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Mechanical Strength Assessment Of Pharmaceutical Compacts With Refractive Index Measurements From Terahertz Time Of Flight Spectroscopy, Shikhar Mohan

Electronic Theses and Dissertations

The mechanical strength of pharmaceutical compacts is often considered as a critical quality attribute for roller and tablet compaction processes. Most traditional mechanical strength tests are destructive, thus, preventing further material testing. This thesis expands on the application of terahertz time of flight spectroscopy (THz-TOF) as a nondestructive technique for assessing mechanical strength. This technique is able to extract the refractive index; which is a function of porosity and crystallinity of the solid. Thus, it was hypothesized that refractive index measurements from terahertz time of flight spectroscopy are directly related to porosity; therefore, these nondestructive measurements are able to correlate …

Impact Of A Nicu Bedside Reading Initiative On Self-Reported Maternal Stress And Mother-Infant Attachment, Lauren Lorenzi Quigley

Electronic Theses and Dissertations

Premature birth and a corresponding hospitalization in the Neonatal Intensive Care Unit (NICU) presents infants and their families with an array of medical and psychosocial stressors that have the potential to impact neurodevelopment and social-emotional functioning in both the long-and short-term. Research has demonstrated the importance of family-integrated, developmental care interventions and a need for supportive environmental and sensory stimulation for the infant to optimize developmental, social, and emotional outcomes. Engaging parents in bedside care that fosters sensory development, supports cognitive and language skills, and lays a strong foundation for bonding and attachment can be monumental for the dyad. Implementation …

Trust In The Nurse And Perceived Quality Nursing Care By Adult Oncology Patients With Implantable Vascular Access Port Devices: A Mixed Methods Study, Lois Rajcan

Electronic Theses and Dissertations

Objective: The purpose of this study was to obtain an understanding of nurse behaviors that promote trust and quality nursing care as perceived by oncology patients with totally implantable vascular access devices (TIVAD).

Methods: An explanatory sequential mixed-method design was used to answer the study questions. This design was comprised of two phases: 1) a quantitative online survey of oncology patients with TIVADs followed by; 2) qualitative interviews using purposively selected patients from the survey sample.

Results: Trust in the nurse and perceived quality of nursing care by patients with TIVADs were determined to be of average levels. Two qualitative …

The Rhetoric Of Jimmy Carter: Renewing America’S Confidence In Civic Leadership Through Speech And Political Education, Christopher Bondi

Electronic Theses and Dissertations

July 15, 2019 marked the fortieth anniversary of President Jimmy Carter’s “Crisis of Confidence” speech, a catalyst for what became an often overlooked yet significant turning point in the nation’s history. Carter’s words were both poignant and pointed as he calmly, yet directly, addressed the nation’s dependence on fossil fuels and engagement in narcissistic practices that led to a coveting of material goods. In an examination of the events that shaped this historical moment, this dissertation contends that, despite President Carter’s attempt to steer America in a more environmentally and socially conscious direction, the nation instead acquiesced to Ronald Reagan’s …

Pharmacological Characterization Of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening, Michael Wasko

Electronic Theses and Dissertations

Depression is a mental health disorder affecting greater than 350 million people worldwide with roughly 7% of the United States population diagnosed as of 2017. The selective serotonin reuptake inhibitors (SSRIs) have been the mainstay of pharmacotherapies for depression for the last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic neurotransmission. The SSRIs are not perfect therapeutics and suffer from delayed response times, inconsistent efficacy among patients, and often produce intolerable side effects. Therefore, a strong need exists to develop new antidepressants that are more efficacious and have fewer adverse effects. …

Railspace: A Geocritical Study Of The Railroad Through American Literature And Culture, Michael A. Smith

Electronic Theses and Dissertations

This dissertation uses geocriticism to argue that the American railroad is best understood as a set of discursively constructed railspaces formed through a variety of viewpoints, a polysensorial awareness of space, and stratified social relationships and power struggles. This study takes up four railspaces, the constituent texts of which demonstrate how intertextual discourse shapes and is shaped by the railroad. The observation car, charted through California Zephyr advertisements and Muriel Rukeyser’s “Campaign,” is an apparatus that produces perpetual spectacle. Three novels—Sister Carrie by Theodore Dreiser, Double Indemnity by James M. Cain, and Strangers on a Train by Patricia Highsmith—and …

