote From The Tumor Site., Sandra M. Waldrop, Patricia C. Davis, Carol A. Padgett, Marla B. Shapiro, Robin D. Morris
Treatment Of Brain Tumors In Children Is Associated With Abnormal Mrs Ratios In Brain Tissue Remote From The Tumor Site., Sandra M. Waldrop, Patricia C. Davis, Carol A. Padgett, Marla B. Shapiro, Robin D. Morris
Psychology Faculty Publications
PURPOSE: Children who have brain tumors are at risk for a variety of treatment-related sequelae, including neuropsychological and cognitive impairment, neurologic deficits, and neuroendocrinologic disturbances. We sought to determine the value of proton MR spectroscopy in assessing brain tissue remote from the tumor site to ascertain the effects of chemotherapy and radiation treatment in these patients.
METHODS: Single-voxel proton MR spectra from 70 patients (111 spectra) and 11 healthy volunteers (11 spectra) were analyzed. NAA/Cr, NAA/Cho, and Cho/Cr ratios based on peak areas were obtained from nonneoplastic regions of the frontal lobe. The relationship between MR spectroscopic ratios and treatment …