The Haven: A Clinical Ethnography Of A Farm-Based Therapeutic Community, Monica Lawson

Electronic Theses and Dissertations

Therapeutic communities are communal spaces where individuals live for an extended period in hopes of recovering from personal crises, or while coping with severe mental illness. They provide a humanistic alternative to inpatient hospitalization. Although they are seldom studied, even less is known about farm-based therapeutic communities in the United States, where communal work is viewed as central to recovery. This dissertation examines the experience of living and working at the Haven. Originally conceived as a farm-based community where suffering individuals could experience reprieve from the demands of the “working world,” and heal by living in community, recent changes in …

Melatonin-Tamoxifen Drug Conjugates As Breast Cancer Drugs: Pharmacological Evaluation In Phenotypically Diverse Breast Cancer Models And Pharmacokinetic Assessment In Liver Microsome And Female Mouse Models, Mahmud Hasan

Electronic Theses and Dissertations

Tamoxifen is a first-generation selective estrogen receptor modulator, which reduces the risk of both invasive and non-invasive breast cancer (BC) as well as tumor recurrence in several clinical trials. However, chronic use of tamoxifen can increase uterine cancer risk and induce tamoxifen resistance. In past studies, melatonin alone reversed tamoxifen resistance induced by light exposure at night in rodents. This study demonstrates that melatonin or melatonin-based ligands (e.g., melatonin-tamoxifen drug conjugates) may be novel BC therapies that are efficacious and free of side effects. To investigate this further, five melatonin-tamoxifen drug conjugates with different linker sizes were synthesized and screened …

Stakeholders' Perceptions Of Inherent Barriers To The Potential Implementation Of Ultrasound In The Prehospital Setting Between The Saudi Red Crescent Authority And The National Guard Hospital, Maher Alsulami

Electronic Theses and Dissertations

This exploratory study was designed to illuminate both the obstacles and the opportunities inherent in the current medical emergency systems within the kingdom of Saudi Arabia in relation to the possible inclusion of ultrasound machines to assist both Saudi Red Crescent Authority professionals and emergency physicians in the hospital. The research explored the issue of implementing the ultrasound from the perspective of multiple institutions: The Saudi Red Crescent Authority and the National Guard Hospital. The research explored multiple healthcare professionals within both organizations including paramedics, EMTs, emergency doctors, and Saudi Red Crescent station administrators.

The purpose of this qualitative method …

Examining The Intersectionality Of Religious Faith, Spirituality, And Healthcare Communication, Felix Okeke

Electronic Theses and Dissertations

This dissertation is my own contribution in responding to the concern raised by certain communication scholars. Their concern was that little research and few publications have been done in the communication field by communication scholars that trace the relationship among religious faith, spirituality, and healthcare communication. While Parrott (2004) describes this apparent neglect as “collective amnesia,” others label it “religion blindness.” Thus, in trying to trace this relationship, this project uses Christian, biblical, and bioethics backgrounds to establish the value, sacredness, and dignity of human life, since these concepts make healthcare and healthcare communication necessary in the first place. These …

The Lived Experiences Of Males Within A Committed Relationship Who Are The Primary Caregivers For A Partner Diagnosed With Frontotemporal Dementia, Aniela Scanlon

Electronic Theses and Dissertations

ABSTRACT

THE LIVED EXPERIENCES OF MALES WITHIN A COMMITTED RELATIONSHIP WHO ARE THE PRIMARY CAREGIVERS FOR A PARTNER DIAGNOSED WITH FRONTOTEMPORAL DEMENTIA

By

Aniela Kathryn Scanlon

August 2020

Dissertation supervised by Dr. David Delmonico

Spouses who are caregivers for their partner with dementia experience significant changes within the relationship and in their daily lives. There is a focus in the extant literature on female caregivers and types of dementia that are more mainstream, like Alzheimer’s disease. However, little is known about the lived experiences of male primary caregivers for a spouse or partner diagnosed with dementia such as frontotemporal dementia. …

An Investigation Of Postsecondary Centers For Teaching Excellence Support For Universal Design For Learning, David Mcgeehan

Electronic Theses and Dissertations

The research examined factors related to support for Universal Design for Learning (UDL) in faculty professional development training programs offered by Centers for Teaching Excellence (CTE) in postsecondary institutions. The factors examined were: administrative support, staffing for CTEs, CTE staff characteristics, CTE level of use of technology, CTE directors’ educational backgrounds, and the espoused support for students with disabilities in university mission statements.

Universal Design for Learning is a pedagogical framework that can be used to design and retrofit curricula to reduce access barriers to course content and activities for all students, particularly students with disabilities. Students with disabilities is …

Effectiveness Of An Interdependent Group Contingency With Randomization Using The Ipad, Chelsea Gyke

Electronic Theses and Dissertations

Classroom management, although considered one of the essentials of the optimal learning experience, is often a challenge for teachers. Certain classroom management strategies, such as group contingency interventions and token economies, are evidence-based strategies to aid teachers in gaining successful management of the classroom. The utilization of Class Dojo, a popular classroom management website, as a mechanism to implement an interdependent group contingency (IGC) intervention with randomized components may increase both the effectiveness of the intervention and the social validity of the intervention when compared to a manual implementation.

Participants included students in an elementary school self-contained special education classroom …

Antiparasitic Peptide From The Ocean: Discovery, Synthesis And Structure-Activity Relationship Study, Kh Tanvir Ahmed

Electronic Theses and Dissertations

Millions of people die every year because of infectious diseases, and malaria is among the top five of the deadliest infectious disease. In 2018, malaria took more than four hundred thousand lives, and more than half of them are children under five years of age. Most malaria-affected parts of the world are also the home of the most underprivileged people. Seemingly, antimalarial drug discovery never achieved the attraction that it requires. Like malaria, another infectious disease that is not extensively explored by drug discovery campaigns is American trypanosomiasis or Chagas disease. More than a hundred years have passed since discovering …

Investigating Teachers’ Perspectives Of Gifted Students With Specific Learning Disabilities In Saudi Arabia, Mohamed Aladsani

Electronic Theses and Dissertations

The purpose of this study was to examine teachers’ perspectives of gifted students with SLD in Saudi Arabia. Specifically, this study aimed at examining the relationships between teachers’ perspectives and background factors, including years of teaching experience and gender, that might affect the teachers’ perspectives. In addition, it investigated the teachers’ perspectives about the existence, identification, and education of gifted students with SLD in different regions in Saudi Arabia. This study used statistical analysis of quantitative data collected from an online survey that was adopted and modified specifically for this study. The study participants included 936 teachers with various backgrounds …

Retrospective Cohort Study Of Patients With Chronic Low Back Pain In An Outpatient Pain Specialist Clinic, Gauri Desai

Electronic Theses and Dissertations

Background: Chronic low back pain (LBP) is a back pain that lasts for three or more than three months in the lumbar region of the spinal cord. A nerve injury or damage in the spinal cord region (neuropathic pain) requires multimodal treatment approach for pain reduction. With various treatment options utilized in the pain management of these patients, identifying demographical and clinical characteristics of patients with chronic LBP utilizing interventional procedures and pharmacologic treatments is imperative.

Objective: (i) To describe the demographics (age, gender, race, ethnicity, smoking status, alcohol consumption status, drug use status) and clinical characteristics (procedures, medications) …

Design And Synthesis Of Pyrimidine Based Fused Heterocyclics In The Potential Treatment Of Cancer And Opportunistic Infection, Farhana Islam

Electronic Theses and Dissertations

Dose-limiting toxicities of clinically used agents and development of resistance are two significant limitations in cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Combination chemotherapy with antiangiogenic agents and microtubule targeting agents has shown an advantage against both these drawbacks. Single agents with dual antiangiogenic activity and cytotoxicity would afford a therapy that circumvents pharmacokinetic problems of multiple agents, avoid drug-drug interactions, lower the drug dose, decrease overlapping toxicities, and delay or prevent tumor cell resistance. The work in this dissertation reflects the progress of fused …

A Catholic Ethic For Smartphones In Tanzania, Faustine Tarimo

Electronic Theses and Dissertations

This project is a synthesis of Church documents and papal encyclicals to form a Catholic ethic for the smartphone use in Tanzania. The research question for this project is how a Catholic communication ethic shapes the use of smartphones for human communication in Tanzania. The problem I want to address is the perceived danger of losing connectivity or ‘real’ face-to-face encounters between people in “let’s talk culture” in Tanzania. The goal of this project is to appreciate the use of smartphones, at the same time to attend to a Catholic ethic to integrate into a “let’s talk culture” some digital …

Subjects Of Economy: Social Documentary Poetics And Contemporary Poetry Of Work, Michelle B. Gaffey

Electronic Theses and Dissertations

Although the term “documentary” originated in film and photography studies, it has been used to describe a range of compositional and research strategies in discussions of twentieth and twenty-first century poetry as well. A study of such documentary poetics, however, requires us to distinguish between documentary poetics in general and social documentary poetics in particular. To illustrate this distinction, I discuss five contemporary books of poetry and photographs: C.D. Wright’s and Deborah Luster’s One Big Self: Prisoners of Louisiana, Cynthia Hogue’s and Rebecca Ross’s When the Water Came: Evacuees of Hurricane Katrina, Chris Llewellyn’s Fragments from the Fire: …

“That Those Hearing Or Reading Might Strive To Imitate”: Donative Intent, Positive Triangular Mimetic Desire, And The Portrayal Of The Mediator-Divine (Non)Object Relationship In Richard Rolle, Julian Of Norwich, And Richard Crashaw, Steven Geitgey

Electronic Theses and Dissertations

Mystical texts often present themselves as possessing a “donative” intent, in which the writer aims to share the significance of their own experience. This dissertation will show how a consideration of donative intent and its textual results can enrich the study of medieval and early-modern mystical writings, approaching them from the broad concept of triangular mimetic desire in conjunction with other theoretical insights in order to examine the methods through which writers seek to portray their mediator-object relationship with God and inspire reading subjects’ mimetic desire.

I will elucidate Richard Rolle’s portrayal of his mediatorial purpose and unique experiences, and …

Identifying The Effects Naturally Forming Bacterial Communities Have On The Efficiency Of Passive Remediation Systems Built To Treat Abandoned Coal Mine Drainage, Michelle M. Valkanas

Electronic Theses and Dissertations

Abandoned mine drainage (AMD) has resulted in worldwide devastation. Passive remediation systems (PRS) are a cost-effective option to treat AMD. While the geochemistry (abiotic) of these systems is well understood, little work has been done to characterize the microbial communities (biotic) that naturally form within these systems. The goal of this dissertation was to identify the effects that bacterial communities have on the efficiency of PRSs. Four passive remediation sites built to treat coal mine drainage were studied: two that treat acidic discharges (Boyce and Middle Branch) and two that treat circumneutral discharges (Wingfield Pines and Lowber). Survey studies suggested …

Atom Transfer Radical Processes: From Catalyst Design To Polymer Synthesis, Characterization, And Application, Michael Novak

Electronic Theses and Dissertations

Due to the toxicity of heavy metals and their prevalence in the environment there exists a need to develop highly active transition metal catalysts ultimately reducing the amount needed for chemical transformations. Additionally, there is interest in the scientific community for creating new materials that can remove these pollutants from industrial wastewater prior to its release into the environment. The work presented here focuses on the reduction and removal of heavy metals from industrial hazardous waste by designing novel highly active catalysts and developing polymeric adsorbents.

Highly active catalyst complexes consisting of novel hybrid ligands, 2-(dimethylamino)ethyl-bis-[2-(pyridylmethyl)amine] (M1-T2), and bis[2-(dimethylamino)ethyl]-2-(pyridylmethyl)amine (M2-T1), …

Rna Structure And Function: Biological Relevance In Neurodegenerative And Infectious Disease Pathogenesis, Joshua Imperatore

Electronic Theses and Dissertations

The studies outlined in this dissertation encompass a broad focus, relating to the pathogenesis of neurological disorders such as Alzheimer’s disease, fragile X syndrome, and amyotrophic lateral sclerosis, as well as a novel infectious disease, COVID-19. However, all four studies detailed within this dissertation contain similar elements, namely, the coordinated role of RNA structure and function in essential molecular mechanisms. The results of these investigations allow us to speculate on various disease- related mechanisms, including dysregulated microRNA processing pathways, nucleocytoplasmic shuttling via distinct RNA-protein interactions, and fine-tuned molecular switches controlling genomic dimerization and viral hijacking of host cellular microRNAs. Taken …

Fluoride Removal With Augmented Bentonite In Drinking Water And Community Perceptions In Arusha, Tanzania, Kara Okular

Electronic Theses and Dissertations

High fluoride concentrations in drinking water affect millions of people around the world. The World Health Organization recommended a fluoride concentration in drinking water of ≤ 1.5 mg/L; fluoride above this concentration can cause long-term dental and skeletal fluorosis. Fluoride imparts no taste to water; therefore, people do not realize that they are ingesting high fluoridated water. Researchers sought to develop a material to remove fluoride from drinking water through sorption. Aluminum was used to form a double ionic layer on the bentonite clay surface. Once mixed in contaminated water, a coagulant, ferric sulfate, was used to separate the bentonite …

Functionalized Materials From Atom Transfer Radical Processes, Sean Fischer

Electronic Theses and Dissertations

This work is focused on the synthesis, characterization, and application of functionalized materials prepared from atom transfer radical processes. Atom transfer radical processes encompass both atom transfer radical addition (ATRA) and polymerization (ATRP) reactions, both of which are catalyzed by ppm amounts of copper complexes. The synthetic efforts of ATRA include increasing adduct selectivity through optimization of reaction conditions to generate small molecules in high to moderate yields. ATRA provides retention of the halogen moiety, which is an attractive functional group that can be further modified with other transformations. Specifically, the copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) allows for the realization …

Accurate Quantitation Of Hexavalent Chromium For Reference Standard Certification And Quality Control Testing Using Speciated Isotope Dilution Mass Spectrometry, James E. Henderson

Electronic Theses and Dissertations

The ability to perform accurate, repeatable, and defensible elemental and molecular speciated analysis is immensely significant for measurements that support human health, environmental science, and industry. This is especially true since trivalent chromium [Cr(III)] is necessary for proper nutrition, while hexavalent chromium [Cr(VI)] is extremely toxic, genotoxic, and carcinogenic. The main challenges associated with speciated analysis are related to reactive species that are continuously transformed or converted to other species during sample processing. Accurate determination of Cr(III) and Cr(VI) species require a method that is capable of monitoring and correcting for interconversion, bias, and instrumental error. Traditional quantitative methods, such …

The Ethical Accountability Of Organizational Leadership To Communities Of Stakeholders In Healthcare, Lisa Martinelli

Electronic Theses and Dissertations

ABSTRACT

THE ETHICAL ACCOUNTABILITY OF ORGANIZATIONAL LEADERSHIP TO COMMUNITIES OF STAKEHOLDERS IN HEALTHCARE

By

Lisa A. Martinelli, JD, MA

October 2020

Dissertation supervised by Professor Gerard Magill

While much is written on organizational ethics in healthcare, this dissertation uniquely links organizational ethics and stakeholder theory to the ethical accountability of leadership to their distinct, vulnerable stakeholder communities. It does so by examining the healthcare organization’s moral agency in relation to stakeholder theory and applies those considerations to three major stakeholder categories: confidentiality and privacy of healthcare information, research and attention to specific pediatric populations, and ethics of care concerning the …

Control Of Corrosion On Ss316l Using Surface Initiated Polymers, Alexander Rupprecht

Electronic Theses and Dissertations

Pitting corrosion is arguably one of the most destructive and dangerous forms of corrosion, resulting in damage to structures, the environment, and public health. In addition, damage caused to structures such as bridges, pipelines, and boats, corrosion also has a profound effect on the biomedical community. Implanted metallic devices (i.e., vascular stents and artificial joints) are prone to pitting corrosion caused by aggressive ions present in extracellular fluid. To provide a corrosion-resistant surface on SS316L, films of poly(styrene), poly(methyl acrylate), and poly(methyl methacrylate) were formed using surface-initiated atom transfer radical polymerization (SI-ATRP). The resulting hydrophobic polymer films had a fractional …

The Ethical Challenge For Hipaa’S Privacy Rule In The Genomics Era Of Data Analytics., Reem Shinawi

Electronic Theses and Dissertations

The thesis of this dissertation focuses on the Ethical Challenge for HIPAA’s Privacy Rule in the Genomics Era of Data Analytics. Data Analytics in Genomic Medicine challenges the individuals’ right to privacy. Hence, a balance is needed between the previous centrality of individual privacy and the need for population information to make breakthroughs in Genomic Medicine using Data Analytics. Such a problem demands regulatory solutions. And such solutions require the collaboration of professionals. Genomic Medicine is a field that deals with sensitive genetic information in both medicine, and research, it is essential to view it through HIPAA as it is …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …